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Human TNFSF13B Protein expressed in Escherichia coli (E. coli) - ABIN1344400
Bossen, Cachero, Tardivel, Ingold, Willen, Dobles, Scott, Maquelin, Belnoue, Siegrist, Chevrier, Acha-Orbea, Leung, Mackay, Tschopp, Schneider: TACI, unlike BAFF-R, is solely activated by oligomeric BAFF and APRIL to support survival of activated B cells and plasmablasts. in Blood 2008
Show all 2 Pubmed References
Human TNFSF13B Protein expressed in Escherichia coli (E. coli) - ABIN413043
Kern, Cornuel, Billard, Tang, Rouillard, Stenou, Defrance, Ajchenbaum-Cymbalista, Simonin, Feldblum, Kolb: Involvement of BAFF and APRIL in the resistance to apoptosis of B-CLL through an autocrine pathway. in Blood 2004
Human TNFSF13B Protein expressed in HEK-293 Cells - ABIN1344293
Huard, Tran, Benkhoucha, Manzin-Lorenzi, Santiago-Raber: Selective APRIL blockade delays systemic lupus erythematosus in mouse. in PLoS ONE 2012
Equine adipose-derived stem cell (ASC (show PYCARD Proteins)) expresses BAFF (TNFSF13B) and its receptors, which may be associated with the differentiation process of ASC (show PYCARD Proteins) towards adipocyte.
BAFF has a role in inducing IL35 (show EBI3 Proteins) production by regulatory B cells in lupus
Inhibition of ADAM10 (show ADAM10 Proteins) augments BAFF-dependent survival of primary human B cells, whereas inhibition of ADAM17 (show ADAM17 Proteins) increases BAFFR (show TNFRSF13C Proteins) expression levels
Data presented show that B-cell activating factor (BAFF) plays a central role in the induction and maintenance of cigarette smoke-induced pulmonary antinuclear antibodies and suggest a therapeutic potential for BAFF blockade in limiting autoimmune processes associated with smoking.
Among the BAFF receptors in a cohort of rheumatoid arthritis (RA) patients, the AA have shown, by fluorescence activated cell sorter (FACS) analysis of median fluorescence intensity (MFI), that transmembrane activator and calcium-modulating cyclophilin ligand (show CAMLG Proteins) interactor (TACI (show TNFRSF13B Proteins)) and B cell maturation antigen (BCMA (show TNFRSF17 Proteins)) do not change
The BAFF promoter increased in response to TNF-alpha (show TNF Proteins) treatment or overexpression of HIF-1alpha (show HIF1A Proteins). However, TNF-alpha (show TNF Proteins)-induced BAFF expression and promoter activity decreased after treatment with the ERK (show EPHB2 Proteins) inhibitor PD98059.
This study indicates that orbital fibroblasts from Graves' orbitopathy can express BAFF and mediate the intraorbital survival of B cells via BAFF mechanism.
Inhibition of B cell plasmablast differentiation by reduction of Aiolos (show IKZF3 Proteins) and Ikaros (show IKZF1 Proteins) may have utility in the treatment of systemic lupus erythematosus , where elevated levels of BAFF and Aiolos (show IKZF3 Proteins) may prime CD27 (show CD27 Proteins)(+) memory and double negative memory-like B cells to become Ab-producing plasmablasts in the presence of BAFF and proinflammatory cytokines.
BCMA (show TNFRSF17 Proteins) has other contributors for ligands binding except DxL motif. The affinity of BCMA (show TNFRSF17 Proteins) for APRIL higher than for BAFF may be caused by the segment outside of the conservative DxL motif. Moreover, the exposition of new binding modes of BCMA2 interacting with APRIL may establish the foundation of designing novel drugs in the future
study demonstrated a high prevalence of endogenous antibodies to BAFF in a multi-ethnic Asian systemic lupus erythematosus (SLE) cohort; while levels of serum BAFF correlated positively with disease activity, levels of anti-BAFF antibody were correlated negatively with levels of its target cytokine, anti-dsDNA antibody and clinical disease activity
this study provides new useful information about the increased levels of BAFF observed during HIV-1 infection and highlights the importance of macrophages as a source of BAFF
This study suggests that BAFF selects IL-10 (show IL10 Proteins)(-)B cells over IL-10 (show IL10 Proteins)(+) regulatory B cells via BAFF receptors in inflammatory responses
BAFF plays a previously unappreciated role in lupus nephritis by inducing renal tertiary lymphoid structures and regulating the position of T cells within the glomeruli.
