Browse our THRA Proteins (THRA)

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Thyroid Hormone Receptor, alpha Proteins (THRA)
On are 20 Thyroid Hormone Receptor, alpha (THRA) Proteins from 5 different suppliers available. Additionally we are shipping THRA Antibodies (122) and THRA Kits (29) and many more products for this protein. A total of 178 THRA products are currently listed.
6430529J03Rik, AR7, AW259572, c-erba, c-ERBA-1, C-ERBA-ALPHA, C-ERBA ALPHA1, c-erbAbeta, CHNG6, ear-1, EAR1, EAR7, ERB-T-1, erba, ERBA1, hRev, NR1A1, nr1a1-A, Nr1a2, Rvr, T3Ralpha, T3Rbeta, T3R[a], T3R[b], THR, thra, thra-A, thra1, THRA2, thral, Thrb1, Thrb2, tra, tra1, TRalpha, TR[a]1, wu:fb59g07
list all proteins Gene Name GeneID UniProt
THRA 9572 P20393
THRA 81812 P63059
THRA 21833 P63058

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THRA Proteins (THRA) by Origin

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Human Thyroid Hormone Receptor, alpha (THRA) interaction partners

  1. THRA predominates in multipotent human adipose derived stem cells (hADSC) whereas THRB (show THRB Proteins) is expressed at lower levels and is upregulated during hADSC differentiation.

  2. Highly quantitative fluorescence anisotropy assays in competition mode revealed that the rev-erbA-alpha (show NR1D1 Proteins) specificity for the NCoR (show NCOR1 Proteins) corepressor lies in the first two residues of the beta-strand in Interaction Domain 1 of NCoR (show NCOR1 Proteins).

  3. 8 different THRA gene abnormalities have been described in 14 patients from 9 families with phenotypes including short stature, dysmorphic syndrome, psychoneuromotor disorders, constipation and bradycardia. Review.

  4. Data show that ubiquitin E3 ligase Siah2 (show SIAH2 Proteins) depletion delays circadian degradation of nuclear hormone receptor (show NR0B1 Proteins) RevErbalpha (Nr1d1 (show NR1D1 Proteins)) and lengthens period length.

  5. The current study aimed to investigate whether TRs may be specifically expressed in BRCA1 associated cancer cases.

  6. the role of NR1D1 (show NR1D1 Proteins) polymorphisms in the regulation of Nuclear receptor REV-ERBalpha (show NR1D1 Proteins) and circadian rhythms regulation

  7. associations between NR1D1 (show NR1D1 Proteins), RORA (show RORA Proteins) and RORB (show RORB Proteins) genes and bipolar disorder.(

  8. CRY2 (show CRY2 Proteins) and REV-ERB ALPHA (show NR1D1 Proteins) as the clock genes upregulated in obesity during the 24 h period and that REV-ERB ALPHA (show NR1D1 Proteins) is an important gene associated with MS.

  9. THRA mutations may be more common than expected. In patients with clinical symptoms of mild hypothyreosis without confirmation in endocrine studies, a molecular study of THRA defects is strongly recommended.

  10. Thyroid hormone receptor (TRalpha1) is shown to occur and determine postischemic remodeling and cardiac recovery depending on the availability of TH. [review]

Mouse (Murine) Thyroid Hormone Receptor, alpha (THRA) interaction partners

  1. Data suggest a novel role for THRbeta1 in secondary ossification at the epiphysis that involves transcriptional upregulation of Ihh (show IHH Proteins) gene.

  2. Hippocampal transcriptome profile of persistent memory rescue in a mouse model of Thra1 mutation-mediated resistance to thyroid hormone (show PTH Proteins) has been reported.

  3. deletion of TRalpha (show GNAT1 Proteins) in ApoE (show APOE Proteins)(-/-) mice alters cardiac structure and contractility; both could contribute to blunted BP response to physical exercise and impaired exercise performance

  4. Data (including data from studies in knockout mice) suggest mitochondrial T3Ralpha in brown adipose tissue is key to regulation of energy metabolism; knockout mice exhibit hypermetabolism/hyperphagia, but not cold intolerance/defective thermogenesis.

