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The expression of progesterone receptor in the uterotubular junction after deep intrauterine insemination with a reduced number of sperm was lower than after conventional artificial insemination and might influence sperm transportation and fertilization.
the digitonin-soluble progesterone binding protein (show PGRMC1 Proteins) has a binding site that differs from that of membrane PR; it is concluded that more than one progesterone receptor is present in porcine spermatozoa.
The expression of mRNAs for ERalpha (show ESR1 Proteins), ERbeta (show ESR2 Proteins) and PR in the sow uterus differed between endometrium and myometrium as well as with stages of the estrous cycle and early pregnancy.
Data suggest that the classical xPR-1, located at the plasma membrane, mediates reinitiation of the meiotic cell cycle in the X. laevis oocyte through a non-genomic mechanism.
Xenopus laevis progesterone receptor is capable of associating with the plasma membrane and this association is through its ligang-binding domain.
Pgr is widely distributed in all regions of the zebrafish brain.
The localization of Pgr suggests that it mediates progestin regulation of reproductive signaling in the brain, early germ cell proliferation in testis, and ovarian follicular functions, but not final oocyte or sperm maturation.
11 beta-hydroxysteroid dehydrogenase activity stimulated by DHP (show DPYS Proteins) via Pgr
Data suggest that there are no changes in expression or localization patterns for PGR and PGRMC1 (show PGRMC1 Proteins) (progesterone receptor membrane component 2 (show PGRMC2 Proteins)) in endometrium in artificially cycled disease-free animals compared with an endometriosis model.
These results indicate that ptger4b expression is regulated by a genomic mechanism involving Pgr.
The endometrial expression of PR and Ki67 (show MKI67 Proteins) along with serum CA125 (show MUC16 Proteins) predicted the development of lymph node metastasis in endometrial cancer.
Overexpression of RNA-binding region-containing protein 1 (RNPC1 (show RBM38 Proteins)) increased, whereas knockdown of RNPC1 (show RBM38 Proteins) decreased, the level of progesterone receptor (PR) protein and transcripts.
analysis of pancreatic adenocarcinoma reveals nPR (show NPTXR Proteins) and the presence of mPR (show PGRMC1 Proteins) of alpha, beta, gamma subtypes both at the mRNA and protein levels
Working model. During most of pregnancy, progesterone via PR-B promotes myometrial cell quiescence in part by repressing responsiveness to proinflammatory stimuli. With advancing gestation, prolabor signals increase the inflammatory load on the uterus until a threshold is reached. The threshold is the point at which inflammatory stimuli augment PR-A stability.
Data suggest the relevance of determining the progesterone receptor (PR) isoform ratio before starting antiprogestin treatments.
The data show that human parturition involves the phosphorylation of PR-A at serine-345 in myometrial cells and that this process is ligand dependent and induced by a proinflammatory stimulus.
PR-B expression was significantly reduced in the eutopic endometrium (p=0.031) and ovarian endometrioma (p=0.036) from women with advanced-stage endometriosis compared with eutopic endometrium tissues from control subjects.
showed a high concordance with immunohistochemistry/in situ hybridization of 95 % (kappa 0.81) for estrogen receptor (show ESR1 Proteins), 81 % (kappa 0.56) for progesterone receptor, and 94 % (kappa 0.76) for HER2 (show ERBB2 Proteins)
Positive results were found in 15 situations when genes were analyzed in groups of 3; the most significant result corresponded to polymorphisms of p53 (show TP53 Proteins), ERb (show ESR2 Proteins) and GSTM1 (show GSTM1 Proteins) seen in 20%; PROGINS, ERb (show ESR2 Proteins) and GSTM1 (show GSTM1 Proteins) in 18%; and p53 (show TP53 Proteins), ERb (show ESR2 Proteins) and PROGINS in 12% patients., while 31.25% patients showed GSTM1 (show GSTM1 Proteins)- PROGINS and GSTT1 (show GSTT1 Proteins)-CYP1A1 (show CYP1A1 Proteins) polymorphism
Progesterone receptor antagonism inhibits progestogen-related carcinogenesis and suppresses tumor cell proliferation.
expression differences among PGR genotypes in oviduct and uterus and when differences appear during gestation
The results show that mPges-1 (show PTGES Proteins) may be a direct downstream target gene of the progesterone receptor.
generated a model to study the consequence of increased Notch (show NOTCH1 Proteins) signaling in female reproduction and provide the first evidence, to our knowledge, that Notch (show NOTCH1 Proteins) signaling can regulate epigenetic modification of the progesterone receptor
Calvarial cells had more potential to differentiate into osteoblasts and displayed more osteogeic markers after the PR expression was ablated from the Mx1+ cells. This indicates that PRs may play a role in the later stages of osteoblast differentiation.
progesterone receptor is a key contributor to the hypoxic ventilatory response in newborn mice
Progesterone receptor rapid and nonclassical transcriptional effects govern breast cancer growth.
PgR expression may play an important role in the maturation of cortical connectivity and sensorimotor
RANKL (show TNFSF11 Proteins) is a direct progesterone receptor (PR) target gene and Stat5a (show STAT5A Proteins) has a novel role as a cofactor in PR-mediated transcriptional signaling in the mammary gland.
Progesterone receptor function may be involved in the development of diabetes mellitus.
Progesterone receptor A stability is mediated by glycogen synthase kinase-3beta in the Brca1-deficient mammary gland.
Progesterone upregulation of Gs proteins increases VIP (show Vip Proteins)-induced inhibition of intestinal smooth muscle cell contraction mediated by progesterone receptor A.(progesterone receptor A)
During early pregnancy mares had the same pattern of progesterone receptor in the endometrium as that reported for other mammals; namely, a loss of progesterone receptor from the endometrial epithelia but continued localization in stromal cells.
This gene encodes a member of the steroid receptor superfamily. The encoded protein mediates the physiological effects of progesterone, which plays a central role in reproductive events associated with the establishment and maintenance of pregnancy. This gene uses two distinct promotors and translation start sites in the first exon to produce two isoforms, A and B. The two isoforms are identical except for the additional 165 amino acids found in the N-terminus of isoform B and mediate their own response genes and physiologic effects with little overlap.
, progesterone receptor
, nuclear progesterone receptor Pgr
, nuclear receptor subfamily 3 group C member 3
, Nuclear receptor subfamily 3 group C member 3