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anti-Human E2F1 Antibodies:
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Human Monoclonal E2F1 Primary Antibody for IP, WB - ABIN967439
Dyson, Dembski, Fattaey, Ngwu, Ewen, Helin: Analysis of p107-associated proteins: p107 associates with a form of E2F that differs from pRB-associated E2F-1. in Journal of virology 1993
Show all 5 Pubmed References
Human Monoclonal E2F1 Primary Antibody for FACS, IHC - ABIN969516
Okazaki, Matsunaga, Okazaki, Utoguchi, Suzuki, Maruyama, Koyanagi, Ohdo: Circadian rhythm of transferrin receptor 1 gene expression controlled by c-Myc in colon cancer-bearing mice. in Cancer research 2010
Show all 3 Pubmed References
Human Polyclonal E2F1 Primary Antibody for WB - ABIN3044440
Zhou, Lu, Liu, Guo, Liu, Zhou, Yang, Mi, Xu: Platycodin D induces tumor growth arrest by activating FOXO3a expression in prostate cancer in vitro and in vivo. in Current cancer drug targets 2015
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Human Monoclonal E2F1 Primary Antibody for ELISA, WB - ABIN3201010
Irwin, Marin, Phillips, Seelan, Smith, Liu, Flores, Tsai, Jacks, Vousden, Kaelin: Role for the p53 homologue p73 in E2F-1-induced apoptosis. in Nature 2000
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Human Monoclonal E2F1 Primary Antibody for ICC, IF - ABIN153153
Liu, Clements, Zhao, Marmorstein: Structure of the human Papillomavirus E7 oncoprotein and its mechanism for inactivation of the retinoblastoma tumor suppressor. in The Journal of biological chemistry 2006
Show all 2 Pubmed References
Human Polyclonal E2F1 Primary Antibody for WB - ABIN391858
ODonnell, Wentzel, Zeller, Dang, Mendell: c-Myc-regulated microRNAs modulate E2F1 expression. in Nature 2005
Show all 6 Pubmed References
Human Monoclonal E2F1 Primary Antibody for ICC, IF - ABIN269710
Zhang, Zhang, Yao, Lowery, Zhang, Huang, Li, Li, Wang, Zhang, Wang, Ellis, Cheerathodi, McCarty, Palmieri, Saunus, Lakhani, Huang, Sahin, Aldape, Steeg, Yu: Microenvironment-induced PTEN loss by exosomal microRNA primes brain metastasis outgrowth. in Nature 2015
Human Polyclonal E2F1 Primary Antibody for IHC, IHC (p) - ABIN4306768
Zellmer, Schmidt-Heck, Godoy, Weng, Meyer, Lehmann, Sparna, Schormann, Hammad, Kreutz, Timmer, von Weizsäcker, Thürmann, Merfort, Guthke, Dooley, Hengstler, Gebhardt: Transcription factors ETF, E2F, and SP-1 are involved in cytokine-independent proliferation of murine hepatocytes. in Hepatology (Baltimore, Md.) 2010
Human Monoclonal E2F1 Primary Antibody for CyTOF, ELISA - ABIN4306767
Lee, Pelletier: Dependence of p53-deficient cells on the DHX9 DExH-box helicase. in Oncotarget 2017
specific alternate transcripts of activator E2F (show E2F2 Antibodies), dE2F1, may have a dual function on cell cycle progression and cannot simply be viewed as a pro-proliferative transcription factor
These findings identify a key function of E2F (show E2F2 Antibodies) in skeletal muscle required for animal viability, and illustrate how the cell cycle regulator (show CDKN2A Antibodies) is repurposed in post-mitotic cells.
Mechanistically, miR (show MYLIP Antibodies)-998 operates by repressing dCbl, a negative regulator of EGFR (show EGFR Antibodies) signaling. Significantly, dCbl is a critical target of miR (show MYLIP Antibodies)-998 since dCbl phenocopies the effects of miR (show MYLIP Antibodies)-998 on dE2f1-dependent apoptosis in rbf (show ATP5I Antibodies) mutants
also demonstrated that an optimum level of dLin52 is needed for dE2F1/2 activity on the hid promoter
Results show that regulation of e2f1 and PCNA (show PCNA Antibodies) by DREF (show ZBED1 Antibodies) in vivo is complex and the regulation mechanism may differ with the tissue and/or positions in the tissue.
Loss of dE2F compromises mitochondrial function.
Data propose that the interaction between ORC5 (show ORC5 Antibodies) and dE2F1 may reflect a feedback mechanism between replication initiation proteins and dE2F1 that ensures that proliferating cells maintain a robust level of replication proteins for the next cell cycle.
results suggest that E2F/DP complexes are essential for all genomic targeting of RBF1
Inappropriate accumulation of E2f1 protein during S phase triggers the elimination of potentially hyperplastic cells via apoptosis in order to ensure normal development of rapidly proliferating tissues.
endocycles of Drosophila are driven by a molecular oscillator in which the E2F1 transcription factor promotes CycE (show CCNE1 Antibodies) expression and S-phase initiation, S-phase then activates the CRL4(CDT2) ubiquitin ligase, and this in turn mediates the destruction of E2F1
Using iterative experimental and computational analyses, the authors show physical and functional interactions between NF-kappaB (show NFKB1 Antibodies) and the E2 Factor 1 (E2F-1) and E2 Factor 4 (E2F-4 (show E2F4 Antibodies)) cell cycle regulators.
