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Browse our Histone Deacetylase 1 Proteins (HDAC1)

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Histone Deacetylase 1 Proteins (HDAC1)
On are 20 Histone Deacetylase 1 (HDAC1) Proteins from 9 different suppliers available. Additionally we are shipping Histone Deacetylase 1 Antibodies (390) and Histone Deacetylase 1 Kits (30) and many more products for this protein. A total of 464 Histone Deacetylase 1 products are currently listed.
ARABIDOPSIS HISTONE DEACETYLASE 1, ARABIDOPSIS HISTONE DEACETYLASE 19, ATHD1, ATHDA19, ATRPD3A, CG7471, chunp6919, dHDAC-1, dHDAC1, Dmel\\CG7471, dmHDA401, DmHDAC1, drpd3, E(var)3-64BC, EG15181, ENSMUSG00000061062, F20D10.250, F20D10_250, GB14706, Gm1824, GON-10, HD1, HDA1, HDA19, HDAC, hdac-1, HDAC1, hdac1-b, Hdac1-ps, hdac1b, HISTONE DEACETYLASE, histone deacetylase 1, HISTONE DEACETYLASE 19, HISTONE DEACETYLASE19, l(3)04556, l(3)64Cc, MommeD5, mp:zf637-2-001987, rpd3, Rpd3/HDAC, RPD3A, RPD3L1, rpd[3], Su(var)3-26, Su(var)326, Su(var)328, wu:fb19h11, wu:fi06f03, yaf1, zgc:65818, zgc:101582
list all proteins Gene Name GeneID UniProt
HDAC1 15181  
HDAC1 84576  
HDAC1 3065 Q13547

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Histone Deacetylase 1 Proteins (HDAC1) by Origin

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Top referenced Histone Deacetylase 1 Proteins

  1. Human HDAC1 Protein expressed in Wheat germ - ABIN1306440 : Esposito, Pierantoni, Battista, Melillo, Scala, Chieffi, Fedele, Fusco: Interaction between HMGA1 and retinoblastoma protein is required for adipocyte differentiation. in The Journal of biological chemistry 2009 (PubMed)
    Show all 2 references for ABIN1306440

More Proteins for Histone Deacetylase 1 Interaction Partners

Mouse (Murine) Histone Deacetylase 1 (HDAC1) interaction partners

  1. Knockdown of HDAC1 recovered Bdnf (show BDNF Proteins) and Pvalb (show PVALB Proteins) gene transcription and also prevented the decrease of inhibitory synapses accompanying whisker deprivation

  2. HDAC1 binds PAX6 (show PAX6 Proteins) and protein-protein interaction leads to transcriptional repression of PAX6 (show PAX6 Proteins) target genes during mouse retinal development

  3. PC3/Tis21 (show BTG2 Proteins) associates with HDAC1, HDAC4 (show HDAC5 Proteins), and HDAC9 (show HDAC9 Proteins) in vivo, in fibroblast cells.

  4. TGF-beta1 (show TGFB1 Proteins)-induced inhibition of PPARgamma (show PPARG Proteins) transcription depends on formation of a functional transcriptional regulatory complex that includes Smad3 (show SMAD3 Proteins), mSin3A and HDAC1 at the PPARgamma (show PPARG Proteins) promoter.

  5. Data suggest that pathological cardiac hypertrophy involved class I histone deacetylases HDAC1 and HdAC2 (show HDAC2 Proteins), tuberous sclerosis complex 2 (TSC2), and mTOR (show FRAP1 Proteins) srine-threonine kinases (mTOR (show FRAP1 Proteins)).

  6. Expression of sperm HDAC1 could be considered as a possible predictor of embryo development in mice with high ovarian response.

  7. Data suggest beta-adrenergic activation of brown adipocytes leads to dissociation of Hdac1 from promoters of Ucp1 (show UCP1 Proteins)/Pgc1a, to up-regulation of histone H3 (show HIST3H3 Proteins) acetylation, to dissociation of polycomb (show CBX2 Proteins) repressive complexes, and to up-regulation of thermogenesis.

  8. Study shows evidence implicating HDAC1 as an important regulator of tissue damage in rheumatoid arthritis (RA). Its inhibition in RA synovial fibroblasts results in attenuation of the autoaggressive phenotype as reduced proliferation and migration.

