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Browse our Histone Deacetylase 2 Proteins (HDAC2)

Full name:
Histone Deacetylase 2 Proteins (HDAC2)
On www.antibodies-online.com are 9 Histone Deacetylase 2 (HDAC2) Proteins from 5 different suppliers available. Additionally we are shipping Histone Deacetylase 2 Antibodies (210) and Histone Deacetylase 2 Kits (35) and many more products for this protein. A total of 270 Histone Deacetylase 2 products are currently listed.
Synonyms:
D10Wsu179e, HD2, HISTONE DEACETYLASE, histone deacetylase 2, mRPD3, RPD3, T1N24.9, T1N24_9, YAF1, Yy1bp
list all proteins Gene Name GeneID UniProt
HDAC2 3066 Q92769
HDAC2 15182 P70288
Rat HDAC2 HDAC2 84577  

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Histone Deacetylase 2 Proteins (HDAC2) by Origin

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Top referenced Histone Deacetylase 2 Proteins

  1. Human HDAC2 Protein expressed in Hi-5 - ABIN667944 : Taunton, Hassig, Schreiber: A mammalian histone deacetylase related to the yeast transcriptional regulator Rpd3p. in Science (New York, N.Y.) 1996 (PubMed)
    Show all 2 references for ABIN667944

More Proteins for Histone Deacetylase 2 Interaction Partners

Human Histone Deacetylase 2 (HDAC2) interaction partners

  1. Decreased HDAC2 expression is associated with cisplatin resistance in ovarian cancer.

  2. In cigarette smoke extract-exposed airway epithelial cells and macrophages, HDAC2 is excessively ubiquitinated and degraded in the proteasome attributed to low expression of USP17.

  3. The results imply that HDAC2 is involved in the transcriptional regulation of human odontoblasts in vivo.

  4. Endothelial-Mesenchymal Transition is initiated by recruitment of aberrantly phosphorylated DNMT1 (show DNMT1 Proteins) to the RASAL1 (show RASAL1 Proteins) CpG island promoter by HDAC2, causing aberrant promoter methylation and transcriptional suppression.

  5. Selective inhibition of HDAC2 in lung tumor cell causes survivin (show BIRC5 Proteins) downregulation through activation of p53 (show TP53 Proteins), which is mediated by downregulation of Mdm2 (show MDM2 Proteins).

  6. our study revealed that HDAC2 is overexpressed in colorectal cancer (CRC (show CALR Proteins)) cells; its knockdown can increase the sensitivity of CRC (show CALR Proteins) cells to doxorubicin via upregulation of ABCB1 (show ABCB1 Proteins)

  7. Pancreatic adenocarcinoma patients with enhanced HDAC-1 (show HDAC1 Proteins) and -6 expression showed significantly longer survival times compared to those with low expression, while a borderline association concerning HDAC-2 expression was noted.

  8. Lymphocyte senescence in COPD (show ARCN1 Proteins) is associated with loss of HDAC2 in CD28nullCD8+ T and NKT (show SLC22A6 Proteins)-like cells.

  9. Results show that mRNA expression of histone deacetylases HDAC1 (show HDAC1 Proteins) and HDAC2 were significantly increased in peripheral blood mononuclear cells of patients with with Graves' disease compared to controls.

  10. HDAC2 may not confer susceptibility to Schizophrenia in Han Chinese.

Mouse (Murine) Histone Deacetylase 2 (HDAC2) interaction partners

  1. HDAC2 may regulate the expression of immediate early (show JUN Proteins) genes, in part, by prolonging the actions of pCREB in the mouse nucleus accumbens.

  2. Injecting these oocytes with Hdac2 partially restores DNMT3A2 (show DNMT3A Proteins) nuclear staining.

  3. Our data show that: i) HDAC2 levels and activity are increased in NPC (show NPC1 Proteins) neuronal models and in Npc1 (show NPC1 Proteins)(-/-) mice; ii) inhibition of c-Abl (show ABL1 Proteins) or c-Abl (show ABL1 Proteins) deficiency prevents the increase of HDAC2 protein levels and activity in NPC (show NPC1 Proteins) neuronal models

  4. This study reveals a dominant negative effect of catalytically inactive HDAC2 on specific corepressor complexes resulting in histone hyperacetylation, transcriptional derepression, and, ultimately, perinatal lethality.

  5. This study demonstrated that hdac2 increase in skeletal muscle in muscle atrophy.

  6. Intestinal epithelial cell (IEC) determination and intestinal homeostasis are highly dependent on Hdac1 (show HDAC1 Proteins) and Hdac2 activity levels, and changes in the IEC acetylome may alter the mucosal environment.

  7. results demonstrate that combined HDAC1 (show HDAC1 Proteins) and HDAC2 ablation promotes survival of axotomized retinal ganglion cells; HDAC1 (show HDAC1 Proteins)/2 ablation inhibited the apoptotic pathway by impairing acetylation status of p53 (show TP53 Proteins) and reducing PUMA (show BBC3 Proteins) expression, thereby contributing to the ensuing enhanced neuroprotection due to HDAC1 (show HDAC1 Proteins)/2 depletion

  8. Scopolamine induced memory impairment along with increased gene expression of HDAC2 in corpus striatum.

  9. mechanistic evidence for the gene-specific transcription repression activity of Tet2 via histone deacetylation and for the prevention of constant transcription activation at the chromatin level for resolving inflammation

  10. HDAC2 might be a downstream effector of Jak2 (show JAK2 Proteins) to mediate cardiac hypertrophic response by pressure overload or Ang-II (show AGT Proteins).

Histone Deacetylase 2 (HDAC2) Protein Profile

Protein Summary

This gene product belongs to the histone deacetylase family. Histone deacetylases act via the formation of large multiprotein complexes, and are responsible for the deacetylation of lysine residues at the N-terminal regions of core histones (H2A, H2B, H3 and H4). This protein forms transcriptional repressor complexes by associating with many different proteins, including YY1, a mammalian zinc-finger transcription factor. Thus, it plays an important role in transcriptional regulation, cell cycle progression and developmental events. Alternative splicing results in multiple transcript variants.

Alternative names and synonyms associated with Histone Deacetylase 2 (HDAC2)

  • histone deacetylase 2 (HDAC2)
  • histone deacetylase 2 (Hdac2)
  • histone deacetylase 2 (hdac2)
  • histone deacetylase 2 (HDA2)
  • histone deacetylase 2-like (LOC100156170)
  • D10Wsu179e protein
  • HD2 protein
  • HISTONE DEACETYLASE protein
  • histone deacetylase 2 protein
  • mRPD3 protein
  • RPD3 protein
  • T1N24.9 protein
  • T1N24_9 protein
  • YAF1 protein
  • Yy1bp protein

Protein level used designations for Histone Deacetylase 2 Proteins (HDAC2)

YY1-associated factor 1 , transcriptional regulator homolog RPD3 , HD2 , YY1 transcription factor-binding protein , histone deacetylase-2

GENE ID SPECIES
3066 Homo sapiens
475035 Canis lupus familiaris
15182 Mus musculus
84577 Rattus norvegicus
407223 Bos taurus
395635 Gallus gallus
399252 Xenopus laevis
100715675 Cavia porcellus
101107708 Ovis aries
832673 Arabidopsis thaliana
100156170 Sus scrofa
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