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ERRalpha is abundantly expressed in H(+)-pump-rich cells, a group of ionocytes responsible for H(+) secretion in the skin of developing embryos, and its expression is stimulated by acidic environments. Knockdown of ERRalpha impairs both basal and low pH-induced H(+) secretion in the yolk-sac (show ADCY10 Proteins) skin, which is accompanied by decreased expression of H(+)-secreting-related transporters.
Results propose Estrogen Receptor (show ESR1 Proteins)-Relatedalpha as a new regulator of morphogenetic movement during gastrulation, independently of cell fate determination.
The results identify TGFB1 (show TGFB1 Proteins) and ESRRA as likely transcriptional regulators of rumen epithelial development and energy metabolism, respectively, and provide targets for modulation of rumen development and function in the growing calf.
ERalpha (show ESR1 Proteins), is only expressed in the caruncle of the placenta.
ERalpha (show ESR1 Proteins) mRNA-expressing neurons (ERalpha (show ESR1 Proteins) neurons) were distributed in some structures of the telencephalon, diencephalon, mesencephalon, and hindbrain.
Findings suggest that PGF (show PGF Proteins)(2alpha) regulates luteolysis by ESR1 (show ESR1 Proteins) mRNA down-regulation.
findings highlight a MYC (show MYC Proteins)/ERRalpha pathway that contributes to physiological and pathological bone loss by integrating the MYC (show MYC Proteins)/ERRalpha axis to drive metabolic reprogramming during osteoclast differentiation
Study performed a structural and functional assessment of glutamatergic synapses on medium spiny neurons in the nucleus accumbens of Esrra-null mice, and discovered sex-specific alterations in miniature excitatory postsynaptic currents frequency and amplitude, reduced paired-pulse ratio, and reduction in glutamatergic synaptic vesicles consistent with altered functional connectivity
The nuclear receptor, estrogen-related receptor alpha (ERRalpha), was shown to regulate the expression of genes required for lactate utilization.
In bone, the effects of cholesterol, statin, and bisphosphonate on osteoclastogenesis require ERRalpha; and consequently, cholesterol-induced bone loss or bisphosphonate osteoprotection is lost in ERRalpha knockout mice.
We conclude that E2-induced ERRalpha expression in endothelium plays an important role for the E2-induced vasculoprotective effect
Exercise-induced changes in tumour LDH-B (show LDHB Proteins) and MCT1 (show MCTS1 Proteins) expression are modulated by oestrogen-related receptor alpha in breast cancer-bearing BALB/c mice
These results indicate that Esrra deficiency in the mouse brain impairs behavioral responses in multiple functional domains.
Suppressed feeding behavior in novelty stress-exposed aged male mice may be mediated by 5-HT(2C)R hypersensitivity, leading to hypoghrelinemia. The hypersensitivity may partly be due to estrogen receptor (show ESR1 Proteins) activation in aged male mice.
ERRa is a negative regulator of TLR-induced inflammatory responses through inducing Tnfaip3 (show TNFAIP3 Proteins) transcription and controlling the metabolic reprogramming.
study shows that ERRalpha plays a key role in directing transcriptional programs required for optimal mitochondrial oxidative potential and muscle fitness
blocking the ERRalpha-controlled mitochondrial program largely inhibits the PLA2R1 (show PLA2R1 Proteins)-induced tumor-suppressive response. Together, our data document ERRalpha and its mitochondrial program as downstream effectors of the PLA2R1 (show PLA2R1 Proteins)-JAK2 (show JAK2 Proteins) pathway leading to oncosuppression.
results suggest that the decreased expression of miR (show MLXIP Proteins)-135a in metastatic tumors leads to elevated ERRalpha expression, resulting in increased cell invasion capacities.
HO-1 (show HMOX1 Proteins)-derived CO enhances mitochondrial biogenesis in astrocytes by activating L-type Ca(2 (show CA2 Proteins)+) channel-mediated PGC-1alpha/ERRalpha axis, leading to maintenance of astrocyte function and neuroprotection/recovery against damage of brain function
in ERalpha (show ESR1 Proteins) negative breast cancer, the low level of ERalpha (show ESR1 Proteins) reduced miR (show MLXIP Proteins)-497 expression, which promoted ERRalpha expression that enhanced cell proliferation, migration, and invasion by increasing MIF (show AMH Proteins) expression and MMP9 (show MMP9 Proteins) activity.
these data show that ERRalpha expression predicts response to tamoxifen treatment, and ERRalpha could be a biomarker of tamoxifen sensitivity and a prognostic factor in TNBC.
ERRalpha suppression inhibits angiogenesis in HUVECs
Incomplete autophagy and cell death by a necrotic processes, as a consequence of the cell energy failure, induced by pharmacological reduction of ERRalpha in adrenocortical carcinoma cells.
CD68 (show CD68 Proteins)(+)CD163 (show CD163 Proteins)(+) macrophages secreted cytokines, such as IL17A (show IL17A Proteins), that upregulated ERalpha (show ESR1 Proteins) expression.
Inhibition of ERRalpha suppresses epithelial mesenchymal transition of triple negative breast cancer cells by directly targeting fibronectin (show FN1 Proteins).
An ERRalpha 23-repeats polymorphisms with BMD (show BEST1 Proteins) in postmenopausal Egyptian women.
Results show that miR (show MYLIP Proteins)-125a inhibits porcine preadipocytes differentiation through targeting ERRa.
XCT790 significantly inhibited the expression of ERR alpha and lipid accumulation in porcine mature adipocytes.
The protein encoded by this gene is a nuclear receptor that is closely related to the estrogen receptor. This protein acts as a site-specific transcription regulator and has been also shown to interact with estrogen and the transcripton factor TFIIB by direct protein-protein contact. The binding and regulatory activities of this protein have been demonstrated in the regulation of a variety of genes including lactoferrin, osteopontin, medium-chain acyl coenzyme A dehydrogenase (MCAD) and thyroid hormone receptor genes. A processed pseudogene of ESRRA is located on chromosome 13q12.1.
, estrogen-related receptor 1
, steroid hormone receptor ERR1
, estrogen-related receptor alpha
, Steroid hormone receptor ERR1 (Estrogen-related receptor, alpha) (ERR-alpha) (Estrogen receptor-like 1)
, estrogen receptor related 1
, estrogen receptor-like 1
, nuclear receptor subfamily 3 group B member 1
, estrogen-related receptor, alpha
, orphan nuclear receptor
, estrogen-related nuclear receptor alpha