Browse our RIPK1 Proteins (RIPK1)

Full name:
Receptor (TNFRSF)-Interacting serine-threonine Kinase 1 Proteins (RIPK1)
On are 29 Receptor (TNFRSF)-Interacting serine-threonine Kinase 1 (RIPK1) Proteins from 8 different suppliers available. Additionally we are shipping RIPK1 Antibodies (133) and RIPK1 Kits (13) and many more products for this protein. A total of 186 RIPK1 products are currently listed.
2400006N03Rik, C9orf12, D330015H01Rik, RGD1311271, Rinp, Rip, Rip1, rIpk1, RP23-83I13.5
list all proteins Gene Name GeneID UniProt
RIPK1 306808 Q5PXE9
RIPK1 8737 Q13546
RIPK1 19766 Q60855

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RIPK1 Proteins (RIPK1) by Origin

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Human Receptor (TNFRSF)-Interacting serine-threonine Kinase 1 (RIPK1) interaction partners

  1. RIPK1 collaborates with TRAF2 (show TRAF2 Proteins) to inhibit murine and human hepatocarcinogenesis.

  2. Necroptosis signaling is modulated by the kinase RIPK1 and requires the kinase RIPK3 and the pseudokinase MLKL. (Review)

  3. CYLD (show CYLD Proteins) Promotes TNF-alpha (show TNF Proteins)-Induced Cell Necrosis Mediated by RIP-1 (show UQCRFS1 Proteins) in Human Lung Cancer Cells

  4. TRAIL can enhance RIP1 (show UQCRFS1 Proteins) and c-FLIPL (show CFLAR Proteins) expression in HepG2 cells.

  5. Data indicate that RIP-1 (show UQCRFS1 Proteins) promote the growth and invasion of gastric cancer in vitro and in vivo, additionally providing evidence that targeting RIP-1 (show UQCRFS1 Proteins) may be useful in the treatment of gastric cancer.

  6. High expression of RIP1 (show UQCRFS1 Proteins) is associated with hepatocellular carcinoma.

  7. Upregulated expression of RIP1 (show UQCRFS1 Proteins) is associated with triple-negative breast cancer.

  8. Innate immune signaling through differential RIPK1 expression promote tumor progression in head and neck squamous cell carcinoma.

  9. Hyperglycemic Conditions Prime Cells for RIP1 (show UQCRFS1 Proteins)-dependent Necroptosis.

  10. In contrast, both necrostatin-1, a RIP1 (show UQCRFS1 Proteins) kinase inhibitor, and Enbrel, a TNFalpha (show TNF Proteins)-blocking antibody, do not interfere with BV6/Drozitumab-induced apoptosis, demonstrating that apoptosis occurs independently of RIP1 (show UQCRFS1 Proteins) kinase activity or an autocrine TNFalpha (show TNF Proteins) loop.

Mouse (Murine) Receptor (TNFRSF)-Interacting serine-threonine Kinase 1 (RIPK1) interaction partners

  1. this study reveals a critical kinase-independent platform role for RIPK1 in protecting against TNF (show TNF Proteins)/caspase (show CASP3 Proteins)-dependent apoptosis of hepatocytes in immune-mediated liver injury

  2. Results revealed that RIPK1 and PGAM5 (show PGAM5 Proteins) function independently to exert optimal control of Leishmania replication in the host.

  3. Knocking down receptor-interacting serine/threonine protein kinase 1 (Ripk1) increased both intracellular and extracellular PGRN (show GRN Proteins) protein levels by increasing the translation rate of PGRN (show GRN Proteins) without affecting mRNA levels.

  4. The findings reported here indicate that palmitate induces RIP1/RIP3-dependent necrosis via MLKL-mediated pore formation of RAW 264.7 cells in the plasma membrane, which could provide a new mechanism to explain the link between elevated levels of free fatty acids (FFAs), palmitate in particular, and macrophage death.

