Browse our anti-KHDRBS1 (KHDRBS1) Antibodies

Full name:
anti-KH Domain Containing, RNA Binding, Signal Transduction Associated 1 Antibodies (KHDRBS1)
On www.antibodies-online.com are 124 KH Domain Containing, RNA Binding, Signal Transduction Associated 1 (KHDRBS1) Antibodies from 19 different suppliers available. Additionally we are shipping KHDRBS1 Proteins (11) and KHDRBS1 Kits (9) and many more products for this protein. A total of 150 KHDRBS1 products are currently listed.
Synonyms:
A170, fj90g10, KHDRBS1, OSIL, p60, P62, p62B, p68, PDB3, Sam68, wu:fa18g12, wu:fa56c01, wu:fc91b01, wu:fj90g10, zgc:113899, ZIP3
list all antibodies Gene Name GeneID UniProt
KHDRBS1 10657 Q07666
KHDRBS1 20218 Q60749
KHDRBS1 117268 Q91V33

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anti-Human KHDRBS1 Antibodies:

anti-Mouse (Murine) KHDRBS1 Antibodies:

anti-Rat (Rattus) KHDRBS1 Antibodies:

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Top referenced anti-KHDRBS1 Antibodies

  1. Human Polyclonal KHDRBS1 Primary Antibody for ICC, IF - ABIN4351941 : Lawrence, Schafer, Rieder: The nuclear protein Sam68 is cleaved by the FMDV 3C protease redistributing Sam68 to the cytoplasm during FMDV infection of host cells. in Virology 2012 (PubMed)
    Show all 2 references for 4351941

  2. Cow (Bovine) Polyclonal KHDRBS1 Primary Antibody for IHC, WB - ABIN2779000 : Duran, Linares, Galvez, Wikenheiser, Flores, Diaz-Meco, Moscat: The signaling adaptor p62 is an important NF-kappaB mediator in tumorigenesis. in Cancer cell 2008 (PubMed)

  3. Human Polyclonal KHDRBS1 Primary Antibody for EIA, IHC (fro) - ABIN1108931 : Grange, Belly, Dupas, Trembleau, Sadoul, Goldberg: Specific interaction between Sam68 and neuronal mRNAs: implication for the activity-dependent biosynthesis of elongation factor eEF1A. in Journal of neuroscience research 2008 (PubMed)

  4. Cow (Bovine) Polyclonal KHDRBS1 Primary Antibody for WB - ABIN2779966 : Paronetto, Zalfa, Botti, Geremia, Bagni, Sette: The nuclear RNA-binding protein Sam68 translocates to the cytoplasm and associates with the polysomes in mouse spermatocytes. in Molecular biology of the cell 2005 (PubMed)

More Antibodies against KHDRBS1 Interaction Partners

Human KH Domain Containing, RNA Binding, Signal Transduction Associated 1 (KHDRBS1) interaction partners

  1. Authors found that p62/SQSTM1 (show SQSTM1 Antibodies), a protein upregulated in liver parenchymal cells but downregulated in HCC (show FAM126A Antibodies)-associated HSCs, negatively controls hepatic stellate cells activation.

  2. necessary for retinal pigmented epithelial cytoprotection under oxidative stress; NFkappaB p65 activity may be critical upstream initiator of p62 expression in retinal pigmented epithelial cells under oxidative stress

  3. p62/SQSTM1 (show SQSTM1 Antibodies), which accumulates in autophagy-defective cells, directly binds to and inhibits nuclear RNF168 (show RNF168 Antibodies), an E3 ligase essential for histone H2A ubiquitination and DNA damage responses. As a result, DNA repair proteins such as BRCA1, RAP80 (show UIMC1 Antibodies), and Rad51 (show RAD51 Antibodies) cannot be recruited to the sites of DNA double-strand breaks (DSBs), which impairs DSB repair.

  4. propose that the interplay between LRRK2 (show LRRK2 Antibodies) and p62 (show GTF2H1 Antibodies) may contribute to the pathophysiological function and homeostasis of LRRK2 (show LRRK2 Antibodies) protein

  5. Frontotemporal dementia -linked mutations in gene p62/SQSTM1 (show SQSTM1 Antibodies) encoding autophagy adaptor proteins , indicate that impaired autophagy might cause Frontotemporal dementia.

  6. Sam68 possibly participated in the progresses of T-acute lymphoblastic leukemia at least partially via AKT (show AKT1 Antibodies)/mTOR (show FRAP1 Antibodies) signaling pathway

  7. These data suggest that SQSTM1 (show SQSTM1 Antibodies) mutations are not a common cause of normal tension glaucoma.

  8. Sam68 is essential for DNA damage-induced NF-kappaB (show NFKB1 Antibodies) activation and colon tumorigenesis.

  9. These findings define a hitherto novel mechanism of action for Sam68 in governing p53 (show TP53 Antibodies) transcriptional activation, and represent the first report of Sam68 in the regulation of tumor suppressor activities.

