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Browse our KHDRBS1 Proteins (KHDRBS1)

Full name:
KH Domain Containing, RNA Binding, Signal Transduction Associated 1 Proteins (KHDRBS1)
On are 12 KH Domain Containing, RNA Binding, Signal Transduction Associated 1 (KHDRBS1) Proteins from 8 different suppliers available. Additionally we are shipping KHDRBS1 Antibodies (123) and KHDRBS1 Kits (8) and many more products for this protein. A total of 149 KHDRBS1 products are currently listed.
A170, fj90g10, KHDRBS1, OSIL, p60, P62, p62B, p68, PDB3, Sam68, wu:fa18g12, wu:fa56c01, wu:fc91b01, wu:fj90g10, zgc:113899, ZIP3
list all proteins Gene Name GeneID UniProt
KHDRBS1 10657 Q07666
KHDRBS1 20218 Q60749
KHDRBS1 117268 Q91V33

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KHDRBS1 Proteins (KHDRBS1) by Origin

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Top referenced KHDRBS1 Proteins

  1. Human KHDRBS1 Protein expressed in Wheat germ - ABIN1308538 : Lawrence, Schafer, Rieder: The nuclear protein Sam68 is cleaved by the FMDV 3C protease redistributing Sam68 to the cytoplasm during FMDV infection of host cells. in Virology 2012 (PubMed)

More Proteins for KHDRBS1 Interaction Partners

Human KH Domain Containing, RNA Binding, Signal Transduction Associated 1 (KHDRBS1) interaction partners

  1. Sam68 was overexpressed in EOC tissue in association with such cancer malignant factors of FIGO stage, histological grade, and lymph node metastasis, and also positively regulated the proliferation of EOC cells.

  2. These studies suggest that p62 is involved in the genesis of nuclear factor kappaB-induced proinflammatory and prolabor mediators.

  3. In this review, we discuss p62-mediated signaling pathways and their roles in liver pathophysiology, especially nonalcoholic steatohepatitis and hepatocellular carcinoma

  4. findings expand the SQSTM1 (show SQSTM1 Proteins)-associated phenotypic spectrum and lend further support to the concept of disturbed selective autophagy pathways in neurodegenerative diseases

  5. Aldo was revealed to induce autophagy, as indicated by the increased conversion from microtubuleassociated protein 1A/1Blight chain 3 (LC3)I to LC3II, the increased expression levels of autophagyrelated gene 7 (Atg7) and the increased degradation of p62, which was accompanied by MC proliferation

  6. Results demonstrate that p62 (show GTF2H1 Proteins) facilitates activation of NRF2 (show GABPA Proteins) and mTORC1 and is essential for hepatocellular carcinomas (HCC (show FAM126A Proteins)) initiation. High levels of p62 (show GTF2H1 Proteins) accumulation in non-tumor liver tissue in early-stage HCC (show FAM126A Proteins) patients.

  7. Taken together, these results illuminated that enterovirus 71 infections can induce stress granule formation, and Sam68, as a stress granule component, migrates alone with stress granules dependent on intact microtubule upon the viral infections.

  8. Results show that Nrf2 (show GABPA Proteins) prevents TM-induced apoptotic cell death and that TM promotes p62 (show GTF2H1 Proteins)-dependent autophagic Keap1 (show KEAP1 Proteins) degradation, leading to Nrf2 (show GABPA Proteins) activation. In addition, we identified that p62 (show GTF2H1 Proteins) is essential to protect cells against TM-mediated oxidative damage through Nrf2 (show GABPA Proteins) activation.

  9. Spinal stenosis emerges as a prominent phenotype in SQSTM1 (show SQSTM1 Proteins) P392L-positive men with aging

  10. p62 is a crucial positive regulator of HIF1alpha, which is a facilitating factor in p62-enhanced tumorigenesis.

Mouse (Murine) KH Domain Containing, RNA Binding, Signal Transduction Associated 1 (KHDRBS1) interaction partners

  1. Sam68 and T-STAR could regulate alternative splicing of some pre-mRNAs by bringing two distant UAA motifs into proximity and looping out regions of the pre-mRNA.

