Browse our PML (PML) ELISA Kits

On www.antibodies-online.com are 7 Promyelocytic Leukemia (PML) ELISA Kits from 6 different suppliers available. Additionally we are shipping PML Antibodies (156) and PML Proteins (8) and many more products for this protein. A total of 180 PML products are currently listed.
Synonyms:
1200009E24Rik, AI661194, MYL, PML, PP8675, RGD1562602, RNF71, Trim19
list all ELISA KIts Gene Name GeneID UniProt
PML 5371 P29590
Mouse PML PML 18854 Q60953
Rat PML PML 315713  

PML (PML) ELISA Kits by Reactivity

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Human Promyelocytic Leukemia (PML) interaction partners

  1. Data show that the cytoplasmic localization of promyelocytic leukaemia (PML) is mediated by its nuclear export in a chromosomal maintenance 1 (CRM1 (show XPO1 ELISA Kits))-dependent manner.

  2. this study, we first observed that PML-positive intranuclear aggregates also appeared in controls and were not specific for the Neuronal Intranuclear Hyaline Inclusion Disease cases.

  3. TRIB3 (show TRIB3 ELISA Kits) promotes acute promyelocytic leukemia progression through stabilization of the oncoprotein PML-RARalpha (show RARA ELISA Kits) and inhibition of p53 (show TP53 ELISA Kits)-mediated senescence.

  4. Data suggest that the binding of Z-10 to RXRalpha (show RXRA ELISA Kits) inhibited the interaction of RXRalpha (show RXRA ELISA Kits) with PML-RARalpha (show RARA ELISA Kits), leading to Z-10's selective induction of PML-RARalpha (show RARA ELISA Kits) degradation.

  5. PML protein prevents the loss of HPV genome following infection implying that the host cell may be able to recognize chromatinized HPV genome or the associated capsid proteins.

  6. findings demonstrate that the PML protein, which mediates an intrinsic immune response against human cytomegalovirus, specifically serves as an E3 ligase for SUMO modification of IE1p72.

  7. During infection, PML undergoes oxidation-mediated multimerization, associates with the nuclear matrix, and becomes de-SUMOylated due to the pore-forming activity of the Listeria toxin listeriolysin O (LLO).

  8. Data suggest PML (promyelocytic leukemia protein) positively regulates STAT1 (show STAT1 ELISA Kits) and STAT2 (show STAT2 ELISA Kits) isgylation, a ubiquitination-like protein modification; PML exhibits potent angiostatic activity, doing so in part by forming a positive feedforward loop with STAT1 (show STAT1 ELISA Kits)/2 and a negative feedback loop with STAT3 (show STAT3 ELISA Kits). (STAT (show STAT1 ELISA Kits) = signal transducer and activator of transcription (show STAT1 ELISA Kits))

  9. PML(nuclear localization signal -) was detected in primary acute promyelocytic leukemia (APL (show FASL ELISA Kits)), but not non-APL (show FASL ELISA Kits) cells. PML was localized to the nucleus, interacted with importin alpha (show KPNA4 ELISA Kits) in vivo, and co-localized in the PML nuclear bodies. PML(NLS (show ALDH1A2 ELISA Kits)-) was primarily localized in the cytoplasm and the interaction with importin alpha (show KPNA4 ELISA Kits) was lost

  10. These data suggest that CACUL1 is a novel regulator that negatively controls p53 (show TP53 ELISA Kits) activity through the regulation of PML SUMOylation.

Mouse (Murine) Promyelocytic Leukemia (PML) interaction partners

  1. Study found that Promyelocytic leukemia protein (PML) is broadly expressed across the gray matter, with the highest levels in the cerebral and cerebellar cortices. PML bodies are broadly involved in activity-dependent nuclear phenomena in adult neurons

  2. These findings suggest that the UBC9/PML/RNF4 axis plays a critical role as an important SUMO pathway in cardiac fibrosis. Modulating the protein levels of the pathway provides an attractive therapeutic target for the treatment of cardiac fibrosis and heart failure.

  3. PML contributes to the intrinsic restriction of HIV-1 infections in a cell type-dependent manner.

  4. both the PML-RARA (show RARA ELISA Kits)-driven competitive transplantation advantage and development of acute promyelocytic leukemia (APL (show FASL ELISA Kits)) required DNMT3A (show DNMT3A ELISA Kits)

  5. PML IV enhances global SUMO-1 (show SUMO1 ELISA Kits) conjugation, particularly that of p53 (show TP53 ELISA Kits), resulting in p53 (show TP53 ELISA Kits) stabilization and activation.

  6. our findings challenge the predominant model in the field and we propose that PML/RARA (show RARA ELISA Kits) initiates leukemia by subtly shifting cell fate decisions within the promyelocyte compartment.

  7. DNA-binding-defective PML/RARA (show RARA ELISA Kits) mutants could not repress the transcription of retinoic acid regulated genes.

  8. A novel antioxidative mechanism by which PML regulates cellular oxidant homeostasis by controlling complex II integrity and Nrf2 (show NFE2L2 ELISA Kits) activity and identified PML as an indispensable mediator of SFN (show SFN ELISA Kits) activity.

  9. pRB (show PGR ELISA Kits) can interact with PML specifically during senescence, suggesting that signaling events in senescence regulate assembly of PML and pRB (show PGR ELISA Kits) to establish heterochromatin and create a permanent cell cycle arrest.

  10. Data suggest that acute promyelocytic leukemia (APL (show FASL ELISA Kits)) differentiation is a default program triggered by clearance of promyelocytic leukemia-retinoic acid receptor alpha (show RARA ELISA Kits) fusion oncoprotein PML/RARA (show RARA ELISA Kits)-bound promoters.

PML Antigen Profile

Antigen Summary

The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This phosphoprotein localizes to nuclear bodies where it functions as a transcription factor and tumor suppressor. Its expression is cell-cycle related and it regulates the p53 response to oncogenic signals. The gene is often involved in the translocation with the retinoic acid receptor alpha gene associated with acute promyelocytic leukemia (APL). Extensive alternative splicing of this gene results in several variations of the protein's central and C-terminal regions\; all variants encode the same N-terminus. Alternatively spliced transcript variants encoding different isoforms have been identified.

Alternative names and synonyms associated with PML

  • promyelocytic leukemia (PML) Elisa Kit
  • promyelocytic leukemia (Pml) Elisa Kit
  • 1200009E24Rik Elisa Kit
  • AI661194 Elisa Kit
  • MYL Elisa Kit
  • PML Elisa Kit
  • PP8675 Elisa Kit
  • RGD1562602 Elisa Kit
  • RNF71 Elisa Kit
  • Trim19 Elisa Kit

Protein level used designations for Promyelocytic Leukemia (PML) ELISA Kits

promyelocytic leukemia , probable transcription factor PML , promyelocytic leukemia protein , protein PML , probable transcription factor PML-like , RING finger protein 71 , promyelocytic leukemia, inducer of , tripartite motif protein TRIM19 , tripartite motif-containing protein 19

GENE ID SPECIES
415302 Gallus gallus
415304 Gallus gallus
453736 Pan troglodytes
700379 Macaca mulatta
100138545 Bos taurus
100388843 Callithrix jacchus
100607016 Nomascus leucogenys
5371 Homo sapiens
18854 Mus musculus
315713 Rattus norvegicus
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