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Human DPP4 ELISA Kit for Sandwich ELISA - ABIN625276
Ahmed, Huri, Al-Hamodi, Salem, Muniandy: Serum Levels of Soluble CD26/Dipeptidyl Peptidase-IV in Type 2 Diabetes Mellitus and Its Association with Metabolic Syndrome and Therapy with Antidiabetic Agents in Malaysian Subjects. in PLoS ONE 2015
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Mouse (Murine) DPP4 ELISA Kit for Sandwich ELISA - ABIN1979371
Lu, Huang, Shih, Chang, Tsai, Lin, Shih: Dipeptidyl peptidase-4 inhibitor decreases abdominal aortic aneurysm formation through GLP-1-dependent monocytic activity in mice. in PLoS ONE 2015
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Human DPP4 ELISA Kit for Sandwich ELISA - ABIN416782
Ma, Li, Li, Wen, Li, Zhang, Zhang, Yu, Li: Expression of recombinant human α-lactalbumin in milk of transgenic cloned pigs is sufficient to enhance intestinal growth and weight gain of suckling piglets. in Gene 2016
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Mouse (Murine) DPP4 ELISA Kit for Sandwich ELISA - ABIN415415
Shih, Chen, Lin, Tsao, Wu, Kao, Chiang, Li, Chang, Lin, Huang, Lin: MK-0626, a dipeptidyl peptidase-4 inhibitor, improves neovascularization by increasing both the number of circulating endothelial progenitor cells and endothelial nitric oxide synthetase expression. in Current medicinal chemistry 2014
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Ervinna, Mita, Yasunari, Azuma, Tanaka, Fujimura, Sukmawati, Nomiyama, Kanazawa, Kawamori, Fujitani, Watada: Anagliptin, a DPP-4 inhibitor, suppresses proliferation of vascular smooth muscles and monocyte inflammatory reaction and attenuates atherosclerosis in male apo E-deficient mice. in Endocrinology 2013
Rat (Rattus) DPP4 ELISA Kit for Sandwich ELISA - ABIN431400
Nakashima, Matsui, Takeuchi, Yamagishi: Linagliptin blocks renal damage in type 1 diabetic rats by suppressing advanced glycation end products-receptor axis. in Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme 2014
suggests that DPP4 T-molecules have modified binding and functions compared with their FL counterparts and may serve regulatory roles in normal and malignant hematopoiesis
Analysis of both the structures and inhibitory activities suggests that the binding of the trifluorophenyl moiety in the S1 pocket and the piperazine-2-one moiety have hydrophobic interactions with Phe357 in the S2 extensive subsite, and that the multiple hydrogen bonds made by the (R)-beta-amine group in the S2 pocket and the contacts made by the (R)-tert (show TERT ELISA Kits)-butyl group with Arg125 contribute to the high potency observed...
the selective expression of DPP4 on the surface of senescent cells enables their preferential elimination.
Study shows that increased DPP4 activities are independently associated with mild cognitive impairment in elderly patients with type 2 diabetes.
A common variant, i.e., single nucleotide polymorphism rs6741949, in the DPP4 gene interacts with body adiposity and negatively affects glucose-stimulated GLP-1 (show GCG ELISA Kits) levels, insulin (show INS ELISA Kits) secretion, and glucose tolerance.
CUX-1 (show CUX1 ELISA Kits) overexpression enhanced TNF (show TNF ELISA Kits)- production on sCD26 (show CDC26 ELISA Kits)/LPS (show IRF6 ELISA Kits) stimulation, while CUX-1 (show CUX1 ELISA Kits) depletion had no effect. Neither CUX-1 (show CUX1 ELISA Kits) overexpression nor CUX-1 (show CUX1 ELISA Kits) depletion had an effect on IL-6 (show IL6 ELISA Kits) stimulation. These results are discussed in the context of a model that describes the mechanisms by which stimulation of monocytic cells by sCD26 (show CDC26 ELISA Kits) and LPS (show IRF6 ELISA Kits) leads to elevation of TNF (show TNF ELISA Kits)- and IL-6 (show IL6 ELISA Kits) expression.
Increased plasma DPP-4 activity may correlate with aneurysmal development. CD26 on monocytes plays a critical role in cell differentiation, possibly mediated by extracellular signal-regulated protein kinase (show CDK7 ELISA Kits) 1/2-p21 (show CDKN1A ELISA Kits) axis signaling pathways and cytoskeletal proteins reassembly.
Plasma DPP4 activity is significantly associated with NAFLD (show TSC2 ELISA Kits). The underlying mechanisms may be partly attributed to the interactions between insulin (show INS ELISA Kits) resistance, oxidative stress, inflammation, and DPP4.
CD26+ fibroblasts possess proliferation advantage in comparison to CD26- fibroblasts, and the advantage caused expansion of CD26 positive fibroblast population promotes keloid progression.
