Browse our XPC Proteins (XPC)

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Xeroderma Pigmentosum, Complementation Group C Proteins (XPC)
On are 8 Xeroderma Pigmentosum, Complementation Group C (XPC) Proteins from 5 different suppliers available. Additionally we are shipping XPC Antibodies (99) and XPC Kits (10) and many more products for this protein. A total of 118 XPC products are currently listed.
list all proteins Gene Name GeneID UniProt
XPC 7508 Q01831
Mouse XPC XPC 22591 P51612
XPC 312560  

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Human Xeroderma Pigmentosum, Complementation Group C (XPC) interaction partners

  1. Allelic variants in the gene XPC are not associated with an increased risk for developing pre-senile cataract

  2. XPC dissociation from the damage site could become a rate-limiting step in nucleotide excision repair (NER (show NR1H2 Proteins)) of certain types of DNA adducts, leading to repression of NER (show NR1H2 Proteins).

  3. Histone deacetylation plays a significant role in the process of DNA damage recognition for nucleotide excision repair and the localization and functions of XPC can be regulated by acetylated states of histones.

  4. The risk of esophageal squamous cell carcinoma associated with XPC rs-2228000 was determined. A homozygous minor allele showed strong association with ESCC risk, especially in smokers, those in adobe houses, and drinkers of salt tea. Variant genotypes of both XPA (show XPA Proteins) and XPC in combination showed an increased risk towards ESCC.

  5. the associations between three XPC gene polymorphisms (rs2228001 A>C, rs2228000 C>T, and rs2229090 G>C) and neuroblastoma risk with 256 neuroblastoma patients and 531 healthy controls in a Chinese Han population, were investigated.

  6. XPC polymorphisms are associated with gastric cancer and atrophic gastritis risks.

  7. A chirality change in XPC- and Sfi1 (show SFI1 Proteins)-derived peptides affects their affinity for centrin (show CETN1 Proteins).

  8. XPC intron11 C/A polymorphism was associated with an increased risk of prostate cancer. Among non-smokers, the A/A genotype was significantly more prevalent in prostate cancer patients than in controls.

  9. No association between XPC polymorphisms and grades/stages of tumors, but report significant association between XPC PAT and reduction of prostate cancer risk in this group of patients.

  10. Structural insight into the mechanism of TFIIH (show GTF2H1 Proteins) recognition by the acidic string of the nucleotide excision repair factor XPC has been uncovered.

Mouse (Murine) Xeroderma Pigmentosum, Complementation Group C (XPC) interaction partners

  1. results suggest that XPC may help repair DNA damage caused by KRAS-mediated production of ROS (show ROS1 Proteins).

  2. OCT4 (show POU5F1 Proteins) and SOX2 (show SOX2 Proteins) are the primary transcription factors recruiting SCC (show CYP11A1 Proteins) to regulatory regions of pluripotency genes; the XPC subunit is essential for interaction with the two proteins

  3. progerin and p16(INK4a) expression, beta-galactosidase (show GLB1 Proteins) activity, and reactive oxygen species, which increase with age, were higher in young Xpc(-/-) mice than in young Xpc(+/+) ones

  4. Study indicates that Xpc(-/-) mice have an increased mutational load upon induction of oxidative stress. The effect of non-functional XPC in vivo appears to have implications in mutagenesis, which can contribute to the carcinogenesis process.

  5. The C-terminal region of Xpc is dispensable for the transcriptional activity of Oct3/4 (show POU5F1 Proteins) in mouse embryonic stem cells.

  6. BRAF (show BRAF Proteins)(V600E) and ARF deletion synergize to inhibit nucleotide excision repair by epigenetically repressing XPC.

  7. Dysmyelination not demyelination causes neurological symptoms in preweaned mice in a cs-b xp-c murine model of Cockayne syndrome

  8. analysis of mHR23A (show RAD23A PLURAL_@39359@)/B double-mutant cells showed that HR23 proteins function in nucleotide excision repair by governing xeroderma pigmentosum group C protein (show HNRNPC PLURAL_@39359@) stability via partial protection against proteasomal degradation

  9. mutational hot spot is not at a dipyrimidine site and is apparently Xpc-specific, suggesting some form of non-dipyrimidine base damage is normally repaired in a manner distinct from conventional nucleotide excision repair, but that requires XPC protein

  10. Deletion of Gadd45a (show GADD45A Proteins) alone does not lead to increased lung tumors in mice, but coupled with an XPC deletion, it results in lung tumor progression

XPC Protein Profile

Protein Summary

This gene encodes a component of the nucleotide excision repair (NER) pathway. There are multiple components involved in the NER pathway, including Xeroderma pigmentosum (XP) A-G and V, Cockayne syndrome (CS) A and B, and trichothiodystrophy (TTD) group A, etc. This component, XPC, plays an important role in the early steps of global genome NER, especially in damage recognition, open complex formation, and repair protein complex formation. Mutations in this gene or some other NER components result in Xeroderma pigmentosum, a rare autosomal recessive disorder characterized by increased sensitivity to sunlight with the development of carcinomas at an early age. Alternatively spliced transcript variants have been found for this gene.

Alternative names and synonyms associated with XPC

  • xeroderma pigmentosum, complementation group C (XPC)
  • xeroderma pigmentosum, complementation group C (LOC100346279)
  • xeroderma pigmentosum, complementation group C (Xpc)
  • RAD4 protein
  • XP3 protein
  • XPCC protein

Protein level used designations for XPC

xeroderma pigmentosum, complementation group C , DNA repair protein complementing XP-C cells , mutant xeroderma pigmentosum group C , p125 , DNA repair protein complementing XP-C cells homolog , xeroderma pigmentosum group C-complementing protein homolog

100050424 Equus caballus
100346279 Oryctolagus cuniculus
7508 Homo sapiens
476521 Canis lupus familiaris
100514251 Sus scrofa
524274 Bos taurus
22591 Mus musculus
312560 Rattus norvegicus
100719007 Cavia porcellus
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