Browse our anti-E2F1 (E2F1) Antibodies

Full name:
anti-E2F Transcription Factor 1 Antibodies (E2F1)
On www.antibodies-online.com are 385 E2F Transcription Factor 1 (E2F1) Antibodies from 29 different suppliers available. Additionally we are shipping E2F1 Kits (18) and E2F1 Proteins (7) and many more products for this protein. A total of 438 E2F1 products are currently listed.
Synonyms:
ATE2FB, CG6376, dE2f, de2f1, def21, DmE2F-1, Dmel\\CG6376, Dp, drosE2F1, DRTF1/E2F, E(Sev-CycE)3A, E(var)3-93E, E(var)3-95E, E(var)93E, e2f, E2F-1, e2f1, E2FB, E2FB TRANSCRIPTION FACTOR, E2F TRANSCRIPTION FACTOR-1 E2F1, E2F transcription factor 1, Evar(3)164, l(3)07172, l(3)j3B1, l(3)j3C2, l(3)rM729, mKIAA4009, RBAP1, RBBP3, RBP3, xE2F
list all antibodies Gene Name GeneID UniProt
E2F1 1869 Q01094
E2F1 13555 Q61501
E2F1 399489  

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anti-Human E2F1 Antibodies:

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Top referenced anti-E2F1 Antibodies

  1. Human Polyclonal E2F1 Primary Antibody for WB - ABIN391858 : ODonnell, Wentzel, Zeller, Dang, Mendell: c-Myc-regulated microRNAs modulate E2F1 expression. in Nature 2005 (PubMed)
    Show all 6 references for 391858

  2. Human Polyclonal E2F1 Primary Antibody for EIA, WB - ABIN359768 : Wang, Hou, Mohapatra, Ma, Cress, Pledger, Chen: Activation of p27Kip1 Expression by E2F1. A negative feedback mechanism. in The Journal of biological chemistry 2005 (PubMed)
    Show all 5 references for 359768

  3. Human Polyclonal E2F1 Primary Antibody for EIA, WB - ABIN359769 : Joshi, Ordonez-Ercan, Dasgupta, Chellappan: Induction of human metallothionein 1G promoter by VEGF and heavy metals: differential involvement of E2F and metal transcription factors. in Oncogene 2005 (PubMed)
    Show all 5 references for 359769

  4. Human Polyclonal E2F1 Primary Antibody for EIA - ABIN358416 : Saberwal, Lucas, Janssen, Deobhakta, Hu, Galili, Raza, Mundle: Increased levels and activity of E2F1 transcription factor in myelodysplastic bone marrow. in International journal of hematology 2004 (PubMed)
    Show all 5 references for 358416

  5. Human Polyclonal E2F1 Primary Antibody for EIA, IHC (p) - ABIN358119 : Chaussepied, Ginsberg: Transcriptional regulation of AKT activation by E2F. in Molecular cell 2004 (PubMed)
    Show all 5 references for 358119

  6. Human Polyclonal E2F1 Primary Antibody for DB - ABIN650836 : Pulikkan, Dengler, Peramangalam, Peer Zada, Müller-Tidow, Bohlander, Tenen, Behre: Cell-cycle regulator E2F1 and microRNA-223 comprise an autoregulatory negative feedback loop in acute myeloid leukemia. in Blood 2010 (PubMed)
    Show all 4 references for 650836

  7. Human Monoclonal E2F1 Primary Antibody for IF, IHC (p) - ABIN115204 : Helin, Harlow: Heterodimerization of the transcription factors E2F-1 and DP-1 is required for binding to the adenovirus E4 (ORF6/7) protein. in Journal of virology 1994 (PubMed)

  8. Dog (Canine) Polyclonal E2F1 Primary Antibody for WB - ABIN2792180 : Unoki, Nishidate, Nakamura: ICBP90, an E2F-1 target, recruits HDAC1 and binds to methyl-CpG through its SRA domain. in Oncogene 2004 (PubMed)

  9. Dog (Canine) Polyclonal E2F1 Primary Antibody for WB - ABIN2792603 : Hu, Sun, Nadiminty, Lou, Pinder, Gao: Transcriptional regulation of human RANK ligand gene expression by E2F1. in Biochemical and biophysical research communications 2008 (PubMed)

More Antibodies against E2F1 Interaction Partners

Fruit Fly (Drosophila melanogaster) E2F Transcription Factor 1 (E2F1) interaction partners

  1. specific alternate transcripts of activator E2F (show E2F2 Antibodies), dE2F1, may have a dual function on cell cycle progression and cannot simply be viewed as a pro-proliferative transcription factor

  2. These findings identify a key function of E2F (show E2F2 Antibodies) in skeletal muscle required for animal viability, and illustrate how the cell cycle regulator (show CDKN2A Antibodies) is repurposed in post-mitotic cells.

