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Sam68 (show KHDRBS1 Proteins) has separable effects on the regulation of AR-V7 expression and transcriptional activity, through its RNA-binding capacity.
These findings identified a biochemical and functional link between miR (show MLXIP Proteins)-190a with reduced expression in advanced prostate cancer, YB-1 (show YBX1 Proteins) and AR signaling in prostate cancer.
Androgen receptor may stimulate or inhibit breast cancer growth depending on estrogen receptor (show ESR1 Proteins) status.
LMO1 (show LMO1 Proteins) appears to be a coactivator of AR involved in the progression of prostate cancer
Increased frequency of CAG repetitions of Androgen receptor gene was directly proportional to the level of psychological development, social adaptation and professional activity but inversely proportional to the masculine sexual traits.
PP-1 (show PPA1 Proteins) and Akt (show AKT1 Proteins) have roles in AR-v7 protein expression and activities when AR is functionally blocked
AR activity was inversely associated with cell proliferation, whereas the expression of Fa complex genes was correlated with elevated cell cycle progression, expression of the E2F transcription factor 1 (E2F1 (show E2F1 Proteins)) and loss of RB1 (show RB1 Proteins).
CCL5 (show CCL5 Proteins) signals from infiltrating bone marrow mesenchymal stem cells to HIF2alpha (show EPAS1 Proteins) signals within prostate cancer (PCa (show FLVCR1 Proteins)) cells might play a key role to increase PCa (show FLVCR1 Proteins) stem cell population and PCa (show FLVCR1 Proteins) metastasis via altering the androgen receptor signals
Androgen receptor splice variant, AR-V7 expression is associated with drug resistance in prostate cancer.
Studies indicate relief from SUMO-mediated inhibition through mutation of the acceptor lysines to arginines abrogated polyQ androgen receptor SUMOylation.
findings will enable us to begin understanding the important roles of AR and Cx43 (show GJA1 Proteins) actions in the regulation of follicular development
Data show that the timing of androgen receptor (AR) disruption determines the class of congenital penile anomaly.
synthetic antisense oligonucleotides inhibit RNA levels of mutant AR in the central nervous system and offer therapeutic effects in a spinal and bulbar muscular atrophy mouse model that harbors a mutant AR gene
Neural androgen nreceptor is critical for the processing of temporal information for visual objects, possibly through the modulation of glutamatergic transmission in the hippocampal CA1 (show CA1 Proteins) area.
AR signaling regulates Mafb expression through the Mafb 3'UTR.
The effects of androgens on the cortical compartment result from AR signaling in osteoprogenitors or cells of the osteoclast lineage; or via estrogen receptor alpha (ERalpha (show ESR1 Proteins)) signaling in either or both of these two cell types.
Abnormal androgen receptor pathway activity may contribute to the pathogenesis of Fabry disease.
Sex differences in ERalpha (show ESR1 Proteins)-IR and AR-IR were observed in all hypothalamic regions of hypothalamus analyzed.
These results indicate that postnatal exposure to a low dose of decaBDE on PNDs 1 through 5 lowers the testosterone level and the levels of Ar and Thra (show THRA Proteins) transcripts in Sertoli cells, accompanied by an imbalance in the ratios of Thra (show THRA Proteins) splicing variants
A catalysis-independent role for AKR1C3 (show AKR1C3 Proteins) on AR activity via Siah2 (show SIAH2 Proteins) has been identified.
substantial up-regulation of androgen receptor expression during trophoblast giant cell differentiation suggests that androgens may be related to this process and are active products of bovine placental steroidogenesis
no association between the AR CAG polymorphism and the relative risk of prostate cancer in white Brazilian individuals with a CAG repeat (show CELF3 Proteins)
FSHR (show FSHR Proteins) is specifically regulated through androgen receptor in granulosa cells
Roles of IGF-I (show IGF1 Proteins) and the estrogen, androgen and IGF-I (show IGF1 Proteins) receptors in estradiol-17beta- and trenbolone acetate-stimulated proliferation of cultured bovine satellite cells.
In GD20 and PD2 (show PAF1 Proteins) males we found the reduction of the luminal compartment, inflammatory changes, decreased androgen receptor and increased Cx43 (show GJA1 Proteins) expression
Data suggest that signal transduction involving androgen receptor is involved in apoptosis of granulosa cells (as seen in follicular atresia).
Pig ejaculated spermatozoa express androgen receptor.
Sertoli cell maturation during puberty in the stallion was accompanied by a reduced expression of anti-Mullerian hormone (show AMH Proteins) and its receptor, arrest of cell proliferation, increased expression of androgen receptor
Androgen receptor (AR) and Wilms' tumor gene 1 expression dramatically decreased after heat treatment in Sertoli cells
The androgen receptor gene is more than 90 kb long and codes for a protein that has 3 major functional domains: the N-terminal domain, DNA-binding domain, and androgen-binding domain. The protein functions as a steroid-hormone activated transcription factor. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. This gene contains 2 polymorphic trinucleotide repeat segments that encode polyglutamine and polyglycine tracts in the N-terminal transactivation domain of its protein. Expansion of the polyglutamine tract causes spinal bulbar muscular atrophy (Kennedy disease). Mutations in this gene are also associated with complete androgen insensitivity (CAIS). Two alternatively spliced variants encoding distinct isoforms have been described.
, Ar beta
, androgen nuclear receptor variant 2
, dihydrotestosterone receptor
, nuclear receptor subfamily 3 group C member 4
, androgen receptor (dihydrotestosterone receptor; testicular feminization; spinal and bulbar muscular atrophy; Kennedy disease)
, testicular feminization
, androgen receptor (Testicular feminization), same as Tfm
, androgen receptor AR
, prostate androgen receptor