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The pregnane X receptor (show NR1I2 ELISA Kits) down-regulates organic cation transporter 1 (SLC22A1) in human hepatocytes by competing for ("squelching") SRC-1 (show SRC ELISA Kits) coactivator.
This study revealed for the first time the involvement of NR1I2 (show NR1I2 ELISA Kits) in the pharmacogenetics of irinotecan and suggest that it may help to predict the toxicity of low-dose irinotecan.
In intrahepatic cholestasis of pregnancy, gene silencing of miR (show MLXIP ELISA Kits)-148a upregulated PXR (show NR1I2 ELISA Kits) expression which was inhibited by estradiol in liver cells. miR (show MLXIP ELISA Kits)-148a may be involved in the estrogen induction in ICP via PXR (show NR1I2 ELISA Kits) signaling. MRP3 (show ABCC3 ELISA Kits) may be involved.
this study shows that PXR (show NR1I2 ELISA Kits) augments Mycobacterium tuberculosis survival inside the host macrophages by promoting the foamy macrophage formation and abrogating phagolysosomal fusion, inflammation, and apoptosis
PXR (show NR1I2 ELISA Kits) is a potential biomarker for predicting outcome and activates MRP3 (show ABCC3 ELISA Kits) transcription by directly binding to its promoter resulting in an increased L-OHP efflux capacity, and resistance to L-OHP or platinum drugs in CRC (show CALR ELISA Kits).
A novel SLC52A2 mutation identified in a family with spinocerebellar ataxia with blindness and deafness.
This is the first time an association between NR1I2 (show NR1I2 ELISA Kits) polymorphism and time of progression to AIDS is reported and supports an apparent relationship between the gene in the immune response and identifies another genetic factor influencing AIDS progression.
MD simulations further revealed that the presence of small molecule at allosteric site disrupts the LBD dynamics and locks the LBD in a "tightly-contracted" conformation. The molecular details provided here could guide new structural studies to understand PXR (show NR1I2 ELISA Kits) activation and antagonism.
Extracellular granzyme K (show GZMK ELISA Kits) mediates endothelial activation through the cleavage of PAR-1 (show MARK2 ELISA Kits).
Pregnane X receptor interacts with liver X receptor to regulate expression of SMPDL3A in primary hepatocytes.
This gene product belongs to the nuclear receptor superfamily, members of which are transcription factors characterized by a ligand-binding domain and a DNA-binding domain. The encoded protein is a transcriptional regulator of the cytochrome P450 gene CYP3A4, binding to the response element of the CYP3A4 promoter as a heterodimer with the 9-cis retinoic acid receptor RXR. It is activated by a range of compounds that induce CYP3A4, including dexamethasone and rifampicin. Several alternatively spliced transcripts encoding different isoforms, some of which use non-AUG (CUG) translation initiation codon, have been described for this gene. Additional transcript variants exist, however, they have not been fully characterized.
G protein-coupled receptor 172A
, PERV-A receptor 1
, porcine endogenous retrovirus A receptor 1
, putative G-protein coupled receptor GPCR41
, riboflavin transporter 3
, solute carrier family 52, riboflavin transporter, member 2
, Proteinase-activated receptor-2 G protein-coupled receptor 11
, Proteinase-activated receptor-2, G protein-coupled receptor 11
, coagulation factor II receptor-like 1
, proteinase-activated receptor 2
, thrombin receptor-like 1
, nuclear receptor subfamily 1 group I member 2
, orphan nuclear receptor PAR1
, orphan nuclear receptor PXR
, pregnane X nuclear receptor variant 2
, pregnane X receptor
, steroid and xenobiotic receptor
, G protein-coupled receptor 172B
, PERV-A receptor 2 homolog
, porcine endogenous retrovirus A receptor 2 homolog
, riboflavin transporter 1