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Human p65 Protein expressed in HEK-293 Cells - ABIN2730698
Srinivasan, Blackburn, Lahiri: Functional characterization of a competitive peptide antagonist of p65 in human macrophage-like cells suggests therapeutic potential for chronic inflammation. in Drug design, development and therapy 2015
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Human p65 Protein expressed in Wheat germ - ABIN1317783
Ba, Bacsi, Luo, Aguilera-Aguirre, Zeng, Radak, Brasier, Boldogh: 8-oxoguanine DNA glycosylase-1 augments proinflammatory gene expression by facilitating the recruitment of site-specific transcription factors. in Journal of immunology (Baltimore, Md. : 1950) 2014
The findings are consistent with rs539846 influencing chronic lymphocytic leukemia (CLL) susceptibility through differential RELA binding, with direct modulation of BMF (show BMF Proteins) expression impacting on anti-apoptotic BCL2 (show BCL2 Proteins), a hallmark of oncogenic dependency in CLL.
Data demonstrate that the FMNL2 (show FMNL2 Proteins)/COMMD10/p65 NF kappaB axis acts as a critical regulator in the maintenance of metastatic phenotypes in colorectal cancer.
Whole-exome sequencing (WES) of the unaffected father and patients P1-P4 revealed seven rare NF-kappaB (show NFKB1 Proteins) subunit RelA (RELA) heterozygous variants shared by the patients and absent in the healthy father.
miR (show MLXIP Proteins)-124 controls NF-kappaB (show NFKB1 Proteins)-dependent inflammatory responses in keratinocytes and chronic skin inflammation in atopic eczema; rescuing miR (show MLXIP Proteins)-124 expression presents a promising strategy for atopic eczema treatment.
Data suggest that only the Fe(III) form of pirin (show PIR Proteins) [not the Fe(II) form] enhances affinity of binding between p65 (show GORASP1 Proteins) and DNA in the pirin (show PIR Proteins)-p65 (show GORASP1 Proteins)-DNA supramolecular complex. (pirin (show PIR Proteins) = quercetin 2,3-dioxygenase; p65 (show GORASP1 Proteins) = RELA proto-oncogene (show RAB1A Proteins) NF-kappaB (show NFKB1 Proteins) subunit)
p21 (show CDKN1A Proteins) adjusts the equilibrium between p65 (show GORASP1 Proteins)-p50 (show CD40 Proteins) and p50-p50 NF-kappaB (show NFKB1 Proteins) pathways to mediate macrophage plasticity in LPS (show IRF6 Proteins) tolerance
knockdown of RPA2 (show RPA2 Proteins) promoted formation of the menin-p65 (show GORASP1 Proteins) complex and repressed the expression of NF-kappaB (show NFKB1 Proteins)-mediated genes. RPA2 (show RPA2 Proteins) expression was induced via an E2F1 (show E2F1 Proteins)-dependent mechanism in MCF7 and MDA-MB-231 cells treated with NF-kappaB (show NFKB1 Proteins) activators, TNF-alpha (show TNF Proteins) or lipopolysaccharide (LPS (show IRF6 Proteins)).
Consistent with these effects, RelA T505A mice exhibit earlier onset of cancer in the N-nitrosodiethylamine model of hepatocellular carcinoma. These data reveal a critical pathway controlling NF-kappaB (show NFKB1 Proteins) function in the liver that acts to suppress the tumour-promoting activities of RelA.
NF-kappaB (show NFKB1 Proteins) RelB (show RELB Proteins) protein, but not RelA, displayed high expression in Endometrial cancer samples and cell lines.
This study demonstrates for the first time that a prominent pathway of reovirus oncolysis of breast cancer is mediated through NF-kB p65 and that PUMA (show BBC3 Proteins) upregulation is dependent on NF-kB p65 activation.
TMZ pretreatment effectively reduced the myocardial damage caused by CME via inhibiting the PDCD4 (show PDCD4 Proteins)/NF-kappaB (show NFKB1 Proteins)/ TNF-alpha (show TNF Proteins) pathway in cardiomyocytes.
Transmissible gastroenteritis virus infection activates NF-kappaB (show NFKB1 Proteins).
Zinc finger nuclease (show DCLRE1C Proteins) in-embryo editing of the RELA locus generated live born domestic pigs with the warthog RELA orthologue, associated with resilience to African Swine Fever.
SIRT1 (show SIRT1 Proteins), p53 (show TP53 Proteins) and NF-kappaB (show NFKB1 Proteins) are involved in the control of both the proliferation and the apoptosis of ovarian cells.
Porcine Coro1A (show CORO1A Proteins) is an important immunity related gene that helps to inhibit NF-kB activation during H. parasuis infection.
We propose that the variation in RELA identified between the warthog and domestic pig has the potential to underlie the difference between tolerance and rapid death upon African swine fever virus infection.
The characterization of porcine NF-kappaB (show NFKB1 Proteins) p65 (show SYT1 Proteins) subunit (pp65 (show LCP1 Proteins)), is reported.
Viral non-structural protein 1 suppressed host TNF-alpha (show TNF Proteins) promoter by inhibiting NF-kappaB (show NFKB1 Proteins) and Sp1 (show SP1 Proteins) promoter binding activity.
