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anti-Mouse (Murine) XDTX1 Antibodies:
anti-Human XDTX1 Antibodies:
anti-Rat (Rattus) XDTX1 Antibodies:
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exerts one level of control on regulatory T-cell stability by sustaining the expression of Foxp3 (show FOXP3 Antibodies) protein
DTX1, similar to Cbl-b and Itch, participates in T cell anergy-induced PKC-theta degradation. there is a coupling of DTX1 to Cbl-b in T cell anergy.
NB-3 (show CNTN6 Antibodies)/Notch1 (show NOTCH1 Antibodies) pathway promotes neural progenitor cell differentiation into
Deltex (show DTX1 Antibodies) selectively suppresses T-cell activation through degradation of a key signaling molecule, MEKK1 (show MAP2K1 Antibodies).
Deltex-1 ubiquitin ligase activity is dispensable for mouse development and immune function.
Deltex (show DTX1 Antibodies) can act as a negative regulator of Notch (show NOTCH1 Antibodies) signals in T cells but that endogenous levels of Deltex1 and Deltex2 (show DTX2 Antibodies) are not important for regulating Notch (show NOTCH1 Antibodies) signals during thymocyte development[Deltex1]
Data show that Deltex1 ablation enabled Id1 (show ID1 Antibodies)-expressing progenitors to differentiate to the DN3 (CD44 (show CD44 Antibodies)(-) CD25 (show IL2RA Antibodies)(+)) stage, which was accompanied by enhanced Notch1 (show NOTCH1 Antibodies) expression in T-cell progenitors.
deficiency of DTX1 (show DTX1 Antibodies) augmented T cell activation, conferred resistance to anergy induction, enhanced autoantibody generation, and increased inflammation
Two SNPs (rs2384077 and rs10744794) in an intron of DTX1 (show DTX1 Antibodies) and the linkage disequilibrium (LD) block are significantly associated with the immune response to HBV vaccination.
this study reports the identification of two new hGIP-interacting partners, DTX1 (show DTX1 Antibodies) and STAU1 (show STAU1 Antibodies).
characterization of two genes expressed in centroblasts of human tonsils: deltex (show DTX1 Antibodies) (Drosophila) homolog 1 (DTX1 (show DTX1 Antibodies)), which is related to the Notch (show NOTCH1 Antibodies) pathway and a new Kelch-like protein, KLHL6 (show KLHL7 Antibodies)
It is reported that BBAP (show DTX3L Antibodies) and the human family of DTX (show DTX1 Antibodies) proteins (DTX1 (show DTX1 Antibodies), DTX2 (show DTX2 Antibodies), and DTX3 (show DTX3 Antibodies)) function as E3 ligases based on their capacity for self-ubiquitination.
Studies in Drosophila have identified this gene as encoding a positive regulator of the Notch-signaling pathway. The human gene encodes a protein of unknown function\; however, it may play a role in basic helix-loop-helix transcription factor activity.
E3 ubiquitin-protein ligase DTX1
, fractionated x-irradiation induced transcript 1
, protein deltex-1