Browse our KHDRBS1 Proteins (KHDRBS1)

Full name:
KH Domain Containing, RNA Binding, Signal Transduction Associated 1 Proteins (KHDRBS1)
On www.antibodies-online.com are 11 KH Domain Containing, RNA Binding, Signal Transduction Associated 1 (KHDRBS1) Proteins from 7 different suppliers available. Additionally we are shipping KHDRBS1 Antibodies (128) and KHDRBS1 Kits (9) and many more products for this protein. A total of 154 KHDRBS1 products are currently listed.
Synonyms:
A170, fj90g10, KHDRBS1, OSIL, p60, P62, p62B, p68, PDB3, Sam68, wu:fa18g12, wu:fa56c01, wu:fc91b01, wu:fj90g10, zgc:113899, ZIP3
list all proteins Gene Name GeneID UniProt
KHDRBS1 10657 Q07666
KHDRBS1 20218 Q60749
KHDRBS1 117268 Q91V33

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KHDRBS1 Proteins (KHDRBS1) by Origin

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Top referenced KHDRBS1 Proteins

  1. Human KHDRBS1 Protein expressed in Wheat germ - ABIN1308538 : Lawrence, Schafer, Rieder: The nuclear protein Sam68 is cleaved by the FMDV 3C protease redistributing Sam68 to the cytoplasm during FMDV infection of host cells. in Virology 2012 (PubMed)

More Proteins for KHDRBS1 Interaction Partners

Human KH Domain Containing, RNA Binding, Signal Transduction Associated 1 (KHDRBS1) interaction partners

  1. Authors found that p62/SQSTM1 (show SQSTM1 Proteins), a protein upregulated in liver parenchymal cells but downregulated in HCC (show FAM126A Proteins)-associated HSCs, negatively controls hepatic stellate cells activation.

  2. necessary for retinal pigmented epithelial cytoprotection under oxidative stress; NFkappaB p65 activity may be critical upstream initiator of p62 expression in retinal pigmented epithelial cells under oxidative stress

  3. p62/SQSTM1 (show SQSTM1 Proteins), which accumulates in autophagy-defective cells, directly binds to and inhibits nuclear RNF168 (show RNF168 Proteins), an E3 ligase essential for histone H2A ubiquitination and DNA damage responses. As a result, DNA repair proteins such as BRCA1, RAP80 (show UIMC1 Proteins), and Rad51 (show RAD51 Proteins) cannot be recruited to the sites of DNA double-strand breaks (DSBs), which impairs DSB repair.

  4. propose that the interplay between LRRK2 (show LRRK2 Proteins) and p62 (show GTF2H1 Proteins) may contribute to the pathophysiological function and homeostasis of LRRK2 (show LRRK2 Proteins) protein

  5. Frontotemporal dementia -linked mutations in gene p62/SQSTM1 (show SQSTM1 Proteins) encoding autophagy adaptor proteins , indicate that impaired autophagy might cause Frontotemporal dementia.

  6. Sam68 possibly participated in the progresses of T-acute lymphoblastic leukemia at least partially via AKT (show AKT1 Proteins)/mTOR (show FRAP1 Proteins) signaling pathway

  7. These data suggest that SQSTM1 (show SQSTM1 Proteins) mutations are not a common cause of normal tension glaucoma.

  8. Sam68 is essential for DNA damage-induced NF-kappaB (show NFKB1 Proteins) activation and colon tumorigenesis.

  9. These findings define a hitherto novel mechanism of action for Sam68 in governing p53 (show TP53 Proteins) transcriptional activation, and represent the first report of Sam68 in the regulation of tumor suppressor activities.

  10. HNRNPL (show HNRNPL Proteins) acts as the adaptor to combine the two substructures and form the intact Sam68 nuclear body through the interaction of two sets of RNA recognition motifs with the putative architectural RNA in the respective substructures.

Mouse (Murine) KH Domain Containing, RNA Binding, Signal Transduction Associated 1 (KHDRBS1) interaction partners

  1. Sam68 may function as an immune rheostat that balances the activation of NF-kappaB (show NFKB1 Proteins) p65 (show NFkBP65 Proteins) and c-Rel (show NFkBP65 Proteins), as well as MAPK (show MAPK1 Proteins), revealing a potential novel target to manipulate TLR signaling.

