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Human MAP3K7 Protein expressed in Wheat germ - ABIN1310225
Salazar, Kashiwada, Krejci, Meyer, Casale, Hallowell, Wilcox, Donoghue, Thompson: Fibroblast growth factor receptor 3 interacts with and activates TGF?-activated kinase 1 tyrosine phosphorylation and NF?B signaling in multiple myeloma and bladder cancer. in PLoS ONE 2014
Show all 3 references for ABIN1310225
This study suggests that aberrant activity of TAK1 impairs autophagy and subsequently leads to alterations in the vitality of retinal pigment epithelial cells.
TAK1 may be an important factor involved in the pathogenesis of thyroid cancer, and targeted down-regulation of TAK1 may improve the prognosis of patients with thyroid cancer.
Loss of MAP3K7 are associated with esophageal squamous cell carcinoma.
This paper highlights that targeting the BMP and TGFbeta (show TGFB1 Proteins) type I and type II receptors causes a downregulation of XIAP (show XIAP Proteins), TAK1, and Id1 (show ID1 Proteins) leading to cell death of lung cancer cells.
Polyubiquitination of Transforming Growth Factor beta-activated Kinase 1 (TAK1) at Lysine 562 Residue Regulates TLR4 (show TLR4 Proteins)-mediated JNK (show MAPK8 Proteins) and p38 MAPK (show MAPK14 Proteins) Activation
The data emphasize the central role of TAK1 in controlling signaling cascades and functional responses in primary neutrophils, making it a promising target for therapeutic intervention in view of the role of neutrophils in chronic inflammatory conditions.
MiR (show MLXIP Proteins)-377 is an important negative regulator of E2F (show E2F1 Proteins) and MAP3K7/NF-kB signaling pathway in melanoma cells.
the TAK1 signaling pathway may represent a suitable target to design new, antifibrotic therapies
Findings indicate that SHIP2 (show INPPL1 Proteins) is a regulator of lymphatic function in humans and that inherited mutations in the INPPL1 (show INPPL1 Proteins) gene may act in concert with HGF (show HGF Proteins), and likely MAP3K7, mutations to exacerbate lymphatic phenotypes.
Data indicate that inhibition of TGF-beta (show TGFB1 Proteins)-activated protein kinase (show CDK7 Proteins) 1 (TAK1) reduces chemokine (C-C motif) receptor 7 (CCR7 (show CCR7 Proteins)) expression.
Data show that TGFbeta (show TGFB1 Proteins)-activated kinase-1 (TAK1 (show NR2C2 Proteins)) activated nuclear factor of activated T-cells (NFAT (show NFATC1 Proteins))/NF-kappa B (NFkappaB (show NFKB1 Proteins)), downregulated BCL2-adenovirus E1B interacting protein 3 (Bnip3 (show BNIP3 Proteins)), and inhibited cardiac cell death.
Crucial functions of inflammatory TAK1 (show NR2C2 Proteins)-NEMO (show IKBKG Proteins) signaling in protecting the brain endothelium and maintaining normal brain function.
Roles of TAK1 (show NR2C2 Proteins) in vascular oxidative stress and its contribution to neointima formation after vascular injury.
Inactivation of TAK1 (show NR2C2 Proteins) in satellite cells inhibits muscle regeneration in adult mice.
our current study highlighted the emerging role of TAK1 (show NR2C2 Proteins) in configuring the gut (show GUSB Proteins)-specialized T cell subset, which regulates mucosal homeostasis under lymphopenic conditions.
the ADAP (show APP Proteins) CARMA1 (show CARD11 Proteins) binding site is required for IKK gamma (show IKBKG Proteins) ubiquitination; both TAK1 (show NR2C2 Proteins) and CARMA1 (show CARD11 Proteins) binding sites are required for IkappaB alpha (show NFKBIA Proteins) phosphorylation and degradation and NF-kappaB (show NFKB1 Proteins) nuclear translocation
Results provide evidence that TAK1 (show NR2C2 Proteins) is required for the activation of NF-kappaB (show NFKB1 Proteins) in thymocytes and suggest that TAK1 (show NR2C2 Proteins) plays a central role in both innate and adaptive immunity.
TAK1 (show NR2C2 Proteins) is essential for connective tissue deposition in the dermis.
Tak1 functions to regulate tongue development by controlling Fgf10 expression and could represent a candidate gene for mutation in human PRS clefting.
In vivo knockdown of TAK1 (show NR2C2 Proteins) accelerates bone marrow proliferation/differentiation and induces systemic inflammation.
The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase mediates the signaling transduction induced by TGF beta and morphogenetic protein (BMP), and controls a variety of cell functions including transcription regulation and apoptosis. In response to IL-1, this protein forms a kinase complex including TRAF6, MAP3K7P1/TAB1 and MAP3K7P2/TAB2\; this complex is required for the activation of nuclear factor kappa B. This kinase can also activate MAPK8/JNK, MAP2K4/MKK4, and thus plays a role in the cell response to environmental stresses. Four alternatively spliced transcript variants encoding distinct isoforms have been reported.
mitogen-activated protein kinase kinase kinase 7
, TGF-beta-activated kinase TAK1
, TGF-beta activated kinase 1
, TGF-beta-activated kinase 1
, transforming growth factor-beta-activated kinase 1
, mitogen activated protein kinase kinase kinase 7
, transforming growth factor beta-activated kinase 1