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Human Polyclonal HDAC1 Primary Antibody for ChIP, ICC - ABIN4316728
Fischle, Emiliani, Hendzel, Nagase, Nomura, Voelter, Verdin: A new family of human histone deacetylases related to Saccharomyces cerevisiae HDA1p. in The Journal of biological chemistry 1999
Show all 12 Pubmed References
Human Polyclonal HDAC1 Primary Antibody for IHC, IHC (fro) - ABIN4316727
Wilting, Yanover, Heideman, Jacobs, Horner, van der Torre, DePinho, Dannenberg: Overlapping functions of Hdac1 and Hdac2 in cell cycle regulation and haematopoiesis. in The EMBO journal 2010
Show all 9 Pubmed References
Human Polyclonal HDAC1 Primary Antibody for WB - ABIN1881405
Yang, Zhou, Wu, Xie, Zhang, Zheng: Combination of polymorphisms within the HDAC1 and HDAC3 gene predict tumor recurrence in hepatocellular carcinoma patients that have undergone transplant therapy. in Clinical chemistry and laboratory medicine : CCLM / FESCC 2010
Show all 5 Pubmed References
Human Monoclonal HDAC1 Primary Antibody for ChIP, ICC - ABIN2668767
Lagger, OCarroll, Rembold, Khier, Tischler, Weitzer, Schuettengruber, Hauser, Brunmeir, Jenuwein, Seiser: Essential function of histone deacetylase 1 in proliferation control and CDK inhibitor repression. in The EMBO journal 2002
Show all 4 Pubmed References
Human Monoclonal HDAC1 Primary Antibody for WB - ABIN1882195
Furukawa, Kawakami, Sudo, Inazawa, Matsumine, Akiyama, Nakamura: Isolation and mapping of a human gene (RPD3L1) that is homologous to RPD3, a transcription factor in Saccharomyces cerevisiae. in Cytogenetics and cell genetics 1996
Show all 5 Pubmed References
Human Polyclonal HDAC1 Primary Antibody for IP, IHC - ABIN223295
Cao, Li, Zhu, Shen, Han, Zhang, Yu, Wang, Wu, Chen, Sun, Tang, Zhao, Qiao, Hou, Mao: The antiparasitic clioquinol induces apoptosis in leukemia and myeloma cells by inhibiting histone deacetylase activity. in The Journal of biological chemistry 2013
Show all 2 Pubmed References
Human Polyclonal HDAC1 Primary Antibody for IF, WB - ABIN387945
Di Padova, Bruno, De Nicola, Iezzi, DAngelo, Gallo, Nicosia, Corbi, Biroccio, Floridi, Passananti, Fanciulli: Che-1 arrests human colon carcinoma cell proliferation by displacing HDAC1 from the p21WAF1/CIP1 promoter. in The Journal of biological chemistry 2003
Show all 4 Pubmed References
Human Polyclonal HDAC1 Primary Antibody for ChIPSeq, ChIP - ABIN2668768
Xiong, Svingen, Sarmento, Smyrk, Dave, Khanna, Lomberk, Urrutia, Faubion: Differential coupling of KLF10 to Sin3-HDAC and PCAF regulates the inducibility of the FOXP3 gene. in American journal of physiology. Regulatory, integrative and comparative physiology 2014
Human Polyclonal HDAC1 Primary Antibody for ELISA, ICC - ABIN4316730
Sirchia, Faversani, Rovina, Russo, Paganini, Savi, Augello, Rosso, Del Gobbo, Tabano, Bosari, Miozzo: Epigenetic effects of chromatin remodeling agents on organotypic cultures. in Epigenomics 2016
Human Polyclonal HDAC1 Primary Antibody for ChIP, ELISA - ABIN4316734
Miyatani, Kurita, Mikami, Kashihara, Higashijima, Yoshikawa, Nishioka, Sato, Iwata, Shimada: Malignant potential of Barrett's esophagus: special reference to HDAC-1 and MTA-1 expression. in Hepato-gastroenterology 2011
Treatment of the haplotype Npr1 (show NPR1 Antibodies)(+/-) mice with histone deacetylase inhibitors significantly lowered blood pressure and reduced the renal inflammation and fibrosis involving the interactive roles of HDAC1/2, NF-kappaB (show NFKB1 Antibodies) (p65 (show NFkBP65 Antibodies)), and STAT1 (show STAT1 Antibodies).
Acetylation-dependent control of global poly(A) RNA degradation by CBP/p300 (show CREBBP Antibodies) and HDAC1-HDAC2 has been described.
