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mRNAs expression and methylation pattern of RARB, NR4A1 and HSD3B2 genes in human adrenal tissues (HAT) and in pediatric virilizing adrenocortical tumors (VAT) were analyzed.
RARb and FHIT promoter methylation may be associated with the carcinogenesis of cervical cancer. FHIT promoter methylation may play a crucial role in cervical cancer progression. Additional studies with large sample sizes are essential to confirm our findings.
Upregulation of RARB enhances the sensitivity of cholangiocarcinoma cells to chemotherapeutic agents in vitro.
Lack of RARbeta nuclear expression is associated with Non-small cell lung cancer development and associated with a worse prognosis.
methylated promoters of DAPK1 (show DAPK1 Proteins) combined with MGMT (show MGMT Proteins), MGMT (show MGMT Proteins) combined with RARB, DAPK1 (show DAPK1 Proteins) combined with RARB were positive correlated with cervical disease grade
Overexpression of miR (show MLXIP Proteins)-146a-5p and miR (show MLXIP Proteins)-146b-5p caused a 31% and 33% decrease in endogenous RARB mRNA levels.
shows that RAR-beta methylation detected in lung tissue may be used as a predictive marker for non-small cell lung cancer diagnosis and that APC (show APC Proteins) methylation in tumor sample may be a useful marker
RARbeta2 methylation is significantly increased in breast cancer samples when compared to non-cancerous controls
Whole-exome sequencing in a South American cohort links ALDH1A3, FOXN1 and RARB/retinoic acid regulation pathways to autism s (show ALDH1A3 Proteins)pectrum di (show FOXN1 Proteins)sorders.
Hypermethylation at promoters of RARB, Dietary folate and cobalamin intake is inversely associated with methylated RARB and BRCA1. High dietary intake of riboflavin and pyridoxine is associated with increased methylation in the RARB promoter.
the low expression of RARbeta, may induce the down regulation of p16(INK4a), chronic inflammation and decreased apoptosis and may be involved in vulnerability to HR-HPV and early stage cervical carcinogenesis.
Upregulation of Rarb increases the cytotoxic effect of 5-FU on xenografted cholangiocarcinoma tumors.
Results found that HPV16 E7 increases RARB mRNA and protein expression both in vitro and in the cervix of young K14E7 transgenic mice suggesting that RARB overexpression is part of the early molecular events induced by the E7 oncoprotein.
Chromatin immunoprecipitation assay using RarB as the immunoprecipitation target suggests retinoic acid regulation of Aldh1a3 (show ALDH1A3 Proteins) and Foxn1 (show FOXN2 Proteins) in mice.
IL-15 (show IL15 Proteins) specifically down-regulates RARB expression, and RARB may play a protective role in lung injury caused by smoking or viral infections.
RARB hypermethylation was involved in the areca-associated oral carcinogenesis.
Report liver RAR-beta mediated response to retinoic acid.
Data indicate that all three retinoic acid receptor (show RARA Proteins) isoforms RARalha, RARbeta and RARgamma are expressed in naive CD8 (show CD8A Proteins)+ T cells, as well as CD8 (show CD8A Proteins)+ T cells activated for 48 or 72 h.
RARbeta is essential for differentiation of ES cells to pancreatic endocrine cells.
Retinoic acid receptor beta stimulates hepatic induction of fibroblast growth factor 21 (show FGF21 Proteins) to promote fatty acid oxidation and control whole-body energy homeostasis in mice.
This gene encodes retinoic acid receptor beta, a member of the thyroid-steroid hormone receptor superfamily of nuclear transcriptional regulators. This receptor localizes to the cytoplasm and to subnuclear compartments. It binds retinoic acid, the biologically active form of vitamin A which mediates cellular signalling in embryonic morphogenesis, cell growth and differentiation. It is thought that this protein limits growth of many cell types by regulating gene expression. The gene was first identified in a hepatocellular carcinoma where it flanks a hepatitis B virus integration site. The gene expresses at least two transcript variants\; one additional transcript has been described, but its full length nature has not been determined.
retinoic acid receptor, beta
, retinoic acid receptor beta
, retinoic acid receptor beta-like
, HBV-activated protein
, hepatitis B virus activated protein
, nuclear receptor subfamily 1 group B member 2
, retinoic acid receptor beta 2
, retinoic acid receptor beta 4
, retinoic acid receptor beta 5
, retinoic acid receptor beta variant 1
, retinoic acid receptor beta variant 2
, retinoic acid receptor, beta polypeptide
, RAR beta 2
, retinoic acid receptor beta 1/ beta 3
, retinoic acid receptor beta4'
, retinoic acid receptor-beta