Browse our High Mobility Group AT-Hook 1 Proteins (HMGA1)

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High Mobility Group AT-Hook 1 Proteins (HMGA1)
On www.antibodies-online.com are 20 High Mobility Group AT-Hook 1 (HMGA1) Proteins from 7 different suppliers available. Additionally we are shipping High Mobility Group AT-Hook 1 Antibodies (133) and High Mobility Group AT-Hook 1 Kits (14) and many more products for this protein. A total of 179 High Mobility Group AT-Hook 1 products are currently listed.
Synonyms:
AL023995, ENSMUSG00000041059, HMG-I(Y), HMG-R, HMG-Y, HMGA1, Hmga1a, Hmga1b, Hmgi, Hmgi-rs1, Hmgiy, Hmgy, wu:fb12b06, wu:fb18f11, wu:fc19f01, wu:fi38b05, zgc:85677
list all proteins Gene Name GeneID UniProt
HMGA1 111241 P17095
HMGA1 3159 P17096
HMGA1 117062 Q8K585

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High Mobility Group AT-Hook 1 Proteins (HMGA1) by Origin

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Top referenced High Mobility Group AT-Hook 1 Proteins

  1. Human HMGA1 Protein expressed in Escherichia coli (E. coli) - ABIN667938 : Massaad-Massade, Navarro, Krummrei, Reeves, Beaune, Barouki: HMGA1 enhances the transcriptional activity and binding of the estrogen receptor to its responsive element. in Biochemistry 2002 (PubMed)
    Show all 2 references for 667938

  2. Human HMGA1 Protein expressed in Wheat germ - ABIN1306792 : Lau, Chan, Pang, Ma, Li, Yeung, Cheng, Feng, Chung, Li, Zhou, Wang, Mao, Ng: Overexpression of HMGA1 deregulates tumor growth via cdc25A and alters migration/invasion through a cdc25A-independent pathway in medulloblastoma. in Acta neuropathologica 2012 (PubMed)

More Proteins for High Mobility Group AT-Hook 1 Interaction Partners

Mouse (Murine) High Mobility Group AT-Hook 1 (HMGA1) interaction partners

  1. Studies define a novel HMGA1-MMP-2 (show MMP2 Proteins) pathway involved in a subset of human carcinosarcomas and tumor progression in murine models.

  2. Mouse embryonic fibroblasts null for the Hmga1 gene show downregulation of Bub1 (show BUB1 Proteins), Bub1b (show BUB1B Proteins), Mad2l1 (show MAD2L1 Proteins) and Ttk SAC (show ADCY10 Proteins) genes, and present several features of chromosomal instability, such as nuclear abnormalities, binucleation, micronuclei and karyotypic alterations.

  3. Taken together, our data demonstrate that miR (show MLXIP Proteins)-625 suppresses cell proliferation and migration by targeting HMGA1 and suggest miR (show MLXIP Proteins)-625 as a promising prognostic biomarker and a potential therapeutic target for breast cancer.

  4. Inactivation of the Cdkn2a locus cooperates with HMGA1 to drive T-cell leukemogenesis.

  5. Increased HMGA1 expression is associated with pituitary and thyroid tumors.

  6. activated HMGA1 regulates cell proliferation through the Notch1 (show NOTCH1 Proteins) signaling pathway, which represents an important molecular pathway leading to leukemogenesis.

  7. Data propose that, by affecting the expression of both IGFBP protein species, HMGA1 can serve as a modulator of IGF-I (show IGF1 Proteins) activity, thus representing an important novel mediator of glucose disposal.

  8. HMGA1 contributes to the neurogenic potential of neural precursor cells in the early stages of neocortical development.

  9. Elevated expression of HMGA1 is associated with the transition of prostate cancer (PCa (show ENPP1 Proteins)) cells from androgen-sensitive to androgen-independent growth and plays a role in the cell growth of androgen-independent PCa (show ENPP1 Proteins) cells.

  10. The data in the present study reveal a role of Hmga1 in transcriptional silencing in T cell lineages and leukemic cells.

Human High Mobility Group AT-Hook 1 (HMGA1) interaction partners

  1. SNP rs5498 in ICAM-1 (show ICAM1 Proteins) gene and IVS5-13insC variant in HMGA1 gene were not associated with the susceptibility of DR in the Chinese T2DM cohort.

  2. We show that the chromatin remodeling protein HMGA1 functions as a downstream effector of these biological responses to miR (show MLXIP Proteins)-296-5p and regulates Sox2 (show SOX2 Proteins) expression, a master driver of cell stemness, by modifying chromatin architecture at the Sox2 (show SOX2 Proteins) promoter

  3. tissue microarray revealed that HMGA1 was expressed in thyroid carcinoma more than that in normal thyroid tissues ; expression of HMGA1 and MMP-2 (show MMP2 Proteins) was identified to be positively correlated . The present study established the first link between HMGA1 and TGF-b1 in the regulation of thyroid cancer proliferation and invasion

  4. our research indicated an H19 (show NCKAP1 Proteins)-miR138-HMGA1 pathway in regulating the migration and invasion of colon cancer, providing new insight for treatment of colon cancer.