  9. an agomir of miR (show MLXIP Proteins)-874-3p induced osteoblast differentiation and mineralization. These actions were mediated through the inhibition of Hdac1 expression and enhanced Runx2 (show RUNX2 Proteins) transcriptional activation.

  10. HDAC (show HDAC3 Proteins) activity down regulates macrophage plasticity favoring the pro-inflammatory phenotype

Arabidopsis thaliana Histone Deacetylase 1 (HDAC1) interaction partners

  1. These results reveal the presence of an MSI1 (show MSI1 Proteins)-HDA19 complex that fine-tunes abscissic acid signaling in Arabidopsis.

  2. HDC1 is a ubiquitously expressed nuclear protein that interacts with at least two deacetylases (HDA6 (show HDAC6 Proteins) and HDA19), promotes histone deacetylation, and attenuates derepression of genes under water stress.

  3. HDA19 and HSL1 may act together to repress seed maturation gene expression during germination. HDA19 and HSL1 may play a vital role during embryogenesis.

  4. findings show that AP2 represses its target genes by physically recruiting the co-repressor TOPLESS and the histone deacetylase HDA19

  5. HDA6 (show HDAC6 Proteins) and HDA19 may play a redundant role in modulating seed germination and salt stress response, as well as ABA- and salt stress-induced gene expression in Arabidopsis.[HDA19]

  6. Data suggest that AtHD1 is a nuclear protein and possesses histone deacetylase activities responsible for global transcriptional regulation important to plant growth and development.

  7. These results suggest that acetylation of specific histone Lys (show LYZ Proteins) residues, regulated by GCN5, TAF1, and HD1, is required for light-regulated gene expression.

  8. These results suggest that during germination in Arabidopsis, HDA6 (show HDAC6 Proteins) and HDA19 redundantly regulate the repression of embryonic properties directly or indirectly via repression of embryo-specific gene function.

Fruit Fly (Drosophila melanogaster) Histone Deacetylase 1 (HDAC1) interaction partners

  1. Rpd3 accumulates in the nucleolus in the early stage of starvation, upregulates rRNA synthesis, maintains the polysome amount for translation, and finally increases stress tolerance proteins, such as autophagy-related proteins, to acquire starvation stress resistance.

  2. Hdac1/Rpd3 functions together with self-renewal transcriptional repressors to maintain the erm (show MSN Proteins) immature intermediate neural progenitors enhancer in an inactive but poised state in neuroblasts.

  3. This study tested the longevity effects of RPD3 on multiple nutrient levels.

  4. Rpd3 deacetylase in the heart plays a significant role in cardiac function and longevity to systemically modulate the fly's response to the environment

  5. the Atro-Rpd3 complex plays a conserved role to function as a Ci(R) corepressor.

  6. Study shows that Fru forms a complex with the transcriptional cofactor Bonus (Bon), which, in turn, recruits either of two chromatin regulators, Histone deacetylase 1 (HDAC1), which masculinizes individual sexually dimorphic neurons, or Heterochromatin protein 1a (HP1a (show CBX5 Proteins)), which demasculinizes them.

  7. The dose of Rpd3 is critical for normal long-term memory.

  8. Work suggests that Drosophila telomere structure is epigenetically regulated by the histone deacetylase Rpd3.

  9. Our study suggests a specific function for the general chromatin remodeling factor (show ASH1L Proteins) Rpd3 in regulating dendrite targeting in neurons, largely through the postmitotic action of the Pros transcription factor.

  10. The SIN3/RPD3 deacetylase complex is essential for G(2) phase cell cycle progression and regulation of SMRTER corepressor levels.

Human Histone Deacetylase 1 (HDAC1) interaction partners

  1. We found that TCF7L1 (show TCF3 Proteins) recruits the C-terminal binding protein (CtBP (show CTBP2 Proteins)) and histone deacetylase 1 (HDAC1) to the DKK4 (show DKK4 Proteins) promoter to repress DKK4 (show DKK4 Proteins) gene expression. In the absence of TCF7L1 (show TCF3 Proteins), TCF7L2 (show TCF7L2 Proteins) and beta-catenin (show CTNNB1 Proteins) occupancy at the DKK4 (show DKK4 Proteins) promoter is stimulated and DKK4 (show DKK4 Proteins) expression is increased. These findings uncover a critical role for TCF7L1 (show TCF3 Proteins) in repressing DKK4 (show DKK4 Proteins) gene expression to promote the oncogenic potential of CRCs.

