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Review/Meta-analysis: GSTM1 null genotype is a low-penetrant risk factor for developing breast cancer in the Chinese population.
the presence of a GSTM1 *null and GSTT1 (show GSTT1 Proteins) *null alleles were independent predictors for COPD (show ARCN1 Proteins) in females.
Our meta-analysis revealed strong association of rs1048943 in CYP1A1 (show CYP1A1 Proteins), but a suggestive association of deletion polymorphisms in GSTT1 (show GSTT1 Proteins) and GSTM1 with lung cancer, which provides a comprehensive insight on the overall effect of the polymorphic variants, reported in various case-control studies on Indian population, on the risk of lung cancer development
The selective effect of PEITC on detoxification in subjects lacking both GSTM1 and GSTT1 (show GSTT1 Proteins) genes supports the epidemiologic findings of stronger protection by dietary isothiocyanates against the development of lung cancer in such individuals
Polymorphisms of GSTM1 is associated with lung cancer.
The loss of GSTM1 was significantly associated with incident kidney and heart failure, independent of traditional risk factors. These results suggest GSTM1 function is a potential treatment target for the prevention of kidney and heart failure
results suggest that combined deletion polymorphisms of GSTT1 (show GSTT1 Proteins) and GSTM1 can have implications in the prediction of the clinical course of the disease
On comparing the prevalence of GSTM1 null polymorphism among the group with subjects with tobacco habits and no oral lesions, oral leukoplakia, and oral squamous cell carcinoma, it was observed that there was a statistically significant association between GSTM1 null polymorphism and the different groups (P < 0.01).
The present case-control study found that GSTM1 and GSTT1 (show GSTT1 Proteins) polymorphism are not associated with JOAG (show MYOC Proteins) risk in North Indian population. The present meta-analysis suggested that there might be a significant association of GSTM1 null genotype with glaucoma (JOAG (show MYOC Proteins) & POAG) risk.
Pesticide-exposed individuals with inherited susceptible metabolic genotypes (particularly, null genotype for GSTM1 and the PON1 (show PON1 Proteins) 192R allele) appear to have an increased risk of genotoxic DNA damage.
Six proteins were regulated at both basal and inducible levels exhibiting the largest dynamic range of Nrf2 (show NFE2L2 Proteins) regulation: cytochrome CYP2A5, GSTM3 (show glutathione S-transferase mu 3 (brain) Proteins), GSTM1, ENTPD5 (show ENTPD5 Proteins),UDPGDH (show UGDH Proteins), and EPHX1 (show EPHX1 Proteins).
mitochondrial Gstb1 is induced under oxidative stress
the gene (GSTM1) encoding the detoxification enzyme glutathione S-transferase M1 is transcriptionally upregulated by Myb (show MYB Proteins)
The Gstm1 gene was represented by two EST (show MAP3K8 Proteins) clones with similar levels of downregulation.
We overexpressed Hoxa9 (show HOXA9 Proteins) and Meis1 (show MEIS1 Proteins) in primary hematopoietic cells. Arrays identified c-Myb (show MYB Proteins) and a c-Myb (show MYB Proteins) target (Gstm1) among the genes with the strongest response to Hoxa9 (show HOXA9 Proteins)/Meis1 (show MEIS1 Proteins).
Genetic variants that cause a decremental change in expression of Gstm1 may permit an environment of exaggerated oxidative stress, leading to susceptibility to vascular remodeling and atherosclerosis
The role of polymorphisms of glutathione S-transferases GSTM1, M3, P1, T1 and A1 in susceptibility to alcoholic liver disease. In addition, oxidant stress is proposed to be an important pathogenic factor in liver damage related to alcohol.
Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-transferase that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13.3 and are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs. Null mutations of this class mu gene have been linked with an increase in a number of cancers, likely due to an increased susceptibility to environmental toxins and carcinogens. Multiple protein isoforms are encoded by transcript variants of this gene.
GST HB subunit 4
, GST class-mu 1
, HB subunit 4
, S-(hydroxyalkyl)glutathione lyase
, glutathione S-alkyltransferase
, glutathione S-aralkyltransferase
, glutathione S-aryltransferase
, glutathione S-transferase M1
, glutathione S-transferase Mu 1
, GST 3-3
, GST Yb1
, glutathione S-transferase Yb-1 subunit
, glutathione-S-transferase mu type 1 (Yb1)
, glutathione-S-transferase, mu type 1 (Yb1)
, glutathione S-transferase M4
, glutathione S-transferase mu 4
, GST 1-1
, glutathione S-transferase GT8.7
, glutathione-S-transferase, mu 1
, glutathione S-transferase mu 1
, glutathione S-transferase mu 2
, glutathione S-transferase, mu 2