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specific alternate transcripts of activator E2F (show E2F2 ELISA Kits), dE2F1, may have a dual function on cell cycle progression and cannot simply be viewed as a pro-proliferative transcription factor
These findings identify a key function of E2F in skeletal muscle required for animal viability, and illustrate how the cell cycle regulator is repurposed in post-mitotic cells.
Mechanistically, miR (show MYLIP ELISA Kits)-998 operates by repressing dCbl, a negative regulator of EGFR (show EGFR ELISA Kits) signaling. Significantly, dCbl is a critical target of miR (show MYLIP ELISA Kits)-998 since dCbl phenocopies the effects of miR (show MYLIP ELISA Kits)-998 on dE2f1-dependent apoptosis in rbf (show ATP5I ELISA Kits) mutants
also demonstrated that an optimum level of dLin52 is needed for dE2F1/2 activity on the hid promoter
Results show that regulation of e2f1 and PCNA by DREF in vivo is complex and the regulation mechanism may differ with the tissue and/or positions in the tissue.
Loss of dE2F compromises mitochondrial function.
Data propose that the interaction between ORC5 and dE2F1 may reflect a feedback mechanism between replication initiation proteins and dE2F1 that ensures that proliferating cells maintain a robust level of replication proteins for the next cell cycle.
results suggest that E2F/DP complexes are essential for all genomic targeting of RBF1
Inappropriate accumulation of E2f1 protein during S phase triggers the elimination of potentially hyperplastic cells via apoptosis in order to ensure normal development of rapidly proliferating tissues.
endocycles of Drosophila are driven by a molecular oscillator in which the E2F1 transcription factor promotes CycE (show CCNE1 ELISA Kits) expression and S-phase initiation, S-phase then activates the CRL4(CDT2) ubiquitin ligase, and this in turn mediates the destruction of E2F1
Taken together, this study reveals evidence demonstrating a mechanism by which the LPR6/ GSK3beta (show GSK3b ELISA Kits)/E2F1 axis-upregulated LSH (show HELLS ELISA Kits) promoted gliomas.
High E2F1 expression is associated with melanoma.
p63alpha protein up-regulates heat shock protein 70 (show HSP70 ELISA Kits) expression via E2F1 transcription factor 1 (show HNF1A ELISA Kits), promoting Wasf3/Wave3 (show WASF3 ELISA Kits)/MMP9 (show MMP9 ELISA Kits) signaling and bladder cancer invasion
E2F1 couples immune cell development to immune response.E2f1 role in the inflammation-associated cancers [review]
These data suggest a model in which cells experiencing oncogene (show RAB1A ELISA Kits)-induced replication stress through deregulation of E2F-dependent transcription.
Describe a regulatory loop miR (show MLXIP ELISA Kits)-218-CDK6 (show CDK6 ELISA Kits)/CyclinD1-E2F1 whose disruption may contribute to cell cycle progression in gastric cancer.
Results demonstrated that somatic mutation within E2F1:MIR136-5p target site impairs miRNA-mediated regulation and leads to increased gene activity.
Specific E2Fs also have prognostic value in breast cancer, independent of clinical parameters. We discuss here recent advances in understanding of the RB-E2F pathway in breast cancer. We also discuss the application of genome-wide genetic screening efforts to gain insight into synthetic lethal interactions of CDK4/6 (show CDK4 ELISA Kits) inhibitors in breast cancer for the development of more effective combination therapies.
Here, we introduce a transcriptional signature to specifically track CDK2 (show CDK2 ELISA Kits) activity. It responds to genetic and chemical perturbations in the CDK (show CDK4 ELISA Kits)-RB-E2F axis, correlates with mitotic rate in vitro and in vivo and reacts rapidly to changes in CDK2 (show CDK2 ELISA Kits) activity during cell cycle progression
E2F transcription factor 1 (E2F1) downregulated micrRNA miR (show MLXIP ELISA Kits)-519d directly and miR (show MLXIP ELISA Kits)-519d downregulated Ras homolog gene family member C (RhoC (show RHOC ELISA Kits)) directly.
The evidence has been presented that the retinoblastoma protein utilizes a cell-cycle-independent interaction with E2F1 to recruit EZH2 (show EZH2 ELISA Kits) to diverse repeat sequences.
germ-line loss of E2f1 or E2f3b, but not E2f3a, protected mice against hepatocellular carcinoma
E2F1 hinders skin wound healing by suppressing VEGF (show VEGFA ELISA Kits) expression, neovascularization, and macrophage recruitment. Strategies that target E2F1 may enhance wound healing.
systems-level control of cell cycle arrest by pRB (show PGR ELISA Kits)-E2F and p27 (show CDKN1B ELISA Kits)-CDK (show CDK4 ELISA Kits) regulation, is reported.
TERT (show TERT ELISA Kits) has a role in neointima formation through epigenetic regulation of proliferative E2F1 target gene expression in smooth muscle cells.
inhibition of PDK4 (show PDK4 ELISA Kits) activity in Hepatocellular carcinoma cells increased cyclin E1 (show CCNE1 ELISA Kits), cyclin A2 (show CCNA2 ELISA Kits), and E2F1 proteins.
Data indicate that adenosine and CGS21680 upregulate CD39 (show ENTPD1 ELISA Kits) and CD73 via E2F-1 and CREB (show CREB1 ELISA Kits).
Expression of Kv10.1 (show KCNG3 ELISA Kits) driven by phosphorylated Rb/E2F1 contributes to G2/M progression of cancer and non-transformed cells.
Spinal cord injury-induced activation of E2F1-2 mediates cell cycle activation, contributing to gliopathy and neuronal/tissue loss associated with motor impairments and post-traumatic hyperesthesia.
Xphb1 represses E2F1 activity.
SIM (show SIM2 ELISA Kits) and SMR1 are involved in hyperphosphorylation of the cell-cycle regulator RBR1 and overexpression of E2F target genes.
S6K1 interacts with retinoblastoma protein RBR via its N-terminal RBR binding motif, promotes its nuclear localization and consequent RBR-dependent repression of cell cycle genes through transcription factor E2FB.
The Arabidopsis (Arabidopsis thaliana) DEL1 gene was identified as a transcriptional target of the classical E2Fb and E2Fc transcription factors.
The authors found that S6K1 associates with the Retinoblastoma-related 1 (RBR1)-E2FB complex and this is partly mediated by its N-terminal LVxCxE motif.
Results suggest that E2FB is one of the key targets for auxin to determine whether cells proliferate or whether they exit the cell cycle, enlarge, and endoreduplicate their DNA.
AtE2Fa and AtE2Fb have specific expression patterns and may play similar but distinct roles during cell cycle progression.
The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F2 and E2F3, have an additional cyclin binding domain. This protein binds preferentially to retinoblastoma protein pRB in a cell-cycle dependent manner. It can mediate both cell proliferation and p53-dependent/independent apoptosis.
, E2-promoter binding factor
, PRB-binding protein E2F-1
, retinoblastoma-associated protein 1
, retinoblastoma-binding protein 3
, transcription factor E2F1
, E2F-1 transcription factor