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Browse our IL1RN Proteins (IL1RN)

Full name:
Interleukin 1 Receptor Antagonist Proteins (IL1RN)
On are 78 Interleukin 1 Receptor Antagonist (IL1RN) Proteins from 17 different suppliers available. Additionally we are shipping IL1RN Antibodies (232) and IL1RN Kits (101) and many more products for this protein. A total of 427 IL1RN products are currently listed.
DIRA, F630041P17Rik, icIL-1ra, IL-1RA, IL-1ra3, IL-1RN, IL1F3, IL1RA, IL1RN, IRAP, IRAP1, MVCD4
list all proteins Gene Name GeneID UniProt
IL1RN 3557 P18510
IL1RN 60582 P25086
IL1RN 16181 P25085

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IL1RN Proteins (IL1RN) by Origin

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Top referenced IL1RN Proteins

  1. Human IL1RN Protein expressed in Escherichia coli (E. coli) - ABIN2666839 : Arend: The balance between IL-1 and IL-1Ra in disease. in Cytokine & growth factor reviews 2002 (PubMed)
    Show all 5 references for ABIN2666839

  2. Rat (Rattus) IL1RN Protein expressed in Human Cells - ABIN2009118 : Haskill, Martin, Van Le, Morris, Peace, Bigler, Jaffe, Hammerberg, Sporn, Fong: cDNA cloning of an intracellular form of the human interleukin 1 receptor antagonist associated with epithelium. in Proceedings of the National Academy of Sciences of the United States of America 1991 (PubMed)
    Show all 4 references for ABIN2009118

  3. Human IL1RN Protein expressed in Escherichia coli (E. coli) - ABIN2002123 : Sehouli, Mustea, Könsgen, Katsares, Lichtenegger: Polymorphism of IL-1 receptor antagonist gene: role in cancer. in Anticancer research 2003 (PubMed)
    Show all 4 references for ABIN2002123

  4. Human IL1RN Protein expressed in Human Cells - ABIN2002122 : Arend, Malyak, Guthridge, Gabay: Interleukin-1 receptor antagonist: role in biology. in Annual review of immunology 1998 (PubMed)
    Show all 4 references for ABIN2002122

  5. Human IL1RN Protein expressed in Escherichia coli (E. coli) - ABIN2667496 : Zhang, Liu, Peng, Zhang, Feng: IL1 receptor antagonist gene IL1-RN variable number of tandem repeats polymorphism and cancer risk: a literature review and meta-analysis. in PLoS ONE 2012 (PubMed)
    Show all 3 references for ABIN2667496

  6. Human IL1RN Protein expressed in Escherichia coli (E. coli) - ABIN667037 : Capper, Maskill, Gordon, Blakemore: Interleukin (IL)-10, IL-1ra and IL-12 profiles in active and quiescent systemic lupus erythematosus: could longitudinal studies reveal patient subgroups of differing pathology? in Clinical and experimental immunology 2004 (PubMed)
    Show all 3 references for ABIN667037

  7. Mouse (Murine) IL1RN Protein expressed in Escherichia coli (E. coli) - ABIN1098264 : Steinkasserer, Spurr, Cox, Jeggo, Sim: The human IL-1 receptor antagonist gene (IL1RN) maps to chromosome 2q14-q21, in the region of the IL-1 alpha and IL-1 beta loci. in Genomics 1992 (PubMed)

More Proteins for IL1RN Interaction Partners

Human Interleukin 1 Receptor Antagonist (IL1RN) interaction partners

  1. The polymorphism in the combinations IL6 (show IL6 Proteins) x IL1beta (show IL1B Proteins) (C and T alleles, respectively), IL1beta (show IL1B Proteins) (T allele) x IL1RN (*2/*2 genotype), IL6 (show IL6 Proteins) (C allele) x TNFalpha (show TNF Proteins) (A allele), IL10 (show IL10 Proteins) (C/T genotype) x TNFalpha (show TNF Proteins) (A/A genotype) (P < 0.01, P = 0.01, P < 0.05 and P = 0.03, respectively) were associated with predisposition to developing Dengue and its symptoms

