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Browse our F2R Proteins (F2R)

Full name:
Coagulation Factor II (thrombin) Receptor Proteins (F2R)
On are 5 Coagulation Factor II (thrombin) Receptor (F2R) Proteins from 3 different suppliers available. Additionally we are shipping F2R Antibodies (139) and F2R Kits (53) and many more products for this protein. A total of 214 F2R products are currently listed.
AI482343, BXR, Cf2r, f2r-a, HTR, ONR1, PAR, Par-1, Par1, PAR2, PARq, PRR, PXR, SAR, SXR, ThrR, TR, TRGPC
list all proteins Gene Name GeneID UniProt
F2R 2149 P25116
F2R 14062 P30558
F2R 25439  

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F2R Proteins (F2R) by Origin

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More Proteins for F2R Interaction Partners

Human Coagulation Factor II (thrombin) Receptor (F2R) interaction partners

  1. hPXR is regulated through its phosphorylation at threonine-408 by PKC, CHIP/chaperone-dependent stability check, and autophagic degradation pathway.

  2. we have identified novel PXR (show NR1I2 Proteins) dependent pathways in human de novo lipogenesis, which may participate in hepatic steatosis and pathogenesis of steatohepatitis

  3. Role of NR1I2 (show NR1I2 Proteins) polymorphisms in head and neck squamous cell carcinoma

  4. These results suggest that stabilization of microtubule-unbound tau by phosphorylation at Ser262/356 via the PAR-1 (show MARK2 Proteins)/MARK may act in the initial steps of tau mismetabolism in AD pathogenesis

  5. The serum levels of PAR1 (show MARK2 Proteins) might have a diagnostic value in lung cancer patients

  6. identified HMGA2 (high mobility group A2) as an important regulator of PAR1-mediated invasion. Inhibition of PAR1 signaling suppresses HMGA2-driven invasion in breast cancer cells

  7. Thrombin (show F2 Proteins) and the PAR-1 (show MARK2 Proteins) activating peptide, TFLLR, lead to the phosphorylation of eNOS (show NOS3 Proteins)-Ser (show SIGLEC1 Proteins)-1177 in human coronary artery endothelial cells, which was blocked by SCH (show NF2 Proteins)-79797 (SCH (show NF2 Proteins)), a PAR-1 (show MARK2 Proteins) inhibitor.

  8. Our results revealed that PXR (show NR1I2 Proteins) could be a determinant of stable warfarin doses.

  9. Carriers of two copies of the ATG haplotypes of NR1I2 (show NR1I2 Proteins)-rs1523130, rs3814055 and rs1523127 were less sensitive to thrombocytopenia than those harboring other haplotypes

  10. Rab11A (show RAB11A Proteins) and Rab11B (show RAB11B Proteins) differentially regulate intracellular trafficking of PAR1 (show MARK2 Proteins) through distinct endosomal sorting mechanisms

Mouse (Murine) Coagulation Factor II (thrombin) Receptor (F2R) interaction partners

  1. Thrombin (show F2 Proteins) upregulates LCN2 (show LCN2 Proteins) through protease-activated receptor-1 activation and causes brain damage.

  2. Matrix metalloproteinases (MMP) are effectors of hippocampal neuroplasticity in the adult central nervous system and that the MMP-1 (show MMP1 Proteins)/protease-activated receptor-1 axis may play a role in neurogenesis following physiological and/or pathological stimuli.

  3. Data indicate an involvement of protease-activated receptor-1 in the neuroinflammation mediated by Eomes (show EOMES Proteins)(+) CD4 (show CD4 Proteins)(+) T cells.

  4. Bladder PAR (show AFG3L2 Proteins) activation elicits urothelial MIF (show MIF Proteins) release and urothelial MIF (show MIF Proteins) receptor signaling at least partly through CXCR4 (show CXCR4 Proteins) to result in abdominal hypersensitivity without overt bladder inflammation

  5. Data suggest that the pro-fibrotic effects of protease-activated receptor PAR-1 (show MARK2 Proteins) require the presence of protease-activated receptor PAR-2 (show F2RL1 Proteins).

