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Browse our Histone Deacetylase 1 Proteins (HDAC1)

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Histone Deacetylase 1 Proteins (HDAC1)
On are 18 Histone Deacetylase 1 (HDAC1) Proteins from 10 different suppliers available. Additionally we are shipping Histone Deacetylase 1 Antibodies (375) and Histone Deacetylase 1 Kits (23) and many more products for this protein. A total of 439 Histone Deacetylase 1 products are currently listed.
ARABIDOPSIS HISTONE DEACETYLASE 1, ARABIDOPSIS HISTONE DEACETYLASE 19, ATHD1, ATHDA19, ATRPD3A, CG7471, chunp6919, dHDAC-1, dHDAC1, Dmel\\CG7471, dmHDA401, DmHDAC1, drpd3, E(var)3-64BC, EG15181, ENSMUSG00000061062, F20D10.250, F20D10_250, GB14706, Gm1824, GON-10, HD1, HDA1, HDA19, HDAC, hdac-1, HDAC1, hdac1-b, Hdac1-ps, hdac1b, HISTONE DEACETYLASE, histone deacetylase 1, HISTONE DEACETYLASE 19, HISTONE DEACETYLASE19, l(3)04556, l(3)64Cc, MommeD5, mp:zf637-2-001987, rpd3, Rpd3/HDAC, RPD3A, RPD3L1, rpd[3], Su(var)3-26, Su(var)326, Su(var)328, wu:fb19h11, wu:fi06f03, yaf1, zgc:65818, zgc:101582
list all proteins Gene Name GeneID UniProt
HDAC1 15181  
HDAC1 84576  
HDAC1 3065 Q13547

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Histone Deacetylase 1 Proteins (HDAC1) by Origin

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Top referenced Histone Deacetylase 1 Proteins

  1. Human HDAC1 Protein expressed in Wheat germ - ABIN1306440 : Esposito, Pierantoni, Battista, Melillo, Scala, Chieffi, Fedele, Fusco: Interaction between HMGA1 and retinoblastoma protein is required for adipocyte differentiation. in The Journal of biological chemistry 2009 (PubMed)
    Show all 2 references for ABIN1306440

More Proteins for Histone Deacetylase 1 Interaction Partners

Mouse (Murine) Histone Deacetylase 1 (HDAC1) interaction partners

  1. Data suggest beta-adrenergic activation of brown adipocytes leads to dissociation of Hdac1 from promoters of Ucp1 (show UCP1 Proteins)/Pgc1a, to up-regulation of histone H3 (show HIST3H3 Proteins) acetylation, to dissociation of polycomb (show CBX2 Proteins) repressive complexes, and to up-regulation of thermogenesis.

  2. Study shows evidence implicating HDAC1 as an important regulator of tissue damage in rheumatoid arthritis (RA). Its inhibition in RA synovial fibroblasts results in attenuation of the autoaggressive phenotype as reduced proliferation and migration.

  3. an agomir of miR (show MLXIP Proteins)-874-3p induced osteoblast differentiation and mineralization. These actions were mediated through the inhibition of Hdac1 expression and enhanced Runx2 (show RUNX2 Proteins) transcriptional activation.

  4. HDAC (show HDAC3 Proteins) activity down regulates macrophage plasticity favoring the pro-inflammatory phenotype

  5. Intestinal epithelial cell (IEC) determination and intestinal homeostasis are highly dependent on Hdac1 and Hdac2 (show HDAC2 Proteins) activity levels, and changes in the IEC acetylome may alter the mucosal environment.

  6. The expression of putative SOX4 target genes during myoblast differentiation is specifically regulated by the molecular switching of the co-activator KAT5 and the co-repressor HDAC1 on SOX4 transcriptional activation.

  7. HDAC1 deficiency in mESCs partially phenocopies the inhibition of histone deacetylation in vitro, and displays reduced incorporation into neural tissues in vivo. Nodal, which is repressed by histone deacetylation, is a direct target of HDAC1.

