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We found that the thyroid hormone receptor (TRalpha 3) has a differential expression profile. Thyroid hormone (show PTH Proteins) is critical for normal brain development. Our results showed that there is a possible link between IGF1 (show IGF1 Proteins)/IGF1R (show IGF1R Proteins) and the TRalpha 3 and that over expression of IGF1R (show IGF1R Proteins) in RTT cells may be the cause of neurites improvement in neural RTT-derived neurons.
Downregulation of NR1D1 (show NR1D1 Proteins) in MCF7 cells resulted in resistance to doxorubicin, both in vitro and in vivo Analysis of four public patient data sets indicated that NR1D1 (show NR1D1 Proteins) expression correlates positively with clinical outcome in breast cancer patients who received chemotherapy. Our findings suggest that NR1D1 (show NR1D1 Proteins) and its ligands provide therapeutic options that could enhance the outcomes of chemotherapy in breast cancer patients
THRA predominates in multipotent human adipose derived stem cells (hADSC) whereas THRB (show THRB Proteins) is expressed at lower levels and is upregulated during hADSC differentiation.
Highly quantitative fluorescence anisotropy assays in competition mode revealed that the rev-erbA-alpha (show NR1D1 Proteins) specificity for the NCoR (show NCOR1 Proteins) corepressor lies in the first two residues of the beta-strand in Interaction Domain 1 of NCoR (show NCOR1 Proteins).
8 different THRA gene abnormalities have been described in 14 patients from 9 families with phenotypes including short stature, dysmorphic syndrome, psychoneuromotor disorders, constipation and bradycardia. Review.
Data show that ubiquitin E3 ligase Siah2 (show SIAH2 Proteins) depletion delays circadian degradation of nuclear hormone receptor (show NR0B1 Proteins) RevErbalpha (Nr1d1 (show NR1D1 Proteins)) and lengthens period length.
The current study aimed to investigate whether TRs may be specifically expressed in BRCA1 associated cancer cases.
the role of NR1D1 (show NR1D1 Proteins) polymorphisms in the regulation of Nuclear receptor REV-ERBalpha (show NR1D1 Proteins) and circadian rhythms regulation
associations between NR1D1 (show NR1D1 Proteins), RORA (show RORA Proteins) and RORB (show RORB Proteins) genes and bipolar disorder.(
CRY2 (show CRY2 Proteins) and REV-ERB ALPHA (show NR1D1 Proteins) as the clock genes upregulated in obesity during the 24 h period and that REV-ERB ALPHA (show NR1D1 Proteins) is an important gene associated with MS.
the Gata-1 (show GATA1 Proteins) gene was a T3-directly regulated gene and that TRa1PV could impair erythropoiesis via repression of the Gata-1 (show GATA1 Proteins) gene and its regulated genes. These results provide new insights into how TRa1 (show HSP90B1 Proteins) mutants acted to cause erythroid abnormalities in patients with mutations of the THRA gene.
Using domain exchanges and individual amino acid switches between THRA1 and THRB2 (show THRB Proteins), three amino acids were identified in helix 10 of the THRB2 (show THRB Proteins) ligand-binding domain that are required for negative regulation and are absent in THRA1.
Data suggest a novel role for THRbeta1 in secondary ossification at the epiphysis that involves transcriptional upregulation of Ihh (show IHH Proteins) gene.
Hippocampal transcriptome profile of persistent memory rescue in a mouse model of Thra1 mutation-mediated resistance to thyroid hormone (show PTH Proteins) has been reported.
deletion of TRalpha (show GNAT1 Proteins) in ApoE (show APOE Proteins)(-/-) mice alters cardiac structure and contractility; both could contribute to blunted BP response to physical exercise and impaired exercise performance
Data (including data from studies in knockout mice) suggest mitochondrial T3Ralpha in brown adipose tissue is key to regulation of energy metabolism; knockout mice exhibit hypermetabolism/hyperphagia, but not cold intolerance/defective thermogenesis.
Data (including data from studies in mutant strains of mice) suggest Thra1 (but not Thrb (show THRB Proteins)) plays role in myogenesis, cell proliferation, and resistance to T3 (triiodothyronine) in skeletal myoblasts; Thra1 promotes muscle regeneration after injury.