  2. Using mass spectrometry and site directed mutagenesis, a new Sp1 (show PSG1 Proteins) phosphorylation site Ser702 was defined to be associated with Sp1 (show PSG1 Proteins)-HDAC1 interaction and may be important in SR-BI (show SCARB1 Proteins) activation, shedding light on the knowledge of delicate mechanism of hepatic HDL (show HSD11B1 Proteins) receptor SR-BI (show SCARB1 Proteins) gene modulation by LDL.

  3. In vitro, uremia induced dysregulation of DNA methylation in differentiating monocytes, which affected several transcription regulators important for monocyte differentiation (e.g., FLT3, HDAC1, MNT) and led to enhanced generation of intermediate monocytes.

  4. findings indicate that WRN interacts with HDACs 1 and 2 to facilitate activity of stalled replication forks under conditions of replication stress.

  5. HDAC1- and SRC (show SRC Proteins)-mediated phosphorylation of RUNX3 (show RUNX3 Proteins) induced by oxidative stress is associated with the cytoplasmic localization of RUNX3 (show RUNX3 Proteins) and can lead to RUNX3 (show RUNX3 Proteins) inactivation and carcinogenesis.

  6. Cutaneous T-cell lymphoma (CTCL (show TSPYL2 Proteins)) pathogenesis remains unknown, and there are no curative therapies. Our findings not only demonstrate a critical role for IL15 (show IL15 Proteins)-mediated inflammation in cutaneous T-cell lymphomagenesis, but also uncover a new oncogenic regulatory loop in CTCL (show TSPYL2 Proteins) involving IL15 (show IL15 Proteins), HDAC1, HDAC6 (show HDAC6 Proteins), and miR (show MLXIP Proteins)-21 that shows differential sensitivity to isotype-specific HDAC (show HDAC3 Proteins) inhibitors

  7. Increased cancer-specific mortality was significantly associated with HDAC2 (show HDAC2 Proteins) expression, mortality was also increased with high HDAC1 expression.

  8. HDAC1 upregulation is associated with hepatocellular carcinoma.

  9. HDAC1 expression in TE-1, Eca109 and EC9706 cells was significantly higher compared with normal esophageal cell line HEEC.The siRNA-mediated HDAC1 knockdown significantly inhibited the proliferation, migration and invasion of TE-1 cells probably by regulating the expression of cell cycle- and EMT (show ITK Proteins)-related proteins.

  10. High HDAC1 expression is associated with osteosarcoma progression.

Cow (Bovine) Histone Deacetylase 1 (HDAC1) interaction partners

  1. The effect of p53 (show TP53 Proteins) expression on the development of cloned embryos, and its interaction with HDAC1 and DNMT3A (show DNMT3A Proteins) are reported.

  2. The results suggest that HDAC1 knock-down in oocytes did not influence the rates of maturation or cleavage of parthenogenetic embryos.

Zebrafish Histone Deacetylase 1 (HDAC1) interaction partners

  1. results indicate that HDAC1 plays an important role in otic vesicle formation.

  2. HDAC (show HDAC3 Proteins) activity is necessary for control of cell proliferation and migration of posterior lateral line primordium and hair cell differentiation during early stages of its development in zebrafish.

  3. This study reveals distinct functional and temporal requirements for zebrafish hdac1 during neural crest-derived craniofacial and peripheral neuron development.

  4. Hdac1 is required for expression of erm (show ETV5 Proteins) and fgf20a in rhombomeres; Hdac1-dependent expression of these two genes is attenuated in rhombomere boundary regions by Notch (show NOTCH1 Proteins) signalling activity

  5. HDAC1 is required for pancreatic epithelial proliferation in development and cancer.

  6. Data indicate a novel role for Hdac1 as a positive regulator of gene transcription during development of the vertebrate CNS.

  7. Findings suggest that Mta3 (show MTA1 Proteins)-NuRD complex, inclding component HDAC1, is essential for the initiation of primitive hematopoiesis.

  8. hdac1 is an essential component of the transcriptional silencing machinery that supports the formation and subsequent differentiation of neuronal precursors.

