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Our results provide molecular insight into the mechanisms by which NLRP4-DTX4 targets TBK1 (show TBK1 Proteins) for degradation.
The results indicate that DTX4 stable knockdown inhibits adipogenesis of 3T3-L1 cells through inhibiting C/EBPalpha (show CEBPA Proteins) and PPARgamma (show PPARG Proteins), arresting mitotic clonal expansion and regulating Wnt (show WNT2 Proteins) signaling pathway.
Functions as an ubiquitin ligase protein in vivo, mediating 'Lys48'-linked polyubiquitination and promoting degradation of TBK1, targeting to TBK1 requires interaction with NLRP4 (By similarity). Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations.
deltex 4 homolog
, E3 ubiquitin-protein ligase DTX4
, RING finger protein 155
, protein deltex-4
, deltex 4, E3 ubiquitin ligase
, deltex homolog 4
, LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase DTX4