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Browse our RIPK1 Proteins (RIPK1)

Full name:
Receptor (TNFRSF)-Interacting serine-threonine Kinase 1 Proteins (RIPK1)
On are 12 Receptor (TNFRSF)-Interacting serine-threonine Kinase 1 (RIPK1) Proteins from 6 different suppliers available. Additionally we are shipping RIPK1 Antibodies (108) and RIPK1 Kits (11) and many more products for this protein. A total of 142 RIPK1 products are currently listed.
2400006N03Rik, C9orf12, D330015H01Rik, RGD1311271, Rinp, Rip, Rip1, rIpk1, RP23-83I13.5
list all proteins Gene Name GeneID UniProt
Rat RIPK1 RIPK1 306808 Q5PXE9
RIPK1 8737 Q13546
RIPK1 19766 Q60855

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RIPK1 Proteins (RIPK1) by Origin

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Top referenced RIPK1 Proteins

  1. Human RIPK1 Protein expressed in Wheat germ - ABIN1318108 : Boutaffala, Bertrand, Remouchamps, Seleznik, Reisinger, Janas, Bénézech, Fernandes, Marchetti, Mair, Ganeff, Hupalowska, Ricci, Becher, Piette, Knolle, Caamano, Vandenabeele, Heikenwalder, Dejardin: NIK promotes tissue destruction independently of the alternative NF-κB pathway through TNFR1/RIP1-induced apoptosis. in Cell death and differentiation 2015 (PubMed)
    Show all 2 references for ABIN1318108

More Proteins for RIPK1 Interaction Partners

Human Receptor (TNFRSF)-Interacting serine-threonine Kinase 1 (RIPK1) interaction partners

  1. By promoting both inflammation and cell death, RIPK1 may be a common mediator of axonal pathology in amyotrophic lateral sclerosis.

  2. Down-regulating RIP1 (show UQCRFS1 Proteins) promotes oxaliplatin induced Tca8113 cells apoptosis

  3. RIPK1 and RIPK2 (show RIPK2 Proteins) are targets of HIV-1 Protease activity during infection, and their inactivation may contribute to modulation of cell death and host defense pathways by HIV-1

  4. These results identify upregulation of RIPK1 as an important resistance mechanism of melanoma cells to tunicamycin- or thapsigargin-induced endoplasmic reticulum stress.

  5. CD40 ligand (show CD40LG Proteins) induces RIP1 (show UQCRFS1 Proteins)-dependent, necroptosis-like cell death in low-grade serous but not serous borderline ovarian tumor cells.

  6. Data show that toll-like receptor 3 (show TLR3 Proteins)/TRIF (show TRIM69 Proteins) protein signalling regulates cytokines IL-32 (show IL32 Proteins) and IFN-beta (show IFNB1 Proteins) secretion by activation of receptor-interacting protein-1 (RIP-1) and tumour necrosis factor (show TNF Proteins) receptor-associated factor 6 (TRAF6 (show TRAF6 Proteins)) in cornea epithelial cells.

  7. in the absence of caspase-8 activity, 24(S)-Hydroxycholesterol induces a necroptosis-like cell death which is RIPK1-dependent but MLKL-independent.

  8. RIP1 represses basal autophagy in part due to (show UQCRFS1 Proteins)its ability to regulate the TFEB transcription factor;RIP1 activates ERK, which negatively regulates TFEB though phosphorylation of serine 142

  9. ZFP36 (show ZFP36 Proteins) controls RIP1 (show UQCRFS1 Proteins) levels in glioma neural stem cell lines.

  10. These data demonstrate that RIP1 (show UQCRFS1 Proteins) is essential for the regulation of death receptor mediated autophagy and apoptosis.

Mouse (Murine) Receptor (TNFRSF)-Interacting serine-threonine Kinase 1 (RIPK1) interaction partners

  1. CNOT3 (show CNOT3 Proteins) suppression promotes necroptosis by stabilizing mRNAs for cell death-inducing proteins, Ripk1 and Ripk3 (show RIPK3 Proteins).

  2. TAKI-induced cytotoxicity is cell context specific, and apoptosis observed in macrophages is dependent on the constitutive autocrine action of TNF-alpha (show TNF Proteins) for RIP1 (show RALBP1 Proteins) activation and ROS (show ROS1 Proteins) production.

