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Browse our FBXW7 Proteins (FBXW7)

Full name:
F-Box and WD Repeat Domain Containing 7 Proteins (FBXW7)
On www.antibodies-online.com are 4 F-Box and WD Repeat Domain Containing 7 (FBXW7) Proteins from 2 different suppliers available. Additionally we are shipping FBXW7 Antibodies (137) and FBXW7 Kits (12) and many more products for this protein. A total of 160 FBXW7 products are currently listed.
Synonyms:
1110001A17Rik, AGO, Cdc4, FBW6, Fbw7, Fbwd6, Fbx30, Fbxo30, Fbxw6, hAgo, hCdc4, SEL-10, SEL10
list all proteins Gene Name GeneID UniProt
Rat FBXW7 FBXW7 100360914  
FBXW7 55294 Q969H0
FBXW7 50754 Q8VBV4

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Human F-Box and WD Repeat Domain Containing 7 (FBXW7) interaction partners

  1. The authors show that STYX binds to the F-box domain of FBXW7 and disables its recruitment into the SCF ubiquitin ligase complex.

  2. In colorectal cancers, mutations in the FBXW7 gene were more common in the younger cohort (27.5% vs 9.7%; P = .0022) as were mutations in the proofreading domain of polymerase epsilon catalytic subunit (POLE) (9.8% vs 1%; P = .0048).

  3. Study found that EYA1 (show EYA1 Proteins) affects FBW7-Myc (show MYC Proteins) binding to regulate the FBW7-mediated Myc (show MYC Proteins) degradation machinery.

  4. Our findings reveal a novel regulatory mechanism for SOX9 (show SOX9 Proteins) stability and uncover a unique function of SOX9 (show SOX9 Proteins) in the cellular response to DNA damage. This new mechanism underlying a FBW7-SOX9 (show SOX9 Proteins) axis in cancer could have implications in therapy resistance.

  5. Our results provide a novel mechanistic insight into the activation of Myc (show MYC Proteins) by 27-HC via transcriptional repression of PP2A (show PPP2R4 Proteins), SCP1 (show SYCP1 Proteins) and FBW7 to increase Myc (show MYC Proteins) protein stability in breast cancer cells.

  6. Tumor suppressor genes deleted in liver cancer 1 (DLC1), F-box/WD-repeat-containing protein 7 (FBXW7), and cadherin-6 (CDH6 (show CDH6 Proteins)) were identified as presumed targets in Cholangiocarcinoma (CC).Inverse correlation between promoter methylation and expression suggested miR (show MLXIP Proteins)-129-2 and members of the miR (show MLXIP Proteins)-200 family (miR (show MLXIP Proteins)-200a, miR (show MLXIP Proteins)-200b, and miR (show MLXIP Proteins)-429) as novel tumor suppressors and oncomiRs, respectively, in CC

  7. Deregulated ERK1/2 MAP kinase (show MAPK1 Proteins) signaling promotes aneuploidy by a Fbxw7beta-Aurora A (show AURKA Proteins) pathway.

  8. The adapter function of EBP1 (show NFKB1 Proteins) P42 (show EPB42 Proteins) stabilized the interaction of FBXW7 with its substrates and promoted FBXW7-mediated degradation of oncogenic targets, enhancing its overall tumor-suppressing function. Results establish distinct physical and functional interactions between FBXW7 and EBP1 (show NFKB1 Proteins) isoforms, which yield their mechanistically unique isoform-specific functions of EBP1 (show NFKB1 Proteins) in cancer.

