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Browse our F2R Proteins (F2R)

Full name:
Coagulation Factor II (thrombin) Receptor Proteins (F2R)
On are 5 Coagulation Factor II (thrombin) Receptor (F2R) Proteins from 3 different suppliers available. Additionally we are shipping F2R Antibodies (180) and F2R Kits (56) and many more products for this protein. A total of 256 F2R products are currently listed.
AI482343, BXR, Cf2r, f2r-a, HTR, ONR1, PAR, Par-1, Par1, PAR2, PARq, PRR, PXR, SAR, SXR, ThrR, TR, TRGPC
list all proteins Gene Name GeneID UniProt
F2R 2149 P25116
F2R 14062 P30558
F2R 25439  

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F2R Proteins (F2R) by Origin

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More Proteins for F2R Interaction Partners

Human Coagulation Factor II (thrombin) Receptor (F2R) interaction partners

  1. FGF21 (show FGF21 Proteins)-PXR (show NR1I2 Proteins) signaling pathway may be involved in decreased hepatic CYP3A4 (show CYP3A4 Proteins) metabolic activity in Nonalcoholic fatty liver disease.

  2. the -831C/T polymorphism has a direct effect on transcriptional regulation of PXR (show NR1I2 Proteins) gene.

  3. These findings demonstrated that rifaximin causes PXR (show NR1I2 Proteins)-mediated inhibition of angiogenic factors in Caco-2 cell line and may be a promising anticancer tool.

  4. rs3842689, 7635G>A (rs6785049), and 24381C>A (rs1523127) PXR (show NR1I2 Proteins) polymorphisms have no obvious impact on FK506; furthermore, the PXR (show NR1I2 Proteins) rs3842689 wild-type homozygous WW genotype is a risk factor of FK506 and results in gastrointestinal reactions.

  5. The agonistic effects of two new flame retardants on PXR (show NR1I2 Proteins) expression and activity are reported.

  6. Identify sixteen novel structurally different PXR (show NR1I2 Proteins) activators capable of inducing CYP3A4 (show CYP3A4 Proteins) expression in HepG2 cells.

  7. result suggests that in Indonesian patients with tuberculosis, the risk of having antituberculosis drug-induced liver injury was associated with TT genotype of the PXR (show NR1I2 Proteins) gene

  8. EPAS-1 (show EPAS1 Proteins) and PXR (show NR1I2 Proteins) may cooperatively participate in development and especially MDR process of stomach cancer

  9. In a Cox (show COX8A Proteins) regression model, fully adjusted for age, race, sex, BMI, and smoking status, carrying a T allele was not associated with MACE (HR 1.19, 95 % CI 0.89-1.59, P = 0.23) or bleeding (HR 0.73, 95 % CI 0.37-1.4, P = 0.34). In conclusion, in our population, F2R IVS-14 PAR1 (show MARK2 Proteins) variability does not affect risk of MACE or bleeding following PCI (show SERPINA5 Proteins).

  10. decreases of CES and CYP3A4 (show CYP3A4 Proteins) expression and enzymatic activities induced by Fluoxetine are through decreasing PXR (show NR1I2 Proteins) and increasing DEC1 (show BHLHE40 Proteins) in HepG2 cells

Mouse (Murine) Coagulation Factor II (thrombin) Receptor (F2R) interaction partners

  1. thrombin (show F2 Proteins)/PAR-1 (show MARK2 Proteins) interaction regulated MCP-1 (show CPT1B Proteins), TF, MCSF (show CSF1 Proteins) and IL-6 (show IL6 Proteins) production.

  2. Thrombin (show F2 Proteins) upregulates LCN2 (show LCN2 Proteins) through protease-activated receptor-1 activation and causes brain damage.

  3. Matrix metalloproteinases (MMP) are effectors of hippocampal neuroplasticity in the adult central nervous system and that the MMP-1 (show MMP1 Proteins)/protease-activated receptor-1 axis may play a role in neurogenesis following physiological and/or pathological stimuli.

  4. Data indicate an involvement of protease-activated receptor-1 in the neuroinflammation mediated by Eomes (show EOMES Proteins)(+) CD4 (show CD4 Proteins)(+) T cells.

