Browse our Insulin Proteins (INS)

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Insulin Proteins (INS)
On www.antibodies-online.com are 48 Insulin (INS) Proteins from 16 different suppliers available. Additionally we are shipping Insulin Antibodies (1086) and Insulin Kits (233) and many more products for this protein. A total of 1376 Insulin products are currently listed.
Synonyms:
AA986540, IDDM2, ILPR, Ins-2, ins1, ins1-a, InsII, Insulin, IRDN, Mody, Mody4, MODY10, proinsulin, xins, zgc:109842
list all proteins Gene Name GeneID UniProt
INS 3630 P01308
INS 16334 P01326
INS 397415 P01315

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Insulin Proteins (INS) by Origin

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More Proteins for Insulin Interaction Partners

Human Insulin (INS) interaction partners

  1. Results indicate that insulin scores, but not glycemic scores, were positively associated with colorectal cancer (CRC (show CALR Proteins)) mortality.

  2. Data suggest that higher dietary intake of glucose, but not of fructose or of sucrose, is associated with insulin resistance; no associations were observed for high dietary intakes of glucose, fructose, or sucrose with loss of function of pancreatic beta-cells in secretion of insulin. This study was conducted in the Netherlands among patients newly diagnosed with prediabetes or type 2 diabetes.

  3. Higher maternal total n-3 PUFAs and specifically DHA levels during pregnancy are associated with higher childhood total-cholesterol, HDL (show HSD11B1 Proteins)-cholesterol and insulin levels.

  4. In pancreas sections from autoantibody-positive (Ab+) donors, insulin area and beta-cell mass are maintained before type 1 diabetes onset and that production of proinsulin increases. The pancreatic proinsulin-to-insulin area ratio was also increased in these donors with prediabetes

  5. microRNA-7 can differentiate human induced pluripotent stem cells into functional isletlike cell clusters secreting insulin in a short time.

  6. describe an alternative open reading frame within human insulin mRNA encoding a highly immunogenic polypeptide that is targeted by T cells in Type 1 Diabetes (T1D) patients. Cytotoxic T cells directed against the N-terminal peptide of this nonconventional product are present in the circulation of T1D patients, and such CD8 (show CD8A Proteins)(+) T cells are capable of killing human beta cells, and thereby may be diabetogenic.

  7. Insulin stimulation of Akt1 (show AKT1 Proteins) and Akt2 (show AKT2 Proteins) signaling in Cystic fibrosis (show S100A8 Proteins) airway cells was diminished compared with that observed in airway cells expressing wild-type CFTR (show CFTR Proteins).

  8. The activation mechanism of insulin, IF-I, and IGF-II upon binding to corresponding receptors using molecular dynamics simulations has been reported.

  9. These data implicate the insulin-FoxM1 (show FOXM1 Proteins)/PLK1/CENP-A (show CENPA Proteins) pathway-regulated mitotic cell-cycle progression as an essential component in the beta cell adaptation to delay and/or prevent progression to diabetes.

  10. The reproducibility of proinsulin:C-peptide ratio (PI:C) benefits from the automated simultaneous determination of both hormones. HOMA2-IR-corrected PI:C may serve as a minimally invasive alternative to the more tedious hyperglycemic clamp test

Pig (Porcine) Insulin (INS) interaction partners

  1. Study used well-tempered bias exchange metadynamics simulations to determine the equilibrium ensembles of an insulin molecule under amyloidogenic conditions of low pH and high temperature. The folded state of a single insulin molecule was shown to be the most stable, longest-lived state even under amyloidogenic conditions.

  2. The findings are consistent with previous studies that indicate a link between Na,K-ATPase (show ATP1A1 Proteins) activity and SFK signaling.

  3. PTPLAD1 (show PTPLAD1 Proteins) and AMPK (show PRKAA1 Proteins) are rapidly compartmentalized within the plasma membrane (PM) and Golgi/endosome fractions after insulin stimulation and that ATIC (show ATIC Proteins) later accumulates in the Golgi/endosome fraction.

  4. Pdx-1 (show PDX1 Proteins), MafA (show MAFA Proteins) and NeuroD1 (show NEUROD1 Proteins) bind to the A, C and E elements in the insulin promoter and regulate the transcriptional activity of the insulin promoter.

  5. The interplay of the adiponectin (show ADIPOQ Proteins) system, TNFalpha (show TNF Proteins) and insulin at a transcriptional level and, their effects on the adipogenic transcription factor PPARgamma (show PPARG Proteins), as well as on the activation of main insulin signaling pathways, is reported.

  6. Thermodynamics of insulin unfolding have been quantified by differential scanning calorimetry and thermal unfolding measurements to determine the extent and nature of their stabilization of the insulin hexamer.

  7. Exposing the hydrophobic core of insulin can induce the increase of amyloidogenicity and formation of higher-order polymerized fibrils, which is less toxic to membranes.

  8. Data suggest that a mutation in INS (C94Y) results a transgenic disease model for the investigation of permanent neonatal diabetes.

  9. The results show that modulation of plasma insulin levels by dietary carbohydrates seems possible in anabolic sows, but IGF-I (show IGF1 Proteins) levels are less easily modified.

  10. insulin increased GCLc (show GCLC Proteins) promoter activity, which required a prerequisite increase or decrease in medium glucose

Cow (Bovine) Insulin (INS) interaction partners

  1. Insulin signaling role in skeletal muscle atrophy and autophagy in in transition and postpartum period

  2. Differences between human and bovine insulin kinetics under shear

  3. increased sensitivity to glucose clearance and skeletal muscle insulin signaling during dietary restriction

  4. Hormonal gene expression involved in residual feed intake in dairy cows may be related to the molecular regulation of the leptin (show LEP Proteins)-NPY (show NPY Proteins) and insulin signaling pathways.