Heavy ion irradiation could induce p53 (show TP53 Antibodies)(-/-) hepatoma cells to undergo apoptosis via E2F1/Bax (show BAX Antibodies)/Casp3 (show CASP3 Antibodies) signaling pathway.
Propose that E2F1 interacts with BRCA1 indirect pathway to induce two different small molecule metabolic pathways or cell cycle regulation pathways in hepatocellular carcinoma.
The pyruvate dehydrogenase (show PDP Antibodies) kinases (PDKs) PDK1 (show PDK1 Antibodies) and PDK3 (show PDK3 Antibodies) are direct targets of KDM4A (show KDM4A Antibodies) and E2F1 and modulate the switch between glycolytic metabolism and mitochondrial oxidation.
Taken together, this study reveals evidence demonstrating a mechanism by which the LPR6/ GSK3beta (show GSK3b Antibodies)/E2F1 axis-upregulated LSH (show HELLS Antibodies) promoted gliomas.
High E2F1 expression is associated with melanoma.
p63alpha protein up-regulates heat shock protein 70 (show HSP70 Antibodies) expression via E2F1 transcription factor 1 (show HNF1A Antibodies), promoting Wasf3/Wave3 (show WASF3 Antibodies)/MMP9 (show MMP9 Antibodies) signaling and bladder cancer invasion
E2F1 couples immune cell development to immune response.E2f1 role in the inflammation-associated cancers [review]
These data suggest a model in which cells experiencing oncogene (show RAB1A Antibodies)-induced replication stress through deregulation of E2F-dependent transcription.
Describe a regulatory loop miR (show MLXIP Antibodies)-218-CDK6 (show CDK6 Antibodies)/CyclinD1-E2F1 whose disruption may contribute to cell cycle progression in gastric cancer.
The evidence has been presented that the retinoblastoma protein utilizes a cell-cycle-independent interaction with E2F1 to recruit EZH2 (show EZH2 Antibodies) to diverse repeat sequences.
germ-line loss of E2f1 or E2f3b, but not E2f3a, protected mice against hepatocellular carcinoma
E2F1 hinders skin wound healing by suppressing VEGF (show VEGFA Antibodies) expression, neovascularization, and macrophage recruitment. Strategies that target E2F1 may enhance wound healing.
systems-level control of cell cycle arrest by pRB (show PGR Antibodies)-E2F and p27 (show CDKN1B Antibodies)-CDK (show CDK4 Antibodies) regulation, is reported.
TERT (show TERT Antibodies) has a role in neointima formation through epigenetic regulation of proliferative E2F1 target gene expression in smooth muscle cells.
inhibition of PDK4 (show PDK4 Antibodies) activity in Hepatocellular carcinoma cells increased cyclin E1 (show CCNE1 Antibodies), cyclin A2 (show CCNA2 Antibodies), and E2F1 proteins.
Data indicate that adenosine and CGS21680 upregulate CD39 (show ENTPD1 Antibodies) and CD73 via E2F-1 and CREB (show CREB1 Antibodies).
Expression of Kv10.1 (show KCNG3 Antibodies) driven by phosphorylated Rb/E2F1 contributes to G2/M progression of cancer and non-transformed cells.
Spinal cord injury-induced activation of E2F1-2 mediates cell cycle activation, contributing to gliopathy and neuronal/tissue loss associated with motor impairments and post-traumatic hyperesthesia.
Xphb1 represses E2F1 activity.
SIM (show SIM2 Antibodies) and SMR1 are involved in hyperphosphorylation of the cell-cycle regulator (show CDKN2A Antibodies) RBR1 and overexpression of E2F target genes.
S6K1 interacts with retinoblastoma protein RBR via its N-terminal RBR binding motif, promotes its nuclear localization and consequent RBR-dependent repression of cell cycle genes through transcription factor E2FB.
The Arabidopsis (Arabidopsis thaliana) DEL1 gene was identified as a transcriptional target of the classical E2Fb and E2Fc transcription factors.
The authors found that S6K1 associates with the Retinoblastoma-related 1 (RBR1)-E2FB complex and this is partly mediated by its N-terminal LVxCxE motif.
Results suggest that E2FB is one of the key targets for auxin to determine whether cells proliferate or whether they exit the cell cycle, enlarge, and endoreduplicate their DNA.
AtE2Fa and AtE2Fb have specific expression patterns and may play similar but distinct roles during cell cycle progression.
The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F2 and E2F3, have an additional cyclin binding domain. This protein binds preferentially to retinoblastoma protein pRB in a cell-cycle dependent manner. It can mediate both cell proliferation and p53-dependent/independent apoptosis.
, E2-promoter binding factor
, PRB-binding protein E2F-1
, retinoblastoma-associated protein 1
, retinoblastoma-binding protein 3
, transcription factor E2F1
, E2F-1 transcription factor