Hepatic SREBP-1c (show SREBF1 Proteins)-mediated lipid synthesis and the NF-kappaB (show NFKB1 Proteins) inflammatory pathway were both overinduced in cows with fatty liver.
Cytopathic bovine viral diarrhea virus strain induces immune marker production in bovine cells through the NF-kappaB (show NFKB1 Proteins) signaling pathway.
The role of NF-kappaB (show NFKB1 Proteins) and C/EBP (show CEBPA Proteins) factors in regulating basal and pathogen-induced expression of both genes from cattle, is investigated.
Altering the extracellular matrix to promote p38 (show MAPK14 Proteins) activation in cells on fibronectin (show FN1 Proteins) suppresses NF-kappaB (show NFKB1 Proteins) activation, suggesting a novel therapeutic strategy for treating
full length coding sequence of the cattle transcription factor p65 was isolated and cloned
the pathogen causing subclinical mastitis impairs NF-kappaB (show NFKB1 Proteins) activation in MEC (show CCL28 Proteins) thereby severely weakening the immune response,induction of IL-8 (show IL8 Proteins) and TNFalpha (show TNF Proteins), in the udder
These results confirm that VEGI (show TNFSF15 Proteins) utilizes NF-kappaB (show NFKB1 Proteins) as a pro-survival role factor in endothelial cells.
Angiotensin II regulates dendritic cells through activation of p65 NF-kappaB, ERK1 (show MAPK3 Proteins), ERK2 (show MAPK1 Proteins) and STAT1 (show STAT1 Proteins) pathways.
The results identify a novel miR (show MLXIP Proteins)-682/PTEN/NF-kappaB (show NFKB1 Proteins) p65 signaling pathway in intestinal epithelial cells injury induced by ischemia-reperfusion that could be targeted for therapy.
An intrinsic constitutively activated feedforward signaling circuit composed of IkappaBalpha (show NFKBIA Proteins)/NF-kappaB (show NFKB1 Proteins)(p65), miR (show MLXIP Proteins)-196b-3p, Meis2 (show MEIS2 Proteins), and PPP3CC (show PPP3CC Proteins) is formed during the emergence of castration-resistant prostate cancer.
Treatment of the haplotype Npr1 (show NPR1 Proteins)(+/-) mice with histone deacetylase (show HDAC1 Proteins) inhibitors significantly lowered blood pressure and reduced the renal inflammation and fibrosis involving the interactive roles of HDAC1 (show HDAC1 Proteins)/2, NF-kappaB (show NFKB1 Proteins) (p65), and STAT1 (show STAT1 Proteins).
RelA has a role in regulating OIS in preneoplastic lesions; the RelA/CXCL1 (show CXCL1 Proteins)/CXCR2 (show CXCR2 Proteins) axis is an essential mechanism of tumor surveillance in pancreatic ductal adenocarcinoma
work reveals that simulated microgravity promotes the apoptotic response through a combined modulation of the Uev1A/TICAM/TRAF (show TRAF1 Proteins)/NF-kappaB (show NFKB1 Proteins)-regulated apoptosis and the p53 (show TP53 Proteins)/PCNA (show PCNA Proteins)- and ATM (show ATM Proteins)/ATR-Chk1 (show CHEK1 Proteins)/2-controlled DNA-damage response pathways.
This study suggests that mTOR (show FRAP1 Proteins) activity in hepatocytes decreases hepatic vulnerability to injury through a mechanism dependent on NF-kappaB (show NFKB1 Proteins) proinflammatory cytokine signaling pathway in both normal and steatotic liver.
this study demonstrates that lipopolysaccharides, TNF-alpha (show TNF Proteins), and viral infection, all of which induce robust inflammatory responses in naturally differentiated cells, failed to activate NF-kappaB (show NFKB1 Proteins), the key transcription factor that mediates inflammatory responses, and were unable to induce the expression of inflammatory genes in mouse embryonic stem cells. Similar results were obtained in human embryonic
this study illustrates a significant role of RelA in mediating the corneal neovascularization
NF-kappa-B is a ubiquitous transcription factor involved in several biological processes. It is held in the cytoplasm in an inactive state by specific inhibitors. Upon degradation of the inhibitor, NF-kappa-B moves to the nucleus and activates transcription of specific genes. NF-kappa-B is composed of NFKB1 or NFKB2 bound to either REL, RELA, or RELB. The most abundant form of NF-kappa-B is NFKB1 complexed with the product of this gene, RELA. Four transcript variants encoding different isoforms have been found for this gene.
, nuclear factor NF-kappa-B p65 subunit
, nuclear factor of kappa light polypeptide gene enhancer in B-cells 3
, transcription factor p65
, v-rel reticuloendotheliosis viral oncogene homolog A
, NF-kappaB transcription factor p65 subunit
, v-rel reticuloendotheliosis viral oncogene homolog A, nuclear factor of kappa light polypeptide gene enhancer in B-cells 3, p65
, nuclear factor kappa B subunit p65
, avian reticuloendotheliosis viral (v-rel) oncogene homolog A
, p65 NF kappaB
, p65 NF-kappa B
, p65 NFkB
, NF-kB p65 subunit