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Browse our LTB Proteins (LTB)

Full name:
Lymphotoxin beta (TNF Superfamily, Member 3) Proteins (LTB)
On are 14 Lymphotoxin beta (TNF Superfamily, Member 3) (LTB) Proteins from 6 different suppliers available. Additionally we are shipping LTB Antibodies (61) and LTB Kits (48) and many more products for this protein. A total of 129 LTB products are currently listed.
AI662801, LT-b, LT-beta, LTbeta, p33, TNF-C, TNFC, TNFSF3
list all proteins Gene Name GeneID UniProt
LTB 16994 P41155
LTB 4050 Q06643
Rat LTB LTB 361795  

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LTB Proteins (LTB) by Origin

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More Proteins for LTB Interaction Partners

Mouse (Murine) Lymphotoxin beta (TNF Superfamily, Member 3) (LTB) interaction partners

  1. The expression of lymphotoxin (LT)-B was significantly downregulated in the absence of T cells from nude mice and was recovered after the transfusion of T cells.

  2. Expression of LT alpha (show LTA Proteins) and beta on acinar cells in mice led to chronic pancreatitis and sufficed to reproduce key features of human autoimmune pancreatitis including the development of autoimmunity and AIP (show AIP Proteins) associated secondary extra pancreatic pathologies.

  3. TNF (show TNF Proteins) is able to upregulate LT-beta expression in hepatic cells at the transcriptional level by the binding of NF-kappaB p50 (show NFKB1 Proteins)/p65 (show NFkBP65 Proteins) heterodimers and Ets1 (show ETS1 Proteins) to their respective sites in the LT-beta promoter.

  4. LTbeta RNA is detectable in embryos ranging from 5.5 to 18.5 days of development, e.g., in peripheral lymph nodes, Peyer's patches, thymus and skin of the E18.5 embryo and fetal liver of E12.5.

  5. membrane lymphotoxin beta contributes to anti-leishmanial immunity by controlling structural integrity of lymphoid organs

  6. The organogenic function of B-LTbeta is almost entirely restricted to spleen, where it supports the correct lymphoid architecture that is critical for an effective humoral immune response.

  7. microenvironment in peripheral lymphoid organs associated with lymphotoxin alpha (show LTA Proteins)/lymphotoxin beta-lymphotoxin beta receptor (show LTBR Proteins) signaling and chemokine (show CCL1 Proteins) production is critical for recruitment efficiency of dendritic cel

  8. membrane LT-beta is important in resistance to Theiler's virus infection

  9. Lymphotoxin-mediated adhesion molecule (show NCAM1 Proteins) expression may be important in the development of graft-versus-host skin disease.

  10. LTbeta, LTbeta receptor, and IFNgamma are involved in oval cell-mediated, but not hepatocyte-mediated, liver regeneration, and the absence of these pathways impairs the oval cell-dependent regenerative response.

Human Lymphotoxin beta (TNF Superfamily, Member 3) (LTB) interaction partners

  1. TNF (show TNF Proteins) is able to upregulate LT-beta expression in hepatic cells at the transcriptional level by the binding of NF-kappaB p50 (show NFKB1 Proteins)/p65 (show GORASP1 Proteins) heterodimers and Ets1 (show ETS1 Proteins) to their respective sites in the LT-beta promoter.

  2. The multifaceted character of lymphotoxin beta may be involved in inflammatory myopathies and muscular dystrophies.

  3. A strong association was found between several single nucleotide polymorphisms in the LTA (show LTA Proteins)/LTB/TNFalpha (show TNF Proteins) locus and Sjogren syndrome.

  4. Data show differential expression of interferon-gamma (show IFNG Proteins), TNFSF3, TNFSF10 (show TNFSF10 Proteins), TNFSF12 (show TNFSF12 Proteins) and PDGFbeta in CD8 (show CD8A Proteins)+, CD14 (show NDUFA2 Proteins)+ and CD4 (show CD4 Proteins)+ cells.

  5. Findings provide evidence of additional complexity in the transcriptional regulation of LTB with implications for coordinate expression of genes in this important genomic locus.

  6. Heterotypic interaction between LTbeta-producing lymphocytes and responding fibroblast-like synoviocytes contributes to establishment of complex lymphoid microstructures. May be one element in susceptibility of synovial membrane to lymphoid organogenesis.

  7. The identification of IL-6 (show IL6 Proteins) and IL-1beta (show IL1B Proteins) as activators of LT-beta supports their involvement in LT-beta signaling in liver regeneration associated with chronic liver damage.

  8. Lymphotoxin (LT) beta receptor ligands LTalpha1 and -beta2 activate both the classical and noncanonical NF-kappa B (show NFKB1 Proteins) pathways in human vascular endothelial cells and dermal microvascular endothelial cells in vitro.

  9. LT-Beta may play a role in rheumatoid arthritis disease pathogenesis by contributing to a more intense inflammatory reaction in the synovium

  10. blocking the lymphotoxin-beta receptor (show LTBR Proteins) pathway results in ablation of the lymphoid organization in the NOD salivary glands and thus an improvement in salivary gland function.

Pig (Porcine) Lymphotoxin beta (TNF Superfamily, Member 3) (LTB) interaction partners

  1. These results suggest that colonization by commensal bacteria may affect the maturation of neonatal ileal Pps (show IRF6 Proteins) by the induction of LT-beta via toll (show TLR4 Proteins)-like receptors.

LTB Protein Profile

Protein Summary

Lymphotoxin beta is a type II membrane protein of the TNF family. It anchors lymphotoxin-alpha to the cell surface through heterotrimer formation. The predominant form on the lymphocyte surface is the lymphotoxin-alpha 1/beta 2 complex (e.g. 1 molecule alpha/2 molecules beta) and this complex is the primary ligand for the lymphotoxin-beta receptor. The minor complex is lymphotoxin-alpha 2/beta 1. LTB is an inducer of the inflammatory response system and involved in normal development of lymphoid tissue. Lymphotoxin-beta isoform b is unable to complex with lymphotoxin-alpha suggesting a function for lymphotoxin-beta which is independent of lympyhotoxin-alpha. Alternative splicing results in multiple transcript variants encoding different isoforms.

Alternative names and synonyms associated with LTB

  • lymphotoxin B (Ltb)
  • lymphotoxin beta (LOC100144336)
  • lymphotoxin beta (TNF superfamily, member 3) (LTB)
  • lymphotoxin beta (TNF superfamily, member 3) (Ltb)
  • AI662801 protein
  • LT-b protein
  • LT-beta protein
  • LTbeta protein
  • p33 protein
  • TNF-C protein
  • TNFC protein
  • TNFSF3 protein

Protein level used designations for LTB

LT-beta , TNF-C , lymphotoxin beta , lymphotoxin-beta , tumor necrosis factor C , tumor necrosis factor ligand superfamily member 3 , lymphotoxin B , Tumor necrosis factor C

16994 Mus musculus
100144336 Oryctolagus cuniculus
4050 Homo sapiens
361795 Rattus norvegicus
100722556 Cavia porcellus
100155581 Sus scrofa
481712 Canis lupus familiaris
529757 Bos taurus
744486 Pan troglodytes
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