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Browse our ATM Proteins (ATM)

Full name:
Ataxia Telangiectasia Mutated Proteins (ATM)
On are 3 Ataxia Telangiectasia Mutated (ATM) Proteins from 2 different suppliers available. Additionally we are shipping ATM Antibodies (333) and ATM Kits (47) and many more products for this protein. A total of 397 ATM products are currently listed.
AI256621, AT1, ATA, ATC, ATD, ATDC, ATE, atm, atm/tefu, C030026E19Rik, CG6535, dATM, Dmel\\CG6535, tef, Tefu, TEL1, TELO1, Xatm
list all proteins Gene Name GeneID UniProt
ATM 472 Q13315
Rat ATM ATM 300711  
Mouse ATM ATM 11920 Q62388

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ATM Proteins (ATM) by Origin

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More Proteins for ATM Interaction Partners

Fruit Fly (Drosophila melanogaster) Ataxia Telangiectasia Mutated (ATM) interaction partners

  1. our data indicate that ATR and ATM are both needed for intestinal stem cell maintenance and proliferation; ATR seems to play a bigger role than does ATM.

  2. TCTP (show TPT1 Proteins) has a role in regulating ATM activity to control genome stability and organ development in Drosophila melanogaster

  3. A stringent requirement for the conserved function of Ataxia Telangiectasia Mutated (ATM) in telomere protection during early embryonic development, is identified.

  4. ATM is primarily required for the meiotic DSB repair response, which includes functions in DNA damage repair and negative feedback control over the level of programmed DSBs during meiosis.

  5. Molecular genetic characterization of Drosophila ATM conserved functional domains.

  6. ATM checkpoint kinase plays a role in telomere maintenance that is independent of telomerase regulation.

  7. Drosophila ATM and Mre11 (show MRE11A Proteins) are essential for the G2/M checkpoint induced by low-dose irradiation.

  8. Results suggest that ATM and ATR protect telomere integrity by safeguarding chromatin architecture that favors the loading of telomere-elongating, capping, and silencing proteins.

Xenopus laevis Ataxia Telangiectasia Mutated (ATM) interaction partners

  1. Dna2 co-localizes in foci with RPA (show RPA1 Proteins) and is found in a complex with replication fork components And-1 and Mcm10 (show MCM10 Proteins). Dna2 interacts with the DSB repair and checkpoint proteins Nbs1 (show NLRP2 Proteins) and ATM.

  2. ATM and ATR prevent accumulation of chromosomal abnormalities by promoting Mre11 (show MRE11A Proteins)/Rad50 (show RAD50 Proteins)/Nbs1 (show NLRP2 Proteins) dependent recovery of collapsed replication forks.

  3. ATM and ATR phosphorylate the functionally critical replication protein Mcm2 (show MCM2 Proteins) during both DNA damage and replication checkpoint responses in Xenopus egg extracts

  4. PP2A counteracts ATM and ATR in a DNA damage checkpoint in Xenopus egg extracts

  5. Data show that ATM (ataxia-telangiectasia mutated) regulates Xenopus TopBP1 (show TOPBP1 Proteins) by phosphorylating serine 1131 and thereby strongly enhancing association of TopBP1 (show TOPBP1 Proteins) with ATR(ATM and Rad3-related).

  6. ATM and ATR control mitotic events in vertebrate cells by targeting CEP63 (show CEP63 Proteins) and centrosome dependent spindle assembly.

  7. These findings suggest that the MRN complex is a crucial mediator in the process whereby ATM promotes the TopBP1 (show TOPBP1 Proteins)-dependent activation of ATR-ATRIP (show ATRIP Proteins) in response to double-stranded DNA breaks.

  8. The Fanconi anemia protein FANCM is controlled by FANCD2 and the ATR/ATM pathways.

Zebrafish Ataxia Telangiectasia Mutated (ATM) interaction partners

  1. molecular cloning of the coding sequence of the catalytic domain of the zebrafish homologue of ATM

  2. Characterization of ataxia (show USP14 Proteins) telangiectasia protein.

Human Ataxia Telangiectasia Mutated (ATM) interaction partners

  1. In human Alzheimer's disease, three independent indices of reduced ataxia telangiectasia mutated protein function-nuclear translocation of histone deacetylase 4 (show HDAC4 Proteins), trimethylation of histone H3 (show HIST3H3 Proteins), and the presence of cell cycle activity-appear coordinately in neurons in regions where degeneration is prevalent.

