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Human TP53I3 Protein expressed in Escherichia coli (E. coli) - ABIN667007
Porté, Valencia, Yakovtseva, Borràs, Shafqat, Debreczeny, Pike, Oppermann, Farrés, Fita, Parés: Three-dimensional structure and enzymatic function of proapoptotic human p53-inducible quinone oxidoreductase PIG3. in The Journal of biological chemistry 2009
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our data suggest that high expression of p53 (show TP53 Proteins)-inducible gene 3 is significant for glioblastoma inhibition and p53 (show TP53 Proteins)-inducible gene 3 independently indicates good prognosis in patients, which might be a novel prognostic biomarker or potential therapeutic target in glioblastoma.
Data indicate that knockdown of p53 (show TP53 Proteins)-induced gene 3 (PIG-3 (show MRPL41 Proteins)) expression by small interfering RNA (siRNA) treatment can inhibit the generation of reactive oxygen species (ROS (show ROS1 Proteins)).
The results suggested that PIG3 (show MRPL41 Proteins) plays an oncogenic role in PTC (show F9 Proteins) via the regulation of the PI3K (show PIK3CA Proteins)/AKT (show AKT1 Proteins)/PTEN pathway and support the exploration of PIG3 (show MRPL41 Proteins) as a novel biomarker for patients with papillary thyroid carcinoma
PIG3 (show MRPL41 Proteins), which functions in DNA damage repair, uses an unexpected catalytic mechanism to suppress Rho-ROCK activity and impair tumor invasion in vivo. This regulation was suppressed by antioxidants.
prohibitin (show PHB Proteins) and prohibiton (PHB2 (show PHB2 Proteins)) contribute to PIG3 (show MRPL41 Proteins)-mediated apoptosis by binding to the PIG3 (show MRPL41 Proteins) promoter (TGYCC)15 motif
study provides evidence that the variant genotypes of (TGYCC)n repeats in the PIG3 (show MRPL41 Proteins) promoter are functional and associated with risk of squamous cell carcinoma of the head and neck in a non-Hispanic white population
a novel signaling pathway of GPx3 (show GPX3 Proteins)-PIG3 (show MRPL41 Proteins) in the regulation of cell death in prostate cancer.
certain p53 (show TP53 Proteins) mutatants activate PIG3 (show MRPL41 Proteins), whereas the result of our study show increased full-length transcript expression in tumor counterparts
Results suggest that PIG3 (show MRPL41 Proteins) is a critical component of the DNA damage response pathway and has a direct role in the transmission of the DNA damage signal from damaged DNA to the intra-S and G2/M checkpoint machinery.
p53 (show TP53 Proteins) activity and PIG3 (show MRPL41 Proteins) gene function are uncoupled by UV-dependent alternative splicing through rapid proteolytic degradation
The protein encoded by this gene is similar to oxidoreductases, which are enzymes involved in cellular responses to oxidative stresses and irradiation. This gene is induced by the tumor suppressor p53 and is thought to be involved in p53-mediated cell death. It contains a p53 consensus binding site in its promoter region and a downstream pentanucleotide microsatellite sequence. P53 has been shown to transcriptionally activate this gene by interacting with the downstream pentanucleotide microsatellite sequence. The microsatellite is polymorphic, with a varying number of pentanucleotide repeats directly correlated with the extent of transcriptional activation by p53. It has been suggested that the microsatellite polymorphism may be associated with differential susceptibility to cancer. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
quinone oxidoreductase PIG3
, tumor protein p53 inducible protein 3
, quinone oxidoreductase PIG3-like
, p53-induced gene 3 protein
, quinone oxidoreductase homolog