  8. The data of this study demonstrated pronounced and distinctively different changes in the expression of class I HDAC (show HDAC3 Proteins) in subfields of the hippocampus after an acute status epilepticus, during epileptogenesis and in chronic TLE.

  9. results demonstrate that combined HDAC1 and HDAC2 (show HDAC2 Proteins) ablation promotes survival of axotomized retinal ganglion cells; HDAC1/2 ablation inhibited the apoptotic pathway by impairing acetylation status of p53 (show TP53 Proteins) and reducing PUMA (show BBC3 Proteins) expression, thereby contributing to the ensuing enhanced neuroprotection due to HDAC1/2 depletion

  10. Results showed that the expression levels of HDAC1 and 3 are decreased gradually during embryonic stem cells (ESCs (show NR2E3 Proteins)) mesodermal differentiation and interact physically with Bry protein, which is critical for mesodermal lineage commitment.

Arabidopsis thaliana Histone Deacetylase 1 (HDAC1) interaction partners

  1. HDC1 is a ubiquitously expressed nuclear protein that interacts with at least two deacetylases (HDA6 (show HDAC6 Proteins) and HDA19), promotes histone deacetylation, and attenuates derepression of genes under water stress.

  2. HDA19 and HSL1 may act together to repress seed maturation gene expression during germination. HDA19 and HSL1 may play a vital role during embryogenesis.

  3. findings show that AP2 represses its target genes by physically recruiting the co-repressor TOPLESS and the histone deacetylase HDA19

  4. HDA6 (show HDAC6 Proteins) and HDA19 may play a redundant role in modulating seed germination and salt stress response, as well as ABA- and salt stress-induced gene expression in Arabidopsis.[HDA19]

  5. Data suggest that AtHD1 is a nuclear protein and possesses histone deacetylase activities responsible for global transcriptional regulation important to plant growth and development.

  6. These results suggest that acetylation of specific histone Lys (show LYZ Proteins) residues, regulated by GCN5, TAF1, and HD1, is required for light-regulated gene expression.

  7. These results suggest that during germination in Arabidopsis, HDA6 (show HDAC6 Proteins) and HDA19 redundantly regulate the repression of embryonic properties directly or indirectly via repression of embryo-specific gene function.

Fruit Fly (Drosophila melanogaster) Histone Deacetylase 1 (HDAC1) interaction partners

  1. Rpd3 deacetylase in the heart plays a significant role in cardiac function and longevity to systemically modulate the fly's response to the environment

  2. the Atro-Rpd3 complex plays a conserved role to function as a Ci(R) corepressor.

  3. Study shows that Fru forms a complex with the transcriptional cofactor Bonus (Bon), which, in turn, recruits either of two chromatin regulators, Histone deacetylase 1 (HDAC1), which masculinizes individual sexually dimorphic neurons, or Heterochromatin protein 1a (HP1a (show CBX5 Proteins)), which demasculinizes them.

  4. The dose of Rpd3 is critical for normal long-term memory.

  5. Work suggests that Drosophila telomere structure is epigenetically regulated by the histone deacetylase Rpd3.

  6. Our study suggests a specific function for the general chromatin remodeling factor (show ASH1L Proteins) Rpd3 in regulating dendrite targeting in neurons, largely through the postmitotic action of the Pros transcription factor.

  7. The SIN3/RPD3 deacetylase complex is essential for G(2) phase cell cycle progression and regulation of SMRTER corepressor levels.

  8. role of Rpd3 deacetylase and caloric restriction in longevity regulation

  9. Consistent with these biochemical and cytological results, Rpd3 mutations enhance the phenotypes of Pcl (show PKD2L1 Proteins) mutants, further indicating that RPD3 is required for PcG silencing and possibly for PCL (show PKD2L1 Proteins) function

  10. findings indicate that Rpd3 contributes to Knirps repression activity in vivo

Human Histone Deacetylase 1 (HDAC1) interaction partners

  1. RORgammat is acetylated, and this acetylation is reciprocally regulated by the histone acetyltransferase p300 (show EP300 Proteins) and the histone deacetylase HDAC1.

