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Browse our ECT2 Proteins (ECT2)

Full name:
Epithelial Cell Transforming Sequence 2 Oncogene Proteins (ECT2)
On are 4 Epithelial Cell Transforming Sequence 2 Oncogene (ECT2) Proteins from 3 different suppliers available. Additionally we are shipping ECT2 Antibodies (89) and many more products for this protein. A total of 100 ECT2 products are currently listed.
AI528536, ARHGEF31, ect2, mKIAA4037, xect2
list all proteins Gene Name GeneID UniProt
ECT2 13605 Q07139
ECT2 1894 Q9H8V3
Rat ECT2 ECT2 361921  

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ECT2 Proteins (ECT2) by Origin

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More Proteins for ECT2 Interaction Partners

Mouse (Murine) Epithelial Cell Transforming Sequence 2 Oncogene (ECT2) interaction partners

  1. It was shown that the guanine exchange factors GEF-H1 (show ARHGEF2 Proteins) and ECT2 must be downregulated for megakaryote polyploidization. The first (2N-4N) endomitotic cycle requires GEF-H1 (show ARHGEF2 Proteins) downregulation, whereas subsequent cycles (>4N) require ECT2 downregulation.

  2. Ect2 may play a role in neuronal differentiation and brain development in vivo.

  3. results demonstrate the functional role of Ect2 in postnatal proliferating cells in the two lobes of the pituitary, thereby suggesting roles in developmental growth of the mammalian pituitary

  4. indispensable role of the maturation-promoting factor ECT2 pathwy in polar body extrusion in mouse oocytes

  5. ECT2 has a role in activating the Rho signaling pathways leading to malignant transformation

Human Epithelial Cell Transforming Sequence 2 Oncogene (ECT2) interaction partners

  1. Colorectal cancer patients with high expression levels of ECT2 had shorter overall survival.

  2. ECT2 can crosstalk with RACGAP1 (show RACGAP1 Proteins) to catalyse the GTP (show AK3 Proteins) exchange involved in Rho signalling to further regulate tumour initiation and metastasis.

  3. Up-regulation of ECT2 might contribute to the progression of gastric carcinogenesis and may be a useful prognostic indicator in gastric cancer.

  4. Poly(ADP-ribosyl)ation is recognized by ECT2.

  5. central spindle assembly and 2 Plk1-dependent phosphorylations are required to establish efficient binding of the Ect2 BRCT in early cytokinesis.

  6. ECT2 expression is positively correlated with WHO pathologic grading and unfavorable survival, suggesting that ECT2 may be a potential therapeutic candidate in human gliomas.

  7. structure of triple-BRCT-domain of ECT2 and insights into the binding characteristics to CYK-4 (show KRT4 Proteins)

  8. the deregulation of miR (show MLXIP Proteins)-223 and its target gene ECT2 may be associated with the aggressive tumor progression of human osteosarcoma

  9. Abnormality of the ECT2 gene occurs at a relatively early stage of lung adenocarcinogenesis and would be applicable as a new biomarker for prognostication of patients with lung adenocarcinoma

  10. Both Pbl and ECT2 repress Wg/Wnt target gene expression in cultured Drosophila and human cells.

ECT2 Protein Profile

Protein Summary

The protein encoded by this gene is a guanine nucleotide exchange factor and transforming protein that is related to Rho-specific exchange factors and yeast cell cycle regulators. The expression of this gene is elevated with the onset of DNA synthesis and remains elevated during G2 and M phases. In situ hybridization analysis showed that expression is at a high level in cells undergoing mitosis in regenerating liver. Thus, this protein is expressed in a cell cycle-dependent manner during liver regeneration, and is thought to have an important role in the regulation of cytokinesis. Several transcript variants encoding two different isoforms have been found for this gene.

Alternative names and synonyms associated with ECT2

  • epithelial cell transforming sequence 2 oncogene (ECT2)
  • epithelial cell transforming sequence 2 oncogene (ect2)
  • ect2 oncogene (Ect2)
  • epithelial cell transforming sequence 2 oncogene (Ect2)
  • AI528536 protein
  • ARHGEF31 protein
  • ect2 protein
  • mKIAA4037 protein
  • xect2 protein

Protein level used designations for ECT2

epithelial cell transforming sequence 2 oncogene , protein ECT2-like , epithelial cell-transforming sequence 2 oncogene , protein ECT2 , epithelial cell transforming sequence 2 oncogene protein , ect2 oncogene

694056 Macaca mulatta
100057917 Equus caballus
100127840 Xenopus (Silurana) tropicalis
100444808 Pongo abelii
100463827 Ailuropoda melanoleuca
100547586 Meleagris gallopavo
100566020 Anolis carolinensis
100581423 Nomascus leucogenys
13605 Mus musculus
1894 Homo sapiens
445406 Danio rerio
495132 Xenopus laevis
424983 Gallus gallus
504746 Bos taurus
361921 Rattus norvegicus
460853 Pan troglodytes
488172 Canis lupus familiaris
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