  9. Fbxw7 suppresses KrasG12D-induced pancreatic tumorigenesis via a Yap (show YAP1 Proteins)-dependent mechanism.

  10. Downregulation of FBXW7 is associated with cholangiocarcinoma.

Mouse (Murine) F-Box and WD Repeat Domain Containing 7 (FBXW7) interaction partners

  1. Fbxw7 suppresses KrasG12D-induced pancreatic tumorigenesis via a Yap (show YAP1 Proteins)-dependent mechanism.

  2. Study identifies a REV-ERBalpha (show NR1D1 Proteins) post-translational regulatory circuit in which cyclin-dependent kinase 1 (CDK1 (show CDK1 Proteins)) phosphorylation of REV-ERBalpha (show NR1D1 Proteins) is recognized by the F-box protein (show FBXO30 Proteins), FBXW7alpha, to direct REV-ERBalpha (show NR1D1 Proteins) degradation via the proteasome. Disruption of this CDK1 (show CDK1 Proteins)-FBXW7-mediated REV-ERBalpha (show NR1D1 Proteins) degradation pathway in mouse liver alters circadian rhythmicity, in particular amplitude, and whole-body lipid/glucose home...

  3. Gene expression profiling reveals transcriptional regulation by Fbxw7/mTOR (show FRAP1 Proteins) pathway in radiation-induced mouse thymic lymphomas.

  4. Prion (show PRNP Proteins) infection induced the expression of FBXW7 in brain.

  5. FBXW7 facilitates nonhomologous end-joining via K63-linked polyubiquitylation of XRCC4 (show XRCC4 Proteins) in tumor cells.

  6. data demonstrate that Fbw7alpha negatively regulates osteogenesis by targeting Runx2 for ubiquitin-mediated degradation in a GSK3beta-dependent manner

  7. In mice, an unusually direct antagonism between an E3 ligase and a deubiquitinase, Fbw7 and Usp28 (show USP28 Proteins), modulate intestinal homeostasis and cancer.

  8. These data show that cell cycle-dependent mechanisms can control ciliary length through a CDK5-FBW7-NDE1 pathway.

  9. Dual regulation of Fbw7 activity by Usp28 (show USP28 Proteins) is a safeguard mechanism for maintaining physiological levels of proto-oncogenic Fbw7 substrates, which is equivalently disrupted by loss or overexpression of Usp28 (show USP28 Proteins).

  10. Ubiquitin-dependent degradation of GATA 2 (show GATA2 Proteins) is promoted by Fbw7, is cyclin B-CDK1 (show CDK1 Proteins)-mediated Thr176 phosphorylation-dependent, and influences hematopoietic cell differentiation.

FBXW7 Protein Profile

Protein Summary

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene was previously referred to as FBX30, and belongs to the Fbws class\; in addition to an F-box, this protein contains 7 tandem WD40 repeats. This protein binds directly to cyclin E and probably targets cyclin E for ubiquitin-mediated degradation. Mutations in this gene are detected in ovarian and breast cancer cell lines, implicating the gene's potential role in the pathogenesis of human cancers. Multiple transcript variants encoding different isoforms have been found for this gene.

Alternative names and synonyms associated with FBXW7

  • F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase (Fbxw7)
  • F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase (FBXW7)
  • F-box and WD repeat domain containing 7 (FBXW7)
  • F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase (fbxw7)
  • F-box and WD-40 domain protein 7 (Fbxw7)
  • 1110001A17Rik protein
  • AGO protein
  • Cdc4 protein
  • FBW6 protein
  • Fbw7 protein
  • Fbwd6 protein
  • Fbx30 protein
  • Fbxo30 protein
  • Fbxw6 protein
  • hAgo protein
  • hCdc4 protein
  • SEL-10 protein
  • SEL10 protein

Protein level used designations for FBXW7

F-box and WD-40 domain protein 7 , F-box/WD repeat-containing protein 7 , F-box and WD-40 domain protein 7 (archipelago homolog, Drosophila) , F-box protein FBW7 , F-box protein FBX30 , F-box protein SEL-10 , archipelago , homolog of C elegans sel-10 , F-box and WD-40 domain protein 7, archipelago homolog , F-box and WD-40 domain-containing protein 7 , F-box protein Fbxw6 , F-box-WD40 repeat protein 6 , f-box only protein 30

GENE ID SPECIES
100360914 Rattus norvegicus
475465 Canis lupus familiaris
100620112 Sus scrofa
540932 Bos taurus
100145670 Xenopus (Silurana) tropicalis
55294 Homo sapiens
101104688 Ovis aries
50754 Mus musculus
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