  2. We demonstrate for the first time that the presence of a T allele or TT genotype at -511 of IL-1beta (show IL1B Proteins) promoter and IL-1RA II/II genotype constitute risk factors for developing Febrile Seizures in Egyptian children

  3. polymorphisms of interleukin 1 complex (show IL1A Proteins) genes (rs1143627, rs16944, rs1143623, rs4848306 in IL1B (show IL1B Proteins) gene and rs4251961, rs419598, rs315952, rs9005 in IL1RN gene) are involved in the pathogenesis of schizophrenia, but do not reach significance level with multiple testing

  4. We found that the mean mRNA levels of the proinflammatory cytokines IL-1beta (show IL1B Proteins), IL-6 (show IL6 Proteins), TNF-alpha (show TNF Proteins), their receptors, TNFR1 (show TNFRSF1A Proteins), TNFR2 (show TNFRSF1B Proteins), IL-1R1 and the antagonist IL-1RA were significantly increased in the lymphocytes of MDD patients compared with NC [normal control subjects]..

  5. C/T genotype of IL-1Ra +2018 prognosticates more aggressive disease in RA

  6. Results show that the presence of IL-1b (show IL1B Proteins) and IL-1RN polymorphisms with Helicobacter pylori infection of the gastric mucosa contributes to the development of gastric carcinoma in an Algerian population.

  7. this study shows that IL-1Ra gene variants are associated with susceptibility to juvenile idiopathic arthritis in Iranian population

  8. The A2 allele of the interleukin 1 receptor antagonist VNTR polymorphism could be a protective factor for pre-eclampsia susceptibility.

  9. There were no significant differences between patients with Behcet's disease and controls with respect to the IL-1Ra, IL-1beta (show IL1B Proteins), IL-2 (show IL2 Proteins), IL-6 (show IL6 Proteins) and the IL-10 (show IL10 Proteins) gene polymorphism distributions. Correlations between the articular involvement and IL-1RN, the ocular involvement and the IL-1beta (show IL1B Proteins), and the age of disease onset and the IL-2 (show IL2 Proteins) and IL-10 (show IL10 Proteins) polymorphisms suggest that that they could be associated with disease symptoms.

  10. A2 allele and the combined IL-4 (show IL4 Proteins) (low) -IL-1Ra (high) genotype might be genetic markers of susceptibility to frailty in Mexican elderly.

Pig (Porcine) Interleukin 1 Receptor Antagonist (IL1RN) interaction partners

  1. This study identified IL-1Ra as an early immunomodulatory mediator that could be involved in the immunopathogenesis of porcine reproductive and respiratory syndrome virus infections.

Mouse (Murine) Interleukin 1 Receptor Antagonist (IL1RN) interaction partners

  1. the suppressed early innate/inflammatory responses instigated by the imbalance between IL-1beta (show IL1B Proteins) and IL-1Ra is an underlying cause for delayed wound healing in the diabetic corneas

  2. we demonstrate that the release of IL1RA in response to genotoxic stress contributes to the immunosuppressive effects of apoptotic cells.

  3. results provide evidence of the key role of IL1RA secreted by MSCs to both control the polarization of macrophages toward a M2 phenotype and inhibit B cell differentiation in vivo.

  4. Allo-transplantation of mesenchymal stem cells reduces Con (show KITLG Proteins) A liver injury by increasing IL10 (show IL10 Proteins) production through an IL1Ra dependent macrophage switch.

  5. results demonstrate that small intestinal eosinophils play a pivotal role in the maintenance of intestinal homeostasis by regulating Th17 cells via production of IL-1Ra.

