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Browse our FBXW7 Proteins (FBXW7)

Full name:
F-Box and WD Repeat Domain Containing 7 Proteins (FBXW7)
On www.antibodies-online.com are 4 F-Box and WD Repeat Domain Containing 7 (FBXW7) Proteins from 2 different suppliers available. Additionally we are shipping FBXW7 Antibodies (136) and FBXW7 Kits (12) and many more products for this protein. A total of 159 FBXW7 products are currently listed.
Synonyms:
1110001A17Rik, AGO, Cdc4, FBW6, Fbw7, Fbwd6, Fbx30, Fbxo30, Fbxw6, hAgo, hCdc4, SEL-10, SEL10
list all proteins Gene Name GeneID UniProt
Rat FBXW7 FBXW7 100360914  
FBXW7 55294 Q969H0
FBXW7 50754 Q8VBV4

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FBXW7 Proteins (FBXW7) by Origin

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More Proteins for FBXW7 Interaction Partners

Human F-Box and WD Repeat Domain Containing 7 (FBXW7) interaction partners

  1. microRNA-770 was identified as an important downstream target of Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) signaling, to inhibit FBXW7 expression through targeting its 3'-untranslated region. Thus, our results suggest a previously unknown Wnt (show WNT2 Proteins)/beta catenin (show CTNNB1 Proteins)-miR (show MLXIP Proteins)-770-FBXW7 molecular network in the HCC (show FAM126A Proteins) development.

  2. The suppression of FBXW7 increased the proliferation.

  3. Low expression of FBXW7 is associated with hepatocellular carcinoma.

  4. FBXW7 is related to the susceptibility and prognosis of cervical squamous carcinoma, indicating FBXW7 may be a potentially important target for the prediction of prognosis

  5. Loss of FBXW7 expression is associated with pancreatic cancer.

  6. FBXW7 expression was downregulated in ovarian cancers, and was associated with p53 (show TP53 Proteins) mutations and the DNA methylation (show HELLS Proteins) status of the 5'-upstream regions of FBXW7.

  7. Study showed that overexpression of miR (show MLXIP Proteins)-92a was identified in osteosarcoma specimens and cells compared to normal bone tissues; miR (show MLXIP Proteins)-92a probably functions as a driver of tumor progression by targeting FBXW7.

  8. This study suggests that FBXW7, normally a tumor suppressor, can act as an oncogene (show RAB1A Proteins) when mutated and may play an important role in the pathogenesis of adult T-cell leukemia.

  9. Notably, other mutations including MET, APC (show APC Proteins), CDH1 (show CDH1 Proteins), and FBXW7 were also identified in Taiwanese oral squamous cell carcinoma patients.

  10. Our observations sustain the role of FBXW7 as cancer predisposition gene and expand the spectrum of its possible associated diseases.

Mouse (Murine) F-Box and WD Repeat Domain Containing 7 (FBXW7) interaction partners

  1. Study identifies a REV-ERBalpha (show NR1D1 Proteins) post-translational regulatory circuit in which cyclin-dependent kinase 1 (CDK1 (show CDK1 Proteins)) phosphorylation of REV-ERBalpha (show NR1D1 Proteins) is recognized by the F-box protein (show FBXO30 Proteins), FBXW7alpha, to direct REV-ERBalpha (show NR1D1 Proteins) degradation via the proteasome. Disruption of this CDK1 (show CDK1 Proteins)-FBXW7-mediated REV-ERBalpha (show NR1D1 Proteins) degradation pathway in mouse liver alters circadian rhythmicity, in particular amplitude, and whole-body lipid/glucose home...

  2. Gene expression profiling reveals transcriptional regulation by Fbxw7/mTOR (show FRAP1 Proteins) pathway in radiation-induced mouse thymic lymphomas.

  3. Prion (show PRNP Proteins) infection induced the expression of FBXW7 in brain.

  4. FBXW7 facilitates nonhomologous end-joining via K63-linked polyubiquitylation of XRCC4 (show XRCC4 Proteins) in tumor cells.

  5. data demonstrate that Fbw7alpha negatively regulates osteogenesis by targeting Runx2 for ubiquitin-mediated degradation in a GSK3beta-dependent manner

  6. In mice, an unusually direct antagonism between an E3 ligase and a deubiquitinase, Fbw7 and Usp28 (show USP28 Proteins), modulate intestinal homeostasis and cancer.

  7. These data show that cell cycle-dependent mechanisms can control ciliary length through a CDK5-FBW7-NDE1 pathway.

  8. Dual regulation of Fbw7 activity by Usp28 (show USP28 Proteins) is a safeguard mechanism for maintaining physiological levels of proto-oncogenic Fbw7 substrates, which is equivalently disrupted by loss or overexpression of Usp28 (show USP28 Proteins).

  9. Ubiquitin-dependent degradation of GATA 2 (show GATA2 Proteins) is promoted by Fbw7, is cyclin B-CDK1 (show CDK1 Proteins)-mediated Thr176 phosphorylation-dependent, and influences hematopoietic cell differentiation.

  10. Fbw7 is a master regulator of cell fate decisions in the pancreas

FBXW7 Protein Profile

Protein Summary

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene was previously referred to as FBX30, and belongs to the Fbws class\; in addition to an F-box, this protein contains 7 tandem WD40 repeats. This protein binds directly to cyclin E and probably targets cyclin E for ubiquitin-mediated degradation. Mutations in this gene are detected in ovarian and breast cancer cell lines, implicating the gene's potential role in the pathogenesis of human cancers. Multiple transcript variants encoding different isoforms have been found for this gene.

Alternative names and synonyms associated with FBXW7

  • F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase (Fbxw7)
  • F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase (FBXW7)
  • F-box and WD repeat domain containing 7 (FBXW7)
  • F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase (fbxw7)
  • F-box and WD-40 domain protein 7 (Fbxw7)
  • 1110001A17Rik protein
  • AGO protein
  • Cdc4 protein
  • FBW6 protein
  • Fbw7 protein
  • Fbwd6 protein
  • Fbx30 protein
  • Fbxo30 protein
  • Fbxw6 protein
  • hAgo protein
  • hCdc4 protein
  • SEL-10 protein
  • SEL10 protein

Protein level used designations for FBXW7

F-box and WD-40 domain protein 7 , F-box/WD repeat-containing protein 7 , F-box and WD-40 domain protein 7 (archipelago homolog, Drosophila) , F-box protein FBW7 , F-box protein FBX30 , F-box protein SEL-10 , archipelago , homolog of C elegans sel-10 , F-box and WD-40 domain protein 7, archipelago homolog , F-box and WD-40 domain-containing protein 7 , F-box protein Fbxw6 , F-box-WD40 repeat protein 6 , f-box only protein 30

GENE ID SPECIES
100360914 Rattus norvegicus
475465 Canis lupus familiaris
100620112 Sus scrofa
540932 Bos taurus
100145670 Xenopus (Silurana) tropicalis
55294 Homo sapiens
101104688 Ovis aries
50754 Mus musculus
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