  2. We demonstrate that HDAC1 is a component of host innate antiviral response against IAV, and IAV undermines HDAC1 to limit its role in antiviral response.

  3. Furthermore, a direct interaction between AnkA and HDAC1 was detected at the CYBB (show CYBB Proteins) promoter, and was critical for AnkA-mediated CYBB (show CYBB Proteins) repression.

  4. Study shows evidence implicating HDAC1 as an important regulator of tissue damage in rheumatoid arthritis (RA). Its inhibition in RA synovial fibroblasts results in attenuation of the autoaggressive phenotype as reduced proliferation and migration.

  5. Enhanced HDAC-1 expression in Pancreatic Adenocarcinoma was significantly associated with increased tumor proliferative capacity, borderline with the absence of lymph node metastases, and showed longer survival times compared to those with low expression.

  6. These observations indicate a HDAC1-mediated IL-12B (show IL12B Proteins) gene expression suppression by live, virulent Mycobacterium tuberculosis to subvert the immune system to survive and replicate in the host.

  7. Results show that mRNA expression of histone deacetylases HDAC1 and HDAC2 (show HDAC2 Proteins) were significantly increased in peripheral blood mononuclear cells of patients with with Graves' disease compared to controls.

  8. Results indicate that HDAC1 depletion inhibits the metastatic abilities of gastric cancer cells by regulating the miRNA-34a/CD44 (show CD44 Proteins) pathway, suggesting that HDAC1 may be a potential target for the treatment of gastric cancer.

  9. DW22 antitumor agent upregulates RXRa (show RXRA Proteins) and downregulates histone deacetylase in lung cancer and breast cancer tissues and cell lines

  10. S6K1 (show RPS6KB1 Proteins), overexpressed in many breast cancers, controls HDAC1-dependent transcriptional regulation of ESR1 (show ESR1 Proteins) levels upon mitogenic stimuli.

Cow (Bovine) Histone Deacetylase 1 (HDAC1) interaction partners

  1. The effect of p53 (show TP53 Proteins) expression on the development of cloned embryos, and its interaction with HDAC1 and DNMT3A (show DNMT3A Proteins) are reported.

  2. The results suggest that HDAC1 knock-down in oocytes did not influence the rates of maturation or cleavage of parthenogenetic embryos.

Zebrafish Histone Deacetylase 1 (HDAC1) interaction partners

  1. HDAC (show HDAC3 Proteins) activity is necessary for control of cell proliferation and migration of posterior lateral line primordium and hair cell differentiation during early stages of its development in zebrafish.

  2. This study reveals distinct functional and temporal requirements for zebrafish hdac1 during neural crest-derived craniofacial and peripheral neuron development.

  3. Hdac1 is required for expression of erm (show ETV5 Proteins) and fgf20a in rhombomeres; Hdac1-dependent expression of these two genes is attenuated in rhombomere boundary regions by Notch (show NOTCH1 Proteins) signalling activity

  4. HDAC1 is required for pancreatic epithelial proliferation in development and cancer.

  5. Data indicate a novel role for Hdac1 as a positive regulator of gene transcription during development of the vertebrate CNS.

  6. Findings suggest that Mta3 (show MTA1 Proteins)-NuRD complex, inclding component HDAC1, is essential for the initiation of primitive hematopoiesis.

  7. hdac1 is an essential component of the transcriptional silencing machinery that supports the formation and subsequent differentiation of neuronal precursors.

  8. hdac1 is required for the normal formation of craniofacial cartilage and pectoral fins.

  9. in vivo role of HDAC1 in regulating cell cycle progression is region-specific, as HDAC1 promotes cell cycle exit in the retina

  10. Hdac1 antagonizes Wnt (show WNT2 Proteins) and notch (show NOTCH1 Proteins) signaling pathways to promote cell-cycle exit and subsequent neurogenesis in zebrafish retina

Xenopus laevis Histone Deacetylase 1 (HDAC1) interaction partners

  1. Data show that proto-oncogene transcription factor Ets1 regulates neural crest development through histone deacetylase 1 HDAC1) to down-regulate bone morphogenetic protein (BMP) signaling output and reduce id3 protein expression.

