Browse our FOXL2 Proteins (FOXL2)

Full name:
Forkhead Box L2 Proteins (FOXL2)
On are 6 Forkhead Box L2 (FOXL2) Proteins from 4 different suppliers available. Additionally we are shipping FOXL2 Antibodies (98) and many more products for this protein. A total of 110 FOXL2 products are currently listed.
AU045128, BPES, BPES1, foxL2, PFRK, PINTO, POF3, zgc:136549
list all proteins Gene Name GeneID UniProt
FOXL2 26927 O88470
Rat FOXL2 FOXL2 367152  
FOXL2 668 P58012

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FOXL2 Proteins (FOXL2) by Origin

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More Proteins for FOXL2 Interaction Partners

Zebrafish Forkhead Box L2 (FOXL2) interaction partners

  1. Data show that cytochrome P450 enzymes Cyp17 (show CYP17A1 Proteins)-I, Cyp11c1 (show CYP11B2 Proteins), Cyp19a1a and Cyp19a1b and one of their regulators forkhead protein (show FOXO4 Proteins) Foxl2a were detected both in the testis and ovary.

  2. Data indicate taht monocrotophos (MCP) exposure modulated gene expression of forkhead transcription factor gene L2 (foxl2), doublesex/mab-3 related transcription factor 1 (dmrt1), gonadal aromatase (cyp19a1a) and brain aromatase (cyp19a1b).

  3. Effects of sexual steroids on the expression of foxl2 in Gobiocypris rarus

Xenopus laevis Forkhead Box L2 (FOXL2) interaction partners

  1. Xenopus W-linked DM-W induces foxl2 expression during ovary formation.

Mouse (Murine) Forkhead Box L2 (FOXL2) interaction partners

  1. evidence that FOXL2 modulates Col1a2 (show COL1A2 Proteins) transcription through interaction with a response element 65 Kb upstream of the transcription start site

  2. Data indicate that a balance between supporting cell (show PTPRJ Proteins) self-renewal and differentiation is maintained in the developing ovary by relative Wnt4 (show WNT4 Proteins) protein/beta-catenin (show CTNNB1 Proteins) and p27Kip1 (show CDKN1B Proteins) protein (p27 (show CDKN1B Proteins))/Forkhead box L2 (FOXL2) activities.

  3. Data indicate that the hypothalamic-pituitary-gonadal axis controls expression of Foxl2 in pituitary gonadotropes primarily through positive feedback from ovarian hormones.

  4. FOXL2 mobilizes estrogen signaling to establish a coherent feed-forward loop repressing Sox9.

  5. Foxl2 has a crucial role in postnatal uterine maturation and could help to understand sub-fertility predisposition in women.

  6. Results support FOXL2 as a master transcription factor in a spectrum of developmental processes, including growth, cartilage and bone formation. Its action overlaps that of SOX9 (show SOX9 Proteins), though they are antagonistic in female vs male gonadal sex determination but conjoint in cartilage and skeletal development.

  7. Microarray expression profiling of whole adrenal mRNA from ovariectomized vs. intact mice demonstrated selective upregulation of gonadal-like genes including Spinlw1 and Insl3 (show INSL3 Proteins) in GDX (show UBL4A Proteins)-induced adrenocortical tumors of the mouse.

  8. our results demonstrate the necessity of FOXL2 for proper FSH (show BRD2 Proteins) production in mice and implicate FOXL2 in integration of transcription factors at the level of the FSHbeta promoter.

  9. Results show that a piggyBac insertion ~160 kb upstream of the transcription start site of Foxl2 partially disrupted its expression resulting in BPES (Blepharophimosis, ptosis, epicanthus inversus syndrome)-like conditions.

  10. AMH (show AMH Proteins) is an endogenous target gene of FOXL2. AMH (show AMH Proteins) and FOXL2 collaboratively work to reserve ovarian follicles.