  5. The results indicate that RIP1 and MLKL contribute to necroptotic cell death after HCoV-OC43 infection to limit viral replication.

  6. this study reveals a unique response of Kupffer cells against liver ischemia reperfusion, that is, RIP1 (show RALBP1 Proteins)-dependent necrosis, which constitutes a novel mechanism of liver inflammatory immune activation in the pathogenesis of liver ischemia reperfusion injury

  7. RIPK1 prevents skin inflammation by inhibiting activation of RIPK3 (show RIPK3 Proteins)-MLKL-dependent necroptosis mediated by Z-DNA binding protein 1 (ZBP1 (show ZBP1 Proteins), also known as DAI (show ZBP1 Proteins) or DLM1 (show ZBP1 Proteins)).

  8. findings indicate that the RHIM of RIPK1 is critical for preventing ZBP1/RIPK3/MLKL-dependent necroptosis during development

  9. Hyperglycemic Conditions Prime Cells for RIP1 (show RALBP1 Proteins)-dependent Necroptosis.

  10. our study suggests that nicotine may induce murine spermatozoal apoptosis via the TNF (show TNF Proteins) apoptotic pathway through up-regulation of deubiquitinated RIP1 (show RALBP1 Proteins) by Trim27 (show RFP Proteins) promoter hypomethylation.

RIPK1 Protein Profile

Protein Summary

Serine-threonine kinase which transduces inflammatory and cell-death signals (necroptosis) following death receptors ligation, activation of pathogen recognition receptors (PRRs), and DNA damage. Upon activation of TNFR1 by the TNF-alpha family cytokines, TRADD and TRAF2 are recruited to the receptor. Ubiquitination by TRAF2 via 'Lys-63'-link chains acts as a critical enhancer of communication with downstream signal transducers in the mitogen-activated protein kinase pathway and the NF-kappa-B pathway, which in turn mediate downstream events including the activation of genes encoding inflammatory molecules. Polyubiquitinated protein binds to IKBKG/NEMO, the regulatory subunit of the IKK complex, a critical event for NF-kappa-B activation. Interaction with other cellular RHIM-containing adapters initiates gene activation and cell death. RIPK1 and RIPK3 association, in particular, forms a necroptosis-inducing complex.

Alternative names and synonyms associated with RIPK1

  • receptor (TNFRSF)-interacting serine-threonine kinase 1 (LOC100230522)
  • inositol 1,3,4,5,6-pentakisphosphate 2-kinase (Ippk)
  • receptor (TNFRSF)-interacting serine-threonine kinase 1 (RIPK1)
  • receptor (TNFRSF)-interacting serine-threonine kinase 1 (Ripk1)
  • RPA interacting protein (Rpain)
  • 2400006N03Rik protein
  • C9orf12 protein
  • D330015H01Rik protein
  • RGD1311271 protein
  • Rinp protein
  • Rip protein
  • Rip1 protein
  • rIpk1 protein
  • RP23-83I13.5 protein

Protein level used designations for RIPK1

receptor (TNFRSF)-interacting serine-threonine kinase 1 , 1,3,4,5,6-pentakisphosphate 2-kinase , inositol polyphosphate kinase 1 , inositol-1,3,4,5,6-pentakisphosphate 2-kinase , inositol-pentakisphosphate 2-kinase , ins(1,3,4,5,6)P5 2-kinase , insP5 2-kinase , RIP-1 , cell death protein RIP , receptor interacting protein , receptor-interacting protein 1 , receptor-interacting serine/threonine-protein kinase 1 , serine/threonine-protein kinase RIP , RPA interacting protein delta 2 , RPA interacting protein epsilon , RPA-interacting protein

100230522 Taeniopygia guttata
306808 Rattus norvegicus
8737 Homo sapiens
504727 Bos taurus
100524751 Sus scrofa
19766 Mus musculus
306886 Rattus norvegicus
69723 Mus musculus
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