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anti-Human TRIP12 Antibodies:
anti-Mouse (Murine) TRIP12 Antibodies:
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Human Polyclonal TRIP12 Primary Antibody for IP, WB - ABIN409120
Keppler, Archer: Ubiquitin-dependent and ubiquitin-independent control of subunit stoichiometry in the SWI/SNF complex. in The Journal of biological chemistry 2010
p16 (show CDKN2A Antibodies) overexpression led to downregulation of TRIP12, which in turn led to increased RNF168 (show RNF168 Antibodies) levels, repressed DNA damage repair (DDR (show DDR1 Antibodies)), increased 53BP1 (show TP53BP1 Antibodies) foci and enhanced radioresponsiveness.
We describe the TRIP12-associated phenotype, showing that TRIP12 is a risk gene for non-syndromic intellectual disability with and without autism spectrum disorder, and that TRIP12 mutation carriers present with a broad phenotypic range within the neurodevelopmental phenotypes.
nine presented pathogenic variants further document that TRIP12 haploinsufficiency causes a childhood-onset neurodevelopmental disorder
modulatory role for Trip12 in the USP7 (show USP7 Antibodies)-dependent DNA damage response
Data indicate that E3 ubiquitin ligase (show MUL1 Antibodies) thyroid hormone receptor (show THRA Antibodies)-interacting protein (show RIPK1 Antibodies) 12 (TRIP12) promotes proteasomal degradation of pancreas transcription factor 1a (PTF1a (show PTF1A Antibodies))and regulates PTF1a (show PTF1A Antibodies) activities.
An exon3-skipping event in TRIP12 was detected in acute myeloid leukemia (show BCL11A Antibodies) patients at remission
HUWE1 and TRIP12 collaborate in degradation of ubiquitin-fusion proteins and misframed ubiquitin.
Study shows that TRIP12 and UBR5 (show UBR5 Antibodies), two HECT domain ubiquitin E3 ligases, control accumulation of RNF168 (show RNF168 Antibodies), a rate-limiting component of a pathway that ubiquitylates histones after DNA breakage.
data indicate that TRADD (show TRADD Antibodies) shuttles dynamically from the cytoplasm into the nucleus to modulate the interaction between p19(Arf (show CDKN2A Antibodies)) and its E3 ubiquitin ligase (show MUL1 Antibodies) ULF, thereby promoting p19(Arf (show CDKN2A Antibodies)) protein stability and tumour suppression
we found somatic mutations of HERC2 (show HERC2 Antibodies), HERC3 (show HERC3 Antibodies), TRIP12, UBE2Q1 (show UBE2Q1 Antibodies) and UBE4B (show UBE4B Antibodies) genes in gastric carcinoma and colorectal carcinomas with microsatellite instability
Trip12 is involved in global gene expression and plays an important role in mouse development.
Component of PA700, an ATP-dependent multisubunit protein that activates the proteolytic activities of the multifunctional proteinase (20S proteasome) of the 26S complex. Specifically interacts with the ligand binding domain of the thyroid hormone receptor (in a thyroid hormone T3-independent manner) and with retinoid X receptor (RXR). Could be E3 ubiquitin- protein ligase which accepts ubiquitin from an E2 ubiquitin- conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.
E3 ubiquitin-protein ligase TRIP12
, E3 ubiquitin-protein ligase for Arf
, TR-interacting protein 12
, probable E3 ubiquitin-protein ligase TRIP12
, thyroid receptor interacting protein 12
, thyroid receptor-interacting protein 12
, thyroid hormone receptor interactor 12
, probable E3 ubiquitin-protein ligase TRIP12-like
, gene trap locus 6
, thyroid receptor interactor TRIP12