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Browse our ATM Proteins (ATM)

Full name:
Ataxia Telangiectasia Mutated Proteins (ATM)
On www.antibodies-online.com are 5 Ataxia Telangiectasia Mutated (ATM) Proteins from 3 different suppliers available. Additionally we are shipping ATM Antibodies (343) and ATM Kits (45) and many more products for this protein. A total of 407 ATM products are currently listed.
Synonyms:
AI256621, AT1, ATA, ATC, ATD, ATDC, ATE, atm, atm/tefu, C030026E19Rik, CG6535, dATM, Dmel\\CG6535, tef, Tefu, TEL1, TELO1, Xatm
list all proteins Gene Name GeneID UniProt
ATM 472 Q13315
Rat ATM ATM 300711  
ATM 11920 Q62388

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ATM Proteins (ATM) by Origin

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More Proteins for ATM Interaction Partners

Fruit Fly (Drosophila melanogaster) Ataxia Telangiectasia Mutated (ATM) interaction partners

  1. our data indicate that ATR and ATM are both needed for intestinal stem cell maintenance and proliferation; ATR seems to play a bigger role than does ATM.

  2. TCTP (show TPT1 Proteins) has a role in regulating ATM activity to control genome stability and organ development in Drosophila melanogaster

  3. A stringent requirement for the conserved function of Ataxia Telangiectasia Mutated (ATM) in telomere protection during early embryonic development, is identified.

  4. ATM is primarily required for the meiotic DSB repair response, which includes functions in DNA damage repair and negative feedback control over the level of programmed DSBs during meiosis.

  5. Molecular genetic characterization of Drosophila ATM conserved functional domains.

  6. ATM checkpoint kinase plays a role in telomere maintenance that is independent of telomerase regulation.

  7. Drosophila ATM and Mre11 (show MRE11A Proteins) are essential for the G2/M checkpoint induced by low-dose irradiation.

  8. Results suggest that ATM and ATR protect telomere integrity by safeguarding chromatin architecture that favors the loading of telomere-elongating, capping, and silencing proteins.

Xenopus laevis Ataxia Telangiectasia Mutated (ATM) interaction partners

  1. Dna2 co-localizes in foci with RPA (show RPA1 Proteins) and is found in a complex with replication fork components And-1 and Mcm10 (show MCM10 Proteins). Dna2 interacts with the DSB repair and checkpoint proteins Nbs1 (show NLRP2 Proteins) and ATM.

  2. ATM and ATR prevent accumulation of chromosomal abnormalities by promoting Mre11 (show MRE11A Proteins)/Rad50 (show RAD50 Proteins)/Nbs1 (show NLRP2 Proteins) dependent recovery of collapsed replication forks.

  3. ATM and ATR phosphorylate the functionally critical replication protein Mcm2 (show MCM2 Proteins) during both DNA damage and replication checkpoint responses in Xenopus egg extracts

  4. PP2A counteracts ATM and ATR in a DNA damage checkpoint in Xenopus egg extracts

  5. Data show that ATM (ataxia-telangiectasia mutated) regulates Xenopus TopBP1 (show TOPBP1 Proteins) by phosphorylating serine 1131 and thereby strongly enhancing association of TopBP1 (show TOPBP1 Proteins) with ATR(ATM and Rad3-related).

  6. ATM and ATR control mitotic events in vertebrate cells by targeting CEP63 (show CEP63 Proteins) and centrosome dependent spindle assembly.

  7. These findings suggest that the MRN complex is a crucial mediator in the process whereby ATM promotes the TopBP1 (show TOPBP1 Proteins)-dependent activation of ATR-ATRIP (show ATRIP Proteins) in response to double-stranded DNA breaks.

  8. The Fanconi anemia protein FANCM is controlled by FANCD2 and the ATR/ATM pathways.

Zebrafish Ataxia Telangiectasia Mutated (ATM) interaction partners

  1. molecular cloning of the coding sequence of the catalytic domain of the zebrafish homologue of ATM

  2. Characterization of ataxia (show USP14 Proteins) telangiectasia protein.

Human Ataxia Telangiectasia Mutated (ATM) interaction partners

  1. the cumulative risk of Breast Cancer in heterozygous ATM mutation carriers to be 6.02% by 50 years of age (95% credible interval: 4.58-7.42%) and 32.83% by 80 years of age (95% credible interval: 24.55-40.43%) (Meta-Analysis)

  2. ATM mutation is associated with sarcoma.

  3. ATM induces MacroD2 (show MACROD2 Proteins) nuclear export upon DNA damage.

  4. TRAF6 (show TRAF6 Proteins) and H2AX (show H2AFX Proteins) overexpression and gammaH2AX (show H2AFX Proteins)-mediated HIF1alpha (show HIF1A Proteins) enrichment in the nucleus of cancer cells lead to overactivation of HIF1alpha (show HIF1A Proteins)-driven tumorigenesis, glycolysis and metastasis.

