Browse our F2R Proteins (F2R)

Full name:
Coagulation Factor II (thrombin) Receptor Proteins (F2R)
On www.antibodies-online.com are 5 Coagulation Factor II (thrombin) Receptor (F2R) Proteins from 3 different suppliers available. Additionally we are shipping F2R Antibodies (186) and F2R Kits (65) and many more products for this protein. A total of 272 F2R products are currently listed.
Synonyms:
AI482343, BXR, Cf2r, f2r-a, HTR, ONR1, PAR, Par-1, Par1, PAR2, PARq, PRR, PXR, SAR, SXR, ThrR, TR, TRGPC
list all proteins Gene Name GeneID UniProt
F2R 2149 P25116
F2R 14062 P30558
F2R 25439  

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F2R Proteins (F2R) by Origin

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More Proteins for F2R Interaction Partners

Human Coagulation Factor II (thrombin) Receptor (F2R) interaction partners

  1. EPCR (show PROCR Proteins) occupancy recruits G-protein coupled receptor kinase 5 (show GRK5 Proteins), thereby inducing beta-arrestin-2 (show ARRB2 Proteins) biased PAR1 (show MARK2 Proteins) signaling by both APC (show APC Proteins) and thrombin (show F2 Proteins). In

  2. In intrahepatic cholestasis of pregnancy, gene silencing of miR (show MLXIP Proteins)-148a upregulated PXR (show NR1I2 Proteins) expression which was inhibited by estradiol in liver cells. miR (show MLXIP Proteins)-148a may be involved in the estrogen induction in ICP via PXR (show NR1I2 Proteins) signaling. MRP3 (show ABCC3 Proteins) may be involved.

  3. Data suggest that the abrogation of protease-activated receptor 1 (PAR1)-dependent signaling pathways may prove a promising strategy for gliomas.

  4. these data indicate that KLKB1 (show KLKB1 Proteins) induces inflammatory reactions in human dental tissues via protease-activated receptor 1

  5. In this study, we found upregulation of several hemostasis-related genes, including the thrombin (show F2 Proteins)-activatable receptor PAR-1 (protease-activated receptor-1), in Runx1 (show RUNX1 Proteins)/Cbfb (show CBFB Proteins)-deleted MLL (show MLL Proteins)-AF9 (show MLLT3 Proteins) cells. Similar to the effect of Runx1 (show RUNX1 Proteins)/Cbfb (show CBFB Proteins) deletion, PAR-1 (show MARK2 Proteins) overexpression induced CDKN1A/p21 (show CDKN1A Proteins) expression and attenuated proliferation in MLL (show MLL Proteins)-AF9 (show MLLT3 Proteins) cells

  6. this study shows that PXR (show NR1I2 Proteins) augments Mycobacterium tuberculosis survival inside the host macrophages by promoting the foamy macrophage formation and abrogating phagolysosomal fusion, inflammation, and apoptosis

  7. PXR (show NR1I2 Proteins) is a potential biomarker for predicting outcome and activates MRP3 (show ABCC3 Proteins) transcription by directly binding to its promoter resulting in an increased L-OHP efflux capacity, and resistance to L-OHP or platinum drugs in CRC (show CALR Proteins).

  8. This is the first time an association between NR1I2 (show NR1I2 Proteins) polymorphism and time of progression to AIDS is reported and supports an apparent relationship between the gene in the immune response and identifies another genetic factor influencing AIDS progression.

  9. Data highlight functional differences in proliferation and barrier integrity between dark keratinocytes and fair keratinocytes that are partly associated with their differential expression of PAR1 (show MARK2 Proteins) and PAR2 (show F2RL1 Proteins).

  10. MD simulations further revealed that the presence of small molecule at allosteric site disrupts the LBD dynamics and locks the LBD in a "tightly-contracted" conformation. The molecular details provided here could guide new structural studies to understand PXR (show NR1I2 Proteins) activation and antagonism.

Mouse (Murine) Coagulation Factor II (thrombin) Receptor (F2R) interaction partners

  1. The results of this study suggested that polarized microglia occur dynamically after ICH (show ACE Proteins) and that PAR-1 (show MARK2 Proteins) plays a role in the microglia activation and polarization.

  2. In this study, we found upregulation of several hemostasis-related genes, including the thrombin (show F2 Proteins)-activatable receptor PAR-1 (protease-activated receptor-1), in Runx1 (show RUNX1 Proteins)/Cbfb (show CBFB Proteins)-deleted MLL (show MLL Proteins)-AF9 (show MLLT3 Proteins) cells. Similar to the effect of Runx1 (show RUNX1 Proteins)/Cbfb (show CBFB Proteins) deletion, PAR-1 (show MARK2 Proteins) overexpression induced CDKN1A/p21 (show CDKN1A Proteins) expression and attenuated proliferation in MLL (show MLL Proteins)-AF9 (show MLLT3 Proteins) cells

  3. our findings define a detrimental role of thrombin (show F2 Proteins)-activated PAR-1 (show MARK2 Proteins) in wound healing in mice with spinal cord injuries.