  5. Raman spectra of amino acids by Density Functional Theory method have been calculated. Experimental Raman spectra of insulin has been done. The simulated Raman spectrum of insulin is obtained from amino acid spectrum.

  6. Contains Binding kinetics for insulin binding

  7. Using synchrotron radiation (SR), the crystal structures of T6 bovine insulin complexed with Ni(2 (show VMP1 Proteins)+) and Cu(2+) were solved to 1.50 and 1.45 A resolution, respectively.

  8. Thermodynamics of insulin unfolding have been quantified by differential scanning calorimetry and thermal unfolding measurements to determine the extent and nature of their stabilization of the insulin hexamer.

  9. The present study examined the effect of insulin-mediated activation of the mammalian target of rapamycin (show FRAP1 Proteins) complex 1 (MTORC1) signaling network on the proliferation of primary culture of theca-interstitial (T-I) cells.

  10. In-situ spectroscopic investigation of ultrasonic assisted unfolding and aggregation of insulin.

Rabbit Insulin (INS) interaction partners

  1. insulin supports early initiation of the mesodermal factor Brachyury (show TBX1 Proteins) and the signalling molecules Wnt3a (show WNT3A Proteins) and Wnt4 (show WNT4 Proteins) as well as the progression of mesoderm formation

  2. Data show that type 1 diabetic blastocyst did not express insulin mRNA.

Mouse (Murine) Insulin (INS) interaction partners

  1. report that EndMTs occur in the diabetic endothelium of Ins2Akita/wt mouse, and show that induction of sex determining region Y-box 2 (Sox2 (show SOX2 Proteins)) is a mediator of excess BMP signaling that results in activation of EndMTs and increased vascular calcification

  2. Transplantation of transduced hematopoietic stem cells (HSCs) expressing proinsulin II prevents diabetes development.

  3. Wnt3a increased the expression of NeuroD1 and Ins2 in the hypothalamus.

  4. Data suggest that resveratrol acts on differentiating preadipocytes by inhibiting insulin signaling, mitochondrial biogenesis, and lipogenesis.

  5. have characterized the distinctive sex-specific phenotypes exhibited by the ApoE(-/-):Ins2(+/Akita) mouse model and present evidence for the action of sex hormones on pancreatic beta-cell function

  6. Data indicate that Src homology-2 domain containing protein B (SHB) deficiency causes a chronic increase in beta-cell focal adhesion kinase (FAK) activity that perturbs the normal insulin secretory characteristics of beta-cells.

  7. Mouse Ins2 and Ins1 promoters were transiently activated in mouse fetal hepatocytes of embryonic days 13.5 and 16.5, respectively.

  8. Data indicate that insulin/incomplete Freund's adjuvant (IFA) does not prevent but induces diabetes in RIP-CD80GP transgenic mice.

  9. RORalpha is a transcriptional activator of insulin.

  10. Mice deficient in coinhibitory PD-L1 (show CD274 Proteins) or PD-1 (show PDCD1 Proteins) molecules (PD-L1 (show CD274 Proteins)(-/-) and PD-1 (show PDCD1 Proteins)(-/-) mice), were used to study induction of preproinsulin (ppins)-specific CD8 (show CD8A Proteins) T-cell responses and experimental autoimmune diabetes.

Zebrafish Insulin (INS) interaction partners

  1. Temporal and spatial expression of two insulin genes (insa and insab) during early developmental stages.

  2. These findings suggest that GHRL (show GHRL Proteins) regulates INS synthesis by mediating its action on growth hormone secretagogue-receptor (show GHSR Proteins) in the central nervous system and partly involved in carbohydrate-glycogen (show GYS2 Proteins) metabolism.

  3. Our results indicate that in adult tilapia insulin expression is not restricted to the endocrine pancreatic cells, but also occurs in endocrine cells of the pituitary gland and in the neuronal cells of the brain.

Insulin (INS) Protein Profile

Protein Summary

After removal of the precursor signal peptide, proinsulin is post-translationally cleaved into three peptides: the B chain and A chain peptides, which are covalently linked via two disulfide bonds to form insulin, and C-peptide. Binding of insulin to the insulin receptor (INSR) stimulates glucose uptake. A multitude of mutant alleles with phenotypic effects have been identified. There is a read-through gene, INS-IGF2, which overlaps with this gene at the 5' region and with the IGF2 gene at the 3' region. Alternative splicing results in multiple transcript variants.

Alternative names and synonyms associated with Insulin (INS)

  • insulin (ins)
  • insulin precursor (PIN)
  • insulin (INS)
  • insulin (Ins)
  • insulin II (Ins2)
  • insulin-like (LOC100060077)
  • preproinsulin (ins)
  • AA986540 protein
  • IDDM2 protein
  • ILPR protein
  • Ins-2 protein
  • ins1 protein
  • ins1-a protein
  • InsII protein
  • Insulin protein
  • IRDN protein
  • Mody protein
  • Mody4 protein
  • MODY10 protein
  • proinsulin protein
  • xins protein
  • zgc:109842 protein

Protein level used designations for Insulin Proteins (INS)

insulin I , insulin , preproinsulin , proinsulin , insulin-2 , insa

GENE ID SPECIES
100101718 Xenopus (Silurana) tropicalis
100533403 Aplysia californica
3630 Homo sapiens
397415 Sus scrofa
280829 Bos taurus
100009181 Oryctolagus cuniculus
101684928 Mustela putorius furo
483665 Canis lupus familiaris
493804 Felis catus
100379579 Cavia porcellus
396145 Gallus gallus
101794427 Anas platyrhynchos
449570 Pan troglodytes
16334 Mus musculus
100060077 Equus caballus
30262 Danio rerio
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