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The metabolic defects of cycG mutant animals are abrogated by a concomitant loss of Wdb, CycG presumably influences Akt1 (show AKT1 Proteins) activity at the PP2A (show PPP2R2B Proteins) nexus; Well rounded (Wrd), another B' subunit of PP2A (show PPP2R2B Proteins) in Drosophila, binds CycG similar to Wdb, and that its loss ameliorates some, but not all, of the metabolic defects of cycG mutants.
Loss of CycG modified dominant wing phenotypes of Notch, Delta and Hairless mutants. Whereas Notch loss of function phenotype was ameliorated by a loss of CycG, phenotypes of Notch gain of function or of Delta or Hairless loss of function were enhanced
CycG acts at the level of Akt1 (show AKT1 Proteins) to regulate growth and metabolism via PP2A (show PPP2R2B Proteins) in Drosophila.
CycG promotes Gurken-mediated activation of EGFR (show EGFR Proteins) signalling.
CycG has a role in an early step of meiotic recombination repair.
Our results highlight the role of CycG in the control of developmental stability in D. melanogaster
Cyclin G is encoded by an essential gene, since either RNAi-disruption or cDNA overexpression resulted in high lethality.
Overproduction of Cyclin G produces small cells whereas shortage produces large cells, suggesting that Cyclin G negatively regulates cell growth.
interaction between the Enhancer of Trithorax (show MLLT1 Proteins) and Polycomb (show CBX2 Proteins) Corto and Cyclin G is involved in regulating the balance between cell proliferation and cell differentiation during abdominal epithelium development
Data show that the miR (show MLXIP Proteins)-27b/cyclin G1 protein (CCNG1)/p53 tumor suppressor protein (P53 (show TP53 Proteins))/miR (show MLXIP Proteins)-508-5p axis plays important roles in gastric cancer (GC)-associated multidrug resistance (MDR).
Results show that miR (show MLXIP Proteins)-23b may inhibit epithelial ovarian tumorigenesis and progression by targeting CCNG1 and modulating the expression of the relevant genes.
OA induced cell cycle arrest in lung cancer cells through miR (show MLXIP Proteins)-122/Cyclin G1/MEF2D (show MEF2D Proteins) pathway. This finding may contribute to the understanding of the molecular mechanism of OA's anti-tumor activity
Progesterone-induced cyclin G1 mediates the inhibitory effect of progesterone on endometrial epithelial cell proliferation.
Post-transcriptional regulation of cyclins D1, D3 and G1 and proliferation of human cancer cells depend on IMP-3 (show IGF2BP3 Proteins) nuclear localization.
cyclin G1 exerts negative control on proliferation of endometrial carcinoma cells (ECCs).
cyclin G1 levels were increased in normal tissue compared with hepatocellular carcinoma tissue and vary over the course of the cell cycle, with equal distribution between the nucleus and cytoplasm.
data suggest that the deficiency of progesterone and its receptors is an important cause of the decreased expression of cyclin G1 in endometrial carcinoma, which may account for carcinogenesis and development of endometrial carcinomas
Cyclin G1 overexpression enhanced Akt activation through interaction with p85 (regulatory subunit of phosphoinositide 3-kinase)
Expression of cyclin G1 and G2 is strongly associated with nasopharyngeal carcinoma cell differentiation.
The expression of Cyclin G1 in mouse ovary is in spatiotemporal pattern.
Cyclin G recruits PP2A (show PPP2R2B Proteins) in order to modulate the phosphorylation of Mdm2 (show MDM2 Proteins) and thereby to regulate both Mdm2 (show MDM2 Proteins) and p53 (show TP53 Proteins).
association with MDM2 (show MDM2 Proteins) and regulation of accumulation and degradation of p53 (show TP53 Proteins) protein
Decrease in tumor incidence, mass, and malignancy in cyclin G1-null mice after treatment with hepatocarcinogen N-diethylnitrosamine. Cyclin G1 with Mdm2 (show MDM2 Proteins) are part of negative feedback attenuating the activity of p53 (show TP53 Proteins).
cyclin G1 and cyclin G2 (show CCNG2 Proteins) genes are differentially regulated in the periimplantation uterus in a spatiotemporal manner; results suggest cyclin G1 and cyclin G2 (show CCNG2 Proteins) genes act as downstream targets of homeobox (show PRRX1 Proteins) A-10 and negatively impact uterine cell proliferation
the cyclin (show PCNA Proteins) box has a role in the proteasome-mediated degradation of cyclin G1
The B'alpha1 subunit of the serine/threonine protein phosphatase 2A, which binds to cyclin G1, can stabilize cyclin G1 under unstressed conditions and upon DNA damage, as well as inhibit the ability of cyclin G1 to be ubiquitinated.
The eukaryotic cell cycle is governed by cyclin-dependent protein kinases (CDKs) whose activities are regulated by cyclins and CDK inhibitors. The protein encoded by this gene is a member of the cyclin family and contains the cyclin box. The encoded protein lacks the protein destabilizing (PEST) sequence that is present in other family members. Transcriptional activation of this gene can be induced by tumor protein p53. Two transcript variants encoding the same protein have been identified for this gene.
, cyclin G
, cyclin G1