  2. SAM68 is a physiological regulator of SMN2 (show SMN1 Proteins) splicing in a spinal muscular atrophy mouse model.

  3. Data (including data from knockout mice) suggest expression of Sam68 plays role in adipogenesis of white adipose tissue versus brown adipose tissue; Sam68 appears to regulate adiposity and energy homeostasis (balance of energy intake/expenditure).

  4. Depletion of p31S6K1 with small interfering RNAs (siRNAs) partially restored adipogenesis of Sam68-deficient preadipocytes.

  5. Emerging roles for Sam68 in adipogenesis and neuronal development.

  6. Our research identifies a role for Sam68 in synaptodendritic posttranscriptional regulation of actb (show ACTB Proteins) and may provide insight into the pathophysiology of fragile X (show FMR1 Proteins) tremor/ataxia (show USP14 Proteins) syndrome

  7. Results suggest a novel role for SAM68 in the miRNA pathway during spermatogenesis.

  8. Sam68 regulates alternative splicing during adipogenesis.

  9. We demonstrated that the FMDV 3C(pro) induced the cleavage of nuclear RNA-binding protein Sam68 C-terminus containing the nuclear localization sequence (NLS (show ALDH1A2 Proteins) and stimulated the redistribution of Sam68 to the cytoplasm.

  10. Findings uncover SAM68 as a key regulator of dynamic control of Nrxn1 (show NRXN1 Proteins) molecular diversity and activity-dependent alternative splicing in the central nervous system.

KHDRBS1 Protein Profile

Protein Summary

This gene encodes a multifunctional protein that binds ubiquitin and regulates activation of the nuclear factor kappa-B (NF-kB) signaling pathway. The protein functions as a scaffolding/adaptor protein in concert with TNF receptor-associated factor 6 to mediate activation of NF-kB in response to upstream signals. Alternatively spliced transcript variants encoding either the same or different isoforms have been identified for this gene. Mutations in this gene result in sporadic and familial Paget disease of bone.

Alternative names and synonyms associated with KHDRBS1

  • KH domain containing, RNA binding, signal transduction associated 1a (khdrbs1a)
  • KH domain containing, RNA binding, signal transduction associated 1 (KHDRBS1)
  • KH domain containing, RNA binding, signal transduction associated 1 (khdrbs1)
  • KH domain containing, RNA binding, signal transduction associated 1 (Khdrbs1)
  • sequestosome 1 (SQSTM1)
  • A170 protein
  • fj90g10 protein
  • KHDRBS1 protein
  • OSIL protein
  • p60 protein
  • P62 protein
  • p62B protein
  • p68 protein
  • PDB3 protein
  • Sam68 protein
  • wu:fa18g12 protein
  • wu:fa56c01 protein
  • wu:fc91b01 protein
  • wu:fj90g10 protein
  • zgc:113899 protein
  • ZIP3 protein

Protein level used designations for KHDRBS1

GAP-associated phosphoprotein p62 , KH domain containing, RNA binding, signal transduction associated 1 , fa18g12 , fa56c01 , fc91b01 , GAP-associated tyrosine phosphoprotein p62 (Sam68) , KH domain-containing, RNA-binding, signal transduction-associated protein 1 , p21 Ras GTPase-activating protein-associated p62 , src-associated in mitosis 68 kDa protein , GAP-associated tyrosine phosphoprotein p62 , src associated in mitosis, 68 kDa , p68 , KH domain RNA-binding protein Sam68 , sam68 , EBI3-associated protein of 60 kDa , EBI3-associated protein p60 , EBIAP , oxidative stress induced like , phosphotyrosine independent ligand for the Lck SH2 domain p62 , phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa , sequestosome-1 , ubiquitin-binding protein p62

30082 Danio rerio
456705 Pan troglodytes
487316 Canis lupus familiaris
549799 Xenopus (Silurana) tropicalis
100025483 Monodelphis domestica
10657 Homo sapiens
538775 Bos taurus
20218 Mus musculus
117268 Rattus norvegicus
398660 Xenopus laevis
374071 Gallus gallus
8878 Homo sapiens
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