  5. Data (including data from studies in mutant strains of mice) suggest Thra1 (but not Thrb (show THRB Proteins)) plays role in myogenesis, cell proliferation, and resistance to T3 (triiodothyronine) in skeletal myoblasts; Thra1 promotes muscle regeneration after injury.

  6. In thyroid receptor-deficient mice, hair follicle stem cells present a clear defect in their mobilization (exit of their quiescent state and migration out of the niche), associated with increased activation of Smad (show SMAD1 Proteins) signaling.

  7. regions of the Xenopus and mouse Klf9 (show KLF9 Proteins) genes 5-6 kb upstream of the transcription start sites that supported synergistic transactivation by TH plus GC.

  8. Data show that TRbeta (show THRB Proteins) deficiency causes dysfunction of the monoaminergic system, accompanied by epigenetic disruption during the brain maturation process.

  9. Results suggest mutually shared roles for thyroid hormone receptor beta (show THRB Proteins) isoforms TRbeta1 (show THRB Proteins) and TRbeta2 in cochlear development.

  10. These results indicate that postnatal exposure to a low dose of decaBDE on PNDs 1 through 5 lowers the testosterone level and the levels of Ar and Thra transcripts in Sertoli cells, accompanied by an imbalance in the ratios of Thra splicing variants

Zebrafish Thyroid Hormone Receptor, alpha (THRA) interaction partners

  1. Data provide evidence that zebrafish represents a valid model to study in vivo the thyroid hormone (show PTH Proteins) (TH) action, and the molecular mechanisms underlying the two syndromes of TH resistance, RTHa and RTHb.

  2. zebrafish uses both alternative splicing and differential expression of TRalpha genes to diversify the cellular response to thyroid hormones.

Pig (Porcine) Thyroid Hormone Receptor, alpha (THRA) interaction partners

  1. there is considerable evidence that TRalpha plays an important role in fat deposition in porcine adipose tissue.

Xenopus laevis Thyroid Hormone Receptor, alpha (THRA) interaction partners

  1. Furthermore, molecular and transgenic studies have shown that unliganded TRalpha accomplishes these via the recruitment of histone deacetylase (HDAC (show HDAC1 Proteins))-containing corepressor complexes to repress the expression of TH-inducible genes

  2. regions of the Xenopus and mouse Klf9 (show KLF9 Proteins) genes 5-6 kb upstream of the transcription start sites that supported synergistic transactivation by TH plus GC.

  3. Type 2 iodothyronine deiodinase (show DIO2 Proteins) activity is required for the death of thyroid hormone receptor (TRalpha)-transfected tail muscle cells induced by a low level of thyroid hormone (show PTH Proteins).

  4. Data provide in vivo evidence for targeted recruitment of N-CoR/SMRT-TBLR1 (show TBL1XR1 Proteins) complexes by unliganded thyroid hormone (show PTH Proteins) receptors in transcriptional repression during vertebrate development.

  5. Data show that thyroid hormone (show PTH Proteins) receptors directly mediate the developmental effects of thyroid hormone (show PTH Proteins) in individual organs by regulating target gene expression in these organs.

  6. investigated the role of steroid receptor coactivator (show SRA1 Proteins) 3 (SRC3 (show NCOA3 Proteins)) in gene activation by thyroid hormone receptor (TR) in vivo during development

  7. Binding of liganded thyroid hormnone receptor to the target promoter is reduced when arginine methyltransferase 1 (show DNMT1 Proteins) was overexpressed, accompanied by a slight reduction in histone methylation.

  8. PRMT1 functions transiently as a coactivator in thyroid hormone (show PTH Proteins) (T3) receptor (TR)-mediated transcription by enhancing TR-T3 response element binding and further suggest that PRMT1 has tissue-specific roles in regulating the rate of metamorphosis.

  9. T(3) acts to induce cell proliferation in the tadpole brain predominantly, if not exclusively, via TRalpha.

THRA Protein Profile

Protein Summary

The protein encoded by this gene is a nuclear hormone receptor for triiodothyronine. It is one of the several receptors for thyroid hormone, and has been shown to mediate the biological activities of thyroid hormone. Knockout studies in mice suggest that the different receptors, while having certain extent of redundancy, may mediate different functions of thyroid hormone. Alternatively spliced transcript variants encoding distinct isoforms have been reported.