  5. The results reported here indicate a critical role of HMGA1 in the development of glioblastoma multiforme; its suppression impairs proliferation and self-renewal of brain tumor stem cells

  6. miR (show MLXIP Proteins)-214 expression was poor while that of HMGA1 was high in cervical and colorectal cancer tissues. miR (show MLXIP Proteins)-214-re-expression or HMGA1 downregulation inhibited proliferation, migration and invasion of cancer cells while miR (show MLXIP Proteins)-214 inhibition had opposite effects. miR (show MLXIP Proteins)-214 was demonstrated to bind to the wild-type 3' untranslated region of HMGA1 but not with its mutant.

  7. HMGA1 is frequently expressed in cirrhotic tissues and HCCs (show HCCS Proteins) and its expression is associated with high Edmondson grade and worse prognosis in HCC (show FAM126A Proteins).

  8. Studies define a novel HMGA1-MMP-2 (show MMP2 Proteins) pathway involved in a subset of human carcinosarcomas and tumor progression in murine models.

  9. HMGA1 may function as an oncogene (show RAB1A Proteins) and modulate endometrial cancer cell migration and invasion by activating Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) pathway.

  10. Increased HMGA1 in pulmonary arterial endothelial cells resulting from dysfunctional BMPr2 (show BMPR2 Proteins) signaling can transition endothelium to smooth muscle-like cells associated with pulmonary arterial hypertension.

Pig (Porcine) High Mobility Group AT-Hook 1 (HMGA1) interaction partners

  1. distinct loci exist for growth and fatness in the two populations and identified HMGA1 and PLAG1 (show PLAG1 Proteins) as strong candidate genes on SSC7 and SSC4, respectively.

  2. Characterization of polymorphisms in the HMGA1 gene in relation to growth and fat deposition.

Cow (Bovine) High Mobility Group AT-Hook 1 (HMGA1) interaction partners

  1. HMGA1 likely regulates certain aspects of the BoHV-1 latency-reactivation cycle.

High Mobility Group AT-Hook 1 (HMGA1) Protein Profile

Protein Summary

This gene encodes a non-histone protein involved in many cellular processes, including regulation of inducible gene transcription, integration of retroviruses into chromosomes, and the metastatic progression of cancer cells. The encoded protein preferentially binds to the minor groove of A+T-rich regions in double-stranded DNA. It has little secondary structure in solution but assumes distinct conformations when bound to substrates such as DNA or other proteins. The encoded protein is frequently acetylated and is found in the nucleus. At least seven transcript variants encoding two different isoforms have been found for this gene.

Alternative names and synonyms associated with High Mobility Group AT-Hook 1 (HMGA1)

  • high mobility group AT-hook I, related sequence 1 (Hmga1-rs1)
  • high mobility group protein HMG-I/HMG-Y (TSC_c24220)
  • high mobility group AT-hook 1a (hmga1a)
  • high mobility group AT-hook 1 (HMGA1)
  • high mobility group AT-hook 1 (Hmga1)
  • high mobility group AT-hook 1 (Hmg-i)
  • AL023995 protein
  • ENSMUSG00000041059 protein
  • HMG-I(Y) protein
  • HMG-R protein
  • HMG-Y protein
  • HMGA1 protein
  • Hmga1a protein
  • Hmga1b protein
  • Hmgi protein
  • Hmgi-rs1 protein
  • Hmgiy protein
  • Hmgy protein
  • wu:fb12b06 protein
  • wu:fb18f11 protein
  • wu:fc19f01 protein
  • wu:fi38b05 protein
  • zgc:85677 protein

Protein level used designations for HMGA1

high mobility group protein HMG-I/HMG-Y , HMG-I(Y) , high mobility group protein A1 , high mobility group AT-hook protein 1 , high mobility group AT-hook 1 , high-mobility group (nonhistone chromosomal) protein isoforms I and Y , high mobility group protein R , nonhistone chromosomal high-mobility group protein HMG-I/HMG-Y , high mobility group HMGA1A , high mobility group HMGA1B , non-histone protein , high-mobility group AT-hook 1 , high mobility group protein I , High mobility group AT-hook protein 1 , High mobility group protein A1 , high mobility group-I protein

GENE ID SPECIES
111241 Mus musculus
10178543 Thermus scotoductus SA-01
406447 Danio rerio
705105 Macaca mulatta
746594 Pan troglodytes
3159 Homo sapiens
442946 Canis lupus familiaris
100157848 Sus scrofa
618849 Bos taurus
15361 Mus musculus
117062 Rattus norvegicus
378795 Gallus gallus
100689040 Cricetulus griseus
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