  2. A spontaneously reverted Induced Pluripotent Stem Cells line was identified from an A-T subject with heterozygous ATM truncation mutations.

  3. Data indicate two germline ataxia telangiectasia mutated protein (ATM) mutations (p.Y1203fs and p.N1223S) in a Chinese family with a history of gastric cancer by screening 83 cancer susceptibility genes.

  4. This study found a significant trend indicating that the risk increases as the number of adverse alleles increase and significant three-locus interaction model involving NBS1 (show NBN Proteins) rs1805794, MRE11 (show MRE11A Proteins) rs10831234, and ATM rs227062.

  5. the interaction of 53BP1 (show TP53BP1 Proteins) with gammaH2AX (show H2AFX Proteins) is required for sustaining the 53BP1 (show TP53BP1 Proteins)-dependent focal concentration of activated ATM that facilitates repair of DNA double-strand breaks in heterochromatin in G1.

  6. ATM acts not only on chromatin marks.

  7. ATM and ATR depletion reduced assembly of the telomerase complex.

  8. the role of both ATM and ATR in DNA repair, cell cycle regulation and apoptosis

  9. ATM inhibition may facilitate the gefitinib-dependent repression of the phosphorylation of EGFR (show EGFR Proteins) and/or its downstream factors, to exert anticancer effects against non-small-cell lung cancer cells with the sensitive EGFR (show EGFR Proteins) mutation

  10. Ataxia (show USP14 Proteins) telangiectasia (AT) is an autosomal recessive multisystem genetic disorder caused by a mutation in the ATM gene encoding for the ATM protein.

Pig (Porcine) Ataxia Telangiectasia Mutated (ATM) interaction partners

  1. Ataxia (show USP14 Proteins) telangiectasia (AT) is a progressive multisystem disorder caused by mutations in the AT-mutated (ATM) gene. We engineered a novel porcine model of AT

  2. ATM influenced the meiotic and cytoplasmic maturation of porcine oocytes.

  3. ATM plays critical role in arsenite induced G2/M phase arrest in aortic endothelial cells possibly via regulation of checkpoint signaling molecules.

Cow (Bovine) Ataxia Telangiectasia Mutated (ATM) interaction partners

  1. radiation-induced eNOS (show NOS3 Proteins) activation in bovine aortic endothelial cells is regulated by ATM and HSP90 (show HSP90 Proteins)

Mouse (Murine) Ataxia Telangiectasia Mutated (ATM) interaction partners

  1. Cerebellar astroglia isolated from Atm mutant mice show decreased expression of the cystine/glutamate (show GRIN1 Proteins) exchanger subunit xCT, glutathione reductase (show GSR Proteins), and glutathione-S-transferase (show GSTa2 Proteins)

  2. Authors generated an inducible Atm mutant mouse model (Atm(tm1Mmpl/tm1Mmpl), referred to as A-T [M]) predicted to express only the first 62 amino acids of Atm

  3. ATM-BID (show BID Proteins)-MTCH2 (show MTCH2 Proteins) pathway that we have identified plays a critical role in the DDR (show DDR1 Proteins) via regulation of mitochondrial metabolism.

  4. TRAX (show TSNAX Proteins) is required for DNA repair, by interacting with activated ATM and protects cells from genotoxic stress-induced apoptosis.

  5. ATM facilitates restriction of signal ends to the classical nonhomologous end-joining pathway.

  6. TET1 (show TET1 Proteins)-mediated 5hmC production is linked to the degenerative process of Purkinje cells and behavioural deficits in Atm(-/-) mice. Taken together, the selective loss of 5hmC plays a critical role in driving Purkinje cell vulnerability in ATM deficiency

  7. The authors demonstrate that ATM can be activated by DNA double-strand breaks in the absence of the Mre11 (show MRE11A Proteins)-Rad50 (show RAD50 Proteins)-NBS1 (show NBN Proteins) (MRN) sensor complex.

  8. Loss of ATM in pancreatic ductal adenocarcinoma enhances acinar-to-ductal reprogramming via altered TGFbeta (show TGFB1 Proteins)-superfamily signalling and is associated with epithelial-to-mesenchymal transition and a gain in tumor initiating properties.

