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Browse our XPC Proteins (XPC)

Full name:
Xeroderma Pigmentosum, Complementation Group C Proteins (XPC)
On www.antibodies-online.com are 5 Xeroderma Pigmentosum, Complementation Group C (XPC) Proteins from 5 different suppliers available. Additionally we are shipping XPC Antibodies (93) and XPC Kits (18) and many more products for this protein. A total of 117 XPC products are currently listed.
Synonyms:
RAD4, XP3, XPCC
list all proteins Gene Name GeneID UniProt
XPC 7508 Q01831
Mouse XPC XPC 22591 P51612
XPC 312560  

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XPC Proteins (XPC) by Origin

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Human Xeroderma Pigmentosum, Complementation Group C (XPC) interaction partners

  1. No association between XPC polymorphisms and grades/stages of tumors, but report significant association between XPC PAT and reduction of prostate cancer risk in this group of patients.

  2. Structural insight into the mechanism of TFIIH (show GTF2H1 Proteins) recognition by the acidic string of the nucleotide excision repair factor XPC has been uncovered.

  3. the present study demonstrates a novel mutation in the XPC gene that may be affecting mRNA synthesis with milder phenotypes.

  4. XPC gene Lys939Gln polymorphism is significantly associated with increased risk of mitral chordae tendineae rupture.

  5. eIF3a (show EIF6 Proteins) improves ovarian cancer patients' response to cisplatin-based chemotherapy by down regulating XPC and p27(Kip1 (show CDKN1B Proteins)).

  6. Missense mutations in the XPC gene may allow partial functionality that could explain this unusual late onset XP. Atypical clinical presentation of XPC could be misdiagnosed when genetic aberrations allow partial DNA repair capacity.

  7. A novel role for the XPC protein in regulating APE1 (show APEX1 Proteins) and OGG1 (show OGG1 Proteins) expression and activity: XPC protein interacts physically with APE1 (show APEX1 Proteins) but not with OGG1 (show OGG1 Proteins).XPC is required for OGG1 (show OGG1 Proteins) activity.

  8. the release of NER (show NR1H2 Proteins) components such as DNA damage binding protein 2 (DDB2 (show DDB2 Proteins)) and Xeroderma Pigmentosum complementation group C protein (show HNRNPC Proteins) (XPC) following oxidative stress might putatively involve their apoptotic role rather than DNA repair function.

  9. These data suggest that RNF111 (show RNF111 Proteins), together with the CRL4(DDB2 (show DDB2 Proteins)) ubiquitin ligase complex, is responsible for sequential XPC ubiquitylation, which regulates the recruitment and release of XPC and is crucial for efficient progression of the NER (show NR1H2 Proteins) reaction.

  10. Data show increased risk of leukemia with XPCC protein (XPC) 939Gln/Gln genotype, ERCC2 (show ERCC2 Proteins) protein (XPD (show ERCC2 Proteins)) 751Gln allele may be protective against chronic myeloid leukemia (show BCL11A Proteins) and acute myeloid leukemia (show BCL11A Proteins), and no significant risk for the ERCC5 (show ERCC5 Proteins) protein (XPG (show ERCC5 Proteins)) gene.

Mouse (Murine) Xeroderma Pigmentosum, Complementation Group C (XPC) interaction partners

  1. results suggest that XPC may help repair DNA damage caused by KRAS-mediated production of ROS (show ROS1 Proteins).

  2. OCT4 (show POU5F1 Proteins) and SOX2 (show SOX2 Proteins) are the primary transcription factors recruiting SCC (show CYP11A1 Proteins) to regulatory regions of pluripotency genes; the XPC subunit is essential for interaction with the two proteins

  3. progerin and p16(INK4a) expression, beta-galactosidase (show GLB1 Proteins) activity, and reactive oxygen species, which increase with age, were higher in young Xpc(-/-) mice than in young Xpc(+/+) ones

  4. Study indicates that Xpc(-/-) mice have an increased mutational load upon induction of oxidative stress. The effect of non-functional XPC in vivo appears to have implications in mutagenesis, which can contribute to the carcinogenesis process.

  5. The C-terminal region of Xpc is dispensable for the transcriptional activity of Oct3/4 (show POU5F1 Proteins) in mouse embryonic stem cells.

  6. BRAF (show BRAF Proteins)(V600E) and ARF deletion synergize to inhibit nucleotide excision repair by epigenetically repressing XPC.

  7. Dysmyelination not demyelination causes neurological symptoms in preweaned mice in a cs-b xp-c murine model of Cockayne syndrome

  8. analysis of mHR23A (show RAD23A Proteins)/B double-mutant cells showed that HR23 proteins function in nucleotide excision repair by governing xeroderma pigmentosum group C protein (show HNRNPC Proteins) stability via partial protection against proteasomal degradation

  9. mutational hot spot is not at a dipyrimidine site and is apparently Xpc-specific, suggesting some form of non-dipyrimidine base damage is normally repaired in a manner distinct from conventional nucleotide excision repair, but that requires XPC protein

  10. Deletion of Gadd45a (show GADD45A Proteins) alone does not lead to increased lung tumors in mice, but coupled with an XPC deletion, it results in lung tumor progression

XPC Protein Profile

Protein Summary

This gene encodes a component of the nucleotide excision repair (NER) pathway. There are multiple components involved in the NER pathway, including Xeroderma pigmentosum (XP) A-G and V, Cockayne syndrome (CS) A and B, and trichothiodystrophy (TTD) group A, etc. This component, XPC, plays an important role in the early steps of global genome NER, especially in damage recognition, open complex formation, and repair protein complex formation. Mutations in this gene or some other NER components result in Xeroderma pigmentosum, a rare autosomal recessive disorder characterized by increased sensitivity to sunlight with the development of carcinomas at an early age. Alternatively spliced transcript variants have been found for this gene.

Alternative names and synonyms associated with XPC

  • xeroderma pigmentosum, complementation group C (XPC)
  • xeroderma pigmentosum, complementation group C (LOC100346279)
  • xeroderma pigmentosum, complementation group C (Xpc)
  • RAD4 protein
  • XP3 protein
  • XPCC protein

Protein level used designations for XPC

xeroderma pigmentosum, complementation group C , DNA repair protein complementing XP-C cells , mutant xeroderma pigmentosum group C , p125 , DNA repair protein complementing XP-C cells homolog , xeroderma pigmentosum group C-complementing protein homolog

GENE ID SPECIES
100050424 Equus caballus
100346279 Oryctolagus cuniculus
7508 Homo sapiens
476521 Canis lupus familiaris
100514251 Sus scrofa
524274 Bos taurus
22591 Mus musculus
312560 Rattus norvegicus
100719007 Cavia porcellus
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