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Histone demethylases KDM3A (show KDM3A Proteins), KDM4A (show KDM4A Proteins), and KDM4C were expressed before and after embryonic genome activation, whereas KDM5B (show KDM5B Proteins) was mainly expressed during the blastocyst period.
KDM4C recognition of H3K4me3 stimulates demethylation of H3K9me3 in cis (show CISH Proteins) on peptide and mononucleosome substrates.
Pharmacological inhibition of KDM4C/PRMT1 (show PRMT1 Proteins) suppresses transcription and transformation ability of MLL (show MLL Proteins) fusions
JMJD2B and JMJD2C play an important role in the pathology of osteosarcoma via the up-regulation of FGF2 (show FGF2 Proteins).
Data suggest that D396N polymorphism of JmjC domain-containing histone demethylase (show MBD2 Proteins) JMJD2C affects the prognosis of breast cancer by altering caspase-3 (show CASP3 Proteins) cleavage and the ability of double strand DNA break repair which may contribute to therapy resistance.
GASC1 expression is higher in adenocarcinoma than squamous cell carcinoma. Smoking decreases GASC1 expression in tumor cells, indicating that tobacco smoke may influence the methylation of histone 3 lysine residues in lung cancer.
KDM4C promotes transcriptional activation by removing the repressive histone mark, H3K9me3, from its target genes. Variation in its expression leads to differences in the growth of normal and some cancer cells.
KDM4C maintains the sphere-forming capacity in CRCs by mediating the beta-catenin (show CTNNB1 Proteins)-dependent transcription of JAG1 (show JAG1 Proteins) in a feed-forward manner.
analysis of the nickel-induced inhibition of truncated constructs of JMJD2A (show KDM4A Proteins) and JMJD2C histone demethylases using X-ray absorption spectroscopy
Patients with GASC1 positive tumors have better breast cancer specific survival and respond better to radiotherapy and hormonal treatment
JMJD2C decreases trimethylation of histone H3 (show HIST3H3 Proteins) at lysine 9, and enhances HIF-1 (show HIF1A Proteins) binding to hypoxia response elements, thereby activating transcription of proteins that are required for metabolic reprogramming and for lung metastasis.
Jmjd2c and G9a (show EHMT2 Proteins) are novel enhancer-associated factors; Jmjd2c is a molecular scaffold for the assembly of essential enhancer-protein complexes with an impact on timely gene activation
The authors show that Jmjd2a (show KDM4A Proteins) and Jmjd2c both localize to H3K4me3-positive promoters, where they have widespread and redundant roles in preventing accumulation of H3K9me3 and H3K36me3.
Number of GFAP (show GFAP Proteins)-positive astrocytes in the brain of Gasc1 hypomorphic mutant mice is increased at 2-3 months of age.
GASC1 has an oncogenic role in mouse skin carcinogenesis.
These findings together demonstrate the essential role of KDM4A (show KDM4A Proteins) and KDM4C in orchestrating mESC differentiation to endothelial cells through the activation of Flk1 (show KDR Proteins) and VE-cadherin (show CDH5 Proteins) promoters, respectively
Jmjd2C increases MyoD (show MYOD1 Proteins) transcriptional activity to facilitate skeletal muscle differentiation by increasing MyoD (show MYOD1 Proteins) stability through inhibiting G9a (show EHMT2 Proteins)-dependent MyoD (show MYOD1 Proteins) degradation.
Jmjd2b unique, Jmjd2c unique, and Jmjd2b-Jmjd2c common target sites belong to functionally separable Core, Polycomb (show CBX2 Proteins) repressive complex (PRC), and Myc (show MYC Proteins) regulatory modules, respectively.
Inositol pyrophosphates regulate JMJD2C-dependent histone demethylation.
stage-specifically expressed during preimplantation development (show MTA2 Proteins), with the highest activity being observed from the two-cell to the eight-cell stage
This gene is a member of the Jumonji domain 2 (JMJD2) family and encodes a protein with one JmjC domain, one JmjN domain, two PHD-type zinc fingers, and two Tudor domains. This nuclear protein functions as a trimethylation-specific demethylase, converting specific trimethylated histone residues to the dimethylated form. Chromosomal aberrations and increased transcriptional expression of this gene are associated with esophageal squamous cell carcinoma. Alternative splicing results in multiple transcript variants.
jumonji domain containing 2C
, lysine (K)-specific demethylase 4C
, jumonji domain containing 2c
, lysine-specific demethylase 4C
, lysine-specific demethylase 4C-like
, GASC-1 protein
, JmjC domain-containing histone demethylation protein 3C
, gene amplified in squamous cell carcinoma 1 protein
, jumonji domain-containing protein 2C
, tudor domain containing 14C
, gene amplified in squamous cell carcinoma 1
, jmjC domain-containing histone demethylation protein 3C