MFSD2B, CCL20 (show CCL20 ELISA Kits) and STAT1 (show STAT1 ELISA Kits), or STARD7 and ZNF512 (show ZNF512 ELISA Kits) genes may be risk or protect factors in prognosis of ADC (show ADC ELISA Kits); HTR2B (show HTR2B ELISA Kits), DPP4, and TGFBRAP1 (show TGFBRAP1 ELISA Kits) genes may be risk factors in prognosis of SQC (show QPCT ELISA Kits).
Results describe a proline-rich cytokine from neurosecretory granules that represents a new natural substrate for Dipeptidyl Peptidase IV (DPPIV).
Data demonstrate that dipeptidyl peptidase II (show DPP7 ELISA Kits) can form a complex with adenosine deaminase (show ADA ELISA Kits), but with one order of magnitude higher dissociation constant than that of DPPIV.
This study shows that porcine DPP-IV is generally inhibited with greater potency by protein-derived peptides than is the human enzyme
DPP-IV from porcine kidney cortex was characterized.
Neutral endopeptidase 24.11 (show MME ELISA Kits) and DPP-IV is superior to DPP-IV inhibition alone in preserving intact GLP-1 (show GCG ELISA Kits), which implies possibility that the combination has therapeutic potential.
Results describe the distribution of dipeptidyl peptidase IV-like activity enzymes in porcine tissue sections by RT-PCR.
SGLT-2 (show SLC5A2 ELISA Kits) inhibition with dapagliflozin reduces the activation of the Nlrp3 (show NLRP3 ELISA Kits)/ASC (show STS ELISA Kits) inflammasome and attenuates the development of diabetic cardiomyopathy in mice with type 2 diabetes. Effects are augmentated of the by DPP4 inhibitor Saxagliptin.
DPP-4 inhibitor teneligliptin inhibited atherogenesis in ApoE (show APOE ELISA Kits) knockout mice, at least partially, through attenuation of the inflammatory phenotype of perivascular adipose tissue.
Increased plasma DPP-4 activity may correlate with aneurysmal development. CD26 on monocytes plays a critical role in cell differentiation, possibly mediated by extracellular signal-regulated protein kinase (show CDK7 ELISA Kits) 1/2-p21 axis signaling pathways and cytoskeletal proteins reassembly.
High DPP4 expression is associated with cardiac ischemia and systolic dysfunction.
DPP4:CD9:TTSP as the protein complexes are necessary for early efficient MERS-coronavirus entry.
these findings identify distinct roles for DPP4 in the endothelial cell versus the bone marrow compartment for selective incretin degradation and DPP4 inhibition-mediated glucoregulation.
The trimeric form receptor-binding domain of MERS-CoV spike protein bound strongly to the receptor of MERS-CoV, dipeptidyl peptidase 4 (DPP4), and elicited robust RBD (show CACNA1D ELISA Kits)-specific neutralizing antibodies in mice.
the data show that glucose-induced expression of Dpp4 in the liver is facilitated by demethylation of the Dpp4 gene early in life. This might contribute to early deteriorations in hepatic function, which in turn result in metabolic disease such as hepatosteatosis later in life.
study reveals a cross talk between ATR (show ATR ELISA Kits) signaling and DPP4 activation in the regulation of megalin (show LRP2 ELISA Kits) and underscores the significance of targeting DPP4 in the prevention of obesity related kidney injury progression.
Data (including data from studies in knockout mice) suggest that Cd26 (dipeptidyl peptidase IV) plays role in development and progression vs. resolution of ulcerative colitis; Cd26 deficiency in knockout mice is associated with heightened response to DSS (show PMP22 ELISA Kits) (dextran sulfate sodium) in inducing colitis and is accompanied by increased expression of NF-kappaB (show NFKB1 ELISA Kits) p65 (show NFkBP65 ELISA Kits) subunit and distinct changes in leukocyte trafficking/infiltra...
The protein encoded by this gene is identical to adenosine deaminase complexing protein-2, and to the T-cell activation antigen CD26. It is an intrinsic membrane glycoprotein and a serine exopeptidase that cleaves X-proline dipeptides from the N-terminus of polypeptides.
, DPP IV
, T-cell activation antigen CD26
, adenosine deaminase complexing protein 2
, dipeptidyl peptidase 4
, dipeptidyl peptidase IV
, dipeptidylpeptidase 4
, dipeptidylpeptidase IV (CD26, adenosine deaminase complexing protein 2)
, activation molecule 3
, adenosine deaminase complexing protein
, dipeptidyl-peptidase 4 (CD26, adenosine deaminase complexing protein 2)
, dipeptidyl-peptidase iv
, dipeptidyl-peptidase 4
, dipeptidyl-peptidase IV
, dipeptidylpeptidase IV
, thymocyte-activating molecule
, GP110 glycoprotein
, bile canaliculus domain-specific membrane glycoprotein