  3. RIP1 (show RALBP1 Proteins)-Tag2 mice that lack serglycin (show SRGN Proteins) develop larger tumors.

  4. Data show that NEMO (show IKBKG Proteins) protein prevents hepatocarcinogenesis by inhibiting receptor (TNFRSF)-interacting serine-threonine kinase 1 (RIPK1) kinase activity-driven hepatocyte apoptosis.

  5. data show that RIP1 (show RALBP1 Proteins)-mediated necroptosis is not present in the postischemic liver and that I/R-induced caspase (show CASP3 Proteins) activation is associated with loss of RIP1 (show RALBP1 Proteins) expression

  6. In addition to other pro-death functions, RIP1 (show RALBP1 Proteins) regulates cellular sensitivity to pro-death stimuli by modulating basal autophagy.

  7. Cisplatin stimulates RIP1/RP3/MLKL-dependent necrotic cell death in renal tubules, which finally causes renal dysfunction

  8. diverse modes of acute liver injury have differing requirements for RIP1 (show RALBP1 Proteins) and RIP3; moreover, within a single injury model, RIP1 (show RALBP1 Proteins) and RIP3 blockade can have diametrically opposite effects on tissue damage

  9. Results demonstrate that RIPK1 is a bona fide substrate of IKKa (show CHUK Proteins) and IKKb (show IKBKB Proteins) and that IKKa (show CHUK Proteins)/IKKb (show IKBKB Proteins)-mediated phosphorylation of RIPK1 in complex I protects cells from RIPK1 kinase-dependent death.

  10. Human herpesvirus 1 ICP6 interacts with mouse RIP1 (show RALBP1 Proteins)/RIP3 through its RHIM domain and forms dimers/oliogmers by its C-terminal R1 domain.

RIPK1 Protein Profile

Protein Summary

Serine-threonine kinase which transduces inflammatory and cell-death signals (necroptosis) following death receptors ligation, activation of pathogen recognition receptors (PRRs), and DNA damage. Upon activation of TNFR1 by the TNF-alpha family cytokines, TRADD and TRAF2 are recruited to the receptor. Ubiquitination by TRAF2 via 'Lys-63'-link chains acts as a critical enhancer of communication with downstream signal transducers in the mitogen-activated protein kinase pathway and the NF-kappa-B pathway, which in turn mediate downstream events including the activation of genes encoding inflammatory molecules. Polyubiquitinated protein binds to IKBKG/NEMO, the regulatory subunit of the IKK complex, a critical event for NF-kappa-B activation. Interaction with other cellular RHIM-containing adapters initiates gene activation and cell death. RIPK1 and RIPK3 association, in particular, forms a necroptosis-inducing complex.

Alternative names and synonyms associated with RIPK1

  • receptor (TNFRSF)-interacting serine-threonine kinase 1 (LOC100230522)
  • inositol 1,3,4,5,6-pentakisphosphate 2-kinase (Ippk)
  • receptor (TNFRSF)-interacting serine-threonine kinase 1 (RIPK1)
  • receptor (TNFRSF)-interacting serine-threonine kinase 1 (Ripk1)
  • RPA interacting protein (Rpain)
  • 2400006N03Rik protein
  • C9orf12 protein
  • D330015H01Rik protein
  • RGD1311271 protein
  • Rinp protein
  • Rip protein
  • Rip1 protein
  • rIpk1 protein
  • RP23-83I13.5 protein

Protein level used designations for RIPK1

receptor (TNFRSF)-interacting serine-threonine kinase 1 , 1,3,4,5,6-pentakisphosphate 2-kinase , inositol polyphosphate kinase 1 , inositol-1,3,4,5,6-pentakisphosphate 2-kinase , inositol-pentakisphosphate 2-kinase , ins(1,3,4,5,6)P5 2-kinase , insP5 2-kinase , RIP-1 , cell death protein RIP , receptor interacting protein , receptor-interacting protein 1 , receptor-interacting serine/threonine-protein kinase 1 , serine/threonine-protein kinase RIP , RPA interacting protein delta 2 , RPA interacting protein epsilon , RPA-interacting protein

100230522 Taeniopygia guttata
306808 Rattus norvegicus
8737 Homo sapiens
504727 Bos taurus
100524751 Sus scrofa
19766 Mus musculus
306886 Rattus norvegicus
69723 Mus musculus
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