  6. While both contributing to pathogen clearance, NLRP3 (show NLRP3 Proteins) more than NLRC4 (show NLRC4 Proteins) contributes to deleterious inflammatory responses in cystic fibrosis (show S100A8 Proteins) and correlates with defective NLRC4 (show NLRC4 Proteins)-dependent IL-1Ra production.

  7. IL-1Ra deficiencies might promote early plaque development in 16-week-old apoE (show APOE Proteins)(-/-) mice.

  8. IL-1Ra is associated with MMP-13 (show MMP13 Proteins) expression and has a novel function in such regulation without interference of the IL-1 (show IL1A Proteins) signaling cascade.

  9. These findings demonstrated novel roles for F-spondin (show SPON1 Proteins) and IL-1Ra in type B CpG oligodeoxynucleotides-mediated cell proliferation and migration of macrophages.

  10. Leading to enhanced interleukin-1 receptor antagonist (IL-1RA) production.

Rabbit Interleukin 1 Receptor Antagonist (IL1RN) interaction partners

  1. IL-8 (show IL8 Proteins) and IL-1ra showed correlation with the severity of colitis. These observations should significantly further understandings on the role of neutrophils and monocytes in the immunopathogenesis of ulcerative colitis

Horse (Equine) Interleukin 1 Receptor Antagonist (IL1RN) interaction partners

  1. Expression of IL-1RN in the endometrium is likely regulated by estradiol and progesterone and suggest that IL-1RN regulates the degree of IL-1 (show IL1A Proteins) signal transduction and thereby plays an important role in the establishment of equine pregnancy.

Rhesus Monkey Interleukin 1 Receptor Antagonist (IL1RN) interaction partners

  1. The variable number of tandem repeats polymorphism in the IL-1RN gene may be a useful predictor of negative symptom improvement in schizophrenic patients treated with antipsychotic drugs.

  2. common variation across the IL-1RN gene is strongly associated with IL-1RA levels.

IL1RN Protein Profile

Protein Summary

The protein encoded by this gene is a member of the interleukin 1 cytokine family. This protein inhibits the activities of interleukin 1, alpha (IL1A) and interleukin 1, beta (IL1B), and modulates a variety of interleukin 1 related immune and inflammatory responses. This gene and five other closely related cytokine genes form a gene cluster spanning approximately 400 kb on chromosome 2. A polymorphism of this gene is reported to be associated with increased risk of osteoporotic fractures and gastric cancer. Four alternatively spliced transcript variants encoding distinct isoforms have been reported.

Alternative names and synonyms associated with IL1RN

  • interleukin 1 receptor antagonist (IL1RN)
  • interleukin 1 receptor antagonist (Il1rn)
  • interleukin 1 receptor, type I (IL1R1)
  • DIRA protein
  • F630041P17Rik protein
  • icIL-1ra protein
  • IL-1RA protein
  • IL-1ra3 protein
  • IL-1RN protein
  • IL1F3 protein
  • IL1RA protein
  • IL1RN protein
  • IRAP protein
  • IRAP1 protein
  • MVCD4 protein

Protein level used designations for IL1RN

interleukin 1 receptor antagonist , IL1 inhibitor , IL1RN (IL1F3) , interleukin-1 receptor antagonist protein , intracellular IL-1 receptor antagonist type II , intracellular interleukin-1 receptor antagonist (icIL-1ra) , type II interleukin-1 receptor antagonist , IL-1RN , IL-1ra , IRAP , interleukin-1 receptor antagonist intracellular form , interleukin-1 receptor antagonist secretory form , secretory interleukin-1 receptor antagonist

459501 Pan troglodytes
3557 Homo sapiens
397499 Sus scrofa
60582 Rattus norvegicus
16181 Mus musculus
281860 Bos taurus
403660 Canis lupus familiaris
100301539 Oryctolagus cuniculus
100034236 Equus caballus
100721865 Cavia porcellus
100861585 Gallus gallus
701658 Macaca mulatta
100009558 Oryctolagus cuniculus
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