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genetic association studies in populations in Estonia, Czech Republic, and Bashkortostan/Russia: Data suggest an SNP in GH2 (rs2006123) is associated with adult height (not body mass index); A-allele is associated with taller stature. [META-ANALYSIS]
results are consistent with a pleiotropic effect of placental hGH/CSH (show CSH1 Proteins) genes at the maternal-fetal interface relating to the regulation of fetal growth and the risk of affected maternal metabolism.
These results suggest that the normal PGH-IGF-I (show IGF1 Proteins)-IGFBP3 (show IGFBP3 Proteins) axis in pregnancy is abnormal in Type 1 Diabetic pregnancies.
The hGH-V promoter activity and the endogenous mRNA expression in human placental choriocarcinoma cell line JAR (show MYO6 Proteins) in the presence of glucose and demethylating genome conditions, were compared.
report that autocrine hGH production by mammary carcinoma cells specifically results in the transcriptional repression of the p53 (show TP53 Proteins)-regulated placental transforming growth factor-beta gene (Placental growth factor (show PGF Proteins)-beta; TGF-beta (show TGFB1 Proteins))
GH-V plays a major role in affecting target cells expressing the GH receptor (show GHR Proteins), thus potentially exerting significant GH-like effects on maternal physiology during pregnancy.
Data show that improved binding affinity of human growth hormone (show GH1 Proteins) (hGH(v)) results from numerous small contributions distributed broadly over the interface.
Using a mutagenesis-scanning analysis of 81 single and 32 pairwise double mutations, it is shown that the GHv hormone's two spatially distal receptor binding sites (Site1 and Site2) are allosterically coupled
results offer the first evidence for a placental role of human placental growth hormone(hPGH) and suggest an autocrine/paracrine role of hPGH in the regulation of trophoblast invasion
Placental growth hormone (show GH1 Proteins) (PGH) secretion by BeWo cells is regulated by hormonal factors and adipokines. Elevated insulin (show INS Proteins) and leptin (show LEP Proteins) levels might down-regulate PGH secretion.
The protein encoded by this gene is a member of the somatotropin/prolactin family of hormones which play an important role in growth control. The gene, along with four other related genes, is located at the growth hormone locus on chromosome 17 where they are interspersed in the same transcriptional orientation\; an arrangement which is thought to have evolved by a series of gene duplications. The five genes share a remarkably high degree of sequence identity. Alternative splicing generates additional isoforms of each of the five growth hormones, leading to further diversity and potential for specialization. As in the case of its pituitary counterpart, growth hormone 1, the predominant isoform of this particular family member shows similar somatogenic activity, with reduced lactogenic activity. Mutations in this gene lead to placental growth hormone/lactogen deficiency.
growth hormone variant
, placenta-specific growth hormone
, placental-specific growth hormone
, Placenta-specific growth hormone