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Browse our Histone Deacetylase 2 Proteins (HDAC2)

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Histone Deacetylase 2 Proteins (HDAC2)
On are 8 Histone Deacetylase 2 (HDAC2) Proteins from 4 different suppliers available. Additionally we are shipping Histone Deacetylase 2 Antibodies (247) and Histone Deacetylase 2 Kits (41) and many more products for this protein. A total of 312 Histone Deacetylase 2 products are currently listed.
D10Wsu179e, HD2, HISTONE DEACETYLASE, histone deacetylase 2, mRPD3, RPD3, T1N24.9, T1N24_9, YAF1, Yy1bp
list all proteins Gene Name GeneID UniProt
HDAC2 3066 Q92769
HDAC2 15182 P70288
Rat HDAC2 HDAC2 84577  

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Histone Deacetylase 2 Proteins (HDAC2) by Origin

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Top referenced Histone Deacetylase 2 Proteins

  1. Human HDAC2 Protein expressed in Hi-5 - ABIN667944 : Taunton, Hassig, Schreiber: A mammalian histone deacetylase related to the yeast transcriptional regulator Rpd3p. in Science (New York, N.Y.) 1996 (PubMed)
    Show all 2 references for ABIN667944

More Proteins for Histone Deacetylase 2 Interaction Partners

Human Histone Deacetylase 2 (HDAC2) interaction partners

  1. the current findings implicate the HDAC2/miR (show MLXIP Proteins)-101/AMPK (show PRKAA1 Proteins) pathway as a critical mediator of AD pathogenesis. These studies also highlight the importance of epigenetics in AD and provide novel therapeutic targets.

  2. Increased cancer-specific mortality was significantly associated with HDAC2 expression, mortality was also increased with high HDAC1 (show HDAC1 Proteins) expression.

  3. HDAC2 upregulation is associated with hepatocellular carcinoma.

  4. Suggest that HDAC2 can trigger migration and invasion of non-small cell lung carcinoma cells by activating NF-kappaB (show NFKB1 Proteins) to up-regulate fibronectin (show FN1 Proteins) expression.

  5. KLF4 (show KLF4 Proteins) acts as a tumor suppressor or oncogene (show RAB1A Proteins) to activate or repress target gene transcription depending on its acetylation status, which is regulated by p21 (show CDKN1A Proteins) and CK2 (show CSNK2A1 Proteins) interaction-mediated HDAC2 phosphorylation

  6. Data indicate that bombesin receptor (show GRPR Proteins)-activated protein (BRAP (show BRAP Proteins)) might increase histone deacetylases 1/2 (HDAC (show HDAC3 Proteins)) activity that leads to NF-kappa B (NF-kappaB (show NFKB1 Proteins)) activation via its putative C-terminal domain.

  7. Decreased HDAC2 expression is associated with cisplatin resistance in ovarian cancer.

  8. In cigarette smoke extract-exposed airway epithelial cells and macrophages, HDAC2 is excessively ubiquitinated and degraded in the proteasome attributed to low expression of USP17.

  9. The results imply that HDAC2 is involved in the transcriptional regulation of human odontoblasts in vivo.

  10. Endothelial-Mesenchymal Transition is initiated by recruitment of aberrantly phosphorylated DNMT1 (show DNMT1 Proteins) to the RASAL1 (show RASAL1 Proteins) CpG island promoter by HDAC2, causing aberrant promoter methylation and transcriptional suppression.

Mouse (Murine) Histone Deacetylase 2 (HDAC2) interaction partners

  1. observations suggest that Methamphetamine may induce large-scale transcriptional changes in the Nuc (show SREBF2 Proteins). Accumbens by regulating the expression of several histone deacetylases in part, via HDAC2-dependent mechanisms.

  2. We also found that glucocorticoid receptor (GR (show NR3C1 Proteins))-mediated histone deacetylase 2 (HDAC) 2 expression and activity are reduced in the Trpv1 (show TRPV1 Proteins)(-/-) mice and that HDAC2-regulated, cell-cycle- and neuroplasticity-related molecules are altered

  3. CRISPR/Cas9-mediated disruption of the Hdac2 gene increased Slc2a1 expression, suggesting that it is one of the responsible histone deacetylases (HDACs). These results confirm that b-OHB is a HDAC inhibitor and show that b-OHB plays an important role in fasting-induced epigenetic activation of a glucose transporter gene in the brain.

  4. Data suggest that pathological cardiac hypertrophy involved class I histone deacetylases HDAC1 (show HDAC1 Proteins) and HdAC2, tuberous sclerosis complex 2 (TSC2), and mTOR (show FRAP1 Proteins) srine-threonine kinases (mTOR (show FRAP1 Proteins)).

  5. Social isolation resulted in down-regulation of Hdac2 mRNA expression in the cerebral cortex.

  6. HDAC2 may regulate the expression of immediate early (show JUN Proteins) genes, in part, by prolonging the actions of pCREB in the mouse nucleus accumbens.

  7. Injecting these oocytes with Hdac2 partially restores DNMT3A2 (show DNMT3A Proteins) nuclear staining.

  8. Our data show that: i) HDAC2 levels and activity are increased in NPC (show NPC1 Proteins) neuronal models and in Npc1 (show NPC1 Proteins)(-/-) mice; ii) inhibition of c-Abl (show ABL1 Proteins) or c-Abl (show ABL1 Proteins) deficiency prevents the increase of HDAC2 protein levels and activity in NPC (show NPC1 Proteins) neuronal models

  9. This study reveals a dominant negative effect of catalytically inactive HDAC2 on specific corepressor complexes resulting in histone hyperacetylation, transcriptional derepression, and, ultimately, perinatal lethality.

  10. This study demonstrated that hdac2 increase in skeletal muscle in muscle atrophy.

Histone Deacetylase 2 (HDAC2) Protein Profile

Protein Summary

This gene product belongs to the histone deacetylase family. Histone deacetylases act via the formation of large multiprotein complexes, and are responsible for the deacetylation of lysine residues at the N-terminal regions of core histones (H2A, H2B, H3 and H4). This protein forms transcriptional repressor complexes by associating with many different proteins, including YY1, a mammalian zinc-finger transcription factor. Thus, it plays an important role in transcriptional regulation, cell cycle progression and developmental events. Alternative splicing results in multiple transcript variants.

Alternative names and synonyms associated with Histone Deacetylase 2 (HDAC2)

  • histone deacetylase 2 (HDAC2)
  • histone deacetylase 2 (Hdac2)
  • histone deacetylase 2 (hdac2)
  • histone deacetylase 2 (HDA2)
  • histone deacetylase 2-like (LOC100156170)
  • D10Wsu179e protein
  • HD2 protein
  • histone deacetylase 2 protein
  • mRPD3 protein
  • RPD3 protein
  • T1N24.9 protein
  • T1N24_9 protein
  • YAF1 protein
  • Yy1bp protein

Protein level used designations for Histone Deacetylase 2 Proteins (HDAC2)

YY1-associated factor 1 , transcriptional regulator homolog RPD3 , HD2 , YY1 transcription factor-binding protein , histone deacetylase-2

3066 Homo sapiens
475035 Canis lupus familiaris
15182 Mus musculus
84577 Rattus norvegicus
407223 Bos taurus
395635 Gallus gallus
399252 Xenopus laevis
100715675 Cavia porcellus
101107708 Ovis aries
832673 Arabidopsis thaliana
100156170 Sus scrofa
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