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Data show that targeting of synoviocytes by a vector, consisting of a baculovirus conjugated to an adenovirus carrying the pro-apoptotic gene PUMA, has therapeutic efficacy in a rat arthritis model.
In the mouse model of silicosis, Bbc3 knockout mice clearly exhibited decreased levels of autophagy and fibrosis progression. These results suggest that downregulation of BBC3 expression may become a novel therapeutic strategy for the treatment of silicosis.
Quantitative real-time PCR analysis indicated higher expression of PUM in renal cell carcinoma tissues compared to that in para-carcinoma tissues.
we have demonstrated that miR (show MLXIP ELISA Kits)-503-5p expression negatively correlates with PUMA expression in colorectal carcinoma cells.
data suggest that PUMA cooperates with p21 (show CDKN1A ELISA Kits) to regulate normal acinus (show ACIN1 ELISA Kits) formation and epithelial-to-mesenchymal transition.
Results show that in PUMA protein adenovirus-infected A2780s ovarian cancer cells, exogenous PUMA was partially accumulated in the cytosol and mainly located to the mitochondria.
Inhibition of mTORC1-mediated 4EBP1 (show EIF4EBP1 ELISA Kits) phosphorylation leads to decreased expression of c-MYC (show MYC ELISA Kits) and subsequent upregulation of the proapoptotic BCL2 (show BCL2 ELISA Kits) family member PUMA, whereas inhibition of mTORC2 (show CRTC2 ELISA Kits) results in nuclear factor-kappaB-mediated expression of the Early Growth Response 1 (EGR1 (show EGR1 ELISA Kits)) gene, which encodes a transcription factor that binds and transactivates the proapoptotic BCL2L11 (show BCL2L11 ELISA Kits) locus encoding BIM (show BCL2L11 ELISA Kits).
These results demonstrated the involvement of BBC3/Bbc3 in cold preservation/rewarming-mediated islet injury, possibly through modulating HMGB1 (show HMGB1 ELISA Kits)- and oxidative stress-mediated injury to islets.
miR (show MLXIP ELISA Kits)-23a-3p, miR (show MLXIP ELISA Kits)-23b-3p, and miR (show MLXIP ELISA Kits)-149-5p, were downregulated by cytokines and selected for further studies. These miRNAs were found to regulate the expression of the proapoptotic Bcl-2 (show BCL2 ELISA Kits) proteins DP5 (show HRK ELISA Kits) and PUMA and consequent human beta-cell apoptosis.
Our results revealed that Slug siRNA transfection in combination with radiation increased the expression of PUMA, which contributed to radiosensitivity of oral squamous cell carcinoma cells
This study has demonstrated that methamphetamine-mediated pericytes migration involves PUMA up-regulation.
Data show that Emu-Myc (show MYC ELISA Kits) mice lacking both p21 and PUMA developed lymphoma at a rate considerably longer latency than Emu-Myc (show MYC ELISA Kits);p53 (show TP53 ELISA Kits)(+/-)mice.
Our data show a novel pathway of infection-induced apoptosis that enhances our understanding of the mechanism by which BH3-only proteins control apoptotic host cell death during Listeria infection.
Overexpression of miR (show MLXIP ELISA Kits)-29 or miR (show MLXIP ELISA Kits)-24 is sufficient to inhibit the induction of Bim (show BCL2L11 ELISA Kits) and Puma in young sympathetic neurons.
loss of PUMA had no impact on the loss of platelets caused by loss of BCL-XL (show BCL2L1 ELISA Kits). It therefore remains to be established whether other BH3-only proteins play a critical role in induction of apoptosis in platelets or whether their death is controlled solely by the interactions between BCL-XL (show BCL2L1 ELISA Kits) with BAK (show BAK1 ELISA Kits) and BAX (show BAX ELISA Kits).
PUMA is dispensable for glucose homeostasis in lean and obese mice, but it can affect leptin (show LEP ELISA Kits) levels and food intake during obesity.
MYSM1 (show MYSM1 ELISA Kits) is a critical negative regulator of p53 (show TP53 ELISA Kits) transcriptional programs in hematopoiesis, and its repression of Bbc3/PUMA expression is essential for multipotent progenitor survival, and partly contributes to maintaining hematopoietic stem cel function.
Therapeutic response to non-genotoxic activation of p53 (show TP53 ELISA Kits) by Nutlin3a is driven by PUMA-mediated apoptosis in lymphoma cells.
Bim (show BCL2L11 ELISA Kits) and Puma overlapped apoptosis only partially during physiological apoptotic stage and they were present in non-apoptotic parts of the follicles.
Bad functions as an essential sensitizer and Puma as an essential activator of IR-induced mitochondrial apoptosis specifically in embryonic neural tissue.
Defective adult oligodendrocyte and Schwann cell development, pigment pattern, and craniofacial morphology in puma mutant zebrafish having an alpha tubulin (show TUBA4A ELISA Kits) mutation
This gene encodes a member of the BCL-2 family of proteins. This family member belongs to the BH3-only pro-apoptotic subclass. The protein cooperates with direct activator proteins to induce mitochondrial outer membrane permeabilization and apoptosis. It can bind to anti-apoptotic Bcl-2 family members to induce mitochondrial dysfunction and caspase activation. Because of its pro-apoptotic role, this gene is a potential drug target for cancer therapy and for tissue injury. Alternative splicing results in multiple transcript variants.
BCL2 binding component 3
, bcl-2-binding component 3
, p53 up-regulated modulator of apoptosis
, Bcl-2 binding component 3