  5. Bladder PAR (show AFG3L2 Proteins) activation elicits urothelial MIF (show MIF Proteins) release and urothelial MIF (show MIF Proteins) receptor signaling at least partly through CXCR4 (show CXCR4 Proteins) to result in abdominal hypersensitivity without overt bladder inflammation

  6. Data suggest that the pro-fibrotic effects of protease-activated receptor PAR-1 (show MARK2 Proteins) require the presence of protease-activated receptor PAR-2 (show F2RL1 Proteins).

  7. Thrombin (show F2 Proteins)-PAR1 signaling, via nitric oxide and EPCR (show PROCR Proteins), promotes hematopoietic stem cell (HSC (show FUT1 Proteins)) mobilization. aPC (show APC Proteins)-EPCR (show PROCR Proteins)-PAR1 signaling promotes HSC (show FUT1 Proteins) retention in bone marrow.

  8. Colonic adenocarcinoma growth was reduced in PAR-1 (show MARK2 Proteins)-deficient mice. Stromal cell-associated PAR-1 (show MARK2 Proteins) as one thrombin (show F2 Proteins) target important for tumor outgrowth.

  9. Interference with the thrombin (show F2 Proteins)-PAR1 system does not reduce the adverse effects of blood on germinal cells of the immature mouse brain.

  10. Protease activated receptor-1 deficiency diminishes bleomycin-induced skin fibrosis

Cow (Bovine) Coagulation Factor II (thrombin) Receptor (F2R) interaction partners

  1. MMP-1 (show MMP1 Proteins) promotes VEGFR2 (show KDR Proteins) expression and proliferation of endothelial cells through stimulation of PAR-1 and activation of NF-kappaB (show NFKB1 Proteins)

  2. PAR1 and PAR2 regulate endothelial NO synthase phosphorylation and activity through G(12/13) and G(q), delineating the signaling pathways by which the proteases act on protease-activated receptors to modulate endothelial functions.

Pig (Porcine) Coagulation Factor II (thrombin) Receptor (F2R) interaction partners

  1. Thrombin stimulates swine smooth muscle cell differentiation from peripheral blood mononuclear cells via protease-activated receptor-1, RhoA, and myocardin.

  2. Thrombin (show F2 Proteins) induces a sustained contraction in the normal pulmonary artery, by activating PAR(1) and thereby increasing the sensitivity of the myofilament to Ca(2 (show CA2 Proteins)+).

F2R Protein Profile

Protein Summary

This gene product belongs to the nuclear receptor superfamily, members of which are transcription factors characterized by a ligand-binding domain and a DNA-binding domain. The encoded protein is a transcriptional regulator of the cytochrome P450 gene CYP3A4, binding to the response element of the CYP3A4 promoter as a heterodimer with the 9-cis retinoic acid receptor RXR. It is activated by a range of compounds that induce CYP3A4, including dexamethasone and rifampicin. Several alternatively spliced transcripts encoding different isoforms, some of which use non-AUG (CUG) translation initiation codon, have been described for this gene. Additional transcript variants exist, however, they have not been fully characterized.

Alternative names and synonyms associated with F2R

  • coagulation factor 2 (thrombin) receptor (f2r)
  • coagulation factor II (thrombin) receptor (F2R)
  • coagulation factor II (thrombin) receptor (F2r)
  • nuclear receptor subfamily 1, group I, member 2 (NR1I2)
  • AI482343 protein
  • BXR protein
  • Cf2r protein
  • f2r-a protein
  • HTR protein
  • ONR1 protein
  • PAR protein
  • Par-1 protein
  • Par1 protein
  • PAR2 protein
  • PARq protein
  • PRR protein
  • PXR protein
  • SAR protein
  • SXR protein
  • ThrR protein
  • TR protein
  • TRGPC protein

Protein level used designations for F2R

PAR-1 , coagulation factor II (thrombin) receptor , coagulation factor II receptor , proteinase-activated receptor 1 , thrombin receptor , protease-activated receptor 1 , Thrombin receptor , protease-activated receptor-1 , nuclear receptor subfamily 1 group I member 2 , orphan nuclear receptor PAR1 , orphan nuclear receptor PXR , pregnane X nuclear receptor variant 2 , pregnane X receptor , steroid and xenobiotic receptor

378526 Xenopus laevis
2149 Homo sapiens
14062 Mus musculus
25439 Rattus norvegicus
526585 Bos taurus
100521609 Sus scrofa
8856 Homo sapiens
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