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Study describes a zebrafish 2 kb glutamyl aminopeptidase (enpep) promoter fragment, and shows that it can drive gene expression specifically in the kidney during early and late development.
de-regulation of both PITX2 (show PITX2 ELISA Kits) and ENPEP could contribute to an increased risk of atrial fibrillation in carriers of disease-associated variants.
Demonstrate a novel role of APA in ANG-(1 (show ANGPT1 ELISA Kits)-7) metabolism and suggest that the upregulation of APA, which occurs after myocardial infarction, may deprive the heart of cardioprotective ANG-(1 (show ANGPT1 ELISA Kits)-7).
Ischemia-induced angiogenesis is impaired in APA-KO mice partly through decreased HIF-1alpha (show HIF1A ELISA Kits) stability by proteasomal degradation and subsequent suppression of HIF-1alpha (show HIF1A ELISA Kits)-driven target protein expression such as growth factors.
Replacement of active site residue glutamate (show GRIN1 ELISA Kits)-215 of aminopeptidase A with aspartate or alanine leads to a strong decrease in the rate of hydrolysis of the synthetic substrate alpha-L-glutamyl-beta-naphthylamide.
the C-terminal domain of aminopeptidase A acts as an intramolecular chaperone
Lack of angiotensin II conversion to angiotensin III increases water but not alcohol consumption in aminopeptidase A-deficient mice.Elevated central concentrations of the vasopressor octapeptide angiotensin (Ang) II (show AGT ELISA Kits) increase the water intake in mammals.
Results demonstrate a key role of Thr (show TRH ELISA Kits)-348 in substrate specificity of aminopeptidase A for N-terminal acidic amino acids by insuring the optimal positioning of the substrate during catalysis.
The substrate Angiotensin II, the enzymes aminopeptidases-A, B, M as well as IRAP (show IL1RN ELISA Kits) were detected in the jejunal mucosa.
miR-125b acts as a tumor suppressor in breast tumorigenesis via its novel direct targets ENPEP, CK2-alpha, CCNJ, and MEGF9.
These results explain the calcium-modulated substrate specificity of APA in central hypertension regulation
There was no significant alteration in plasma APA activity in the patients with Chagas disease or dilated cardiomyopathies, as compared with that in health controls
Rieger syndrome with microdeletions including only the PITX2 (show PITX2 ELISA Kits) and ENPEP (glutamyl aminopeptidase) genes.
Data show that APA appears to be an essential enzyme in the control of blood pressure via degradation of Angiotensin II.
Data show that aminopeptidase A (APA) plays important roles in the regulation of blood pressure under both the physiological and pathological conditions.
Data show that brain aminopeptidases act upon Ang I (show AGT ELISA Kits), Ang II (show AGT ELISA Kits) and Ang III (show AGT ELISA Kits) in order to activate brain AT(1) receptors.
rare and common variation in ENPEP may contribute to the development of renal and hypertensive disorders and warrants further study
The presence of APA in several human brain nuclei sensitive to angiotensins and involved in blood pressure regulation suggests that APA in humans is an integral component of the brain renin (show REN ELISA Kits) angiotensin system.
ectoenzyme that selectively hydrolyzes acidic amino acid residues from the amino terminus of oligopeptides
glutamyl aminopeptidase (aminopeptidase A)
, aminopeptidase A
, glutamyl aminopeptidase
, BP-1/6C3 antigen
, differentiation antigen gp160