Human Forkhead Box L2 (FOXL2) interaction partners

  1. Despite exhibiting an immunophenotype characteristic of a sex cord-stromal tumor, mutations in FOXL2 and DICER1 (show DICER1 Proteins), the 2 most common mutations hitherto reported in ovarian sex cord-stromal tumors, are not a feature of Uterine tumor resembling ovarian sex cord tumor (UTROSCT).

  2. This report describes the preservation of heterozygous c.402C>G FOXL2 mutation in recurrent aGCTs. This finding adds further credence to the concept that the c.402C>G FOXL2 mutation is oncogenic and integral to this disease.

  3. The novel mutations of the FOXL2 are associated with blepharophimosis, ptosis and epicanthus inversus syndrome.

  4. this study identified a novel regulatory circuit for ovarian AMH (show AMH Proteins) production; specifically, through the coordinated interplay between FOXL2 and SF-1 (show NR5A1 Proteins) that could control ovarian follicle development.

  5. we report the identification of two novel and two recurrent heterozygous NOBOX (show NOBOX Proteins) variants in 7 out of 107 patients, with a prevalence of 6.5% (upper 95% confidence limit of 11.17%). Several variants conserve the ability to interact with FOXL2 in intracellular aggregates

  6. This is the first study reporting lacrimal gland(LG) volumes in BPES, describing a significant number of patients with LG agenesis. Molecular analysis of the FOXL2 gene revealed the presence of 8 distinct mutations.

  7. In the case of aGCT, a well characterized mutation in the FOXL2 transcription factor (FOXL2 C134W) is found in almost all cases, which arguably defines the disease, although the molecular events that determine the stage, behavior and prognosis of aGCT remain to be determined.

  8. We highlight the cooperation of WNT4 (show WNT4 Proteins), RSPO1 (show RSPO1 Proteins) and FOXL2 within a regulatory network and the need for further research to better understand their role in defining and maintaining ovarian identity.

  9. The de novo mutation rate in FOXL2 is exceptionally high compared with other dominant disorders manifesting with an ocular phenotype.

  10. SUMOylation of FOXL2 and PML (show PML Proteins) Bodies

Cow (Bovine) Forkhead Box L2 (FOXL2) interaction partners

FOXL2 Protein Profile

Protein Summary

This gene encodes a forkhead transcription factor. The protein contains a fork-head DNA-binding domain and may play a role in ovarian development and function. Mutations in this gene are a cause of blepharophimosis syndrome and premature ovarian failure 3.

Alternative names and synonyms associated with FOXL2

  • forkhead box L2 (FOXL2)
  • forkhead box L2 (foxl2)
  • forkhead box L2 (Foxl2)
  • FoxL protein (foxL)
  • forkhead transcription factor L2 (FoxL2)
  • foxl2 protein (foxl2)
  • fork-head box L2 transcription factor (foxL2)
  • AU045128 protein
  • BPES protein
  • BPES1 protein
  • foxL2 protein
  • PFRK protein
  • PINTO protein
  • POF3 protein
  • zgc:136549 protein

Protein level used designations for Forkhead Box L2 Proteins (FOXL2)

forkhead box L2 , forkhead box protein L2 , transcription factor FOXL2 , forkhead transcription factor L2 , foxl2 protein , fork-head box L2 transcription factor , P-Frk , pituitary forkhead factor , putative transcription factor foxl2 , forkhead transcription factor FOXL2 , Forkhead box protein L2

470940 Pan troglodytes
503512 Gallus gallus
692279 Danio rerio
100125429 Oryzias latipes
100188926 Xenopus laevis
100534517 Oreochromis niloticus
445798 Ciona intestinalis
751846 Strongylocentrotus purpuratus
100169941 Ciona intestinalis
100328989 Saccoglossus kowalevskii
26927 Mus musculus
367152 Rattus norvegicus
668 Homo sapiens
281770 Bos taurus
100687445 Canis lupus familiaris
100622956 Sus scrofa
100328926 Oryctolagus cuniculus
100750236 Capra hircus
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