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It was shown that the guanine exchange factors GEF-H1 (show ARHGEF2 Proteins) and ECT2 must be downregulated for megakaryote polyploidization. The first (2N-4N) endomitotic cycle requires GEF-H1 (show ARHGEF2 Proteins) downregulation, whereas subsequent cycles (>4N) require ECT2 downregulation.
Ect2 may play a role in neuronal differentiation and brain development in vivo.
results demonstrate the functional role of Ect2 in postnatal proliferating cells in the two lobes of the pituitary, thereby suggesting roles in developmental growth of the mammalian pituitary
indispensable role of the maturation-promoting factor ECT2 pathwy in polar body extrusion in mouse oocytes
ECT2 has a role in activating the Rho signaling pathways leading to malignant transformation
Colorectal cancer patients with high expression levels of ECT2 had shorter overall survival.
ECT2 can crosstalk with RACGAP1 (show RACGAP1 Proteins) to catalyse the GTP (show AK3 Proteins) exchange involved in Rho signalling to further regulate tumour initiation and metastasis.
Up-regulation of ECT2 might contribute to the progression of gastric carcinogenesis and may be a useful prognostic indicator in gastric cancer.
Poly(ADP-ribosyl)ation is recognized by ECT2.
central spindle assembly and 2 Plk1-dependent phosphorylations are required to establish efficient binding of the Ect2 BRCT in early cytokinesis.
ECT2 expression is positively correlated with WHO pathologic grading and unfavorable survival, suggesting that ECT2 may be a potential therapeutic candidate in human gliomas.
structure of triple-BRCT-domain of ECT2 and insights into the binding characteristics to CYK-4 (show KRT4 Proteins)
the deregulation of miR (show MLXIP Proteins)-223 and its target gene ECT2 may be associated with the aggressive tumor progression of human osteosarcoma
Abnormality of the ECT2 gene occurs at a relatively early stage of lung adenocarcinogenesis and would be applicable as a new biomarker for prognostication of patients with lung adenocarcinoma
Both Pbl and ECT2 repress Wg/Wnt target gene expression in cultured Drosophila and human cells.
The protein encoded by this gene is a guanine nucleotide exchange factor and transforming protein that is related to Rho-specific exchange factors and yeast cell cycle regulators. The expression of this gene is elevated with the onset of DNA synthesis and remains elevated during G2 and M phases. In situ hybridization analysis showed that expression is at a high level in cells undergoing mitosis in regenerating liver. Thus, this protein is expressed in a cell cycle-dependent manner during liver regeneration, and is thought to have an important role in the regulation of cytokinesis. Several transcript variants encoding two different isoforms have been found for this gene.
epithelial cell transforming sequence 2 oncogene
, protein ECT2-like
, epithelial cell-transforming sequence 2 oncogene
, protein ECT2
, epithelial cell transforming sequence 2 oncogene protein
, ect2 oncogene