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these results reveal that the IL-1 (show IL1A Proteins)/IL-1R2 axis is differentially regulated in the remitting intestinal mucosa of ulcerative colitis patients
Data show that all the six inflammation-related CpG-SNPs genotypes including IL1B (show IL1B Proteins) rs16944, IL1R2 rs2071008, PLA2G7 (show Lp-PLA2 Proteins) rs9395208, FAM5C rs12732361, CD40 (show CD40 Proteins) rs1800686, and CD36 (show CD36 Proteins) rs2065666 were associated with coronary heart disease (CHD (show CHDH Proteins)), suggesting an important role of inflammation in the risk of CHD (show CHDH Proteins).
Expression level of IL1R2 was down regulated in cervical squamous cell carcinoma.
No significant differences in the lymphocyte mRNA levels of IL-1R2, IL-6R, and Gp130 were observed between MDD patients and NC. These studies suggest abnormal gene expression of these cytokines and their membrane-bound receptors in the lymphocytes of MDD patients, and that their mRNA expression levels in the lymphocytes could be a useful biomarker for depression.
IL1R2 rs2310173 genotype GT was mildly protective against ankylosing spontylitis only in HLA-B27-negative patients.
IL1R2 hypomethylation and androgen receptor (show AR Proteins) hypermethylation may constitute an important determinant of disease severity, whereas NPR2 (show NPRL2 Proteins) hypomethylation and SP140 (show SP140 Proteins) hypermethylation may provide a biomarker for vulnerability to excessive daytime sleepiness in Obstructive Sleep Apnea
This is the first detection that the genetic variation rs2302589 in IL-1R2 gene was associated with ankylosing spondylitis in Northern Han Chinese.
Data show that interleukin-1 receptor type 2 (IL1R2) forms a complex with c-Fos proto-oncogene protein and activates the interleukin-6 (IL-6 (show IL6 Proteins)) and vascular endothelial growth factor A (VEGF-A (show VEGFA Proteins)) promoters.
Cerebrospinal fluid soluble interleukin-1 Receptor II, but not log interleukin-6 (show IL6 Proteins), levels were positively correlated with a composite measure of aggression.
results suggested that IL1R2 could have oncogenic potential in osteosarcoma
Our data demonstrate that the decoy receptor IL-1R2 plays an important inhibitory role in local IL-1 (show IL1A Proteins)- and neutrophil-dependent tissue inflammation
Data indicate that a disintegrin and metallopeptidase domain 17 (ADAM17 (show ADAM17 Proteins)) regulates interleukin (IL)-1 (show IL1A Proteins) signaling via cleavage of IL-1 (show IL1A Proteins) receptor type 2 (IL-1R2).
IL-1 (show IL1A Proteins) receptor type 2 suppresses collagen-induced arthritis by inhibiting IL-1 (show IL1A Proteins) signal on macrophages.
Interleukin-1 receptor type II is significantly upregulated in decidual cells close to the embryo during days 5 to 8 of pregnancy.
Data show that bee venom detected by inflammasome and trigger activation of caspase-1 (show CASP1 Proteins) and secretion of proinflammatory cytokine IL-1beta (show IL1B Proteins) is pyrin domain-containing 3 NLRP3 (show NLRP3 Proteins), apoptosis-associated speck-like protein ASC (show STS Proteins), and IL-1 (show IL1A Proteins) receptor dependent.
inoculation of young CD4 (show CD4 Proteins)(+) T cells or a fetal thymus graft led to down regulation of the interleukin 1 receptor type II (IL-1R2) gene in CD4 (show CD4 Proteins)(+) T cells and reduced age-related hearing loss
BACE1 (show BACE Proteins) and BACE2 (show BACE2 Proteins) may act as alternative alpha-secretase-like proteases in proteolytic processing of IL-1R2 and APP (show APP Proteins)
The protein encoded by this gene is a cytokine receptor that belongs to the interleukin 1 receptor family. This protein binds interleukin alpha (IL1A), interleukin beta (IL1B), and interleukin 1 receptor, type I(IL1R1/IL1RA), and acts as a decoy receptor that inhibits the activity of its ligands. Interleukin 4 (IL4) is reported to antagonize the activity of interleukin 1 by inducing the expression and release of this cytokine. This gene and three other genes form a cytokine receptor gene cluster on chromosome 2q12. Alternative splicing results in multiple transcript variants and protein isoforms. Alternative splicing produces both membrane-bound and soluble proteins. A soluble protein is also produced by proteolytic cleavage.
interleukin-1 receptor type 2
, soluble type II IL-1 receptor
, CD121 antigen-like family member B
, IL-1 type II receptor
, antigen CDw121b
, interleukin 1 receptor type II variant 3
, interleukin-1 receptor beta
, interleukin-1 receptor type II
, type II interleukin-1 receptor, beta
, IL-1 receptor beta chain