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Browse our MAP3K7 Proteins (MAP3K7)

Full name:
Mitogen-Activated Protein Kinase Kinase Kinase 7 Proteins (MAP3K7)
On are 6 Mitogen-Activated Protein Kinase Kinase Kinase 7 (MAP3K7) Proteins from 4 different suppliers available. Additionally we are shipping MAP3K7 Antibodies (171) and MAP3K7 Kits (10) and many more products for this protein. A total of 207 MAP3K7 products are currently listed.
B430101B05, C87327, MEKK7, si:ch211-225h9.1, TAK1, TGF1a, zgc:110612
list all proteins Gene Name GeneID UniProt
MAP3K7 313121 P0C8E4
MAP3K7 6885 O43318
MAP3K7 26409 Q62073

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MAP3K7 Proteins (MAP3K7) by Origin

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Top referenced MAP3K7 Proteins

  1. Human MAP3K7 Protein expressed in Wheat germ - ABIN1310225 : Salazar, Kashiwada, Krejci, Meyer, Casale, Hallowell, Wilcox, Donoghue, Thompson: Fibroblast growth factor receptor 3 interacts with and activates TGF?-activated kinase 1 tyrosine phosphorylation and NF?B signaling in multiple myeloma and bladder cancer. in PLoS ONE 2014 (PubMed)
    Show all 3 references for ABIN1310225

More Proteins for MAP3K7 Interaction Partners

Human Mitogen-Activated Protein Kinase Kinase Kinase 7 (MAP3K7) interaction partners

  1. dysregulation of the TAK1 complex produces a close phenocopy of Frontometaphyseal Dysplasia caused by FLNA (show FLNA Proteins) mutations; furthermore, the pathogenesis of some of the filaminopathies caused by FLNA (show FLNA Proteins) mutations might be mediated by misregulation of signaling coordinated through the TAK1 signaling complex

  2. although TAK1 is located at the crossroad of inflammation, immunity, and cancer, this study reports MAP3K7 mutations in a developmental disorder affecting mainly cartilage, bone, and heart

  3. This study suggests that aberrant activity of TAK1 impairs autophagy and subsequently leads to alterations in the vitality of retinal pigment epithelial cells.

  4. TAK1 may be an important factor involved in the pathogenesis of thyroid cancer, and targeted down-regulation of TAK1 may improve the prognosis of patients with thyroid cancer.

  5. Loss of MAP3K7 are associated with esophageal squamous cell carcinoma.

  6. This paper highlights that targeting the BMP and TGFbeta (show TGFB1 Proteins) type I and type II receptors causes a downregulation of XIAP (show XIAP Proteins), TAK1, and Id1 (show ID1 Proteins) leading to cell death of lung cancer cells.

  7. Polyubiquitination of Transforming Growth Factor beta-activated Kinase 1 (TAK1) at Lysine 562 Residue Regulates TLR4 (show TLR4 Proteins)-mediated JNK (show MAPK8 Proteins) and p38 MAPK (show MAPK14 Proteins) Activation

  8. The data emphasize the central role of TAK1 in controlling signaling cascades and functional responses in primary neutrophils, making it a promising target for therapeutic intervention in view of the role of neutrophils in chronic inflammatory conditions.

  9. MiR (show MLXIP Proteins)-377 is an important negative regulator of E2F (show E2F1 Proteins) and MAP3K7/NF-kB signaling pathway in melanoma cells.

  10. the TAK1 signaling pathway may represent a suitable target to design new, antifibrotic therapies

Mouse (Murine) Mitogen-Activated Protein Kinase Kinase Kinase 7 (MAP3K7) interaction partners

  1. Mekk1 (show MAP2K1 Proteins) (encoded by Map3k1 (show MAP3K1 Proteins)) signaling activates Mapks to regulate Cdkn1b (show CDKN1B Proteins) (encoding p27(Kip1 (show CDKN1B Proteins))) expression and p27(Kip1 (show CDKN1B Proteins))-dependent proliferative expansion in response to antigen.

