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Our result demonstrated that a shorter GGN (show GGN Proteins) repeat polymorphism cannot increase the risk of prostate cancer compared to the longer GGN (show GGN Proteins) repeats. That's different with previous meta-analysis.
miR (show MLXIP Proteins)-221/-222 are AR-repressed genes and their expression and oncogenic function are associated with AR status in PCa (show FLVCR1 Proteins) cells. The findings provide an explanation of why miR (show MLXIP Proteins)-221/-222 act as oncogenes in the development of CRPC, but their overexpression is not observed in CRPC tumors.
Glyoxalase 2 expression in prostate cancer was dependent on androgen receptor and was aimed at stimulating cell proliferation and eluding apoptosis through a mechanism involving the p53 (show TP53 Proteins)-p21 (show CDKN1A Proteins) axis
AR levels increased in TNBC cells grown in forced suspension culture compared with those in attached conditions, and cells that expressed AR resisted detachment-induced apoptosis. Culturing TNBC cells in suspension increased the CSC-like population, an effect reversed by AR inhibition.
Findings provide evidence that SULT2B1b (show SULT2B1 Proteins) is a novel regulator of AR activity and cell growth in prostate cancer
Results suggest that amino enhancer of split (show AES Proteins) protein (AES (show AES Proteins)) plays an important role in controlling tumor growth and metastasis of prostate cancer (PCa (show FLVCR1 Proteins)) by regulating both androgen receptor (AR) and Notch (show NOTCH1 Proteins) signaling pathway.
ChIP-Seq of the androgen response element (ARE), a palindromic, dihexameric motif present in promoters or enhancers of genes targeted by the androgen receptor (AR). Refinement of AR-binding and AREs at a genome-scale in androgen-insensitive and androgen-responsive prostate cancer cell lines by ChIP-Seq.
study shows that androgen receptor and miR (show MLXIP Proteins)-2909 drives the down-regulation of TGFBR2 (show TGFBR2 Proteins) by acting through positive feedback loop and thereby attenuating the inhibitory effects of TGFbeta (show TGFB1 Proteins) signaling
The negative feedback modulation between LncRNA-SARCC/AR complex and HIF-2alpha (show EPAS1 Proteins) signaling may then lead to differentially modulated RCC (show XRCC1 Proteins) progression in a VHL (show VHL Proteins)-dependent manner. Together, these results may provide us a new therapeutic approach via targeting this newly identified signal from LncRNA-SARCC to AR-mediated HIF-2alpha (show EPAS1 Proteins)/C-MYC (show MYC Proteins) signals against RCC (show XRCC1 Proteins) progression
Prostate 5aR1 levels were positively correlated with adjusted prostate most severe lesion scores. Downregulation of androgen receptor and 5alpha-reductase 2, along with upregulation of 5a-reductase 1 in tumors may promote prostatic intraepithelial neoplasia and prostate cancer development in TRAMP (show DPT Proteins) mice
Bisphenol A inhibits Sertoli cell proliferation by interfering with androgen receptor signaling pathway.
Findings indicate that targeting androgen receptor (AR) with ASC (show STS Proteins)-J9 in experimental autoimmune myocarditis (EAM) resulted in an attenuation in the severity of disease and cardiac injury.
The findings suggest that Cyp3a deficiency stimulated the expression of Scap via activation of the AR, which elevated cholesterogenic gene expression levels through activation of SREBP2 (show SREBF2 Proteins) and increased total cholesterol contents in the prostate.
Gli1 and Gli2 exhibited different functions in the regulation of p63 expression or proliferation of p63(+) cells in Kras-AR driven tumors.
Therefore, BA321 is a novel selective androgen receptor modulator (SARM (show SARM1 Proteins)) that may offer a new therapy option for osteoporosis in the male.
We show that Foxp1 (show FOXP1 Proteins) and the androgen receptor are co-expressed in striatal medium spiny neurons and that brain-specific (show CALY Proteins) androgen receptor KO (ArNesCre) mice exhibit reduced Foxp1 (show FOXP1 Proteins) expression in the striatum at E17.5 and P7.5 and an increased Foxp2 (show FOXP2 Proteins) level in the cortex at P7.5. Thus, androgens may contribute to sex-specific differences in Foxp1 (show FOXP1 Proteins) and Foxp2 (show FOXP2 Proteins) expression and ultrasonic vocalizations
Pharmacologic and genetic androgen receptor blockade causes attenuation of abdominal aortic aneurysm formation.
The results of the present study indicate that Aard is a target of AR action in mouse Sertoli cells and suggest a novel finding by which the loss of AR function in Sertoli cells blocks spermatogenesis and results in male infertility.
Seminal vesicles were evaluated by morphological and immunohistochemical parameters; androgenic receptor (AR), Insulin-like growth factor 1 (show IGF1 Proteins) (IGFR-1) and metalloproteinase 9 (MMP-9 (show MMP9 Proteins)). Intense AR reactivity was seen in both stroma and epithelial regions in the TRAMP (show DPT Proteins) 22 group. Intense IGFR-1 and MMP-9 (show MMP9 Proteins) stromal immunolabeling was identified in both TRAMP (show DPT Proteins) groups
substantial up-regulation of androgen receptor expression during trophoblast giant cell differentiation suggests that androgens may be related to this process and are active products of bovine placental steroidogenesis
no association between the AR CAG polymorphism and the relative risk of prostate cancer in white Brazilian individuals with a CAG repeat (show CELF3 Proteins)
FSHR (show FSHR Proteins) is specifically regulated through androgen receptor in granulosa cells
Roles of IGF-I (show IGF1 Proteins) and the estrogen, androgen and IGF-I (show IGF1 Proteins) receptors in estradiol-17beta- and trenbolone acetate-stimulated proliferation of cultured bovine satellite cells.
In GD20 and PD2 (show PAF1 Proteins) males we found the reduction of the luminal compartment, inflammatory changes, decreased androgen receptor and increased Cx43 (show GJA1 Proteins) expression
Data suggest that signal transduction involving androgen receptor is involved in apoptosis of granulosa cells (as seen in follicular atresia).
Pig ejaculated spermatozoa express androgen receptor.
Sertoli cell maturation during puberty in the stallion was accompanied by a reduced expression of anti-Mullerian hormone (show AMH Proteins) and its receptor, arrest of cell proliferation, increased expression of androgen receptor
The vesicular gland of castrated goats showed significantly lower AR and COX-2 immuno-expression than intact goats indicating that both AR and COX-2 are androgen dependent.
Androgen receptor (AR) and Wilms' tumor gene 1 expression dramatically decreased after heat treatment in Sertoli cells
The androgen receptor gene is more than 90 kb long and codes for a protein that has 3 major functional domains: the N-terminal domain, DNA-binding domain, and androgen-binding domain. The protein functions as a steroid-hormone activated transcription factor. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. This gene contains 2 polymorphic trinucleotide repeat segments that encode polyglutamine and polyglycine tracts in the N-terminal transactivation domain of its protein. Expansion of the polyglutamine tract causes spinal bulbar muscular atrophy (Kennedy disease). Mutations in this gene are also associated with complete androgen insensitivity (CAIS). Two alternatively spliced variants encoding distinct isoforms have been described.
, Ar beta
, androgen nuclear receptor variant 2
, dihydrotestosterone receptor
, nuclear receptor subfamily 3 group C member 4
, androgen receptor (dihydrotestosterone receptor; testicular feminization; spinal and bulbar muscular atrophy; Kennedy disease)
, testicular feminization
, androgen receptor (Testicular feminization), same as Tfm
, androgen receptor AR
, prostate androgen receptor