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Human Retinoic Acid Receptor alpha ELISA Kit for Sandwich ELISA - ABIN417071
Johansson, Sanchez, Mundt, Forshed, Kovacs, Panizza, Hultin-Rosenberg, Lundgren, Martens, Máthé, Yakhini, Helou, Krawiec, Kanter, Hjerpe, Stål, Linderholm, Lehtiö: Retinoic acid receptor alpha is associated with tamoxifen resistance in breast cancer. in Nature communications 2013
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RARalpha regulates Arp2/3-mediated actin cytoskeletal dynamics through a non-genomic signaling pathway
It has been shown that the AP-1 (show FOSB ELISA Kits) family member JunB (show JUNB ELISA Kits) and retinoic acid receptor alpha (RARa) mediate catalase (show CAT ELISA Kits) transcriptional activation and repression, respectively, by controlling chromatin remodeling through a histone deacetylases-dependent mechanism.
Work identifies the TP53 (show TP53 ELISA Kits) tumor suppressor as a novel target through which NPM1 (show NPM1 ELISA Kits)-RARA impacts leukemogenesis.
Dual small interfering RNA (siRNA) silencing of RARalpha and RARgamma reversed RA blockade of P4-induced CK5 (show KRT5 ELISA Kits). Using promoter deletion analysis, we identified a region 1.1 kb upstream of the CK5 (show KRT5 ELISA Kits) transcriptional start site that is necessary for P4 activation and contains a putative progesterone response element (PRE
High RARA expression is associated with acute myeloid leukemia (show BCL11A ELISA Kits).
Data suggest that the binding of Z-10 to RXRalpha (show RXRA ELISA Kits) inhibited the interaction of RXRalpha (show RXRA ELISA Kits) with PML (show PML ELISA Kits)-RARalpha, leading to Z-10's selective induction of PML (show PML ELISA Kits)-RARalpha degradation.
PML (show PML ELISA Kits)-RARa bcr1 (show BCR ELISA Kits) fusion is not responsible for colorectal tumor development.
overexpression of NLS (show ALDH1A2 ELISA Kits)-RARalpha promoted the proliferation of APL (show FASL ELISA Kits) cells and inhibited their differentiation via the PI3K (show PIK3CA ELISA Kits)/AKT (show AKT1 ELISA Kits) signaling pathway.
r study demonstrated that ATRA cound promote differentiation while inhibit proliferation of acute promyelocytic leukemia (show PML ELISA Kits) NB4 cells via activating p38a (show MAPK14 ELISA Kits) protein after recruiting p38a (show MAPK14 ELISA Kits)-combinded NLS (show ALDH1A2 ELISA Kits)-RARa, while NLS (show ALDH1A2 ELISA Kits)-RARa could inhibit the effects of ATRA in the process.
Low expression of RARalpha was independently associated with worse progression-free survival following platinum-based chemotherapy of advanced Non-small cell lung cancer.
RARalpha competes with other PFN2a-binding proteins bearing PRMs and involved in actin filaments elongation. Consequently, the actin filament network is altered and MEFs adhesion is decreased. This novel role opens novel avenues for the understanding of pathologies characterized by increased levels of cytoplasmic RARalpha.
These data suggest that impairment of cardiac RARalpha signaling may be a novel mechanism that is directly linked to pathological stimuli-induced diastolic dysfunction.
Retinoic acid receptor alpha agonist all trans retinoic acid can protect the liver from ischemia reperfusion injury by promoting autophagy, which is dependent on Foxo3 (show FOXO3 ELISA Kits)/p-Akt (show AKT1 ELISA Kits)/Foxo1 (show FOXO1 ELISA Kits) signaling.
both the PML (show PML ELISA Kits)-RARA-driven competitive transplantation advantage and development of acute promyelocytic leukemia (show PML ELISA Kits) (APL (show FASL ELISA Kits)) required DNMT3A (show DNMT3A ELISA Kits)
the reprogramming of epiblast stem cells into embryonic stem cell-like cells also requires low levels of retinoic acid (RA), which can modulate Wnt (show WNT2 ELISA Kits) signalling through physical interactions of RARs (show RARS ELISA Kits) with beta-catenin (show CTNNB1 ELISA Kits).
our findings challenge the predominant model in the field and we propose that PML (show PML ELISA Kits)/RARA initiates leukemia by subtly shifting cell fate decisions within the promyelocyte compartment.
DNA-binding-defective PML (show PML ELISA Kits)/RARA mutants could not repress the transcription of retinoic acid regulated genes.
although X-RARA fusion proteins have been suggested to act by blocking retinoid-dependent transcriptional programs , we observed a surprising paucity of natural retinoids capable of transactivating Gal4 (show LGALS4 ELISA Kits)-RARA in primary mouse bone marrow cells
The results indicate a physiological role for RARgamma as a negative regulator of osteoclastogenesis in vivo and in vitro, and reveal distinct influences of RARalpha and RARgamma in bone structure regulation.
Data suggest that retinoic acid and GM-CSF (show CSF2 ELISA Kits)-induced retinal dehydrogenase 2 (RALDH2 (show ALDH1A2 ELISA Kits)) expression in dendritic cells requires cooperative binding of transcription factor Sp1 (show SP1 ELISA Kits) via the RA receptor/retinoid X receptor (show RXRB ELISA Kits) complex to the Aldh1a2 (show ALDH1A1 ELISA Kits) promoter.
Increased expression of mammary TRbeta1 (show THRB ELISA Kits) and DIO2 (show DIO2 ELISA Kits), and decreased RXRalpha (show RXRA ELISA Kits), provide a mechanism to increase thyroid hormone (show PTH ELISA Kits) activity within the mammary gland during lactation.
results show role for retinoic acid receptor (show RARB ELISA Kits) as a regulator of spatial patterning of the pre-placodal ectoderm (PPE)through Tbx1 and RIPPLY3; demonstrate that Ripply3, acting downstream of RAR (show RAB40B ELISA Kits) signaling, is key player in establishing boundaries in the PPE
This gene represents a nuclear retinoic acid receptor. The encoded protein, retinoic acid receptor alpha, regulates transcription in a ligand-dependent manner. This gene has been implicated in regulation of development, differentiation, apoptosis, granulopoeisis, and transcription of clock genes. Translocations between this locus and several other loci have been associated with acute promyelocytic leukemia. Alternatively spliced transcript variants have been found for this locus.
retinoic acid receptor alpha
, retinoic acid receptor, alpha
, retinoic acid receptor alpha-like
, nuclear receptor subfamily 1 group B member 1
, nucleophosmin-retinoic acid receptor alpha fusion protein NPM-RAR long form
, retinoic acid nuclear receptor alpha variant 1
, retinoic acid nuclear receptor alpha variant 2
, retinoic acid receptor, alpha polypeptide
, RAR alpha 1
, rar alpha
, xRAR alpha
, retinoic acid receptor alpha 1 isoform