  2. Sam68 plays a crucial role in DNA damage response via regulating DNA damage-initiated PAR (show AFG3L2 Proteins) production.

  3. Sam68 is essential for DNA damage-induced NF-kappaB (show NFKB1 Proteins) activation and colon tumorigenesis.

  4. Sam68 and T-STAR could regulate alternative splicing of some pre-mRNAs by bringing two distant UAA motifs into proximity and looping out regions of the pre-mRNA.

  5. SAM68 is a physiological regulator of SMN2 (show SMN1 Proteins) splicing in a spinal muscular atrophy mouse model.

  6. Data (including data from knockout mice) suggest expression of Sam68 plays role in adipogenesis of white adipose tissue versus brown adipose tissue; Sam68 appears to regulate adiposity and energy homeostasis (balance of energy intake/expenditure).

  7. Depletion of p31S6K1 with small interfering RNAs (siRNAs) partially restored adipogenesis of Sam68-deficient preadipocytes.

  8. Emerging roles for Sam68 in adipogenesis and neuronal development.

  9. Our research identifies a role for Sam68 in synaptodendritic posttranscriptional regulation of actb (show ACTB Proteins) and may provide insight into the pathophysiology of fragile X (show FMR1 Proteins) tremor/ataxia (show USP14 Proteins) syndrome

  10. Results suggest a novel role for SAM68 in the miRNA pathway during spermatogenesis.

KHDRBS1 Protein Profile

Protein Summary

This gene encodes a multifunctional protein that binds ubiquitin and regulates activation of the nuclear factor kappa-B (NF-kB) signaling pathway. The protein functions as a scaffolding/adaptor protein in concert with TNF receptor-associated factor 6 to mediate activation of NF-kB in response to upstream signals. Alternatively spliced transcript variants encoding either the same or different isoforms have been identified for this gene. Mutations in this gene result in sporadic and familial Paget disease of bone.

Alternative names and synonyms associated with KHDRBS1

  • KH domain containing, RNA binding, signal transduction associated 1a (khdrbs1a)
  • KH domain containing, RNA binding, signal transduction associated 1 (KHDRBS1)
  • KH domain containing, RNA binding, signal transduction associated 1 (khdrbs1)
  • KH domain containing, RNA binding, signal transduction associated 1 (Khdrbs1)
  • sequestosome 1 (SQSTM1)
  • A170 protein
  • fj90g10 protein
  • KHDRBS1 protein
  • OSIL protein
  • p60 protein
  • P62 protein
  • p62B protein
  • p68 protein
  • PDB3 protein
  • Sam68 protein
  • wu:fa18g12 protein
  • wu:fa56c01 protein
  • wu:fc91b01 protein
  • wu:fj90g10 protein
  • zgc:113899 protein
  • ZIP3 protein

Protein level used designations for KHDRBS1

GAP-associated phosphoprotein p62 , KH domain containing, RNA binding, signal transduction associated 1 , fa18g12 , fa56c01 , fc91b01 , GAP-associated tyrosine phosphoprotein p62 (Sam68) , KH domain-containing, RNA-binding, signal transduction-associated protein 1 , p21 Ras GTPase-activating protein-associated p62 , src-associated in mitosis 68 kDa protein , GAP-associated tyrosine phosphoprotein p62 , src associated in mitosis, 68 kDa , p68 , KH domain RNA-binding protein Sam68 , sam68 , EBI3-associated protein of 60 kDa , EBI3-associated protein p60 , EBIAP , oxidative stress induced like , phosphotyrosine independent ligand for the Lck SH2 domain p62 , phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa , sequestosome-1 , ubiquitin-binding protein p62

GENE ID SPECIES
30082 Danio rerio
456705 Pan troglodytes
487316 Canis lupus familiaris
549799 Xenopus (Silurana) tropicalis
100025483 Monodelphis domestica
10657 Homo sapiens
538775 Bos taurus
20218 Mus musculus
117268 Rattus norvegicus
398660 Xenopus laevis
374071 Gallus gallus
8878 Homo sapiens
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