Here, we use transgenic lines to define the in vivo relevance of HDAC1 and identify calcineurin-dependent serine dephosphorylation as the signal modulating the neurotoxic role of HDAC1 in response to neurotoxic stimuli.
In line with the acetyltransferase activity of p300 (show NOTCH1 Antibodies), H3K27 acetylation was reduced after HDACi and resulted in the formation of heterochromatin in the PTGES1 gene. In conclusion, HDAC (show HDAC3 Antibodies) activity maintains PTGES1 expression by recruiting p300 (show NOTCH1 Antibodies) to its gene
provide new insight into the upstream regulation of Sap90/Psd95 (show DLG4 Antibodies)-associated protein 3 (show HSPB3 Antibodies) and establish the essential role of striatal Hdac1, Hdac2 (show HDAC2 Antibodies) and MeCP2 for suppression of repetitive behaviors
Taken together, Fam60a is an essential core subunit of a variant Sin3a (show SIN3A Antibodies)-Hdac (show HDAC3 Antibodies) complex in embryonic stem cells that is required to promote rapid proliferation and prevent unscheduled differentiation.
HDAC1 may be an essential epigenetic regulator of the transition from progenitor cells to terminally differentiated photoreceptors
Knockdown of HDAC1 recovered Bdnf (show BDNF Antibodies) and Pvalb (show PVALB Antibodies) gene transcription and also prevented the decrease of inhibitory synapses accompanying whisker deprivation
HDAC1 binds PAX6 (show PAX6 Antibodies) and protein-protein interaction leads to transcriptional repression of PAX6 (show PAX6 Antibodies) target genes during mouse retinal development
PC3/Tis21 (show BTG2 Antibodies) associates with HDAC1, HDAC4 (show HDAC5 Antibodies), and HDAC9 (show HDAC9 Antibodies) in vivo, in fibroblast cells.
These results reveal the presence of an MSI1 (show MSI1 Antibodies)-HDA19 complex that fine-tunes abscissic acid signaling in Arabidopsis.
HDC1 is a ubiquitously expressed nuclear protein (show UBN1 Antibodies) that interacts with at least two deacetylases (HDA6 (show HDAC6 Antibodies) and HDA19), promotes histone deacetylation, and attenuates derepression of genes under water stress.
HDA19 and HSL1 may act together to repress seed maturation gene expression during germination. HDA19 and HSL1 may play a vital role during embryogenesis.
findings show that AP2 represses its target genes by physically recruiting the co-repressor TOPLESS and the histone deacetylase HDA19
HDA6 (show HDAC6 Antibodies) and HDA19 may play a redundant role in modulating seed germination and salt stress response, as well as ABA- and salt stress-induced gene expression in Arabidopsis.[HDA19]
Data suggest that AtHD1 is a nuclear protein and possesses histone deacetylase activities responsible for global transcriptional regulation important to plant growth and development.
These results suggest that acetylation of specific histone Lys (show LYZ Antibodies) residues, regulated by GCN5, TAF1, and HD1, is required for light-regulated gene expression.
These results suggest that during germination in Arabidopsis, HDA6 (show HDAC6 Antibodies) and HDA19 redundantly regulate the repression of embryonic properties directly or indirectly via repression of embryo-specific gene function.
Rpd3 accumulates in the nucleolus in the early stage of starvation, upregulates rRNA synthesis, maintains the polysome amount for translation, and finally increases stress tolerance proteins, such as autophagy-related proteins, to acquire starvation stress resistance.
Hdac1/Rpd3 functions together with self-renewal transcriptional repressors to maintain the erm (show MSN Antibodies) immature intermediate neural progenitors enhancer in an inactive but poised state in neuroblasts.
This study tested the longevity effects of RPD3 on multiple nutrient levels.
Rpd3 deacetylase in the heart plays a significant role in cardiac function and longevity to systemically modulate the fly's response to the environment
the Atro-Rpd3 complex plays a conserved role to function as a Ci(R) corepressor.
Study shows that Fru (show ZBTB22 Antibodies) forms a complex with the transcriptional cofactor Bonus (Bon), which, in turn, recruits either of two chromatin regulators, Histone deacetylase 1 (HDAC1), which masculinizes individual sexually dimorphic neurons, or Heterochromatin protein 1a (HP1a (show CBX5 Antibodies)), which demasculinizes them.
The dose of Rpd3 is critical for normal long-term memory.
Work suggests that Drosophila telomere structure is epigenetically regulated by the histone deacetylase Rpd3.