  9. This study reveals that ATM protects against development of B-cell lymphomas that model human ABC (show ABCB6 Proteins) DLBCL and identifies a potential role for T cells in preventing the emergence of these tumors.

  10. Inhibition of ATM kinase decreased manganese-dependent phosphorylation of p53 (show TP53 Proteins).

ATM Protein Profile

Protein Summary

The protein encoded by this gene belongs to the PI3/PI4-kinase family. This protein is an important cell cycle checkpoint kinase that phosphorylates\; thus, it functions as a regulator of a wide variety of downstream proteins, including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2, checkpoint proteins RAD17 and RAD9, and DNA repair protein NBS1. This protein and the closely related kinase ATR are thought to be master controllers of cell cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability. Mutations in this gene are associated with ataxia telangiectasia, an autosomal recessive disorder.

Alternative names and synonyms associated with ATM

  • telomere fusion (tefu)
  • ataxia telangiectasia mutated (atm)
  • ataxia telangiectasia mutated (ATM)
  • ataxia telangiectasia mutated (EDI_100660)
  • ataxia telangiectasia mutated (CpipJ_CPIJ001772)
  • ataxia telangiectasia mutated (BDBG_08252)
  • ataxia telangiectasia mutated (PAAG_02532)
  • ataxia telangiectasia mutated (MCYG_05088)
  • ataxia telangiectasia mutated (VDBG_06833)
  • ataxia telangiectasia mutated (atm) (ACLA_015700)
  • ataxia telangiectasia mutated (atm) (AaeL_AAEL014900)
  • ataxia telangiectasia mutated (MGYG_07634)
  • ataxia telangiectasia mutated (PGTG_14279)
  • ataxia telangiectasia mutated (Atm)
  • ataxia telangiectasia mutated (LOC100349299)
  • ataxia telangiectasia mutated homolog (human) (Atm)
  • AI256621 protein
  • AT1 protein
  • ATA protein
  • ATC protein
  • ATD protein
  • ATDC protein
  • ATE protein
  • atm protein
  • atm/tefu protein
  • C030026E19Rik protein
  • CG6535 protein
  • dATM protein
  • Dmel\\CG6535 protein
  • tef protein
  • Tefu protein
  • TEL1 protein
  • TELO1 protein
  • Xatm protein

Protein level used designations for ATM

CG6535-PB , ataxia telangiectasia mutated , ataxia telengiesctasia mutated , ataxia-telangiectasia mutated , drosophila ATM , tefu-PB , chunp9624 , ataxia telangiectasia mutated (includes complementation groups A, C and D) , ataxia telangiectasia mutated protein , serine-protein kinase ATM-like , ataxia telangiectasia mutated (atm) , A-T mutated , AT mutated , TEL1, telomere maintenance 1, homolog , serine-protein kinase ATM , Ataxia telangiectasia gene mutated in human beings , ataxia telangiectasia mutated homolog , A-T mutated homolog , ATM (ataxia telangiectasia mutated) , ataxia telangiectasia gene mutated in human beings

41839 Drosophila melanogaster
398148 Xenopus laevis
403064 Danio rerio
451530 Pan troglodytes
577188 Strongylocentrotus purpuratus
5882524 Entamoeba dispar SAW760
6032926 Culex quinquefasciatus
8501759 Ajellomyces dermatitidis SLH14081
9099145 Paracoccidioides sp. 'lutzii' Pb01
9230975 Arthroderma otae CBS 113480
9537397 Verticillium alfalfae VaMs.102
100026797 Monodelphis domestica
100061765 Equus caballus
100217707 Taeniopygia guttata
100427400 Macaca mulatta
100451505 Pongo abelii
100480638 Ailuropoda melanoleuca
4706457 Aspergillus clavatus NRRL 1
5565620 Aedes aegypti
10025630 Arthroderma gypseum CBS 118893
10535503 Puccinia graminis f. sp. tritici CRL 75-36-700-3
472 Homo sapiens
300711 Rattus norvegicus
100349299 Oryctolagus cuniculus
100717983 Cavia porcellus
100101922 Sus scrofa
479450 Canis lupus familiaris
526824 Bos taurus
395401 Gallus gallus
101105847 Ovis aries
11920 Mus musculus
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