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Human MAP3K7 Protein expressed in Wheat germ - ABIN1310225
Salazar, Kashiwada, Krejci, Meyer, Casale, Hallowell, Wilcox, Donoghue, Thompson: Fibroblast growth factor receptor 3 interacts with and activates TGF?-activated kinase 1 tyrosine phosphorylation and NF?B signaling in multiple myeloma and bladder cancer. in PLoS ONE 2014
Show all 3 references for ABIN1310225
Polyubiquitination of Transforming Growth Factor beta-activated Kinase 1 (TAK1) at Lysine 562 Residue Regulates TLR4 (show TLR4 Proteins)-mediated JNK (show MAPK8 Proteins) and p38 MAPK (show MAPK14 Proteins) Activation
The data emphasize the central role of TAK1 in controlling signaling cascades and functional responses in primary neutrophils, making it a promising target for therapeutic intervention in view of the role of neutrophils in chronic inflammatory conditions.
MiR (show MLXIP Proteins)-377 is an important negative regulator of E2F (show E2F1 Proteins) and MAP3K7/NF-kB signaling pathway in melanoma cells.
the TAK1 signaling pathway may represent a suitable target to design new, antifibrotic therapies
Findings indicate that SHIP2 (show INPPL1 Proteins) is a regulator of lymphatic function in humans and that inherited mutations in the INPPL1 (show INPPL1 Proteins) gene may act in concert with HGF (show HGF Proteins), and likely MAP3K7, mutations to exacerbate lymphatic phenotypes.
Data indicate that inhibition of TGF-beta (show TGFB1 Proteins)-activated protein kinase (show CDK7 Proteins) 1 (TAK1) reduces chemokine (C-C motif) receptor 7 (CCR7 (show CCR7 Proteins)) expression.
identify coordinate loss of MAP3K7 and CHD1 as a unique driver of aggressive prostate cancer development
Data indicate 4-substituted 1H-pyrrolo[2,3-b]pyridines as potent inhibitors against TGFbeta (show TGFB1 Proteins)-activated kinase 1 (TAK1) and mitogen-activated protein kinase kinase kinase kinase 2 (MAP4K2 (show MAP4K2 Proteins)).
Ubc13 (show UBE2N Proteins) was dispensable for transforming growth factor beta (TGFbeta (show TGFB1 Proteins))-induced SMAD (show SMAD1 Proteins) activation but was required for activation of non-SMAD (show SMAD1 Proteins) signaling via TGFbeta (show TGFB1 Proteins)-activating kinase 1 (TAK1) and p38 (show CRK Proteins)
Data show that the ECSIT (show ECSIT Proteins) (evolutionarily conserved signaling intermediate in Toll (show TLR4 Proteins) pathways) complex, including MEKK7 (TAK1) and TNF receptor-associated factor 6 (TRAF6 (show TRAF6 Proteins)), plays a role in Toll-like receptor 4 (show TLR4 Proteins) -mediated signals to activate NF-kappa B (show NFKB1 Proteins).
TAK1 and IKK2 are novel mediators of SCF-induced signaling and potential targets for c-Kit-driven diseases.
TAKI-induced cytotoxicity is cell context specific, and apoptosis observed in macrophages is dependent on the constitutive autocrine action of TNF-alpha (show TNF Proteins) for RIP1 (show RALBP1 Proteins) activation and ROS (show ROS1 Proteins) production.
These results suggest a crucial role for TAK1 (show NR2C2 Proteins) for maintaining the survival of committed regulatory T cells under physiological conditions.
A possible mechanism by which tomoregulin-1 regulates the development of cardiac hypertrophy in TAC (show IL2RA Proteins)-induced cardiac hypertrophy is through inhibiting TGFbeta (show TGFB1 Proteins) non-canonical (TAK1 (show NR2C2 Proteins)-JNK (show MAPK8 Proteins)) pathways in the myocardium.
findings demonstrate that GC resistance for TAK1 (show NR2C2 Proteins) activation associated with TLR4 (show TLR4 Proteins) engagement may be an important contributor to GC resistance in inflammatory disorders.
TAK1 (show NR2C2 Proteins) regulates osteoclastogenesis by integrating activation of NF-kappaB (show NFKB1 Proteins) and derepression of NOTCH (show NOTCH1 Proteins)/RBPJ (show RBPJ Proteins) in myeloid cells through inhibition of NUMBL (show NUMBL Proteins).
Epithelium-specific Tak1 (show NR2C2 Proteins):Smad4 (show SMAD4 Proteins)- and Trim33 (show TRIM33 Proteins):Smad4 (show SMAD4 Proteins)-double mutants display reduced expression of Mmp13 (show MMP13 Proteins) in palatal medial edge epithelial cells.
TAK1 (show NR2C2 Proteins) regulates hepatic lipid metabolism and tumorigenesis via the AMPK (show PRKAA1 Proteins)/mTORC1 axis, affecting both autophagy and PPARalpha (show PPARA Proteins) activity.
Nef markedly activated TAK1 (show NR2C2 Proteins) in M-CSF (show CSF1R Proteins)-derived M2-MPhi but not in GM-CSF (show CSF2 Proteins)-derived M1-MPhi.
The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase mediates the signaling transduction induced by TGF beta and morphogenetic protein (BMP), and controls a variety of cell functions including transcription regulation and apoptosis. In response to IL-1, this protein forms a kinase complex including TRAF6, MAP3K7P1/TAB1 and MAP3K7P2/TAB2\; this complex is required for the activation of nuclear factor kappa B. This kinase can also activate MAPK8/JNK, MAP2K4/MKK4, and thus plays a role in the cell response to environmental stresses. Four alternatively spliced transcript variants encoding distinct isoforms have been reported.
mitogen-activated protein kinase kinase kinase 7
, TGF-beta-activated kinase TAK1
, TGF-beta activated kinase 1
, TGF-beta-activated kinase 1
, transforming growth factor-beta-activated kinase 1
, mitogen activated protein kinase kinase kinase 7
, transforming growth factor beta-activated kinase 1