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depletion induces phosphorylation of the microtubule-associated GEF-H1 on Ser886, and thereby promotes RhoA activity and actin stress fiber assembly.
human brain malformation is recapitulated in Arhgef2 (show ARHGEF2 Proteins) mutant mice and identify an aberrant migration of distinct components of the precerebellar system as a pathomechanism underlying the midbrain-hindbrain phenotype. Our results highlight the crucial function of ARHGEF2 (show ARHGEF2 Proteins) in human brain development and identify a mutation in ARHGEF2 (show ARHGEF2 Proteins) as novel cause of a neurodevelopmental disorder.
Overexpression of miR (show MLXIP Proteins)-194 downregulates the GEF-H1 (show ARHGEF2 Proteins)/RhoA (show RHOA Proteins) pathway, inhibits melanoma cancer cell proliferation and metastasis. Furthermore, miR (show MLXIP Proteins)-194 expression is negatively associated with tumor-node-metastasis (TNM (show ODZ1 Proteins)) stages
data suggest that the induction of SGK1 (show SGK1 Proteins) through treatment with dexamethasone alters MT dynamics to increase Sec5-GEF-H1 (show ARHGEF2 Proteins) interactions, which promote GEF-H1 (show ARHGEF2 Proteins) targeting to adhesion sites.
this study reports the crystal structure of human GEF-H1 (show ARHGEF2 Proteins) PH domain to 2.45 A resolution.
By stimulating cofilin (show CFL1 Proteins)/PP2A (show PPP2R4 Proteins)-mediated dephosphorylation of the guanine nucleotide exchange factor (show RASGRF1 Proteins) GEF-H1 (show ARHGEF2 Proteins).
regulation of c-Src trafficking requires both microtubules and actin polymerization, and GEF-H1 coordinates c-Src trafficking, acting as a molecular switch between these two mechanisms
Results supported that miR-512-3p could inhibit tumor cell adhesion, migration, and invasion by regulating the RAC1 activity via DOCK3 in NSCLC A549 and H1299 cell lines.
Data indicate that forchlorfenuron (FCF) exhibits differential binding preference for septins SEPT2 (show SEPT2 Proteins) and SEPT3.
TGF-beta (show TGFB1 Proteins) regulates LARG (show ARHGEF12 Proteins) and GEF-H1 (show ARHGEF2 Proteins) during epithelial-mesenchymal transition to affect stiffening response to force and cell invasion.
Sept3 is dispensable for normal neuronal development
SEPT3 and SEPT5 (show SEPT5 Proteins) are dispensable for neuronal development as well as for synaptic vesicle fusion and recycling.
This gene belongs to the septin family of GTPases. Members of this family are required for cytokinesis. Expression is upregulated by retinoic acid in a human teratocarcinoma cell line. The specific function of this gene has not been determined. Alternative splicing of this gene results in two transcript variants encoding different isoforms.
, septin 12
, putative septin 3 variant 1
, neuronal-specific septin-3-like
, Rho/Rac guanine nucleotide exchange factor 2
, guanine nucleotide exchange factor H1
, microtubule-regulated Rho-GEF
, proliferating cell nucleolar antigen p40
, rho guanine nucleotide exchange factor 2
, neuronal-specific septin 3
, neuronal-specific septin-3
, G-septin alpha
, ANT2-binding protein
, solute carrier family 35 member F6
, transmembrane protein C2orf18 homolog
, transport and Golgi organization 9 homolog