Browse our anti-F2R (F2R) Antibodies

Full name:
anti-Coagulation Factor II (thrombin) Receptor Antibodies (F2R)
On are 181 Coagulation Factor II (thrombin) Receptor (F2R) Antibodies from 27 different suppliers available. Additionally we are shipping F2R Kits (62) and F2R Proteins (5) and many more products for this protein. A total of 264 F2R products are currently listed.
AI482343, BXR, Cf2r, f2r-a, HTR, ONR1, PAR, Par-1, Par1, PAR2, PARq, PRR, PXR, SAR, SXR, ThrR, TR, TRGPC
list all antibodies Gene Name GeneID UniProt
F2R 2149 P25116
F2R 14062 P30558
F2R 25439  

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Top referenced anti-F2R Antibodies

  1. Human Monoclonal F2R Primary Antibody for IF, WB - ABIN968573 : Coughlin: How the protease thrombin talks to cells. in Proceedings of the National Academy of Sciences of the United States of America 1999 (PubMed)
    Show all 4 references for 968573

  2. Human Polyclonal F2R Primary Antibody for WB - ABIN611146 : Gradin, Larsson, Marklund, Gullberg: Regulation of microtubule dynamics by extracellular signals: cAMP-dependent protein kinase switches off the activity of oncoprotein 18 in intact cells. in The Journal of cell biology 1998 (PubMed)
    Show all 3 references for 611146

  3. Human Polyclonal F2R Primary Antibody for ICC, IF - ABIN1742020 : Ossovskaya, Bunnett: Protease-activated receptors: contribution to physiology and disease. in Physiological reviews 2004 (PubMed)

  4. Human Polyclonal F2R Primary Antibody for ELISA, WB - ABIN1533416 : Vu, Hung, Wheaton, Coughlin: Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation. in Cell 1991 (PubMed)

  5. Human Monoclonal F2R Primary Antibody for FACS - ABIN4897018 : Hagag, Nosair, Ghaith, Elshenawy: Prognostic value of protease activated receptor-1 in children with acute lymphoblastic leukemia. in Mediterranean journal of hematology and infectious diseases 2014 (PubMed)

  6. Guinea Pig Polyclonal F2R Primary Antibody for WB - ABIN2784606 : Kamio, Hashizume, Nakao, Matsushima, Sugiya: Plasmin is involved in inflammation via protease-activated receptor-1 activation in human dental pulp. in Biochemical pharmacology 2008 (PubMed)

  7. Human Polyclonal F2R Primary Antibody for WB - ABIN452298 : Niessen, Schaffner, Furlan-Freguia, Pawlinski, Bhattacharjee, Chun, Derian, Andrade-Gordon, Rosen, Ruf: Dendritic cell PAR1-S1P3 signalling couples coagulation and inflammation. in Nature 2008 (PubMed)

More Antibodies against F2R Interaction Partners

Human Coagulation Factor II (thrombin) Receptor (F2R) interaction partners

  1. this study shows that PXR (show NR1I2 Antibodies) augments Mycobacterium tuberculosis survival inside the host macrophages by promoting the foamy macrophage formation and abrogating phagolysosomal fusion, inflammation, and apoptosis

  2. PXR (show NR1I2 Antibodies) is a potential biomarker for predicting outcome and activates MRP3 (show ABCC3 Antibodies) transcription by directly binding to its promoter resulting in an increased L-OHP efflux capacity, and resistance to L-OHP or platinum drugs in CRC (show CALR Antibodies).

  3. This is the first time an association between NR1I2 (show NR1I2 Antibodies) polymorphism and time of progression to AIDS is reported and supports an apparent relationship between the gene in the immune response and identifies another genetic factor influencing AIDS progression.

  4. Data highlight functional differences in proliferation and barrier integrity between dark keratinocytes and fair keratinocytes that are partly associated with their differential expression of PAR1 (show MARK2 Antibodies) and PAR2 (show F2RL1 Antibodies).

  5. MD simulations further revealed that the presence of small molecule at allosteric site disrupts the LBD dynamics and locks the LBD in a "tightly-contracted" conformation. The molecular details provided here could guide new structural studies to understand PXR (show NR1I2 Antibodies) activation and antagonism.

  6. Extracellular granzyme K (show GZMK Antibodies) mediates endothelial activation through the cleavage of PAR-1 (show MARK2 Antibodies).

  7. Pregnane X receptor interacts with liver X receptor to regulate expression of SMPDL3A in primary hepatocytes.

  8. 66034T/C polymorphism of the human pregnane X receptor (show NR1I2 Antibodies) (hPXR) is potential risk factor for drug-resistant epilepsy.

  9. The data suggest that some of the natural PXR (show NR1I2 Antibodies) variants may have adverse physiological consequences owing to its influence on the expression levels and functional output of drug-metabolizing enzymes and transporters.

  10. miR (show MLXIP Antibodies)-30c-1-3p was shown to alter the expression of CYP3A4 (show CYP3A4 Antibodies), a prototypical target gene of PXR (show NR1I2 Antibodies).

Mouse (Murine) Coagulation Factor II (thrombin) Receptor (F2R) interaction partners

  1. our findings define a detrimental role of thrombin (show F2 Antibodies)-activated PAR-1 (show MARK2 Antibodies) in wound healing in mice with spinal cord injuries.