  5. ATM mutation carriers have a reduced life expectancy because of mortality from cancer and ischemic heart diseases, and an increased risk of developing cancer, in particular, breast cancer and cancers of the digestive tract. (Meta-analysis)

  6. The bocavirus large viral nonstructural protein NS1 (show PTPN11 Proteins) is sufficient to induce the DNA damage response and the activation of the host ATM, ATR (show ANTXR1 Proteins), and DNAPK (show PRKDC Proteins).

  7. This study establishes TRIM29 (show TRIM29 Proteins) as a hypoxia-induced tumor suppressor gene and provides a novel molecular mechanism for ATM-dependent breast cancer suppression.

  8. findings underscore the importance of a mitophagy regulatory network of ATM and PINK1 (show PINK1 Proteins)/Parkin (show PARK2 Proteins) and elucidate a novel mechanism by which ATM influences spermidine-induced mitophagy

  9. This study demonstrated that the significantly positive for Age x ATM activity but not Age x protein expression.

  10. We functionally validated several elements for metformin-induced promoter and enhancer activity. These include an enhancer in an ataxia telangiectasia mutated (ATM) intron that has SNPs in linkage disequilibrium .Using ChIP-seq and siRNA knockdown, we further show that activating transcription factor 3 (ATF3 (show ATF3 Proteins)), our top metformin upregulated AMPK (show PRKAA1 Proteins)-dependent gene, could have an important role in gluconeogenesis repression.

Pig (Porcine) Ataxia Telangiectasia Mutated (ATM) interaction partners

  1. Ataxia (show USP14 Proteins) telangiectasia (AT) is a progressive multisystem disorder caused by mutations in the AT-mutated (ATM) gene. We engineered a novel porcine model of AT

  2. ATM influenced the meiotic and cytoplasmic maturation of porcine oocytes.

  3. ATM plays critical role in arsenite induced G2/M phase arrest in aortic endothelial cells possibly via regulation of checkpoint signaling molecules.

Cow (Bovine) Ataxia Telangiectasia Mutated (ATM) interaction partners

  1. radiation-induced eNOS (show NOS3 Proteins) activation in bovine aortic endothelial cells is regulated by ATM and HSP90 (show HSP90 Proteins)

Mouse (Murine) Ataxia Telangiectasia Mutated (ATM) interaction partners

  1. TRAF6 (show TRAF6 Proteins) and H2AX (show H2AFX Proteins) overexpression and gammaH2AX (show H2AFX Proteins)-mediated HIF1alpha (show HIF1A Proteins) enrichment in the nucleus of cancer cells lead to overactivation of HIF1alpha (show HIF1A Proteins)-driven tumorigenesis, glycolysis and metastasis.

  2. These results reveal a new requirement for ATMIN (show ATMIN Proteins)-dependent ATM signaling in TP53 (show TP53 Proteins)-deficient glioblastoma multiforme, indicating a pro-tumorigenic role for ATM in the context of these tumors.

  3. results demonstrate that even low-dose IR results in ATM activation. In the absence of ATM, low-dose IR leads to increased inflammation, oxidative stress and lethality in the Atm-deficient mouse model.

  4. Findings indicate that miR (show MLXIP Proteins)-302b plays a relevant role in breast cancer cell response to cisplatin through the modulation of the E2F1 transcription factor (E2F1 (show E2F1 Proteins))/ataxia telangiectasia mutated protein (ATM) axis.

  5. study highlights using rodent models and human subjects, the critical role of ATM in microvascular repair in DR.

  6. Cerebellar astroglia isolated from Atm mutant mice show decreased expression of the cystine/glutamate (show GRIN1 Proteins) exchanger subunit xCT, glutathione reductase (show GSR Proteins), and glutathione-S-transferase (show GSTa2 Proteins)

  7. Authors generated an inducible Atm mutant mouse model (Atm(tm1Mmpl/tm1Mmpl), referred to as A-T [M]) predicted to express only the first 62 amino acids of Atm

  8. ATM-BID (show BID Proteins)-MTCH2 (show MTCH2 Proteins) pathway that we have identified plays a critical role in the DDR (show DDR1 Proteins) via regulation of mitochondrial metabolism.

