Browse our Manic Fringe Proteins (MFNG)

Full name:
MFNG Proteins (MFNG)
On are 11 MFNG Proteins from 5 different suppliers available. Additionally we are shipping Manic Fringe Antibodies (60) and Manic Fringe Kits (10) and many more products for this protein. A total of 87 Manic Fringe products are currently listed.
list all proteins Gene Name GeneID UniProt
MFNG 4242 O00587
MFNG 17305 O09008
MFNG 315119  

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Manic Fringe Proteins (MFNG) by Origin

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More Proteins for Manic Fringe Interaction Partners

Human MFNG interaction partners

  1. Mfng is an oncogene (show RAB1A Proteins) acting through Notch (show NOTCH1 Proteins)-mediated induction of Pik3cg (show PIK3CG Proteins).

Mouse (Murine) MFNG interaction partners

  1. Fringe modifications at EGF8 and EGF12 enhanced Notch1 binding to and activation from Delta-like 1, while modifications at EGF6 and EGF36 (added by Manic and Lunatic but not Radical) inhibited Notch1 activation from Jagged1.

  2. the presence of Gal (show GAL Proteins) on O-fucose glycans differentially affects DLL1 (show DLL1 Proteins)-induced NOTCH (show NOTCH1 Proteins) signaling modulated by LFNG (show LFNG Proteins) versus MFNG

  3. Myt1 (show MYT1 Proteins), Myt3, and Ngn3 (show NEUROG3 Proteins) are induced by Mfng and have roles in Mfng-mediated repression of Notch (show NOTCH1 Proteins) signaling which could serve as a trigger for endocrine islet differentiation

  4. Jag1 (show JAG1 Proteins)/fringe genes (Lfng (show LFNG Proteins), Rfng, and Mfng) may regulate postnatal bile duct growth and remodeling, and serve as candidate modifiers of the hepatic phenotype in Alagille syndrome.

  5. Lunatic Fringe (Lfng (show LFNG Proteins)) and Manic Fringe (Mfng) cooperatively enhanced the DL1-Notch2 (show NOTCH2 Proteins) interaction to promote marginal zone B cell development

  6. MFng colocalized with the proendocrine transcription factor Ngn3 (show NEUROG3 Proteins) in the developing mouse pancreas between embryonic days 9 and 14

Manic Fringe (MFNG) Protein Profile

Protein Summary

This gene is a member of the fringe gene family which also includes radical and lunatic fringe genes. They all encode evolutionarily conserved secreted proteins that act in the Notch receptor pathway to demarcate boundaries during embryonic development. While their genomic structure is distinct from other glycosyltransferases, fringe proteins have a fucose-specific beta-1,3-N-acetylglucosaminyltransferase activity that leads to elongation of O-linked fucose residues on Notch, which alters Notch signaling.

Alternative names and synonyms associated with Manic Fringe (MFNG)

  • MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase (MFNG)
  • MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase (Mfng)
  • AW546563 protein

Protein level used designations for MFNG Proteins (MFNG)

O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase , beta-1,3-N-acetylglucosaminyltransferase manic fringe , manic fringe homolog

4242 Homo sapiens
610303 Canis lupus familiaris
505267 Bos taurus
17305 Mus musculus
315119 Rattus norvegicus
418042 Gallus gallus
458811 Pan troglodytes
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