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anti-Human THRA Antibodies:
anti-Rat (Rattus) THRA Antibodies:
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Human Polyclonal THRA Primary Antibody for IF (p), IHC (p) - ABIN715946
Sun, Yang, Luo, Wang, Chen, Zhang, Wang, Li: Thyroid hormone inhibits the proliferation of piglet Sertoli cell via PI3K signaling pathway. in Theriogenology 2014
Human Polyclonal THRA Primary Antibody for IHC, ELISA - ABIN1579928
Wang, Wei, Guan, Xue: Triiodothyronine regulates distribution of thyroid hormone receptors by activating AMP-activated protein kinase in 3T3-L1 adipocytes and induces uncoupling protein-1 expression. in Molecular and cellular biochemistry 2014
Human Polyclonal THRA Primary Antibody for ELISA, WB - ABIN261110
Nishiyama, Baba, Yamada, Matsushita, Natsume, Nakano, Sasaki, Nakamura: Embryonic lethal effect of expressing a dominant negative mutant human thyroid hormone receptor alpha1 in mice. in Endocrine journal 2003
Cow (Bovine) Polyclonal THRA Primary Antibody for WB - ABIN2776019
Kiss-Toth, Harlock, Lath, Quertermous, Wilkinson: A TNF variant that associates with susceptibility to musculoskeletal disease modulates thyroid hormone receptor binding to control promoter activation. in PLoS ONE 2013
We found that the thyroid hormone receptor (TRalpha 3) has a differential expression profile. Thyroid hormone (show PTH Antibodies) is critical for normal brain development. Our results showed that there is a possible link between IGF1 (show IGF1 Antibodies)/IGF1R (show IGF1R Antibodies) and the TRalpha 3 and that over expression of IGF1R (show IGF1R Antibodies) in RTT cells may be the cause of neurites improvement in neural RTT-derived neurons.
Downregulation of NR1D1 (show NR1D1 Antibodies) in MCF7 cells resulted in resistance to doxorubicin, both in vitro and in vivo Analysis of four public patient data sets indicated that NR1D1 (show NR1D1 Antibodies) expression correlates positively with clinical outcome in breast cancer patients who received chemotherapy. Our findings suggest that NR1D1 (show NR1D1 Antibodies) and its ligands provide therapeutic options that could enhance the outcomes of chemotherapy in breast cancer patients
THRA predominates in multipotent human adipose derived stem cells (hADSC) whereas THRB (show THRB Antibodies) is expressed at lower levels and is upregulated during hADSC differentiation.
Highly quantitative fluorescence anisotropy assays in competition mode revealed that the rev-erbA-alpha (show NR1D1 Antibodies) specificity for the NCoR (show NCOR1 Antibodies) corepressor lies in the first two residues of the beta-strand in Interaction Domain 1 of NCoR (show NCOR1 Antibodies).
8 different THRA gene abnormalities have been described in 14 patients from 9 families with phenotypes including short stature, dysmorphic syndrome, psychoneuromotor disorders, constipation and bradycardia. Review.
Data show that ubiquitin E3 ligase Siah2 (show SIAH2 Antibodies) depletion delays circadian degradation of nuclear hormone receptor (show NR0B1 Antibodies) RevErbalpha (Nr1d1 (show NR1D1 Antibodies)) and lengthens period length.
The current study aimed to investigate whether TRs may be specifically expressed in BRCA1 associated cancer cases.
the role of NR1D1 (show NR1D1 Antibodies) polymorphisms in the regulation of Nuclear receptor REV-ERBalpha (show NR1D1 Antibodies) and circadian rhythms regulation
associations between NR1D1 (show NR1D1 Antibodies), RORA (show RORA Antibodies) and RORB (show RORB Antibodies) genes and bipolar disorder.(
CRY2 (show CRY2 Antibodies) and REV-ERB ALPHA (show NR1D1 Antibodies) as the clock genes upregulated in obesity during the 24 h period and that REV-ERB ALPHA (show NR1D1 Antibodies) is an important gene associated with MS.
the Gata-1 (show GATA1 Antibodies) gene was a T3-directly regulated gene and that TRa1PV could impair erythropoiesis via repression of the Gata-1 (show GATA1 Antibodies) gene and its regulated genes. These results provide new insights into how TRa1 (show HSP90B1 Antibodies) mutants acted to cause erythroid abnormalities in patients with mutations of the THRA gene.
Using domain exchanges and individual amino acid switches between THRA1 and THRB2 (show THRB Antibodies), three amino acids were identified in helix 10 of the THRB2 (show THRB Antibodies) ligand-binding domain that are required for negative regulation and are absent in THRA1.
Data suggest a novel role for THRbeta1 in secondary ossification at the epiphysis that involves transcriptional upregulation of Ihh (show IHH Antibodies) gene.
Hippocampal transcriptome profile of persistent memory rescue in a mouse model of Thra1 mutation-mediated resistance to thyroid hormone (show PTH Antibodies) has been reported.
deletion of TRalpha (show GNAT1 Antibodies) in ApoE (show APOE Antibodies)(-/-) mice alters cardiac structure and contractility; both could contribute to blunted BP response to physical exercise and impaired exercise performance
Data (including data from studies in knockout mice) suggest mitochondrial T3Ralpha in brown adipose tissue is key to regulation of energy metabolism; knockout mice exhibit hypermetabolism/hyperphagia, but not cold intolerance/defective thermogenesis.