  9. TRAX (show TSNAX Proteins) is required for DNA repair, by interacting with activated ATM and protects cells from genotoxic stress-induced apoptosis.

  10. ATM facilitates restriction of signal ends to the classical nonhomologous end-joining pathway.

ATM Protein Profile

Protein Summary

The protein encoded by this gene belongs to the PI3/PI4-kinase family. This protein is an important cell cycle checkpoint kinase that phosphorylates\; thus, it functions as a regulator of a wide variety of downstream proteins, including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2, checkpoint proteins RAD17 and RAD9, and DNA repair protein NBS1. This protein and the closely related kinase ATR are thought to be master controllers of cell cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability. Mutations in this gene are associated with ataxia telangiectasia, an autosomal recessive disorder.

Alternative names and synonyms associated with ATM

  • telomere fusion (tefu)
  • ataxia telangiectasia mutated (atm)
  • ataxia telangiectasia mutated (ATM)
  • ataxia telangiectasia mutated (EDI_100660)
  • ataxia telangiectasia mutated (CpipJ_CPIJ001772)
  • ataxia telangiectasia mutated (BDBG_08252)
  • ataxia telangiectasia mutated (PAAG_02532)
  • ataxia telangiectasia mutated (MCYG_05088)
  • ataxia telangiectasia mutated (VDBG_06833)
  • ataxia telangiectasia mutated (atm) (ACLA_015700)
  • ataxia telangiectasia mutated (atm) (AaeL_AAEL014900)
  • ataxia telangiectasia mutated (MGYG_07634)
  • ataxia telangiectasia mutated (PGTG_14279)
  • ataxia telangiectasia mutated (Atm)
  • ataxia telangiectasia mutated (LOC100349299)
  • ataxia telangiectasia mutated homolog (human) (Atm)
  • AI256621 protein
  • AT1 protein
  • ATA protein
  • ATC protein
  • ATD protein
  • ATDC protein
  • ATE protein
  • atm protein
  • atm/tefu protein
  • C030026E19Rik protein
  • CG6535 protein
  • dATM protein
  • Dmel\\CG6535 protein
  • tef protein
  • Tefu protein
  • TEL1 protein
  • TELO1 protein
  • Xatm protein

Protein level used designations for ATM

CG6535-PB , ataxia telangiectasia mutated , ataxia telengiesctasia mutated , ataxia-telangiectasia mutated , drosophila ATM , tefu-PB , chunp9624 , ataxia telangiectasia mutated (includes complementation groups A, C and D) , ataxia telangiectasia mutated protein , serine-protein kinase ATM-like , ataxia telangiectasia mutated (atm) , A-T mutated , AT mutated , TEL1, telomere maintenance 1, homolog , serine-protein kinase ATM , Ataxia telangiectasia gene mutated in human beings , ataxia telangiectasia mutated homolog , A-T mutated homolog , ATM (ataxia telangiectasia mutated) , ataxia telangiectasia gene mutated in human beings

GENE ID SPECIES
41839 Drosophila melanogaster
398148 Xenopus laevis
403064 Danio rerio
451530 Pan troglodytes
577188 Strongylocentrotus purpuratus
5882524 Entamoeba dispar SAW760
6032926 Culex quinquefasciatus
8501759 Ajellomyces dermatitidis SLH14081
9099145 Paracoccidioides sp. 'lutzii' Pb01
9230975 Arthroderma otae CBS 113480
9537397 Verticillium alfalfae VaMs.102
100026797 Monodelphis domestica
100061765 Equus caballus
100217707 Taeniopygia guttata
100427400 Macaca mulatta
100451505 Pongo abelii
100480638 Ailuropoda melanoleuca
4706457 Aspergillus clavatus NRRL 1
5565620 Aedes aegypti
10025630 Arthroderma gypseum CBS 118893
10535503 Puccinia graminis f. sp. tritici CRL 75-36-700-3
472 Homo sapiens
300711 Rattus norvegicus
100349299 Oryctolagus cuniculus
100717983 Cavia porcellus
100101922 Sus scrofa
479450 Canis lupus familiaris
526824 Bos taurus
395401 Gallus gallus
101105847 Ovis aries
11920 Mus musculus
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