In thyroid receptor-deficient mice, hair follicle stem cells present a clear defect in their mobilization (exit of their quiescent state and migration out of the niche), associated with increased activation of Smad (show SMAD1 Proteins) signaling.
regions of the Xenopus and mouse Klf9 (show KLF9 Proteins) genes 5-6 kb upstream of the transcription start sites that supported synergistic transactivation by TH plus GC.
Data show that TRbeta (show THRB Proteins) deficiency causes dysfunction of the monoaminergic system, accompanied by epigenetic disruption during the brain maturation process.
Data provide evidence that zebrafish represents a valid model to study in vivo the thyroid hormone (show PTH Proteins) (TH) action, and the molecular mechanisms underlying the two syndromes of TH resistance, RTHa and RTHb.
zebrafish uses both alternative splicing and differential expression of TRalpha genes to diversify the cellular response to thyroid hormones.
there is considerable evidence that TRalpha plays an important role in fat deposition in porcine adipose tissue.
Furthermore, molecular and transgenic studies have shown that unliganded TRalpha accomplishes these via the recruitment of histone deacetylase (HDAC (show HDAC1 Proteins))-containing corepressor complexes to repress the expression of TH-inducible genes
Type 2 iodothyronine deiodinase (show DIO2 Proteins) activity is required for the death of thyroid hormone receptor (TRalpha)-transfected tail muscle cells induced by a low level of thyroid hormone (show PTH Proteins).
Data provide in vivo evidence for targeted recruitment of N-CoR/SMRT-TBLR1 (show TBL1XR1 Proteins) complexes by unliganded thyroid hormone (show PTH Proteins) receptors in transcriptional repression during vertebrate development.
Data show that thyroid hormone (show PTH Proteins) receptors directly mediate the developmental effects of thyroid hormone (show PTH Proteins) in individual organs by regulating target gene expression in these organs.
investigated the role of steroid receptor coactivator (show SRA1 Proteins) 3 (SRC3 (show NCOA3 Proteins)) in gene activation by thyroid hormone receptor (TR) in vivo during development
Binding of liganded thyroid hormnone receptor to the target promoter is reduced when arginine methyltransferase 1 (show DNMT1 Proteins) was overexpressed, accompanied by a slight reduction in histone methylation.
PRMT1 functions transiently as a coactivator in thyroid hormone (show PTH Proteins) (T3) receptor (TR)-mediated transcription by enhancing TR-T3 response element binding and further suggest that PRMT1 has tissue-specific roles in regulating the rate of metamorphosis.
T(3) acts to induce cell proliferation in the tadpole brain predominantly, if not exclusively, via TRalpha.
The protein encoded by this gene is a nuclear hormone receptor for triiodothyronine. It is one of the several receptors for thyroid hormone, and has been shown to mediate the biological activities of thyroid hormone. Knockout studies in mice suggest that the different receptors, while having certain extent of redundancy, may mediate different functions of thyroid hormone. Alternatively spliced transcript variants encoding distinct isoforms have been reported.
, V-erbA-related protein 1
, nuclear receptor Rev-ErbA-alpha
, nuclear receptor subfamily 1 group D member 1
, Thyroid hormone receptor alpha 1 (avian erythroblastic leukemia viral (v-erb-a) oncogene homolog 1 formerly ERBA1)
, avian erythroblastic leukemia viral (v-erb-a) oncogene homolog 1
, c-erb-A thyroid hormone receptor
, nuclear receptor subfamily 1 group A member 1
, TR alpha 1
, TR alpha 2
, nuclear receptor subfamily 1 group A member 1-A
, thyroid hormone receptor alpha 1
, thyroid hormone receptor alpha-1
, thyroid hormone receptor alpha-A
, TR beta
, nuclear receptor subfamily 1 group A member 2
, ERBA-related 7
, V-erbA-related protein 7
, thyroid hormone receptor alpha
, thyroid hormone receptor, alpha (erythroblastic leukemia viral (v-erb-a) oncogene homolog, avian)
, thyroid normone nuclear receptor alpha variant 1
, triiodothyronine receptor
, thyroid hormone receptor alpha2
, thyroid hormone receptor alpha 2
, c-erb-A protein
, thyroid hormone receptor alpha1
, thyroid hormone receptor, alpha (erythroblastic leukemia viral (v-erb-a) oncogene homolog)
, thyroid hormone receptor beta2
, thyroid hormone receptor, beta (erythroblastic leukemia viral (v-erb-a) oncogene homolog 2, avian)