  3. Mechanistically, miR (show MYLIP Antibodies)-998 operates by repressing dCbl, a negative regulator of EGFR (show EGFR Antibodies) signaling. Significantly, dCbl is a critical target of miR (show MYLIP Antibodies)-998 since dCbl phenocopies the effects of miR (show MYLIP Antibodies)-998 on dE2f1-dependent apoptosis in rbf (show ATP5I Antibodies) mutants

  4. also demonstrated that an optimum level of dLin52 is needed for dE2F1/2 activity on the hid promoter

  5. Results show that regulation of e2f1 and PCNA (show PCNA Antibodies) by DREF (show ZBED1 Antibodies) in vivo is complex and the regulation mechanism may differ with the tissue and/or positions in the tissue.

  6. Loss of dE2F compromises mitochondrial function.

  7. Data propose that the interaction between ORC5 (show ORC5 Antibodies) and dE2F1 may reflect a feedback mechanism between replication initiation proteins and dE2F1 that ensures that proliferating cells maintain a robust level of replication proteins for the next cell cycle.

  8. results suggest that E2F/DP complexes are essential for all genomic targeting of RBF1

  9. Inappropriate accumulation of E2f1 protein during S phase triggers the elimination of potentially hyperplastic cells via apoptosis in order to ensure normal development of rapidly proliferating tissues.

  10. endocycles of Drosophila are driven by a molecular oscillator in which the E2F1 transcription factor promotes CycE (show CCNE1 Antibodies) expression and S-phase initiation, S-phase then activates the CRL4(CDT2) ubiquitin ligase, and this in turn mediates the destruction of E2F1

Human E2F Transcription Factor 1 (E2F1) interaction partners

  1. Specific E2Fs also have prognostic value in breast cancer, independent of clinical parameters. We discuss here recent advances in understanding of the RB-E2F pathway in breast cancer. We also discuss the application of genome-wide genetic screening efforts to gain insight into synthetic lethal interactions of CDK4/6 (show CDK4 Antibodies) inhibitors in breast cancer for the development of more effective combination therapies.

  2. Here, we introduce a transcriptional signature to specifically track CDK2 (show CDK2 Antibodies) activity. It responds to genetic and chemical perturbations in the CDK (show CDK4 Antibodies)-RB-E2F axis, correlates with mitotic rate in vitro and in vivo and reacts rapidly to changes in CDK2 (show CDK2 Antibodies) activity during cell cycle progression

  3. E2F transcription factor 1 (E2F1) downregulated micrRNA miR (show MLXIP Antibodies)-519d directly and miR (show MLXIP Antibodies)-519d downregulated Ras homolog gene family member C (RhoC (show RHOC Antibodies)) directly.

  4. REVIEW: the data available so far indicate that the proliferative and apoptotic functions of E2F1 in Hepatocellular carcinoma (HCC (show FAM126A Antibodies)) may coexist but the proliferative effect seems to be more pronounced than the apoptotic one

  5. our results established the significance of activating the KLF6 (show KLF6 Antibodies)-E2F1 axis in aggressive primary metastatic clear cell renal cell carcinoma (show MOK Antibodies)

  6. High E2F1 expression is associated with glioma.

  7. H19 (show NCKAP1 Antibodies) is overexpressed and plays oncogenic role in PDAC through promoting cancer cell proliferation via the upregulation of E2F-1.

  8. E2F1 was significantly increased during Oral Tongue Carcinoma Metastasis.

  9. High E2F1 expression is associated with decreased radiosensitivity in nasopharyngeal carcinoma .

  10. nicotine-mediated induction of alpha7 nAChR (show CHRNA7 Antibodies) was reduced when E2F1 was depleted and in contrast elevated when STAT1 (show STAT1 Antibodies) was depleted by siRNAs.

Mouse (Murine) E2F Transcription Factor 1 (E2F1) interaction partners

  1. The evidence has been presented that the retinoblastoma protein utilizes a cell-cycle-independent interaction with E2F1 to recruit EZH2 (show EZH2 Antibodies) to diverse repeat sequences.

  2. germ-line loss of E2f1 or E2f3b, but not E2f3a, protected mice against hepatocellular carcinoma

  3. E2F1 hinders skin wound healing by suppressing VEGF (show VEGFA Antibodies) expression, neovascularization, and macrophage recruitment. Strategies that target E2F1 may enhance wound healing.

  4. systems-level control of cell cycle arrest by pRB (show PGR Antibodies)-E2F and p27 (show CDKN1B Antibodies)-CDK (show CDK4 Antibodies) regulation, is reported.

  5. TERT (show TERT Antibodies) has a role in neointima formation through epigenetic regulation of proliferative E2F1 target gene expression in smooth muscle cells.