  6. Thrombin (show F2 Proteins)-PAR1 signaling, via nitric oxide and EPCR (show PROCR Proteins), promotes hematopoietic stem cell (HSC (show FUT1 Proteins)) mobilization. aPC (show APC Proteins)-EPCR (show PROCR Proteins)-PAR1 signaling promotes HSC (show FUT1 Proteins) retention in bone marrow.

  7. Colonic adenocarcinoma growth was reduced in PAR-1 (show MARK2 Proteins)-deficient mice. Stromal cell-associated PAR-1 (show MARK2 Proteins) as one thrombin (show F2 Proteins) target important for tumor outgrowth.

  8. Interference with the thrombin (show F2 Proteins)-PAR1 system does not reduce the adverse effects of blood on germinal cells of the immature mouse brain.

  9. Protease activated receptor-1 deficiency diminishes bleomycin-induced skin fibrosis

  10. this study demonstrated that PAR1-mediated protection against H. pylori gastritis requires bone marrow-derived cells.

Cow (Bovine) Coagulation Factor II (thrombin) Receptor (F2R) interaction partners

  1. MMP-1 (show MMP1 Proteins) promotes VEGFR2 (show KDR Proteins) expression and proliferation of endothelial cells through stimulation of PAR-1 and activation of NF-kappaB (show NFKB1 Proteins)

  2. PAR1 and PAR2 regulate endothelial NO synthase phosphorylation and activity through G(12/13) and G(q), delineating the signaling pathways by which the proteases act on protease-activated receptors to modulate endothelial functions.

Pig (Porcine) Coagulation Factor II (thrombin) Receptor (F2R) interaction partners

  1. Thrombin stimulates swine smooth muscle cell differentiation from peripheral blood mononuclear cells via protease-activated receptor-1, RhoA, and myocardin.

  2. Thrombin (show F2 Proteins) induces a sustained contraction in the normal pulmonary artery, by activating PAR(1) and thereby increasing the sensitivity of the myofilament to Ca(2 (show CA2 Proteins)+).

F2R Protein Profile

Protein Summary

This gene product belongs to the nuclear receptor superfamily, members of which are transcription factors characterized by a ligand-binding domain and a DNA-binding domain. The encoded protein is a transcriptional regulator of the cytochrome P450 gene CYP3A4, binding to the response element of the CYP3A4 promoter as a heterodimer with the 9-cis retinoic acid receptor RXR. It is activated by a range of compounds that induce CYP3A4, including dexamethasone and rifampicin. Several alternatively spliced transcripts encoding different isoforms, some of which use non-AUG (CUG) translation initiation codon, have been described for this gene. Additional transcript variants exist, however, they have not been fully characterized.

Alternative names and synonyms associated with F2R

  • coagulation factor 2 (thrombin) receptor (f2r)
  • coagulation factor II (thrombin) receptor (F2R)
  • coagulation factor II (thrombin) receptor (F2r)
  • nuclear receptor subfamily 1, group I, member 2 (NR1I2)
  • AI482343 protein
  • BXR protein
  • Cf2r protein
  • f2r-a protein
  • HTR protein
  • ONR1 protein
  • PAR protein
  • Par-1 protein
  • Par1 protein
  • PAR2 protein
  • PARq protein
  • PRR protein
  • PXR protein
  • SAR protein
  • SXR protein
  • ThrR protein
  • TR protein
  • TRGPC protein

Protein level used designations for F2R

PAR-1 , coagulation factor II (thrombin) receptor , coagulation factor II receptor , proteinase-activated receptor 1 , thrombin receptor , protease-activated receptor 1 , Thrombin receptor , protease-activated receptor-1 , nuclear receptor subfamily 1 group I member 2 , orphan nuclear receptor PAR1 , orphan nuclear receptor PXR , pregnane X nuclear receptor variant 2 , pregnane X receptor , steroid and xenobiotic receptor

378526 Xenopus laevis
2149 Homo sapiens
14062 Mus musculus
25439 Rattus norvegicus
526585 Bos taurus
100521609 Sus scrofa
8856 Homo sapiens
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