  10. HNRNPL (show HNRNPL Antibodies) acts as the adaptor to combine the two substructures and form the intact Sam68 nuclear body through the interaction of two sets of RNA recognition motifs with the putative architectural RNA in the respective substructures.

Mouse (Murine) KH Domain Containing, RNA Binding, Signal Transduction Associated 1 (KHDRBS1) interaction partners

  1. Sam68 may function as an immune rheostat that balances the activation of NF-kappaB (show NFKB1 Antibodies) p65 (show NFkBP65 Antibodies) and c-Rel (show NFkBP65 Antibodies), as well as MAPK (show MAPK1 Antibodies), revealing a potential novel target to manipulate TLR signaling.

  2. Sam68 plays a crucial role in DNA damage response via regulating DNA damage-initiated PAR (show AFG3L2 Antibodies) production.

  3. Sam68 is essential for DNA damage-induced NF-kappaB (show NFKB1 Antibodies) activation and colon tumorigenesis.

  4. Sam68 and T-STAR (show KHDRBS3 Antibodies) could regulate alternative splicing of some pre-mRNAs by bringing two distant UAA motifs into proximity and looping out regions of the pre-mRNA.

  5. SAM68 is a physiological regulator of SMN2 (show SMN1 Antibodies) splicing in a spinal muscular atrophy mouse model.

  6. Data (including data from knockout mice) suggest expression of Sam68 plays role in adipogenesis of white adipose tissue versus brown adipose tissue; Sam68 appears to regulate adiposity and energy homeostasis (balance of energy intake/expenditure).

  7. Depletion of p31S6K1 with small interfering RNAs (siRNAs) partially restored adipogenesis of Sam68-deficient preadipocytes.

  8. Emerging roles for Sam68 in adipogenesis and neuronal development.

  9. Our research identifies a role for Sam68 in synaptodendritic posttranscriptional regulation of actb (show ACTB Antibodies) and may provide insight into the pathophysiology of fragile X (show FMR1 Antibodies) tremor/ataxia (show USP14 Antibodies) syndrome

  10. Results suggest a novel role for SAM68 in the miRNA pathway during spermatogenesis.

KHDRBS1 Antigen Profile

Antigen Summary

This gene encodes a multifunctional protein that binds ubiquitin and regulates activation of the nuclear factor kappa-B (NF-kB) signaling pathway. The protein functions as a scaffolding/adaptor protein in concert with TNF receptor-associated factor 6 to mediate activation of NF-kB in response to upstream signals. Alternatively spliced transcript variants encoding either the same or different isoforms have been identified for this gene. Mutations in this gene result in sporadic and familial Paget disease of bone.

Alternative names and synonyms associated with KHDRBS1

  • KH domain containing, RNA binding, signal transduction associated 1a (khdrbs1a) antibody
  • KH domain containing, RNA binding, signal transduction associated 1 (KHDRBS1) antibody
  • KH domain containing, RNA binding, signal transduction associated 1 (khdrbs1) antibody
  • KH domain containing, RNA binding, signal transduction associated 1 (Khdrbs1) antibody
  • sequestosome 1 (SQSTM1) antibody
  • A170 antibody
  • fj90g10 antibody
  • KHDRBS1 antibody
  • OSIL antibody
  • p60 antibody
  • P62 antibody
  • p62B antibody
  • p68 antibody
  • PDB3 antibody
  • Sam68 antibody
  • wu:fa18g12 antibody
  • wu:fa56c01 antibody
  • wu:fc91b01 antibody
  • wu:fj90g10 antibody
  • zgc:113899 antibody
  • ZIP3 antibody

Protein level used designations for KHDRBS1

GAP-associated phosphoprotein p62 , KH domain containing, RNA binding, signal transduction associated 1 , fa18g12 , fa56c01 , fc91b01 , GAP-associated tyrosine phosphoprotein p62 (Sam68) , KH domain-containing, RNA-binding, signal transduction-associated protein 1 , p21 Ras GTPase-activating protein-associated p62 , src-associated in mitosis 68 kDa protein , GAP-associated tyrosine phosphoprotein p62 , src associated in mitosis, 68 kDa , p68 , KH domain RNA-binding protein Sam68 , sam68 , EBI3-associated protein of 60 kDa , EBI3-associated protein p60 , EBIAP , oxidative stress induced like , phosphotyrosine independent ligand for the Lck SH2 domain p62 , phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa , sequestosome-1 , ubiquitin-binding protein p62

GENE ID SPECIES
30082 Danio rerio
456705 Pan troglodytes
487316 Canis lupus familiaris
549799 Xenopus (Silurana) tropicalis
100025483 Monodelphis domestica
10657 Homo sapiens
538775 Bos taurus
20218 Mus musculus
117268 Rattus norvegicus
398660 Xenopus laevis
374071 Gallus gallus
8878 Homo sapiens
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