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TET1 mediates insulin-induced GPER up-regulation and endometrial cancer cells proliferation.
Data suggest that postprandial up-regulation of plasma insulin stimulates amino acid uptake into skeletal muscle but does not further augment postprandial muscle protein synthesis or stimulate postprandial deposition of dietary protein derived amino acids into de novo muscle protein in healthy young and older men.
Obesity is associated with increased betatrophin suppression after an oral glucose load; this response appears to be driven by hyperglycemia. Data suggest that human insulin or low glucose (as in hypoglycemia) increases betatrophin expression/secretion in adipocytes (3T3-L1 cells here); elevation of glucose levels (as in hyperglycemia) blunts this effect.
results indicate that insulin acts on the small intestine to increase OATP2B1 (show SLCO2B1 Proteins)-mediated absorption
Mutation of INS is associated with type 1B diabetes.
homozygous likely-pathogenic intronic variant in INS is associated with permanent neonatal diabetes.
Proinsulin C-peptide self-assembles into amyloid-like fibrils and the aggregation propensity of C-peptide is a characteristic feature that could be related to physiological and also pathological conditions.
A trend for a causal effect of IR on higher levels of tyrosine reached significance only in meta-analysis. In one of the largest studies combining "gold standard" measures for insulin responsiveness with non-targeted metabolomics, we found distinct metabolic profiles related to IR or impaired insulin secretion
The measurement of commercial insulin allowed the identification of species ranging from monomers to hexamers and their complexes with zinc ions.
Leptin (show LEP Proteins) to insulin and adiponectin (show ADIPOQ Proteins) to endothelin ratios are novel derived biomarkers useful for noninvasive diagnostics of initial stages of coronary lesions in patients with coronary artery disease.
The findings are consistent with previous studies that indicate a link between Na,K-ATPase (show ATP1A1 Proteins) activity and SFK signaling.
PTPLAD1 (show PTPLAD1 Proteins) and AMPK (show PRKAA1 Proteins) are rapidly compartmentalized within the plasma membrane (PM) and Golgi/endosome fractions after insulin stimulation and that ATIC (show ATIC Proteins) later accumulates in the Golgi/endosome fraction.
Pdx-1 (show PDX1 Proteins), MafA (show MAFA Proteins) and NeuroD1 (show NEUROD1 Proteins) bind to the A, C and E elements in the insulin promoter and regulate the transcriptional activity of the insulin promoter.
The interplay of the adiponectin (show ADIPOQ Proteins) system, TNFalpha (show TNF Proteins) and insulin at a transcriptional level and, their effects on the adipogenic transcription factor PPARgamma (show PPARG Proteins), as well as on the activation of main insulin signaling pathways, is reported.
Thermodynamics of insulin unfolding have been quantified by differential scanning calorimetry and thermal unfolding measurements to determine the extent and nature of their stabilization of the insulin hexamer.
Exposing the hydrophobic core of insulin can induce the increase of amyloidogenicity and formation of higher-order polymerized fibrils, which is less toxic to membranes.
Data suggest that a mutation in INS (C94Y) results a transgenic disease model for the investigation of permanent neonatal diabetes.
The results show that modulation of plasma insulin levels by dietary carbohydrates seems possible in anabolic sows, but IGF-I (show IGF1 Proteins) levels are less easily modified.
insulin increased GCLc (show GCLC Proteins) promoter activity, which required a prerequisite increase or decrease in medium glucose
SOCS3 (show SOCS3 Proteins) is an important negative regulator of insulin signaling in porcine adipocytes.
Insulin signaling role in skeletal muscle atrophy and autophagy in in transition and postpartum period
Differences between human and bovine insulin kinetics under shear
increased sensitivity to glucose clearance and skeletal muscle insulin signaling during dietary restriction
Hormonal gene expression involved in residual feed intake in dairy cows may be related to the molecular regulation of the leptin (show LEP Proteins)-NPY (show NPY Proteins) and insulin signaling pathways.
Raman spectra of amino acids by Density Functional Theory method have been calculated. Experimental Raman spectra of insulin has been done. The simulated Raman spectrum of insulin is obtained from amino acid spectrum.
Contains Binding kinetics for insulin binding
Using synchrotron radiation (SR), the crystal structures of T6 bovine insulin complexed with Ni(2 (show VMP1 Proteins)+) and Cu(2+) were solved to 1.50 and 1.45 A resolution, respectively.
The present study examined the effect of insulin-mediated activation of the mammalian target of rapamycin (show FRAP1 Proteins) complex 1 (MTORC1) signaling network on the proliferation of primary culture of theca-interstitial (T-I) cells.
In-situ spectroscopic investigation of ultrasonic assisted unfolding and aggregation of insulin.
insulin supports early initiation of the mesodermal factor Brachyury (show TBX1 Proteins) and the signalling molecules Wnt3a (show WNT3A Proteins) and Wnt4 (show WNT4 Proteins) as well as the progression of mesoderm formation
Data show that type 1 diabetic blastocyst did not express insulin mRNA.
Transplantation of transduced hematopoietic stem cells (HSCs) expressing proinsulin II prevents diabetes development.
Wnt3a increased the expression of NeuroD1 and Ins2 in the hypothalamus.
Data suggest that resveratrol acts on differentiating preadipocytes by inhibiting insulin signaling, mitochondrial biogenesis, and lipogenesis.
have characterized the distinctive sex-specific phenotypes exhibited by the ApoE(-/-):Ins2(+/Akita) mouse model and present evidence for the action of sex hormones on pancreatic beta-cell function
Data indicate that Src homology-2 domain containing protein B (SHB) deficiency causes a chronic increase in beta-cell focal adhesion kinase (FAK) activity that perturbs the normal insulin secretory characteristics of beta-cells.
Mouse Ins2 and Ins1 promoters were transiently activated in mouse fetal hepatocytes of embryonic days 13.5 and 16.5, respectively.
Data indicate that insulin/incomplete Freund's adjuvant (IFA) does not prevent but induces diabetes in RIP-CD80GP transgenic mice.
RORalpha is a transcriptional activator of insulin.
Mice deficient in coinhibitory PD-L1 (show CD274 Proteins) or PD-1 (show PDCD1 Proteins) molecules (PD-L1 (show CD274 Proteins)(-/-) and PD-1 (show PDCD1 Proteins)(-/-) mice), were used to study induction of preproinsulin (ppins)-specific CD8 (show CD8A Proteins) T-cell responses and experimental autoimmune diabetes.
Data suggest that CD34 (show CD34 Proteins) may be a specific marker for functionality, with some specificity for insulin.
Temporal and spatial expression of two insulin genes (insa and insab) during early developmental stages.
These findings suggest that GHRL (show GHRL Proteins) regulates INS synthesis by mediating its action on growth hormone secretagogue-receptor (show GHSR Proteins) in the central nervous system and partly involved in carbohydrate-glycogen (show GYS2 Proteins) metabolism.
Our results indicate that in adult tilapia insulin expression is not restricted to the endocrine pancreatic cells, but also occurs in endocrine cells of the pituitary gland and in the neuronal cells of the brain.
After removal of the precursor signal peptide, proinsulin is post-translationally cleaved into three peptides: the B chain and A chain peptides, which are covalently linked via two disulfide bonds to form insulin, and C-peptide. Binding of insulin to the insulin receptor (INSR) stimulates glucose uptake. A multitude of mutant alleles with phenotypic effects have been identified. There is a read-through gene, INS-IGF2, which overlaps with this gene at the 5' region and with the IGF2 gene at the 3' region. Alternative splicing results in multiple transcript variants.