Data (including data from studies in mutant strains of mice) suggest Thra1 (but not Thrb (show THRB Antibodies)) plays role in myogenesis, cell proliferation, and resistance to T3 (triiodothyronine) in skeletal myoblasts; Thra1 promotes muscle regeneration after injury.
In thyroid receptor-deficient mice, hair follicle stem cells present a clear defect in their mobilization (exit of their quiescent state and migration out of the niche), associated with increased activation of Smad (show SMAD1 Antibodies) signaling.
regions of the Xenopus and mouse Klf9 (show KLF9 Antibodies) genes 5-6 kb upstream of the transcription start sites that supported synergistic transactivation by TH plus GC.
Data show that TRbeta (show THRB Antibodies) deficiency causes dysfunction of the monoaminergic system, accompanied by epigenetic disruption during the brain maturation process.
Data provide evidence that zebrafish represents a valid model to study in vivo the thyroid hormone (show PTH Antibodies) (TH) action, and the molecular mechanisms underlying the two syndromes of TH resistance, RTHa and RTHb.
zebrafish uses both alternative splicing and differential expression of TRalpha genes to diversify the cellular response to thyroid hormones.
there is considerable evidence that TRalpha plays an important role in fat deposition in porcine adipose tissue.
Furthermore, molecular and transgenic studies have shown that unliganded TRalpha accomplishes these via the recruitment of histone deacetylase (HDAC (show HDAC1 Antibodies))-containing corepressor complexes to repress the expression of TH-inducible genes
Type 2 iodothyronine deiodinase (show DIO2 Antibodies) activity is required for the death of thyroid hormone receptor (TRalpha)-transfected tail muscle cells induced by a low level of thyroid hormone (show PTH Antibodies).
Data provide in vivo evidence for targeted recruitment of N-CoR/SMRT-TBLR1 (show TBL1XR1 Antibodies) complexes by unliganded thyroid hormone (show PTH Antibodies) receptors in transcriptional repression during vertebrate development.
Data show that thyroid hormone (show PTH Antibodies) receptors directly mediate the developmental effects of thyroid hormone (show PTH Antibodies) in individual organs by regulating target gene expression in these organs.
investigated the role of steroid receptor coactivator (show SRA1 Antibodies) 3 (SRC3 (show NCOA3 Antibodies)) in gene activation by thyroid hormone receptor (TR) in vivo during development
Binding of liganded thyroid hormnone receptor to the target promoter is reduced when arginine methyltransferase 1 (show DNMT1 Antibodies) was overexpressed, accompanied by a slight reduction in histone methylation.
PRMT1 functions transiently as a coactivator in thyroid hormone (show PTH Antibodies) (T3) receptor (TR)-mediated transcription by enhancing TR-T3 response element binding and further suggest that PRMT1 has tissue-specific roles in regulating the rate of metamorphosis.
T(3) acts to induce cell proliferation in the tadpole brain predominantly, if not exclusively, via TRalpha.
The protein encoded by this gene is a nuclear hormone receptor for triiodothyronine. It is one of the several receptors for thyroid hormone, and has been shown to mediate the biological activities of thyroid hormone. Knockout studies in mice suggest that the different receptors, while having certain extent of redundancy, may mediate different functions of thyroid hormone. Alternatively spliced transcript variants encoding distinct isoforms have been reported.
, V-erbA-related protein 1
, nuclear receptor Rev-ErbA-alpha
, nuclear receptor subfamily 1 group D member 1
, Thyroid hormone receptor alpha 1 (avian erythroblastic leukemia viral (v-erb-a) oncogene homolog 1 formerly ERBA1)
, avian erythroblastic leukemia viral (v-erb-a) oncogene homolog 1
, c-erb-A thyroid hormone receptor
, nuclear receptor subfamily 1 group A member 1
, TR alpha 1
, TR alpha 2
, nuclear receptor subfamily 1 group A member 1-A
, thyroid hormone receptor alpha 1
, thyroid hormone receptor alpha-1
, thyroid hormone receptor alpha-A
, TR beta
, nuclear receptor subfamily 1 group A member 2
, ERBA-related 7
, V-erbA-related protein 7
, thyroid hormone receptor alpha
, thyroid hormone receptor, alpha (erythroblastic leukemia viral (v-erb-a) oncogene homolog, avian)
, thyroid normone nuclear receptor alpha variant 1
, triiodothyronine receptor
, thyroid hormone receptor alpha2
, thyroid hormone receptor alpha 2
, c-erb-A protein
, thyroid hormone receptor alpha1
, thyroid hormone receptor, alpha (erythroblastic leukemia viral (v-erb-a) oncogene homolog)
, thyroid hormone receptor beta2
, thyroid hormone receptor, beta (erythroblastic leukemia viral (v-erb-a) oncogene homolog 2, avian)