Browse our ATM Proteins (ATM)

Full name:
Ataxia Telangiectasia Mutated Proteins (ATM)
On are 5 Ataxia Telangiectasia Mutated (ATM) Proteins from 3 different suppliers available. Additionally we are shipping ATM Antibodies (355) and ATM Kits (46) and many more products for this protein. A total of 420 ATM products are currently listed.
AI256621, AT1, ATA, ATC, ATD, ATDC, ATE, atm, atm/tefu, C030026E19Rik, CG6535, dATM, Dmel\\CG6535, tef, Tefu, TEL1, TELO1, Xatm
list all proteins Gene Name GeneID UniProt
ATM 472 Q13315
Rat ATM ATM 300711  
ATM 11920 Q62388

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ATM Proteins (ATM) by Origin

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More Proteins for ATM Interaction Partners

Fruit Fly (Drosophila melanogaster) Ataxia Telangiectasia Mutated (ATM) interaction partners

  1. our data indicate that ATR and ATM are both needed for intestinal stem cell maintenance and proliferation; ATR seems to play a bigger role than does ATM.

  2. TCTP (show TPT1 Proteins) has a role in regulating ATM activity to control genome stability and organ development in Drosophila melanogaster

  3. A stringent requirement for the conserved function of Ataxia Telangiectasia Mutated (ATM) in telomere protection during early embryonic development, is identified.

  4. ATM is primarily required for the meiotic DSB repair response, which includes functions in DNA damage repair and negative feedback control over the level of programmed DSBs during meiosis.

  5. Molecular genetic characterization of Drosophila ATM conserved functional domains.

  6. ATM checkpoint kinase plays a role in telomere maintenance that is independent of telomerase regulation.

  7. Drosophila ATM and Mre11 (show MRE11A Proteins) are essential for the G2/M checkpoint induced by low-dose irradiation.

  8. Results suggest that ATM and ATR protect telomere integrity by safeguarding chromatin architecture that favors the loading of telomere-elongating, capping, and silencing proteins.

Xenopus laevis Ataxia Telangiectasia Mutated (ATM) interaction partners

  1. Dna2 co-localizes in foci with RPA (show RPA1 Proteins) and is found in a complex with replication fork components And-1 and Mcm10 (show MCM10 Proteins). Dna2 interacts with the DSB repair and checkpoint proteins Nbs1 (show NLRP2 Proteins) and ATM.

  2. ATM and ATR prevent accumulation of chromosomal abnormalities by promoting Mre11 (show MRE11A Proteins)/Rad50 (show RAD50 Proteins)/Nbs1 (show NLRP2 Proteins) dependent recovery of collapsed replication forks.

  3. ATM and ATR phosphorylate the functionally critical replication protein Mcm2 (show MCM2 Proteins) during both DNA damage and replication checkpoint responses in Xenopus egg extracts

  4. PP2A counteracts ATM and ATR in a DNA damage checkpoint in Xenopus egg extracts

  5. Data show that ATM (ataxia-telangiectasia mutated) regulates Xenopus TopBP1 (show TOPBP1 Proteins) by phosphorylating serine 1131 and thereby strongly enhancing association of TopBP1 (show TOPBP1 Proteins) with ATR(ATM and Rad3-related).

  6. ATM and ATR control mitotic events in vertebrate cells by targeting CEP63 (show CEP63 Proteins) and centrosome dependent spindle assembly.

  7. These findings suggest that the MRN complex is a crucial mediator in the process whereby ATM promotes the TopBP1 (show TOPBP1 Proteins)-dependent activation of ATR-ATRIP (show ATRIP Proteins) in response to double-stranded DNA breaks.

  8. The Fanconi anemia protein FANCM is controlled by FANCD2 and the ATR/ATM pathways.

Zebrafish Ataxia Telangiectasia Mutated (ATM) interaction partners

  1. molecular cloning of the coding sequence of the catalytic domain of the zebrafish homologue of ATM

  2. Characterization of ataxia (show USP14 Proteins) telangiectasia protein.

Human Ataxia Telangiectasia Mutated (ATM) interaction partners

  1. We report that endogenous huntingtin (show HTT Proteins) protein directly participates in oxidative DNA damage repair. Using novel chromobodies to detect endogenous human huntingtin (show HTT Proteins) in live cells, we show that localization of huntingtin (show HTT Proteins) to DNA damage sites is dependent on the kinase activity of ataxia telangiectasia mutated (ATM) protein.

