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The mechanism of IL-6-induced AR activation is mediated through enhancing AR-SRC-1 interaction and inhibiting AR-SMRT interaction.
IL-6-mediated AR antagonism induced by cypermethrin is related to repress the recruitment of co-regulators SRC-1 and SMRT to the AR in a ligand-independent manner
this study identifies NCOR2 as a new gene for FVC, indicating the importance of further research into the role of vitamin A intake/supplementation and its interactions with related genes in the regulation of FVC.
Molecular basis for the specific interactions between HDAC4 and the SMRT corepressor.
SNPs in Notch (show NOTCH1 ELISA Kits) pathway genes may be predictors of cutaneous melanoma disease-specific survival.
Significant methylation changes in the SLC23A2 and NCOR2 regulatory regions.
A repeated peptide motif present in both SMRT and NCoR is sufficient to mediate specific interaction, with micromolar affinity, with all the Class IIa Histone Deacetylases (HDACs 4, 5, 7, and 9).
SMRT enhances cell growth of estrogen receptor-alpha (show ESR1 ELISA Kits)-positive breast cancer cells by promotion of cell cycle progression and inhibition of apoptosis.
Phosphorylation of the CK2 site on SMRT significantly increased affinity for SHARP.
model where p53 (show TP53 ELISA Kits) binding to the SMRT deacetylase activation domain (DAD) limits HDAC3 (show HDAC3 ELISA Kits) interaction with this coregulator, thereby facilitating SMRT coactivation of p53 (show TP53 ELISA Kits)-dependent gene expression
Both the acetylation and SUMOylation status of the PXR protein is affected by its ability to associate with the lysine de-acetylating enzyme HDAC3 in a complex with SMRT.
These studies support a model in which NCOR1 (show NCOR1 ELISA Kits)/2 mediates direct Retinoic acid-dependent repression of Fgf8 (show FGF8 ELISA Kits) in caudal (show CAD ELISA Kits) progenitors in order to control somitogenesis.
demonstrate that the binding of HDAC3 (show HDAC3 ELISA Kits) to IR nGREs in vivo is mediated through interaction with SMRT/NCoR1 (show NCOR1 ELISA Kits)
GR SUMOylation site is mandatory for the formation of a GR-small ubiquitin-related modifiers (SUMOs)-SMRT/NCoR1 (show NCOR1 ELISA Kits)-HDAC3 (show HDAC3 ELISA Kits) repressing complex, which is indispensable for NF-kappaB (show NFKB1 ELISA Kits)/AP1 (show JUN ELISA Kits)-mediated GC-induced tethered indirect transrepression in vitro
changes in dietary components can consistently, if moderately, modulate the total transcript levels and the mRNA splicing of NCoR and SMRT in both cultured cells and intact mice.
SMRT regulates glucocorticoid action in adipocytes.
While silencing mediator of retinoid and thyroid hormone receptor (show THRA ELISA Kits) played little role in TH-regulated pathways, when disrupted in combination with nuclear receptor corepressor, it greatly accentuated the synthesis and storage of hepatic lipid
HDAC3 enzyme activity is undetectable in mice bearing point mutations in the deacetylase-activating domain of both NCOR1 and SMRT.
These results reveal that Bcl6 (show BCL6 ELISA Kits)-SMRT/NCoR (show NCOR1 ELISA Kits) complexes constrain immune responses and contribute to the prevention of atherosclerosis.
SMRT is an adipogenic gatekeeper as it directly fine-tunes transcription of pro- and antiadipogenic genes.
Ncor1 and Ncor2 play essential but distinct roles in zebrafish primitive myelopoiesis
A novel regulatory mechanism for Ncor2 through Fos-Vegfd-Notch signaling cascade during hematopoietic stem cell development in zebrafish embryos.
rar-ncor2 corepressor complex may be part of an embryonic, epigenetic switch that keeps retinoic acid responsive genes off before retinoic becomes available to the embryo
This gene encodes a nuclear receptor co-repressor that mediates transcriptional silencing of certain target genes. The encoded protein is a member of a family of thyroid hormone- and retinoic acid receptor-associated co-repressors. This protein acts as part of a multisubunit complex which includes histone deacetylases to modify chromatin structure that prevents basal transcriptional activity of target genes. Aberrant expression of this gene is associated with certain cancers. Alternate splicing results in multiple transcript variants encoding different isoforms.
CTG repeat protein 26
, T3 receptor-associating factor
, silencing mediator for retinoid and thyroid hormone receptors
, thyroid-, retinoic-acid-receptor-associated corepressor
, nuclear receptor corepressor 2
, nuclear receptor co-repressor 2
, silencing mediator of retinoic acid and thyroid hormone receptor
, silencing mediator of retinoid acid and thyroid hormone receptor
, silencing mediator
, thyroid hormone receptor