this study shows that BAFF overexpression reduces hypercholesterolemia and atherosclerosis in hyperlipidemic mice via TACI (show TNFRSF13B Proteins)-dependent B cell activation (show BLNK Proteins)
B cell-activating factor (BAFF) upregulates CD28 (show CD28 Proteins)/B7 and CD40 (show CD40 Proteins)/CD154 (show CD40LG Proteins) expression, and promotes the interactions between T and B cells in a BAFF receptor (show TNFRSF13C Proteins)-dependent manner.
findings highlight a novel mechanism through which BAFF promotes humoral autoimmunity via direct, TACI (show TNFRSF13B Proteins)-dependent activation of transitional B cells
neutrophils secreted a B cell-activating factor that highly accelerated plasma cell generation and antigen-specific antibody production.
The enhanced thermogenic program was confirmed by higher protein levels of UCP1 (show UCP1 Proteins) and irisin (show FNDC5 Proteins) in female BAFF-/- than in WT mice.
Antibodies That Block or Activate Mouse B Cell Activating Factor of the Tumor Necrosis Factor (TNF (show TNF Proteins)) Family (BAFF), Respectively, Induce B Cell Depletion or B Cell Hyperplasia.
Increased B-cell activating factor (BAFF) induced B cell differentiation into germinal center (GC) B (show NPR2 Proteins) cells within the autoimmune target tissue.
study reports the molecular cloning, expression and bioactivity of the porcine homologue of human BAFF
This study demonstrated expression of BAFF on cultured monocyte-derived dendritic cells, which was further enhanced by interferon-alpha (show IFNA Proteins) or interferon-gamma (show IFNG Proteins) treatment.
Although BAFF expression is dispensable for B cell development in the bone marrow, it is required for B cell development in gut (show GUSB Proteins)-associated lymphoid tissue.
BAFF and its receptors during B-cell activation (show BLNK Proteins) and autoantibody production in rabbits derived from selective breeding to develop a reproducible rabbit model of Systemic Lupus Erythematosus, were investigated.
Cloning and expression analysis of B-cell activating factor (BAFF) provide the basis for investigation of its role in regulating rabbit B-lymphocyte (show AKAP17A Proteins) development and immune responses.
BAFF was detected in developing appendix of young rabbits by immunohistochemical staining suggesting that BAFF plays a role during the period following birth when rabbit B-cell development is occurring.
The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for receptors TNFRSF13B/TACI, TNFRSF17/BCMA, and TNFRSF13C/BAFFR. This cytokine is expressed in B cell lineage cells, and acts as a potent B cell activator. It has been also shown to play an important role in the proliferation and differentiation of B cells. Alternatively spliced transcript variants encoding distinct isoforms have been identified.
tumor necrosis factor ligand superfamily member 13B
, tumor necrosis factor (ligand) superfamily, member 13b
, B-cell activating factor
, B-lymphocyte stimulator
, TNF- and APOL-related leukocyte expressed ligand 1
, ApoL related ligand TALL-1
, B-cell-activating factor
, Delta4 BAFF
, TNF and ApoL-related leukocyte expressed ligand 1
, TNF homolog that activates apoptosis
, delta BAFF
, dendritic cell-derived TNF-like molecule
, tumor necrosis factor (ligand) superfamily, member 20
, tumor necrosis factor-like protein ZTNF4
, b cell-activating factor
, tumor necrosis factor superfamily member 13b