  2. Specific knockdown of HDAC1 by a morpholino (HDAC1-MO) decreased the number of BrdU- and BLBP-labeled cells and increased the acetylation level of histone H4 at lysine 12.

Histone Deacetylase 1 (HDAC1) Protein Profile

Protein Summary

Histone acetylation and deacetylation, catalyzed by multisubunit complexes, play a key role in the regulation of eukaryotic gene expression. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family and is a component of the histone deacetylase complex. It also interacts with retinoblastoma tumor-suppressor protein and this complex is a key element in the control of cell proliferation and differentiation. Together with metastasis-associated protein-2, it deacetylates p53 and modulates its effect on cell growth and apoptosis.

Alternative names and synonyms associated with Histone Deacetylase 1 (HDAC1)

  • histone deacetylase 1 pseudogene (Gm10093)
  • histone deacetylase (HDAC1)
  • histone deacetylase 1 (HDAC1)
  • histone deacetylase 2 (hdac2)
  • histone deacetylase 1 (hdac1)
  • histone deacetylase 1-like (Hdac1l)
  • histone deacetylase 19 (HD1)
  • CG7471 gene product from transcript CG7471-RA (Rpd3)
  • histone deacetylase 1 (Hdac1)
  • histone deacetylase 1 (hdac1-b)
  • ATHD1 protein
  • ATHDA19 protein
  • ATRPD3A protein
  • CG7471 protein
  • chunp6919 protein
  • dHDAC-1 protein
  • dHDAC1 protein
  • Dmel\\CG7471 protein
  • dmHDA401 protein
  • DmHDAC1 protein
  • drpd3 protein
  • E(var)3-64BC protein
  • EG15181 protein
  • ENSMUSG00000061062 protein
  • F20D10.250 protein
  • F20D10_250 protein
  • GB14706 protein
  • Gm1824 protein
  • GON-10 protein
  • HD1 protein
  • HDA1 protein
  • HDA19 protein
  • HDAC protein
  • hdac-1 protein
  • HDAC1 protein
  • hdac1-b protein
  • Hdac1-ps protein
  • hdac1b protein
  • histone deacetylase 1 protein
  • l(3)04556 protein
  • l(3)64Cc protein
  • MommeD5 protein
  • mp:zf637-2-001987 protein
  • rpd3 protein
  • Rpd3/HDAC protein
  • RPD3A protein
  • RPD3L1 protein
  • rpd[3] protein
  • Su(var)3-26 protein
  • Su(var)326 protein
  • Su(var)328 protein
  • wu:fb19h11 protein
  • wu:fi06f03 protein
  • yaf1 protein
  • zgc:65818 protein
  • zgc:101582 protein

Protein level used designations for Histone Deacetylase 1 Proteins (HDAC1)

HD1 , histone deacetylase 1 , histone deacetylase 1-B , CG7471-PA , Rpd3 histone deacetylase , Rpd3-PA , histone Deacetylase-1 , histone deacetylase , histone deacetylase 1 (HDAC1) , reduced potassium dependency 3 , suppressor of variegation 326 , reduced potassium dependency, yeast homolog-like 1 , col , colgate , histone deacetylase 1 b

15181 Mus musculus
373339 Strongylocentrotus purpuratus
411503 Apis mellifera
447995 Xenopus (Silurana) tropicalis
594953 Xenopus (Silurana) tropicalis
84576 Rattus norvegicus
829969 Arabidopsis thaliana
38565 Drosophila melanogaster
3065 Homo sapiens
487309 Canis lupus familiaris
433759 Mus musculus
297893 Rattus norvegicus
404126 Bos taurus
373961 Gallus gallus
748850 Pan troglodytes
192302 Danio rerio
379083 Xenopus laevis
100172663 Pongo abelii
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