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A rare 2182C>T mutation in exon 14 of the NOTCH3 gene was identified in all available cases
Loss of Notch3 expression is associated with small cell lung carcinoma.
Immunohistochemistry showed a reverse correlation between MUC2 and Notch3 or Jagged1 (P = 0.033 and P = 0.005, respectively) and between MUC5AC and Jagged1 or Hes1
Transfection of antisense oligonucleotides into CADASIL patient-derived cerebral vascular smooth muscle cells resulted in exon skipping in NOTCH3 protein without abrogating signalling.
The therapeutic potential of PKCiota-ELF3-NOTCH3 signal inhibition to more effectively treat KRAS LADC.
IL6 (show IL6 ELISA Kits)/Notch3 signaling mediates hormone therapy resistance in metastatic breast cancer via self renewal of cancer stem cells.
Mutations in NOTCH3 were associated with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy.
This study developed a novel, unique human NOTCH3 transgenic mouse model and a NOTCH3 score which is a robust and sensitive biomarker for CADASIL.
Study reports a family with CADASIL in Rungus ethnicity and identifies a missense mutation (c.160C>T) in exon 2 of NOTCH3.
The NOTCH3 mutation spectrum in our group was diverse and consistent with those in Caucasians but differed from those in Korea and Taiwan.
In this study, authors use a smooth muscle-specific (show EIF3K ELISA Kits) deletion of Notch2 (show NOTCH2 ELISA Kits) together with a global Notch3 deletion to produce mice with combinations of mutant and wild-type Notch2 (show NOTCH2 ELISA Kits)/3 alleles in vascular smooth muscle cells
Elevated levels of TIMP3 (show TIMP3 ELISA Kits) and vitronectin (show VTN ELISA Kits), acting downstream of Notch3(ECD) deposition, play a role in CADASIL, producing divergent influences on early CBF (show CEBPZ ELISA Kits) deficits and later white matter lesions.
Mutant Notch3 accumulates in pericytes and causes progressive pericyte loss and BBB (show ALMS1 ELISA Kits) leakage in the cerebral cortex in CADASIL mouse model.
Relative to air-exposed controls, ozone increased bronchoalveolar lavage fluid protein, a marker of lung permeability, in all genotypes, but significantly greater concentrations were found in Notch4 (show NOTCH4 ELISA Kits)-/- compared with wild-type and Notch3-/- mice.
The mechanism of Oncostatin M (show OSM ELISA Kits) on cardiac ischemia/reperfusion injury is partly mediated by the Notch3/Akt (show AKT1 ELISA Kits) pathway.
miR (show MLXIP ELISA Kits)-7a regulates the differentiation of Muller glia through the suppression of Notch3 expression.
Study showed Notch3 expressed in proliferating hippocampal precursor cells and down-regulates their activation and proliferation; adult neurogenesis in CADASIL transgenic mice was altered prior to vascular abnormalities due to deficits in Notch3 signaling
NOTCH3, but not NOTCH2 (show NOTCH2 ELISA Kits) protects vascular smooth muscle cell from apoptosis.
Notch3 protein activation in glomeruli promotes the development of progressive renal disease.
A viral cyclin (show PCNA ELISA Kits)-CDK6 (show CDK6 ELISA Kits) complex was found to be a regulator of Notch3 in lymphoma cells.
The Notch3 receptor is required earlier within the developing somite to regulate hematopoietic stem cell (HSC (show FUT1 ELISA Kits)) emergence in a non-cell-autonomous manner.
90 % of proliferating radial glia express notch1a, notch1b and notch3. In contrast, the proliferating non-glial populations of the dorsal telencephalon and hypothalamus rarely express notch3 and about half express notch1a/1b.
Notch3 regulates oligodendrocyte precursor cells development and mbp (show MBP ELISA Kits) gene expression in larvae, and maintains vascular integrity in adults.
new role for Notch (show NOTCH1 ELISA Kits) signaling in brain vascular development whereby Notch3 signaling promotes expansion of the brain pericyte population
Notch3 activity gates neural stem cell activation in the adult pallium.
Cellular correlates of Notch (show NOTCH1 ELISA Kits)-delta gene expression in the regenerating zebrafish retina.
knockdown of notch3 function in notch1a mutants leads to the loss of rhombomere boundary cells and causes neuronal hyperplasia
This gene encodes the third discovered human homologue of the Drosophilia melanogaster type I membrane protein notch. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signalling pathway that plays a key role in neural development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remains to be determined. Mutations in NOTCH3 have been identified as the underlying cause of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL).
Notch homolog 3
, neurogenic locus notch homolog protein 3
, Notch gene homolog 3