  4. thrombin (show F2 Proteins)/PAR-1 (show MARK2 Proteins) interaction regulated MCP-1 (show CPT1B Proteins), TF, MCSF (show CSF1 Proteins) and IL-6 (show IL6 Proteins) production.

  5. Thrombin (show F2 Proteins) upregulates LCN2 (show LCN2 Proteins) through protease-activated receptor-1 activation and causes brain damage.

  6. Matrix metalloproteinases (MMP) are effectors of hippocampal neuroplasticity in the adult central nervous system and that the MMP-1 (show MMP1 Proteins)/protease-activated receptor-1 axis may play a role in neurogenesis following physiological and/or pathological stimuli.

  7. Data indicate an involvement of protease-activated receptor-1 in the neuroinflammation mediated by Eomes (show EOMES Proteins)(+) CD4 (show CD4 Proteins)(+) T cells.

  8. Bladder PAR (show AFG3L2 Proteins) activation elicits urothelial MIF (show MIF Proteins) release and urothelial MIF (show MIF Proteins) receptor signaling at least partly through CXCR4 (show CXCR4 Proteins) to result in abdominal hypersensitivity without overt bladder inflammation

  9. Data suggest that the pro-fibrotic effects of protease-activated receptor PAR-1 (show MARK2 Proteins) require the presence of protease-activated receptor PAR-2 (show F2RL1 Proteins).

  10. Thrombin (show F2 Proteins)-PAR1 signaling, via nitric oxide and EPCR (show PROCR Proteins), promotes hematopoietic stem cell (HSC (show FUT1 Proteins)) mobilization. aPC (show APC Proteins)-EPCR (show PROCR Proteins)-PAR1 signaling promotes HSC (show FUT1 Proteins) retention in bone marrow.

Cow (Bovine) Coagulation Factor II (thrombin) Receptor (F2R) interaction partners

  1. MMP-1 (show MMP1 Proteins) promotes VEGFR2 (show KDR Proteins) expression and proliferation of endothelial cells through stimulation of PAR-1 and activation of NF-kappaB (show NFKB1 Proteins)

  2. PAR1 and PAR2 regulate endothelial NO synthase phosphorylation and activity through G(12/13) and G(q), delineating the signaling pathways by which the proteases act on protease-activated receptors to modulate endothelial functions.

Pig (Porcine) Coagulation Factor II (thrombin) Receptor (F2R) interaction partners

  1. Thrombin stimulates swine smooth muscle cell differentiation from peripheral blood mononuclear cells via protease-activated receptor-1, RhoA, and myocardin.

  2. Thrombin (show F2 Proteins) induces a sustained contraction in the normal pulmonary artery, by activating PAR(1) and thereby increasing the sensitivity of the myofilament to Ca(2 (show CA2 Proteins)+).

F2R Protein Profile

Protein Summary

This gene product belongs to the nuclear receptor superfamily, members of which are transcription factors characterized by a ligand-binding domain and a DNA-binding domain. The encoded protein is a transcriptional regulator of the cytochrome P450 gene CYP3A4, binding to the response element of the CYP3A4 promoter as a heterodimer with the 9-cis retinoic acid receptor RXR. It is activated by a range of compounds that induce CYP3A4, including dexamethasone and rifampicin. Several alternatively spliced transcripts encoding different isoforms, some of which use non-AUG (CUG) translation initiation codon, have been described for this gene. Additional transcript variants exist, however, they have not been fully characterized.

Alternative names and synonyms associated with F2R

  • coagulation factor 2 (thrombin) receptor (f2r)
  • coagulation factor II (thrombin) receptor (F2R)
  • coagulation factor II (thrombin) receptor (F2r)
  • nuclear receptor subfamily 1, group I, member 2 (NR1I2)
  • AI482343 protein
  • BXR protein
  • Cf2r protein
  • f2r-a protein
  • HTR protein
  • ONR1 protein
  • PAR protein
  • Par-1 protein
  • Par1 protein
  • PAR2 protein
  • PARq protein
  • PRR protein
  • PXR protein
  • SAR protein
  • SXR protein
  • ThrR protein
  • TR protein
  • TRGPC protein

Protein level used designations for F2R

PAR-1 , coagulation factor II (thrombin) receptor , coagulation factor II receptor , proteinase-activated receptor 1 , thrombin receptor , protease-activated receptor 1 , Thrombin receptor , protease-activated receptor-1 , nuclear receptor subfamily 1 group I member 2 , orphan nuclear receptor PAR1 , orphan nuclear receptor PXR , pregnane X nuclear receptor variant 2 , pregnane X receptor , steroid and xenobiotic receptor

GENE ID SPECIES
378526 Xenopus laevis
2149 Homo sapiens
14062 Mus musculus
25439 Rattus norvegicus
526585 Bos taurus
100521609 Sus scrofa
8856 Homo sapiens
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