Alternative names and synonyms associated with THRA

  • nuclear receptor subfamily 1, group D, member 1 (NR1D1)
  • thyroid hormone receptor alpha (Thra)
  • thyroid hormone receptor alpha (tr-alpha)
  • thyroid hormone receptor alpha a (thraa)
  • thyroid hormone receptor beta (Thrb)
  • thyroid hormone receptor, alpha (THRA)
  • thyroid hormone receptor, alpha (Thra)
  • thyroid hormone receptor, alpha (thra)
  • thyroid hormone receptor, beta (THRB)
  • 6430529J03Rik protein
  • AR7 protein
  • AW259572 protein
  • c-erba protein
  • c-ERBA-1 protein
  • C-ERBA-ALPHA protein
  • C-ERBA ALPHA1 protein
  • c-erbAbeta protein
  • CHNG6 protein
  • ear-1 protein
  • EAR1 protein
  • EAR7 protein
  • ERB-T-1 protein
  • erba protein
  • ERBA1 protein
  • hRev protein
  • NR1A1 protein
  • nr1a1-A protein
  • Nr1a2 protein
  • Rvr protein
  • T3Ralpha protein
  • T3Rbeta protein
  • T3R[a] protein
  • T3R[b] protein
  • THR protein
  • thra protein
  • thra-A protein
  • thra1 protein
  • THRA2 protein
  • thral protein
  • Thrb1 protein
  • Thrb2 protein
  • tra protein
  • tra1 protein
  • TRalpha protein
  • TR[a]1 protein
  • wu:fb59g07 protein

Protein level used designations for THRA

Rev-ErbAalpha , V-erbA-related protein 1 , nuclear receptor Rev-ErbA-alpha , nuclear receptor subfamily 1 group D member 1 , rev-erbA-alpha , C-erbA-alpha , Thyroid hormone receptor alpha 1 (avian erythroblastic leukemia viral (v-erb-a) oncogene homolog 1 formerly ERBA1) , avian erythroblastic leukemia viral (v-erb-a) oncogene homolog 1 , c-erb-A thyroid hormone receptor , c-erbA-1 , c-erbA-alpha2 , nuclear receptor subfamily 1 group A member 1 , TR alpha 1 , TR alpha 2 , c-erbA-alpha , c-erbAalpha , NR1A1-A , TRalpha-1 , c-erbA , nuclear receptor subfamily 1 group A member 1-A , thyroid hormone receptor alpha 1 , thyroid hormone receptor alpha-1 , thyroid hormone receptor alpha-A , zTRalpha-A , TR beta , c-erbA-2 , c-erbA-beta , nuclear receptor subfamily 1 group A member 2 , EAR-7 , ERBA-related 7 , V-erbA-related protein 7 , thyroid hormone receptor alpha , thyroid hormone receptor, alpha (erythroblastic leukemia viral (v-erb-a) oncogene homolog, avian) , thyroid normone nuclear receptor alpha variant 1 , triiodothyronine receptor , thyroid hormone receptor alpha2 , thyroid hormone receptor alpha 2 , c-erb-A protein , thyroid hormone receptor alpha1 , TRalphaA , thyroid hormone receptor, alpha (erythroblastic leukemia viral (v-erb-a) oncogene homolog) , xenTR-alpha1 , thyroid hormone receptor beta2 , thyroid hormone receptor, beta (erythroblastic leukemia viral (v-erb-a) oncogene homolog 2, avian)

9572 Homo sapiens
81812 Rattus norvegicus
21833 Mus musculus
100136523 Salmo salar
30670 Danio rerio
21834 Mus musculus
7067 Homo sapiens
403601 Canis lupus familiaris
397387 Sus scrofa
532621 Bos taurus
396251 Gallus gallus
100303772 Oryctolagus cuniculus
100726737 Cavia porcellus
443446 Ovis aries
397942 Xenopus laevis
403599 Canis lupus familiaris
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