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During vest (show BCR Proteins)ibular morphogenesis, Abr and Bcr play complementary roles. Small Rho-related GTPases like Abr and Bcr are important for balance and motor coordination.
Loss of abr expression causes defects in spine development.
These results identify Abr-regulated CD4 (show CD4 Proteins)(+) T cell migration as an important component of severe cockroach allergen-evoked allergic asthma in mice.
Bcr and Abr play a critical role in down-regulating hypoxia-induced pulmonary hypertension by deactivating Rac1.
Abr and Bcr (show BCR Proteins) play important complementary roles during vestibular morphogenesis
These results identify Abr and Bcr (show BCR Proteins) as the only GTPase (show RACGAP1 Proteins)-activating proteins to date that specifically negatively regulate Rac (show AKT1 Proteins) function in vivo in primary macrophages.
These data show that Abr and Bcr (show BCR Proteins) normally curb very specific functions of mature tissue innate immune cells.
This gene encodes a protein that is similar to the protein encoded by the breakpoint cluster region gene located on chromosome 22. The protein encoded by this gene contains a GTPase-activating protein domain, a domain found in members of the Rho family of GTP-binding proteins. Functional studies in mice determined that this protein plays a role in vestibular morphogenesis. Alternatively spliced transcript variants have been reported for this gene.
active breakpoint cluster region-related protein