  6. inhibition of PDK4 (show PDK4 Antibodies) activity in Hepatocellular carcinoma cells increased cyclin E1 (show CCNE1 Antibodies), cyclin A2 (show CCNA2 Antibodies), and E2F1 proteins.

  7. Data indicate that adenosine and CGS21680 upregulate CD39 (show ENTPD1 Antibodies) and CD73 via E2F-1 and CREB (show CREB1 Antibodies).

  8. Expression of Kv10.1 (show KCNG3 Antibodies) driven by phosphorylated Rb/E2F1 contributes to G2/M progression of cancer and non-transformed cells.

  9. Spinal cord injury-induced activation of E2F1-2 mediates cell cycle activation, contributing to gliopathy and neuronal/tissue loss associated with motor impairments and post-traumatic hyperesthesia.

  10. In the initial stage of myocyte differentiation, transcription of the YB-1 (show YBX1 Antibodies) gene was regulated by E2F1 and Sp1 (show SP1 Antibodies), and was then gradually replaced under the control of both MyoD (show MYOD1 Antibodies) and myogenin (show MYOG Antibodies).

Xenopus laevis E2F Transcription Factor 1 (E2F1) interaction partners

  1. Xphb1 represses E2F1 activity.

Arabidopsis thaliana E2F Transcription Factor 1 (E2F1) interaction partners

  1. SIM (show SIM2 Antibodies) and SMR1 are involved in hyperphosphorylation of the cell-cycle regulator (show CDKN2A Antibodies) RBR1 and overexpression of E2F target genes.

  2. S6K1 interacts with retinoblastoma protein RBR via its N-terminal RBR binding motif, promotes its nuclear localization and consequent RBR-dependent repression of cell cycle genes through transcription factor E2FB.

  3. The Arabidopsis (Arabidopsis thaliana) DEL1 gene was identified as a transcriptional target of the classical E2Fb and E2Fc transcription factors.

  4. The authors found that S6K1 associates with the Retinoblastoma-related 1 (RBR1)-E2FB complex and this is partly mediated by its N-terminal LVxCxE motif.

  5. Results suggest that E2FB is one of the key targets for auxin to determine whether cells proliferate or whether they exit the cell cycle, enlarge, and endoreduplicate their DNA.

  6. AtE2Fa and AtE2Fb have specific expression patterns and may play similar but distinct roles during cell cycle progression.

E2F1 Antigen Profile

Antigen Summary

The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F2 and E2F3, have an additional cyclin binding domain. This protein binds preferentially to retinoblastoma protein pRB in a cell-cycle dependent manner. It can mediate both cell proliferation and p53-dependent/independent apoptosis.

Alternative names and synonyms associated with E2F1

  • E2F transcription factor (E2f) antibody
  • E2F transcription factor 1 (E2F1) antibody
  • E2F transcription factor 1 (E2f1) antibody
  • E2F transcription factor 1 (e2f1) antibody
  • ATE2FB antibody
  • CG6376 antibody
  • dE2f antibody
  • de2f1 antibody
  • def21 antibody
  • DmE2F-1 antibody
  • Dmel\\CG6376 antibody
  • Dp antibody
  • drosE2F1 antibody
  • DRTF1/E2F antibody
  • E(Sev-CycE)3A antibody
  • E(var)3-93E antibody
  • E(var)3-95E antibody
  • E(var)93E antibody
  • e2f antibody
  • E2F-1 antibody
  • e2f1 antibody
  • E2FB antibody
  • E2FB TRANSCRIPTION FACTOR antibody
  • E2F TRANSCRIPTION FACTOR-1 E2F1 antibody
  • E2F transcription factor 1 antibody
  • Evar(3)164 antibody
  • l(3)07172 antibody
  • l(3)j3B1 antibody
  • l(3)j3C2 antibody
  • l(3)rM729 antibody
  • mKIAA4009 antibody
  • RBAP1 antibody
  • RBBP3 antibody
  • RBP3 antibody
  • xE2F antibody

Protein level used designations for E2F1

CG6376-PA , CG6376-PB , CG6376-PC , CG6376-PD , E2-promoter binding factor , E2f-PA , E2f-PB , E2f-PC , E2f-PD , PBR3 , PRB-binding protein E2F-1 , RBAP-1 , RBBP-3 , retinoblastoma-associated protein 1 , retinoblastoma-binding protein 3 , transcription factor E2F1 , E2F-1 transcription factor , E2F-1

GENE ID SPECIES
42550 Drosophila melanogaster
100069192 Equus caballus
1869 Homo sapiens
13555 Mus musculus
485839 Canis lupus familiaris
535369 Bos taurus
458184 Pan troglodytes
100036852 Xenopus laevis
396142 Gallus gallus
399489 Rattus norvegicus
100729531 Cavia porcellus
832283 Arabidopsis thaliana
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