Our study suggests a specific function for the general chromatin remodeling factor (show ASH1L Antibodies) Rpd3 in regulating dendrite targeting in neurons, largely through the postmitotic action of the Pros transcription factor.
The SIN3/RPD3 deacetylase complex is essential for G(2) phase cell cycle progression and regulation of SMRTER corepressor levels.
these results suggest that HDAC1 and HDAC6 (show HDAC6 Antibodies) may play a role in clear cell renal cell carcinoma (show MOK Antibodies) biology
Histone deacetylase 1 regulates the expression of progesterone receptor (show PGR Antibodies) A during human parturition by occupying the progesterone receptor (show PGR Antibodies) A promoter.
High HDAC1 expression may contribute to the aggressiveness of human breast cancer with cytoplasmic-only expression of maspin (show SERPINB5 Antibodies)
Results indicate that HCV core induced epithelial-mesenchymal transition (EMT (show ITK Antibodies)) by interacting with the transcriptional repressor complex Snail (show SNAI1 Antibodies)/HDAC1/2 at the E-cadherin (show CDH1 Antibodies) promoter, which led to E-cadherin (show CDH1 Antibodies) repression and increased invasiveness of hepatoma cells.
Coexpression of SALL4 (show SALL4 Antibodies) with HDAC1 and/or HDAC2 (show HDAC2 Antibodies) was associated with PTEN (show PTEN Antibodies) underexpression and a poor prognosis in hepatocellular carcinoma.
Meta-analysis results suggest that HDAC1 mRNA or protein expression may serve as a good diagnostic and prognostic marker for lung cancer.
Histone deacetylase assays confirmed that MIER2 (show MIER2 Antibodies), but not MIER3 (show MIER3 Antibodies) complexes, have associated deacetylase activity.
High HDAC1 expression is associated with drug Resistance in Malignant Melanoma.
HDAC1 overexpression is associated with Breast Cancer.
The effect of p53 (show TP53 Antibodies) expression on the development of cloned embryos, and its interaction with HDAC1 and DNMT3A (show DNMT3A Antibodies) are reported.
The results suggest that HDAC1 knock-down in oocytes did not influence the rates of maturation or cleavage of parthenogenetic embryos.
results indicate that HDAC1 plays an important role in otic vesicle formation.
HDAC (show HDAC3 Antibodies) activity is necessary for control of cell proliferation and migration of posterior lateral line primordium and hair cell differentiation during early stages of its development in zebrafish.
This study reveals distinct functional and temporal requirements for zebrafish hdac1 during neural crest-derived craniofacial and peripheral neuron development.
Hdac1 is required for expression of erm (show ETV5 Antibodies) and fgf20a in rhombomeres; Hdac1-dependent expression of these two genes is attenuated in rhombomere boundary regions by Notch (show NOTCH1 Antibodies) signalling activity
HDAC1 is required for pancreatic epithelial proliferation in development and cancer.
Data indicate a novel role for Hdac1 as a positive regulator of gene transcription during development of the vertebrate CNS.
Findings suggest that Mta3 (show MTA1 Antibodies)-NuRD complex, inclding component HDAC1, is essential for the initiation of primitive hematopoiesis.
hdac1 is an essential component of the transcriptional silencing machinery that supports the formation and subsequent differentiation of neuronal precursors.
hdac1 is required for the normal formation of craniofacial cartilage and pectoral fins.
in vivo role of HDAC1 in regulating cell cycle progression is region-specific, as HDAC1 promotes cell cycle exit in the retina
Data show that proto-oncogene transcription factor Ets1 regulates neural crest development through histone deacetylase 1 HDAC1) to down-regulate bone morphogenetic protein (BMP) signaling output and reduce id3 protein expression.
Specific knockdown of HDAC1 by a morpholino (HDAC1-MO) decreased the number of BrdU- and BLBP-labeled cells and increased the acetylation level of histone H4 at lysine 12.
Histone acetylation and deacetylation, catalyzed by multisubunit complexes, play a key role in the regulation of eukaryotic gene expression. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family and is a component of the histone deacetylase complex. It also interacts with retinoblastoma tumor-suppressor protein and this complex is a key element in the control of cell proliferation and differentiation. Together with metastasis-associated protein-2, it deacetylates p53 and modulates its effect on cell growth and apoptosis.
, histone deacetylase 1
, histone deacetylase 1-B
, Rpd3 histone deacetylase
, histone Deacetylase-1
, histone deacetylase
, histone deacetylase 1 (HDAC1)
, reduced potassium dependency 3
, suppressor of variegation 326
, reduced potassium dependency, yeast homolog-like 1
, histone deacetylase 1 b