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Nuclear-encoded mitochondrial MTO1 and MRPL41 are regulated in an opposite epigenetic mode based on estrogen receptor (show ESR1 Proteins) status in breast cancer.
Apoptosis-inducing ability of wild-type BMRP is blocked by Bcl-2 (show BCL2 Proteins) through several mechanisms.
region of BMRP required for the interaction with Bcl-2 (show BCL2 Proteins) is very relevant for the cell death-inducing activity of the protein
BMRP is a mitochondrial ribosomal protein involved in the regulation of cell death by apoptosis, probably affecting pathways mediated by Bcl-2 (show BCL2 Proteins) and caspases.
mitochondrial ribosomal protein L41 (MRPL41) is localized in the mitochondria, stabilizes the p53 (show TP53 Proteins) protein, and enhances its translocation to the mitochondria, thereby inducing apoptosis.
Overall, these results suggest that MRPL41 arrests the cell cycle by increasing the p21(WAF1/CIP1 (show CDKN1A Proteins)) and p27(Kip1 (show CDKN1B Proteins)) levels under the growth inhibitory conditions.
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein that belongs to the YmL27 ribosomal protein family.
, 39S ribosomal protein L41, mitochondrial
, mitochondrial ribosomal protein L41
, 39S ribosomal protein L27 homolog
, MRP-L27 homolog
, bcl-2-interacting mitochondrial ribosomal protein L41
, cell proliferation-inducing gene 3 protein
, proliferation-inducing gene 3
, 39S ribosomal protein L41-A, mitochondrial