  2. TRADD (show TRADD Proteins) knockout blunts pressure overload-induced cardiac hypertrophy through mediating TAK1 (show NR2C2 Proteins)/p38 MAPK (show MAPK14 Proteins) but not AKT (show AKT1 Proteins) phosphorylation

  3. this study demonstrates a pivotal role of TAK1 (show NR2C2 Proteins) in dendritic cells in controlling trichloroethylene-induced contact hypersensitivity response and suggests that targeting TAK1 (show NR2C2 Proteins) function in DCs may be a viable approach to preventing and treating TCE-related occupational health hazards

  4. The E3 ligase TRIM8 (show TRIM8 Proteins) is a potent regulator that exacerbates steatohepatitis and metabolic disorders dependent on its binding and ubiquitinating capacity on transforming growth factor-beta-activated kinase 1.

  5. Angiotensin-II up-regulates the Ampkalpha1 (show PRKAA1 Proteins) isoform in renal tissue. Ampkalpha1 (show PRKAA1 Proteins) participates in renal Tak1 (show NR2C2 Proteins) activation and Tak1 (show NR2C2 Proteins)-dependent signaling induced by angiotensin-II.

  6. TRIM8 (show TRIM8 Proteins) could promote K63-linked polyubiquitination of transforming growth factor beta-activated kinase 1 (TAK1), leading to the activation of TAK1 (show NR2C2 Proteins) and enhanced inflammatory responses.

  7. TAK1 (show NR2C2 Proteins) signaling preserved the viability of lambda-chain-positive B cells by maintaining Bcl-2 (show BCL2 Proteins) expression through IKK (show CHUK Proteins)-NF-kappaB (show NFKB1 Proteins) signaling

  8. Data show that TGFbeta (show TGFB1 Proteins)-activated kinase-1 (TAK1 (show NR2C2 Proteins)) activated nuclear factor of activated T-cells (NFAT (show NFATC1 Proteins))/NF-kappa B (NFkappaB (show NFKB1 Proteins)), downregulated BCL2-adenovirus E1B interacting protein 3 (Bnip3 (show BNIP3 Proteins)), and inhibited cardiac cell death.

  9. Crucial functions of inflammatory TAK1 (show NR2C2 Proteins)-NEMO (show IKBKG Proteins) signaling in protecting the brain endothelium and maintaining normal brain function.

  10. Roles of TAK1 (show NR2C2 Proteins) in vascular oxidative stress and its contribution to neointima formation after vascular injury.

MAP3K7 Protein Profile

Protein Summary

The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase mediates the signaling transduction induced by TGF beta and morphogenetic protein (BMP), and controls a variety of cell functions including transcription regulation and apoptosis. In response to IL-1, this protein forms a kinase complex including TRAF6, MAP3K7P1/TAB1 and MAP3K7P2/TAB2\; this complex is required for the activation of nuclear factor kappa B. This kinase can also activate MAPK8/JNK, MAP2K4/MKK4, and thus plays a role in the cell response to environmental stresses. Four alternatively spliced transcript variants encoding distinct isoforms have been reported.

Alternative names and synonyms associated with MAP3K7

  • mitogen activated protein kinase kinase kinase 7 (map3k7)
  • mitogen activated protein kinase kinase kinase 7 (Map3k7)
  • mitogen-activated protein kinase kinase kinase 7 (MAP3K7)
  • mitogen-activated protein kinase kinase kinase 7 (Map3k7)
  • B430101B05 protein
  • C87327 protein
  • MEKK7 protein
  • si:ch211-225h9.1 protein
  • TAK1 protein
  • TGF1a protein
  • zgc:110612 protein

Protein level used designations for MAP3K7

mitogen-activated protein kinase kinase kinase 7 , tak1 , TGF-beta-activated kinase TAK1 , TGF-beta activated kinase 1 , TGF-beta-activated kinase 1 , transforming growth factor-beta-activated kinase 1 , mitogen activated protein kinase kinase kinase 7 , transforming growth factor beta-activated kinase 1

553788 Danio rerio
313121 Rattus norvegicus
6885 Homo sapiens
26409 Mus musculus
529146 Bos taurus
100171454 Pongo abelii
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