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Loss of FBW7 expression is associated with breast cancer.
FBXW7 could be a potential biomarker for predicting not only the clinical response to chemoradiotherapy but also overall survival in patients with oral squamous cell carcinoma
Our results reveal a new mechanism of ZNF322A (show ZNF322A Proteins) oncoprotein destruction regulated by the CK1delta/GSK3beta/FBXW7a axis. Deregulation of this signaling axis results in ZNF322A (show ZNF322A Proteins) overexpression and promotes cancer progression
Low FBXW7 expression is associated with pancreatic cancer.
siRNA interference of FBXW7 reversed the inhibitory effect of MAGEA1 (show MAGEA1 Proteins) on migration and proliferation of MCF-7 and MDA-MB-231 cells.
Endogenous circRNA encodes a functional protein in human cells, and circ-FBXW7 and FBXW7-185aa have potential prognostic implications in brain cancer.
Dual FBXW7-GAK (show GAK Proteins) inhibition increases multipolar mitoses.
EXT1 (show EXT1 Proteins), a gene not previously linked to acute lymphoblastic leukemia via mutations, is a common interactor of NOTCH1 (show NOTCH1 Proteins) and FBXW7 regulating the NOTCH (show NOTCH1 Proteins) pathway in an FBXW7-dependend manner.
C-MYC (show MYC Proteins) and FBXW7 affect Adult T-cell Leukemia/Lymphoma proliferation and progression, and low FBXW7 may increase C-MYC (show MYC Proteins) expression. C-MYC (show MYC Proteins) was a critical prognostic factor in Adult T-cell Leukemia/Lymphoma patients.
The findings reveal a PLK1-Fbw7-Myc (show MYC Proteins) signaling circuit that underlies tumorigenesis and validate PLK1 inhibitors, alone or with Bcl2 (show BCL2 Proteins) antagonists, as potential effective therapeutics for MYC (show MYC Proteins)-overexpressing cancers.
Fbxw7 suppresses KrasG12D-induced pancreatic tumorigenesis via a Yap (show YAP1 Proteins)-dependent mechanism.
Study identifies a REV-ERBalpha (show NR1D1 Proteins) post-translational regulatory circuit in which cyclin-dependent kinase 1 (CDK1 (show CDK1 Proteins)) phosphorylation of REV-ERBalpha (show NR1D1 Proteins) is recognized by the F-box protein (show FBXO30 Proteins), FBXW7alpha, to direct REV-ERBalpha (show NR1D1 Proteins) degradation via the proteasome. Disruption of this CDK1 (show CDK1 Proteins)-FBXW7-mediated REV-ERBalpha (show NR1D1 Proteins) degradation pathway in mouse liver alters circadian rhythmicity, in particular amplitude, and whole-body lipid/glucose home...
Gene expression profiling reveals transcriptional regulation by Fbxw7/mTOR (show FRAP1 Proteins) pathway in radiation-induced mouse thymic lymphomas.
Prion (show PRNP Proteins) infection induced the expression of FBXW7 in brain.
FBXW7 facilitates nonhomologous end-joining via K63-linked polyubiquitylation of XRCC4 (show XRCC4 Proteins) in tumor cells.
data demonstrate that Fbw7alpha negatively regulates osteogenesis by targeting Runx2 for ubiquitin-mediated degradation in a GSK3beta-dependent manner
In mice, an unusually direct antagonism between an E3 ligase and a deubiquitinase, Fbw7 and Usp28 (show USP28 Proteins), modulate intestinal homeostasis and cancer.
These data show that cell cycle-dependent mechanisms can control ciliary length through a CDK5-FBW7-NDE1 pathway.
Dual regulation of Fbw7 activity by Usp28 (show USP28 Proteins) is a safeguard mechanism for maintaining physiological levels of proto-oncogenic Fbw7 substrates, which is equivalently disrupted by loss or overexpression of Usp28 (show USP28 Proteins).
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene was previously referred to as FBX30, and belongs to the Fbws class\; in addition to an F-box, this protein contains 7 tandem WD40 repeats. This protein binds directly to cyclin E and probably targets cyclin E for ubiquitin-mediated degradation. Mutations in this gene are detected in ovarian and breast cancer cell lines, implicating the gene's potential role in the pathogenesis of human cancers. Multiple transcript variants encoding different isoforms have been found for this gene.
F-box and WD-40 domain protein 7
, F-box/WD repeat-containing protein 7
, F-box and WD-40 domain protein 7 (archipelago homolog, Drosophila)
, F-box protein FBW7
, F-box protein FBX30
, F-box protein SEL-10
, homolog of C elegans sel-10
, F-box and WD-40 domain protein 7, archipelago homolog
, F-box and WD-40 domain-containing protein 7
, F-box protein Fbxw6
, F-box-WD40 repeat protein 6
, f-box only protein 30