  9. hdac1 is required for the normal formation of craniofacial cartilage and pectoral fins.

  10. in vivo role of HDAC1 in regulating cell cycle progression is region-specific, as HDAC1 promotes cell cycle exit in the retina

Xenopus laevis Histone Deacetylase 1 (HDAC1) interaction partners

  1. Data show that proto-oncogene transcription factor Ets1 regulates neural crest development through histone deacetylase 1 HDAC1) to down-regulate bone morphogenetic protein (BMP) signaling output and reduce id3 protein expression.

  2. Specific knockdown of HDAC1 by a morpholino (HDAC1-MO) decreased the number of BrdU- and BLBP-labeled cells and increased the acetylation level of histone H4 at lysine 12.

Histone Deacetylase 1 (HDAC1) Protein Profile

Protein Summary

Histone acetylation and deacetylation, catalyzed by multisubunit complexes, play a key role in the regulation of eukaryotic gene expression. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family and is a component of the histone deacetylase complex. It also interacts with retinoblastoma tumor-suppressor protein and this complex is a key element in the control of cell proliferation and differentiation. Together with metastasis-associated protein-2, it deacetylates p53 and modulates its effect on cell growth and apoptosis.

Alternative names and synonyms associated with Histone Deacetylase 1 (HDAC1)

  • histone deacetylase 1 pseudogene (Gm10093)
  • histone deacetylase (HDAC1)
  • histone deacetylase 1 (HDAC1)
  • histone deacetylase 2 (hdac2)
  • histone deacetylase 1 (hdac1)
  • histone deacetylase 1-like (Hdac1l)
  • histone deacetylase 19 (HD1)
  • CG7471 gene product from transcript CG7471-RA (Rpd3)
  • histone deacetylase 1 (Hdac1)
  • histone deacetylase 1 (hdac1-b)
  • ATHD1 protein
  • ATHDA19 protein
  • ATRPD3A protein
  • CG7471 protein
  • chunp6919 protein
  • dHDAC-1 protein
  • dHDAC1 protein
  • Dmel\\CG7471 protein
  • dmHDA401 protein
  • DmHDAC1 protein
  • drpd3 protein
  • E(var)3-64BC protein
  • EG15181 protein
  • ENSMUSG00000061062 protein
  • F20D10.250 protein
  • F20D10_250 protein
  • GB14706 protein
  • Gm1824 protein
  • GON-10 protein
  • HD1 protein
  • HDA1 protein
  • HDA19 protein
  • HDAC protein
  • hdac-1 protein
  • HDAC1 protein
  • hdac1-b protein
  • Hdac1-ps protein
  • hdac1b protein
  • histone deacetylase 1 protein
  • l(3)04556 protein
  • l(3)64Cc protein
  • MommeD5 protein
  • mp:zf637-2-001987 protein
  • rpd3 protein
  • Rpd3/HDAC protein
  • RPD3A protein
  • RPD3L1 protein
  • rpd[3] protein
  • Su(var)3-26 protein
  • Su(var)326 protein
  • Su(var)328 protein
  • wu:fb19h11 protein
  • wu:fi06f03 protein
  • yaf1 protein
  • zgc:65818 protein
  • zgc:101582 protein

Protein level used designations for Histone Deacetylase 1 Proteins (HDAC1)

HD1 , histone deacetylase 1 , histone deacetylase 1-B , CG7471-PA , Rpd3 histone deacetylase , Rpd3-PA , histone Deacetylase-1 , histone deacetylase , histone deacetylase 1 (HDAC1) , reduced potassium dependency 3 , suppressor of variegation 326 , reduced potassium dependency, yeast homolog-like 1 , col , colgate , histone deacetylase 1 b

15181 Mus musculus
373339 Strongylocentrotus purpuratus
411503 Apis mellifera
447995 Xenopus (Silurana) tropicalis
594953 Xenopus (Silurana) tropicalis
84576 Rattus norvegicus
829969 Arabidopsis thaliana
38565 Drosophila melanogaster
3065 Homo sapiens
487309 Canis lupus familiaris
433759 Mus musculus
297893 Rattus norvegicus
404126 Bos taurus
373961 Gallus gallus
748850 Pan troglodytes
192302 Danio rerio
379083 Xenopus laevis
100172663 Pongo abelii
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