You are viewing an incomplete version of our website. Please click to reload the website as full version.

Browse our FBXW7 Proteins (FBXW7)

Full name:
F-Box and WD Repeat Domain Containing 7 Proteins (FBXW7)
On are 4 F-Box and WD Repeat Domain Containing 7 (FBXW7) Proteins from 2 different suppliers available. Additionally we are shipping FBXW7 Antibodies (99) and FBXW7 Kits (15) and many more products for this protein. A total of 125 FBXW7 products are currently listed.
1110001A17Rik, AGO, Cdc4, FBW6, Fbw7, Fbwd6, Fbx30, Fbxo30, Fbxw6, hAgo, hCdc4, SEL-10, SEL10
list all proteins Gene Name GeneID UniProt
Rat FBXW7 FBXW7 100360914  
FBXW7 55294 Q969H0
FBXW7 50754 Q8VBV4

Show all synonyms

FBXW7 Proteins (FBXW7) by Origin

Select your origin of interest

More Proteins for FBXW7 Interaction Partners

Human F-Box and WD Repeat Domain Containing 7 (FBXW7) interaction partners

  1. Our observations sustain the role of FBXW7 as cancer predisposition gene and expand the spectrum of its possible associated diseases.

  2. cells lacking FBW7 are sensitive to knockdown of the spindle assembly checkpoint (SAC (show ADCY10 Proteins)) protein BUBR1 (show BUB1B Proteins)

  3. miR (show MLXIP Proteins)-25 is up-regulated in non-small cell lung cancer and promotes NSCLC cells proliferation and motility partially by targeting FBXW7.

  4. Results show that the expression of miR (show MLXIP Proteins)-92a is up-regulated in hepatocellular carcinoma (HCC (show FAM126A Proteins)) tissues and cell lines and confirm it as an independent prognostic marker. MiR (show MLXIP Proteins)-92a functions as a novel oncomiRNA by promoting tumor growth of HCC (show FAM126A Proteins) by targeting.

  5. we observed an association of FBW7 with p105 (show CDH13 Proteins) and p65 (show GORASP1 Proteins), as well as p100 (show CUX1 Proteins), and knockdown of FBW7 eliminated 1,25D-dependent subunit turnover

  6. Inhibition of proteasome, GSK3 or the E3 ubiquitin ligase (show MUL1 Proteins), FBXW7, prevented mSREBP1 reduction induced by mTORC2 (show CRTC2 Proteins) inhibition.

  7. FBXW7 facilitates nonhomologous end-joining via K63-linked polyubiquitylation of XRCC4 (show XRCC4 Proteins) in tumor cells.

  8. When endogenous Fbw7 was knocked down, both NS5B protein abundance and HCV replication were remarkably up-regulated.

  9. Fbxw7 induces apoptosis and growth arrest and inhibits theepithelial-to-mesenchymal transition (EMT (show ITK Proteins)) in part by down-regulating the RhoA (show RHOA Proteins) signaling pathway.

  10. FBXW7 is a significant tumor suppressor gene in renal cancer.FBXW7 overexpression suppresses renal cancer cell proliferation and induces apoptosis.

Mouse (Murine) F-Box and WD Repeat Domain Containing 7 (FBXW7) interaction partners

  1. FBXW7 facilitates nonhomologous end-joining via K63-linked polyubiquitylation of XRCC4 (show XRCC4 Proteins) in tumor cells.

  2. data demonstrate that Fbw7alpha negatively regulates osteogenesis by targeting Runx2 for ubiquitin-mediated degradation in a GSK3beta-dependent manner

  3. In mice, an unusually direct antagonism between an E3 ligase and a deubiquitinase, Fbw7 and Usp28 (show USP28 Proteins), modulate intestinal homeostasis and cancer.

  4. These data show that cell cycle-dependent mechanisms can control ciliary length through a CDK5-FBW7-NDE1 pathway.

  5. Dual regulation of Fbw7 activity by Usp28 (show USP28 Proteins) is a safeguard mechanism for maintaining physiological levels of proto-oncogenic Fbw7 substrates, which is equivalently disrupted by loss or overexpression of Usp28 (show USP28 Proteins).

  6. Ubiquitin-dependent degradation of GATA 2 (show GATA2 Proteins) is promoted by Fbw7, is cyclin B-CDK1 (show CDK1 Proteins)-mediated Thr176 phosphorylation-dependent, and influences hematopoietic cell differentiation.

  7. Fbw7 is a master regulator of cell fate decisions in the pancreas

  8. FBXW7 modulates cellular stress response and metastatic potential through HSF1 (show HSF1 Proteins) post-translational modification.

  9. these results suggest that FBXW7 antagonizes cancer development in not only a cell-autonomous manner, but also a non-cell-autonomous manner

  10. demonstrate the importance of Fbw7-dependent cyclin E (show CCNE1 Proteins) control to the hematopoietic system and highlight chromosome instability as a characteristic feature of dysfunction and malignancy induced by deregulated cyclin E (show CCNE1 Proteins)

FBXW7 Protein Profile

Protein Summary

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene was previously referred to as FBX30, and belongs to the Fbws class\; in addition to an F-box, this protein contains 7 tandem WD40 repeats. This protein binds directly to cyclin E and probably targets cyclin E for ubiquitin-mediated degradation. Mutations in this gene are detected in ovarian and breast cancer cell lines, implicating the gene's potential role in the pathogenesis of human cancers. Multiple transcript variants encoding different isoforms have been found for this gene.

Alternative names and synonyms associated with FBXW7

  • F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase (Fbxw7)
  • F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase (FBXW7)
  • F-box and WD repeat domain containing 7 (FBXW7)
  • F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase (fbxw7)
  • F-box and WD-40 domain protein 7 (Fbxw7)
  • 1110001A17Rik protein
  • AGO protein
  • Cdc4 protein
  • FBW6 protein
  • Fbw7 protein
  • Fbwd6 protein
  • Fbx30 protein
  • Fbxo30 protein
  • Fbxw6 protein
  • hAgo protein
  • hCdc4 protein
  • SEL-10 protein
  • SEL10 protein

Protein level used designations for FBXW7

F-box and WD-40 domain protein 7 , F-box/WD repeat-containing protein 7 , F-box and WD-40 domain protein 7 (archipelago homolog, Drosophila) , F-box protein FBW7 , F-box protein FBX30 , F-box protein SEL-10 , archipelago , homolog of C elegans sel-10 , F-box and WD-40 domain protein 7, archipelago homolog , F-box and WD-40 domain-containing protein 7 , F-box protein Fbxw6 , F-box-WD40 repeat protein 6 , f-box only protein 30

100360914 Rattus norvegicus
475465 Canis lupus familiaris
100620112 Sus scrofa
540932 Bos taurus
100145670 Xenopus (Silurana) tropicalis
55294 Homo sapiens
101104688 Ovis aries
50754 Mus musculus
Selected quality suppliers for FBXW7 Proteins (FBXW7)
Did you look for something else?