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Browse our KHDRBS1 Proteins (KHDRBS1)

Full name:
KH Domain Containing, RNA Binding, Signal Transduction Associated 1 Proteins (KHDRBS1)
On are 11 KH Domain Containing, RNA Binding, Signal Transduction Associated 1 (KHDRBS1) Proteins from 8 different suppliers available. Additionally we are shipping KHDRBS1 Antibodies (103) and KHDRBS1 Kits (8) and many more products for this protein. A total of 128 KHDRBS1 products are currently listed.
A170, fj90g10, KHDRBS1, OSIL, p60, P62, p62B, p68, PDB3, Sam68, wu:fa18g12, wu:fa56c01, wu:fc91b01, wu:fj90g10, zgc:113899, ZIP3
list all proteins Gene Name GeneID UniProt
KHDRBS1 10657 Q07666
KHDRBS1 20218 Q60749
KHDRBS1 117268 Q91V33

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KHDRBS1 Proteins (KHDRBS1) by Origin

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Top referenced KHDRBS1 Proteins

  1. Human KHDRBS1 Protein expressed in Wheat germ - ABIN1308538 : Lawrence, Schafer, Rieder: The nuclear protein Sam68 is cleaved by the FMDV 3C protease redistributing Sam68 to the cytoplasm during FMDV infection of host cells. in Virology 2012 (PubMed)

More Proteins for KHDRBS1 Interaction Partners

Human KH Domain Containing, RNA Binding, Signal Transduction Associated 1 (KHDRBS1) interaction partners

  1. Spinal stenosis emerges as a prominent phenotype in SQSTM1 (show SQSTM1 Proteins) P392L-positive men with aging

  2. p62 is a crucial positive regulator of HIF1alpha, which is a facilitating factor in p62-enhanced tumorigenesis.

  3. SQSTM1 (show SQSTM1 Proteins) mutations were initially associated with Paget disease of bone (PDB), they have been also identified in FTD (show FTL Proteins)(familial frontotemporal dementia).

  4. new evidence supports an autophagy-independent key role of the adaptor p62 (show GTF2H1 Proteins) (encoded by the gene Sqstm1 (show SQSTM1 Proteins)) in signaling functions central to tumor initiation in the epithelium and suppression of tumor progression in the stroma. [Review]

  5. FRET-based translocation assays reveal that insulin (show INS Proteins) promotes the association of both p62 (show GTF2H1 Proteins) and aPKC with the insulin (show INS Proteins)-regulated scaffold IRS-1 (show IRS1 Proteins).

  6. p62 (show GTF2H1 Proteins) are subjected to parkin (show PARK2 Proteins) mediated proteasomal degradation

  7. The present study, for the first time, examined the expression of central autophagy proteins BAG3 and p62 in testicular cancer

  8. The present study supports previous observations on amyotrophic lateral sclerosis that SQSTM1 (show SQSTM1 Proteins) mutations consistently associate with TDP-43 (show TARDBP Proteins) pathology

  9. The host factor Sam68 interact with both, foot-and-mouth disease virus RNA motifs in the internal ribosome binding site and viral non-structural proteins 3C(pro) and 3D(pol).

  10. Suggest that Beclin 1 and p62 could serve as potential indicators for the prognosis of patients with non-small cell lung cancer.

Mouse (Murine) KH Domain Containing, RNA Binding, Signal Transduction Associated 1 (KHDRBS1) interaction partners

  1. Sam68 and T-STAR could regulate alternative splicing of some pre-mRNAs by bringing two distant UAA motifs into proximity and looping out regions of the pre-mRNA.

  2. SAM68 is a physiological regulator of SMN2 (show SMN1 Proteins) splicing in a spinal muscular atrophy mouse model.

  3. Data (including data from knockout mice) suggest expression of Sam68 plays role in adipogenesis of white adipose tissue versus brown adipose tissue; Sam68 appears to regulate adiposity and energy homeostasis (balance of energy intake/expenditure).

  4. Depletion of p31S6K1 with small interfering RNAs (siRNAs) partially restored adipogenesis of Sam68-deficient preadipocytes.

  5. Emerging roles for Sam68 in adipogenesis and neuronal development.

  6. Our research identifies a role for Sam68 in synaptodendritic posttranscriptional regulation of actb (show ACTB Proteins) and may provide insight into the pathophysiology of fragile X (show FMR1 Proteins) tremor/ataxia (show USP14 Proteins) syndrome

  7. Results suggest a novel role for SAM68 in the miRNA pathway during spermatogenesis.

  8. Sam68 regulates alternative splicing during adipogenesis.

  9. We demonstrated that the FMDV 3C(pro) induced the cleavage of nuclear RNA-binding protein Sam68 C-terminus containing the nuclear localization sequence (NLS (show ALDH1A2 Proteins) and stimulated the redistribution of Sam68 to the cytoplasm.

  10. Findings uncover SAM68 as a key regulator of dynamic control of Nrxn1 (show NRXN1 Proteins) molecular diversity and activity-dependent alternative splicing in the central nervous system.

KHDRBS1 Protein Profile

Protein Summary

This gene encodes a multifunctional protein that binds ubiquitin and regulates activation of the nuclear factor kappa-B (NF-kB) signaling pathway. The protein functions as a scaffolding/adaptor protein in concert with TNF receptor-associated factor 6 to mediate activation of NF-kB in response to upstream signals. Alternatively spliced transcript variants encoding either the same or different isoforms have been identified for this gene. Mutations in this gene result in sporadic and familial Paget disease of bone.

Alternative names and synonyms associated with KHDRBS1

  • KH domain containing, RNA binding, signal transduction associated 1a (khdrbs1a)
  • KH domain containing, RNA binding, signal transduction associated 1 (KHDRBS1)
  • KH domain containing, RNA binding, signal transduction associated 1 (khdrbs1)
  • KH domain containing, RNA binding, signal transduction associated 1 (Khdrbs1)
  • sequestosome 1 (SQSTM1)
  • A170 protein
  • fj90g10 protein
  • KHDRBS1 protein
  • OSIL protein
  • p60 protein
  • P62 protein
  • p62B protein
  • p68 protein
  • PDB3 protein
  • Sam68 protein
  • wu:fa18g12 protein
  • wu:fa56c01 protein
  • wu:fc91b01 protein
  • wu:fj90g10 protein
  • zgc:113899 protein
  • ZIP3 protein

Protein level used designations for KHDRBS1

GAP-associated phosphoprotein p62 , KH domain containing, RNA binding, signal transduction associated 1 , fa18g12 , fa56c01 , fc91b01 , GAP-associated tyrosine phosphoprotein p62 (Sam68) , KH domain-containing, RNA-binding, signal transduction-associated protein 1 , p21 Ras GTPase-activating protein-associated p62 , src-associated in mitosis 68 kDa protein , GAP-associated tyrosine phosphoprotein p62 , src associated in mitosis, 68 kDa , p68 , KH domain RNA-binding protein Sam68 , sam68 , EBI3-associated protein of 60 kDa , EBI3-associated protein p60 , EBIAP , oxidative stress induced like , phosphotyrosine independent ligand for the Lck SH2 domain p62 , phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa , sequestosome-1 , ubiquitin-binding protein p62

30082 Danio rerio
456705 Pan troglodytes
487316 Canis lupus familiaris
549799 Xenopus (Silurana) tropicalis
100025483 Monodelphis domestica
10657 Homo sapiens
538775 Bos taurus
20218 Mus musculus
117268 Rattus norvegicus
398660 Xenopus laevis
374071 Gallus gallus
8878 Homo sapiens
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