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We show here that both molecules (Deltex (DTX (show DTX1 Proteins)) and AIP4 (show ITCH Proteins)) interact and partially colocalize to endocytic vesicles, and that AIP4 (show ITCH Proteins) targets DTX (show DTX1 Proteins) for lysosomal degradation.
It is reported that BBAP (show DTX3L Proteins) and the human family of DTX (show DTX1 Proteins) proteins (DTX1 (show DTX1 Proteins), DTX2 (show DTX2 Proteins), and DTX3) function as E3 ligases based on their capacity for self-ubiquitination.
DTX3 functions as an E3 ubiquitin ligase (Takeyama et al., 2003
deltex 3 homolog
, protein deltex-3
, deltex 3-like protein
, deltex homolog 3 (Drosophila)
, probable E3 ubiquitin-protein ligase DTX3
, RING finger protein 154
, Protein deltex-3