  2. thrombin (show F2 Antibodies)/PAR-1 (show MARK2 Antibodies) interaction regulated MCP-1 (show CPT1B Antibodies), TF, MCSF (show CSF1 Antibodies) and IL-6 (show IL6 Antibodies) production.

  3. Thrombin (show F2 Antibodies) upregulates LCN2 (show LCN2 Antibodies) through protease-activated receptor-1 activation and causes brain damage.

  4. Matrix metalloproteinases (MMP) are effectors of hippocampal neuroplasticity in the adult central nervous system and that the MMP-1 (show MMP1 Antibodies)/protease-activated receptor-1 axis may play a role in neurogenesis following physiological and/or pathological stimuli.

  5. Data indicate an involvement of protease-activated receptor-1 in the neuroinflammation mediated by Eomes (show EOMES Antibodies)(+) CD4 (show CD4 Antibodies)(+) T cells.

  6. Bladder PAR (show AFG3L2 Antibodies) activation elicits urothelial MIF (show MIF Antibodies) release and urothelial MIF (show MIF Antibodies) receptor signaling at least partly through CXCR4 (show CXCR4 Antibodies) to result in abdominal hypersensitivity without overt bladder inflammation

  7. Data suggest that the pro-fibrotic effects of protease-activated receptor PAR-1 (show MARK2 Antibodies) require the presence of protease-activated receptor PAR-2 (show F2RL1 Antibodies).

  8. Thrombin (show F2 Antibodies)-PAR1 signaling, via nitric oxide and EPCR (show PROCR Antibodies), promotes hematopoietic stem cell (HSC (show FUT1 Antibodies)) mobilization. aPC (show APC Antibodies)-EPCR (show PROCR Antibodies)-PAR1 signaling promotes HSC (show FUT1 Antibodies) retention in bone marrow.

  9. Colonic adenocarcinoma growth was reduced in PAR-1 (show MARK2 Antibodies)-deficient mice. Stromal cell-associated PAR-1 (show MARK2 Antibodies) as one thrombin (show F2 Antibodies) target important for tumor outgrowth.

  10. Interference with the thrombin (show F2 Antibodies)-PAR1 system does not reduce the adverse effects of blood on germinal cells of the immature mouse brain.

Cow (Bovine) Coagulation Factor II (thrombin) Receptor (F2R) interaction partners

  1. MMP-1 (show MMP1 Antibodies) promotes VEGFR2 (show KDR Antibodies) expression and proliferation of endothelial cells through stimulation of PAR-1 and activation of NF-kappaB (show NFKB1 Antibodies)

  2. PAR1 and PAR2 (show F2RL1 Antibodies) regulate endothelial NO synthase (show NOS Antibodies) phosphorylation and activity through G(12/13) and G(q), delineating the signaling pathways by which the proteases act on protease-activated receptors to modulate endothelial functions.

Pig (Porcine) Coagulation Factor II (thrombin) Receptor (F2R) interaction partners

  1. Thrombin (show F2 Antibodies) stimulates swine smooth muscle cell differentiation from peripheral blood mononuclear cells via protease-activated receptor-1, RhoA (show RHOA Antibodies), and myocardin (show MYOCD Antibodies).

  2. Thrombin (show F2 Antibodies) induces a sustained contraction in the normal pulmonary artery, by activating PAR(1) and thereby increasing the sensitivity of the myofilament to Ca(2 (show CA2 Antibodies)+).

F2R Antigen Profile

Antigen Summary

This gene product belongs to the nuclear receptor superfamily, members of which are transcription factors characterized by a ligand-binding domain and a DNA-binding domain. The encoded protein is a transcriptional regulator of the cytochrome P450 gene CYP3A4, binding to the response element of the CYP3A4 promoter as a heterodimer with the 9-cis retinoic acid receptor RXR. It is activated by a range of compounds that induce CYP3A4, including dexamethasone and rifampicin. Several alternatively spliced transcripts encoding different isoforms, some of which use non-AUG (CUG) translation initiation codon, have been described for this gene. Additional transcript variants exist, however, they have not been fully characterized.

Alternative names and synonyms associated with F2R

  • coagulation factor 2 (thrombin) receptor (f2r) antibody
  • coagulation factor II (thrombin) receptor (F2R) antibody
  • coagulation factor II (thrombin) receptor (F2r) antibody
  • nuclear receptor subfamily 1, group I, member 2 (NR1I2) antibody
  • AI482343 antibody
  • BXR antibody
  • Cf2r antibody
  • f2r-a antibody
  • HTR antibody
  • ONR1 antibody
  • PAR antibody
  • Par-1 antibody
  • Par1 antibody
  • PAR2 antibody
  • PARq antibody
  • PRR antibody
  • PXR antibody
  • SAR antibody
  • SXR antibody
  • ThrR antibody
  • TR antibody
  • TRGPC antibody

Protein level used designations for F2R

PAR-1 , coagulation factor II (thrombin) receptor , coagulation factor II receptor , proteinase-activated receptor 1 , thrombin receptor , protease-activated receptor 1 , Thrombin receptor , protease-activated receptor-1 , nuclear receptor subfamily 1 group I member 2 , orphan nuclear receptor PAR1 , orphan nuclear receptor PXR , pregnane X nuclear receptor variant 2 , pregnane X receptor , steroid and xenobiotic receptor

378526 Xenopus laevis
2149 Homo sapiens
14062 Mus musculus
25439 Rattus norvegicus
526585 Bos taurus
100521609 Sus scrofa
8856 Homo sapiens
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