  2. The study showed a significant association between the ATM rs1801516 Asn allele and increased risk of radiation-induced normal tissue toxicity.

  3. In this paper, we describe an extension to the BOADICEA model to incorporate the effects of intermediate risk variants for breast cancer, specifically loss of function mutations in the three genes for which the evidence for association is clearest and the risk estimates most precise: PALB2 (show PALB2 Proteins), CHEK2 (show CHEK2 Proteins) and ATM

  4. Taken together, the findings suggest that a protein-protein interaction between ATM and p400 ATPase occurs independently of DNA damage and contributes to efficient DNA damage response and repair.

  5. following reprogramming the early and late replicating genome is differentially affected by copy number variations in ATM-deficient induced pluripotent stem cells (iPSCs) relative to wild-type iPSCs.

  6. ATM mutation is associated with ataxia (show USP14 Proteins)-telangiectasia.

  7. Results provide evidence that ATM along with 53BP1 (show TP53BP1 Proteins) is involved in breast cancer cells resistance for PARP inhibitor; its deficiency causes resistance in 53BP1 (show TP53BP1 Proteins)-depleted tumor cells.

  8. WRNIP1 (show WRNIP1 Proteins) connects PCNA (show PCNA Proteins) monoubiquitination with ATMIN (show ATMIN Proteins)/ATM to activate ATM signalling in response to replication stress and contribute to the maintenance of genomic stability.

  9. Mutant IDH1 downregulates the DNA damage (DD) sensor ATM by altering histone methylation, leading to impaired DNA repair, increased sensitivity to DD, and reduced HSC self-renewal, independent of TET2.

  10. ATM rs189037 polymorphism is associated with reduced risk of T2DM

Pig (Porcine) Ataxia Telangiectasia Mutated (ATM) interaction partners

  1. Ataxia (show USP14 Proteins) telangiectasia (AT) is a progressive multisystem disorder caused by mutations in the AT-mutated (ATM) gene. We engineered a novel porcine model of AT

  2. ATM influenced the meiotic and cytoplasmic maturation of porcine oocytes.

  3. ATM plays critical role in arsenite induced G2/M phase arrest in aortic endothelial cells possibly via regulation of checkpoint signaling molecules.

Cow (Bovine) Ataxia Telangiectasia Mutated (ATM) interaction partners

  1. radiation-induced eNOS (show NOS3 Proteins) activation in bovine aortic endothelial cells is regulated by ATM and HSP90 (show HSP90 Proteins)

Mouse (Murine) Ataxia Telangiectasia Mutated (ATM) interaction partners

  1. work reveals that simulated microgravity promotes the apoptotic response through a combined modulation of the Uev1A/TICAM/TRAF (show TRAF1 Proteins)/NF-kappaB (show NFKB1 Proteins)-regulated apoptosis and the p53 (show TP53 Proteins)/PCNA (show PCNA Proteins)- and ATM/ATR-Chk1 (show CHEK1 Proteins)/2-controlled DNA-damage response pathways.

  2. this study shows that Atm-/- mice are more susceptible to pulmonary Streptococcus pneumoniae infection in a manner consistent with inflammasome defects

  3. This study show that like ataxia (show USP14 Proteins) telangiectasia cells, ISG15 (show ISG15 Proteins) is elevated in Atm-deficient mouse cerebellums.

  4. This study identifies attenuation of type I interferon (show IFNA Proteins) responses as the primary mechanism underlying proviral function of ATM during gammaherpesvirus infection.

  5. Mutant IDH1 downregulates the DNA damage (DD) sensor ATM by altering histone methylation, leading to impaired DNA repair, increased sensitivity to DD, and reduced HSC self-renewal, independent of TET2.

  6. USP7 (show USP7 Proteins) inhibition is selectively cytotoxic to CLL cells independently of ATM and p53 (show TP53 Proteins) and synergizes with chemotherapy.

  7. Fractionated exposure to low doses of X-rays resulted in accumulation of DNA damage in the murine spleen and induction of apoptotic response in p53 (show TP53 Proteins)/Atm-independent manner. Further studies are needed to understand the outcomes and molecular mechanisms underlying cellular responses and early induction of p38 (show CRK Proteins) in response to prolonged exposure to IR.

  8. ATM, ATR and DNA-PKcs (show PRKDC Proteins) have unique and essential roles during the DNA damage response in the nervous system.

  9. TRAF6 (show TRAF6 Proteins) and H2AX (show H2AFX Proteins) overexpression and gammaH2AX (show H2AFX Proteins)-mediated HIF1alpha (show HIF1A Proteins) enrichment in the nucleus of cancer cells lead to overactivation of HIF1alpha (show HIF1A Proteins)-driven tumorigenesis, glycolysis and metastasis.

  10. These results reveal a new requirement for ATMIN (show ATMIN Proteins)-dependent ATM signaling in TP53 (show TP53 Proteins)-deficient glioblastoma multiforme, indicating a pro-tumorigenic role for ATM in the context of these tumors.

ATM Protein Profile

Protein Summary

The protein encoded by this gene belongs to the PI3/PI4-kinase family. This protein is an important cell cycle checkpoint kinase that phosphorylates\; thus, it functions as a regulator of a wide variety of downstream proteins, including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2, checkpoint proteins RAD17 and RAD9, and DNA repair protein NBS1. This protein and the closely related kinase ATR are thought to be master controllers of cell cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability. Mutations in this gene are associated with ataxia telangiectasia, an autosomal recessive disorder.

Alternative names and synonyms associated with ATM

  • telomere fusion (tefu)
  • ataxia telangiectasia mutated (atm)
  • ataxia telangiectasia mutated (ATM)
  • ataxia telangiectasia mutated (EDI_100660)
  • ataxia telangiectasia mutated (CpipJ_CPIJ001772)
  • ataxia telangiectasia mutated (BDBG_08252)
  • ataxia telangiectasia mutated (PAAG_02532)
  • ataxia telangiectasia mutated (MCYG_05088)
  • ataxia telangiectasia mutated (VDBG_06833)
  • ataxia telangiectasia mutated (atm) (ACLA_015700)
  • ataxia telangiectasia mutated (atm) (AaeL_AAEL014900)
  • ataxia telangiectasia mutated (MGYG_07634)
  • ataxia telangiectasia mutated (PGTG_14279)
  • ataxia telangiectasia mutated (Atm)
  • ataxia telangiectasia mutated (LOC100349299)
  • ataxia telangiectasia mutated homolog (human) (Atm)
  • AI256621 protein
  • AT1 protein
  • ATA protein
  • ATC protein
  • ATD protein
  • ATDC protein
  • ATE protein
  • atm protein
  • atm/tefu protein
  • C030026E19Rik protein
  • CG6535 protein
  • dATM protein
  • Dmel\\CG6535 protein
  • tef protein
  • Tefu protein
  • TEL1 protein
  • TELO1 protein
  • Xatm protein

Protein level used designations for ATM

CG6535-PB , ataxia telangiectasia mutated , ataxia telengiesctasia mutated , ataxia-telangiectasia mutated , drosophila ATM , tefu-PB , chunp9624 , ataxia telangiectasia mutated (includes complementation groups A, C and D) , ataxia telangiectasia mutated protein , serine-protein kinase ATM-like , ataxia telangiectasia mutated (atm) , A-T mutated , AT mutated , TEL1, telomere maintenance 1, homolog , serine-protein kinase ATM , Ataxia telangiectasia gene mutated in human beings , ataxia telangiectasia mutated homolog , A-T mutated homolog , ATM (ataxia telangiectasia mutated) , ataxia telangiectasia gene mutated in human beings

41839 Drosophila melanogaster
398148 Xenopus laevis
403064 Danio rerio
451530 Pan troglodytes
577188 Strongylocentrotus purpuratus
5882524 Entamoeba dispar SAW760
6032926 Culex quinquefasciatus
8501759 Ajellomyces dermatitidis SLH14081
9099145 Paracoccidioides sp. 'lutzii' Pb01
9230975 Arthroderma otae CBS 113480
9537397 Verticillium alfalfae VaMs.102
100026797 Monodelphis domestica
100061765 Equus caballus
100217707 Taeniopygia guttata
100427400 Macaca mulatta
100451505 Pongo abelii
100480638 Ailuropoda melanoleuca
4706457 Aspergillus clavatus NRRL 1
5565620 Aedes aegypti
10025630 Arthroderma gypseum CBS 118893
10535503 Puccinia graminis f. sp. tritici CRL 75-36-700-3
472 Homo sapiens
300711 Rattus norvegicus
100349299 Oryctolagus cuniculus
100717983 Cavia porcellus
100101922 Sus scrofa
479450 Canis lupus familiaris
526824 Bos taurus
395401 Gallus gallus
101105847 Ovis aries
11920 Mus musculus
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